Feasibility Of Design Research Articles

Tumor Microenvironment‐Activatable Metal‐Phenolic Nanoformulations for Ultrasound‐Boosted Ferroptosis through Triple Regulatory Pathways

AbstractDespite its effectiveness in exterminating tumor cells, ferroptosis is seriously hampered by the high expression of antioxidant glutathione (GSH) and the inadequacy of endogenous H2O2 in tumors. Herein, metal‐phenolic nanoformulations (FNCP NFs) composed of sonosensitizer Chlorin e6 (Ce6), the phenolic GSH consumer naphthazarin, and Fe3+, followed by the modification of PEG2000, are strategically designed and fabricated for ultrasound‐boosted ferroptosis in tumor cells through triple regulatory pathways. The carrier‐free FNCP NFs can rapidly dissociate under tumor microenvironment response with the assistance of ultrasound, releasing Fe2+, Ce6, and naphthazarin. Ce6 and Fe2+ are capable of producing singlet oxygen (1O2) and hydroxyl radicals (·OH) by ultrasound‐activated sonodynamic therapy and Fenton reaction‐mediated chemodynamic therapy (CDT), respectively, which not only induce apoptotic cell death but also lead to the effective accumulation of lipid peroxidation (LPO), resulting in ferroptosis. Meanwhile, the released naphthazarin and the self‐cycling valence alternations of Fe3+/Fe2+ promote the significant decrease of intracellular GSH contents, further inducing the inactivation of glutathione peroxidase 4 (GPX4) and the up‐regulation of LPO levels, eventually realizing the synergistically enhanced ferroptosis. This facile and feasible design for versatile metal‐phenolic nanoformulations offers a new strategy for effectively improving ferroptosis efficiency and multimodal cancer therapies.

Analysis, optimization, and testing of a tilt-body aircraft

This paper proposes a new multidisciplinary design optimization framework for tilt-bodies to obtain the optimal combination of geometry and powertrain, achieving both long endurance and low transition power consumption at a 5 kg takeoff weight. A low-fidelity vortex lattice method is used to derive the aerodynamic coefficients. The tandem wings are trimmed using an optimization-based method, considering the effect of distributed propulsion on the trim solution through aero-propulsive interaction at low flight speed. Detailed powertrain parameters are fitted with fewer design variables to calculate power consumption. By analyzing the unique constraints of tilt-bodies, the optimization problem is established as a simultaneous analysis and design architecture, and solved with different numbers of rotors. The impact of the relative geometric relationship between the front and rear wings on aerodynamic performance and constraints is analyzed. Results demonstrate the full angle-of-attack flight capability of tilt-bodies. The optimal design can save nearly 1000 W in transition, with a pure cruise endurance of over 1 hour, which is competitive among other configurations. With an empty weight of only 2 kg, a portion of the battery can be allocated to a heavier payload. High-fidelity computational fluid dynamics corrects the errors of the vortex lattice method on non-lifting components, including the fuselage, nacelles, and landing gear. Finally, the feasibility of the optimal design and the accuracy of the framework are validated by wind tunnel tests and in-flight drag measurements on a test platform.

Methodology for optimally designing hydrogen refueling station barriers using RSM and ANN: Considering explosion and jet fire

Hydrogen is gaining attention as a sustainable energy source with the potential to replace fossil fuels. Due to its high diffusivity and wide flammability range, hydrogen can easily ignite with minimal electrical energy, leading to explosion and fires with minimal friction. Effective blast walls can restrict the dispersion of hydrogen, reducing the explosion overpressure due to delayed ignition. In addition, firewalls can improve safety by minimizing the impact behind the walls, thereby reducing the radiant heat caused by jet fires. This study proposes to optimize the distance between leak sources and barriers, as well as the height and width of barriers, to address explosion overpressure and radiation heat at hydrogen refueling stations (HRS). The optimization was carried out using Response Surface Methodology (RSM) and Artificial Neural Networks (ANN) and validated by simulations. This study confirms the feasibility of the barrier design at HRS and contributes to the improvement of safety.

Architecting CubeSat constellations for messaging service, Part I

In today’s modern and globalized world, connectivity is a key factor for businesses, production facilities, sensor networks, and ordinary people. However, there are still populated areas which are not covered by ground-based telecommunications infrastructure. This is where telecommunication satellite constellations come in, as they can provide coverage to remote and uninhabited regions and fill existing connectivity gaps to ensure data transfer.LoRa is one of the technologies designed for data transmissions over long distances with low power consumption. Alongside with other technologies of the Low-Power Wide Area Network family, it is widely used for Internet of Things applications. LoRa chirp spread spectrum modulation is robust against the Doppler frequency shifts encountered in low earth orbits, and it has already been used in IoT satellite communications. Due to the low transmitted signal power, the achieved data rate is not high, making it a suitable technology for telecommunications payloads on CubeSat platforms for messaging services. As compared to existing traditional communication satellite systems, CubeSat constellations are low-cost and may offer an affordable connectivity service to developing regions.This study is divided in two parts. In Part I the demand model is built based on the population distribution not covered by cell towers. The LoRa link performance is analyzed, considering the impact of LoRa channel parameters variation, such as spreading factor and channel bandwidth, while satellite orbital height, transmission antenna beamwidth, and transmitter peak power have a direct impact on the payload mass. Among thousands of possible configurations, 73 feasible payload designs have been downselected. In Part II of the study, the satellite mass and the total system cost are estimated based on the payload parameters obtained. Messages transmission simulation via a constellation is conducted in order to identify optimal constellation architectures for messaging service, as well as the main drivers of the system economic profitability.The presented analysis results provide a deeper understanding of LoRa connectivity advantages and limitations together with the performance drivers, which will support the optimization of future LoRa-based satellite communication systems and other IoT satellite constellations.

Research on the Spatiotemporal Pattern and Influencing Mechanism of Coastal Urban Vitality: A Case Study of Bayuquan

Enhancing the spatial vitality of coastal cities is beneficial for the sustainable development of urban construction. However, how to fully utilize coastal resources and boost urban vitality is an important issue. This study takes the coastal city of Bayuquan in China’s cold region as an example. Firstly, we conducted field investigations and data mining in Bayuquan, utilizing Baidu heat map data to measure the spatial–temporal vitality of different areas in Bayuquan. Secondly, we used Moran’s I test to examine the spatial autocorrelation of coastal spatial vitality. Lastly, with the help of the OLS and GWR models, we explored the factors influencing spatial vitality and the urban built environment. The research findings indicate the following: (1) There are spatial–temporal differences in the vitality of different areas in Bayuquan, heavily influenced by the tourist season. (2) The OLS results show that the impact of the built environment on spatial vitality exhibits spatial heterogeneity during different tourist seasons. However, we found no spatial heterogeneity in the influencing factors in the harbor district. (3) The harbor district and the tourism-driven district re quire differentiated construction guidance. Facility functions and block morphology mainly influence the vitality of the harbor district, while the vitality of the tourism-driven district is primarily affected by its aesthetic characteristics. This study can propose differentiated regional construction guidance and specific feasible coastal urban design strategies for seasonally influenced coastal city construction. It holds significant implications for improving urban living quality and is vital to urban decision-makers, planners, and stakeholders.

EPIC-CP pilot trial study protocol: a multicentre, randomised controlled trial investigating the feasibility and acceptability of social prescribing for Australian children with cerebral palsy

IntroductionThe social determinants of health contribute to poorer health outcomes for children with cerebral palsy (CP) and are barriers to families accessing health services. At an individual level, social determinants...

Can Glamping be a Vacation to Help Dink Couples Relax and Maintain Close Relationships?

Glamping brings a glamorous tourism experience providing potential opportunities to escape from daily routines and maintain relationships during difficult/special times, such as the pandemic with travel restrictions or postpandemic travel concerns. It is innovative to explore the unique group of DINK (dual income, no kids) couples using glamping as context. This study examines the variations in closeness among DINK couples based on four individual attachment styles (i.e., secure, anxious, dismissive, fearful), and explores the relationships between closeness and subjective well-being. A pilot test with 118 valid responses was adopted to ensure the validity of items and feasibility of the study design. Utilizing attachment theory with four attachment styles, the main study analyzed 940 valid responses using confirmatory factory analysis, ANOVA, and multigroup path analysis. This study highlights that people with a secure attachment style have a significantly 1) higher level of closeness with their partner and 2) stronger relationship between closeness and subjective well-being compared to the other three attachment styles (i.e., anxious, dismissive, and fearful). The results suggest that glamping providers could improve glamping environments to be peaceful and comfortable to attract potential glampers who have higher anxiety (i.e., anxious and fearful attachment styles). Further, the results indicate that glamping could serve as a setting for couples??? therapy and to celebrate special events to enhance close relationships. These promoting/marketing strategies can benefit small glamping businesses develop their products and potentially draw different types of visitors.

Pengembangan Media Pembelajaran Berbasis Power Point Interaktif Pada Materi Sistem Pencernaan Manusia Kelas XI

The purpose of this study is to develop Power Point -based interactive learning media on digestive system material that is valid, practical, and effective. This research is development research using the Research and Development (R&D) development model. This research was carried out in class XI. The instrument used is a validation questionnaire which includes aspects of content feasibility (material), language feasibility, and design feasibility (media), student response questionnaires and learning outcomes. The data analysis in this study was carried out descriptively on all the data obtained. The results of the analysis show that the learning media is also very practical to be used by students. Based on the results of the study, it can be concluded that the media developed is suitable for use in the learning process of the digestive system

The Development of Interactive Reading Digital Module with Contextual Approach for BIPA International School Students

Teaching BIPA (Indonesian for Foreign Speakers) in SPK (Satuan Pendidikan Kerjasama) has its polemics. Based on the needs analysis, one of them is that not all BIPA learners in SPK exhibit enthusiasm toward engaging with Indonesian reading materials. This displeasure comes from several factors including a general disinterest in reading, a lack of motivation to utilize the Indonesian language beyond the confines of language classes, and other obstacles like unappealing teaching materials. Thereby, this research aims to develop an Interactive Reading digital Module based on Contextual Approach in SPK. This research uses the RD method with the ADDIE Model design and has evaluation sessions at each stage. This article will focus on the developing stage and show validation results from the expert validators. The results showed that based on expert validators, the interactive reading digital module can be used with the material, media design feasibility percentage of 83% of eligible excellent predicate.

Miniature snapshot mid-infrared spectrometer based on metal-insulator-metal metasurface

Metasurfaces showcase the performance of light field manipulation at the subwavelength scale, generating tremendous applications in the field of optical imaging and sensing, especially in spectroscopic detection. Here, we demonstrate a spectral detector comprising metal-insulator-metal composite structures working in the mid-infrared band, which can effectively collect and restore target spectral characteristics in the mid-infrared band with a trained reconstruction algorithm. The proposed device consists of snapshot multichannel detection and spectral reconstruction, showing an average spectral reconstruction accuracy approaching 80% of the system. Moreover, we discuss the feasibility of applying this structural design to a miniature spectrometer over a wider infrared wavelength range by proposing a feasible design strategy. Our results provide a novel approach for low-cost and portable mid-infrared spectroscopic detection in ultracompact mid-infrared spectral imaging and sensing elements.

Liquid-liquid reactions performed by cellular reactors

Liquid-liquid reactions play a significant role in organic synthesis. However, control of the phase interface between incompatible two-phase liquids remains challenging. Moreover, separating liquid acid, base and oxidants from the reactor takes a long time and high cost. To address these issues, we draw inspiration from the structure and function of cells in living organisms and develop a biomimetic 3D-printed cellular reactor. The cellular reactor houses an aqueous phase containing the catalyst or oxidant while immersed in the organic phase reactant. This setup controls the distribution of the phase interface within the organic phase and increases the interface area by 2.3 times. Notably, the cellular reactor and the aqueous phase are removed from the organic phase upon completing the reaction, eliminating additional separation steps and preventing direct contact between the reactor and acidic, alkaline, or oxidizing substances. Furthermore, the cellular reactor offers the advantages of digital design feasibility and cost-effective manufacturing.

Aerodynamic Investigation on a Coaxial-Rotors Unmanned Aerial Vehicle of Bionic Chinese Parasol Seed.

Aerodynamic investigation of a bionic coaxial-rotors unmanned aerial vehicle (UAV) is performed. According to Chinese parasol seed features and flight requirements, the bionic conceptual design of a coaxial-rotors UAV is described. A solution procedure for the numerical simulation method, based on a multi-reference frame (MRF) model, is expressed, and a verification study is presented using the typical case. The aerodynamic design is conducted for airfoil, blade, and coaxial-rotors interference. The aerodynamic performance of the coaxial rotors is investigated by numerical simulation analysis. The rotor/motor integrated experiment verification is conducted to assess the performance of the coaxial-rotors UAV. The results indicate that the UAV has excellent aerodynamic performance and bionic configuration, allowing it to adapt to task requirements. The bionic UAV has a good cruise power load reach of 8.36 kg/kw, and the cruise flying thrust force is not less than 78 N at coaxial-rotor and rotor-balloon distance ratios of 0.39 and 1.12, respectively. It has the "blocks stability phenomenon" formed by the rotor downwash speed decreases and the balloon's additional negative pressure. The present method and the bionic configuration provide a feasible design and analysis strategy for coaxial-rotors UAVs.

Improved Metallic Thermal Protection Systems for Reentry Vehicles: Thermomechanical and Impact Considerations

A design for a metallic thermal protection system (TPS) panel made of SS304 stainless steel was developed to withstand a simulated aerodynamic heating rate of 7.1 W/cm2. The TPS panel, which comprised an outer sandwich structure, thermal insulation material, stand-off brackets, and an interior base frame, faced challenges from its thermomechanical and impact properties. These challenges were addressed through a combined analytical and numerical approach, optimizing the design parameters, namely, deflection, low-velocity impact peak load, and weight balance, to enhance the performance of the sandwich structure. The results indicated consistency between the analytical and numerical models, effectively predicting deflection and initial peak load for the TPS design. The proposed TPS design was then manufactured and evaluated through both experimental and numerical analysis to assess its thermomechanical behavior. The underlying structure of the TPS panel remained within specified temperature limits, and the exterior sandwich structure demonstrated acceptable levels of impact energy. The experiment confirmed the feasibility of the TPS panel design, with no significant damage observed after 10 simulated flight missions. This study not only validates the proposed analytical method for initial TPS development stages but also confirms the viability of a SS304 stainless-steel TPS panel design for high thermal-stress environments, marking a significant step in advancing thermal protection technology.

A shared-link type wireless power and data simultaneous transfer system based on a series–parallel resonant network

Wireless Power Transmission (WPT) is widely used. In practical engineering applications, the transmitter and receiver of a stable and reliable WPT system need to establish not only a power transmission channel but also a data transmission channel to realize closed-loop control and information interaction. In this paper, a novel simultaneous wireless power and data transfer system based on a series–parallel (SP) resonant network is proposed. The system integrates an SP higher-order resonant network with series carrier injection, which makes power transmission and data transmission share a magnetic coupling channel. The isolation between power and data is realized by exploiting the frequency characteristics of the compensation network, thus realizing efficient power transmission and data transmission. In this paper, accurate and detailed mathematical modeling of the system is conducted, and the gain characteristics of the power transmission channel and the data transmission channel are demonstrated. Meanwhile, the mutual interference between the two channels is analyzed, and a feasible and effective parameter design method is developed. Finally, an experimental prototype with an output power of 16 W and a backward data rate of 100 Kbps is constructed to verify the feasibility of the proposed system and the correctness of the parameter design.

Recent advances in the study of zika virus structure, drug targets, and inhibitors.

Zika Virus (ZIKV) is a positive-strand RNA virus that can lead to Guillain-Barré syndrome or encephalitis in some individuals and hence presents a serious public health risk. Since the first outbreak of ZIKV in Brazil in 2015, no effective clinical inhibitors have been developed, making the development of effective ZIKV drugs an urgent issue that needs to be addressed. ZIKV belongs to the Flaviviridae family, and its structure includes three structural proteins, namely, capsular (C), premembrane (prM), and envelope (E) proteins, as well as seven nonstructural proteins, namely, NS1, NS2A, NS2B, NS3, NS4A, NS4B, and NS5. To provide a reference for the development of future ZIKV drugs, this paper reviews the structure of the ZIKV based on recent literature reports, analyzes the potential therapeutic targets of various proteins, and proposes feasible drug design strategies. Additionally, this paper reviews and classifies the latest research progress on several protease inhibitors, such as E protein inhibitors, NS2B-NS3 inhibitors, and NS5 inhibitors, so that researchers can quickly understand the current status of development and the interconnections among these inhibitors.

Multi-objective optimization and thermodynamic assessment of a solar unit with a novel tube shape equipped with a helical tape

The performance of several heat transfer mechanisms, including solar energy sources, is being improved through optimization, which also effectively supports the most efficient feasible design. A numerical study has been done on a turbulator-enhanced flat plate solar collector (FPSC) while also introducing the utilization of a quad-lobed tube as a pioneering innovation in the system’s design. The incorporation of nanoparticles into the working fluid was implemented to enhance performance, with aluminum oxide particles selected for this purpose. Furthermore, assessing the second law and analyzing exergy generation was employed to discern irreversibility within the system. Optimization of both geometric and non-geometric elements has been accomplished through the integration of a multi-objective optimization (MOO) method with machine learning (ML). Random Forest (RF), LASSO Regression (LaR), and Support Vector Regression (SVR) are the machine learning models that were utilized in order to ascertain the correlations that exist between the system’s inputs and outputs. According to the findings, RF was found to be the most appropriate algorithm for capturing the impacts of parameter variations. This was demonstrated by the high coefficient of determination (R2) quantities that RF possessed, which were 0.95, 0.99, and 0.99 for friction factor (f), exergy loss (Xd), and second law effectiveness (ηII), respectively. However, the SVR and LaR algorithms showed significant deviations from the FPSC simulation results. The SVR algorithm achieved R2 values of 0.54 for f, 0.78 for Xd, and 0.84 for ηII, while the LaR algorithm achieved R2 values of 0.65 for f, 0.99 for Xd, and 0.98 for ηII. This research aims to find the optimal input parameters that minimize f and Xd while maximizing ηII. Therefore, to determine the Pareto optimal solutions the non-dominated sorting genetic algorithm (NSGA-II) has been utilized. The result was an illustration of the Pareto set, which stands for a collection of optimal solutions. Every solution in this collection achieved the desiredbalance, obtaining the best outcomes without compromising any objectives.

Feasibility of Holographic Team Training Simulation: An Information Technology (IT) Perspective for Healthcare and Educational Institutions.

Introduction This study examines the feasibility and practicality of holographic display technology (HDT) in health professions educationfrom an information technology (IT) support staff perspective. Considering a lack of feasibility studies for introducing newer technologies, it focuses on feasibility's acceptance and practicality dimensions during a simulation-based team training workshop. Method A multimethod design feasibility study assessed the acceptability and practicality of HDT for the IT staff through a Unified Theory of Acceptance and Use of Technology (UTAUT)-based survey and a focus group discussion after a team training simulation workshop. Results Quantitative results showed a reliability coefficient (α=0.83) and a positive correlation between facilitating conditions (FC) and effort expectancy (EE), self-efficacy (SE) and social influence (SI), SI and attitude toward technology (AT), SE and attitude to use, and behavioral intention (BI) and EE. Negative correlations included SE and performance expectancy (PE), comfort with technology and FC, comfort and anxiety, and attitude to use and experience. Qualitative findings yielded four key themes from the focus group discussions that corroborated the quantitative findings. Discussion The study findings highlight the promising potential for HDT feasibility in educational settings. Future research should extend to diverse contexts to validate these preliminary findings and explore broader educational applications.

A Low-profile Dual-band Frequency Selective Surface with High Selectivity at its Higher Passband

In order to meet the requirements for multiband communication, a dual-band passband frequency selective surface (FSS) with low-profile and high selectivity at its higher passband is proposed in this paper. The proposed FSS is a three-layer structure. An arc-cross patch (ACP) and four quarter-circular patches (QCP) are introduced on the outer layers to produce two transmission nulls of the higher passband, which result in high selectivity of higher passband. The inductively complementary structure on the middle layer is introduced to manipulate the coupling between layers which contribute to the low-profile and angular stability. The segmental study method is used to establish the equivalent circuit model (ECM) and analyze its mechanism. The proposed dual-band FSS, whose high selectivity was verified by experiment, is low-profile and shows good polarization insensitivity and angular stability. A feasible FSS design solution is provided for dual-band communication.

Feasibility Design and Analysis of Process-aware Accounting Information System for Business Management

Accounting Information Systems (AIS), as a fundamental element of Enterprise Information Systems (EIS), are experiencing dual pressures from the enterprise management surroundings and the advancement of accounting control. The current AIS focused on functional applications needs to be revised to meet contemporary enterprise management requirements. This study suggests implementing a Process-Aware Accounting Information System (PA-AIS) that utilizes data mining techniques to enhance managing business processes. The objective is to enhance the accounting effectiveness of organizations and provide valuable insights for building AIS. This paper compares the benefits and drawbacks of standard methods employed in building AIS. It also assesses the potential of process-aware AIS to enhance business Process Management (PM) by considering factors such as enterprise effectiveness, accounting expenses, accounting duration, etc. An analysis assesses the viability of improving the PA-AIS for managing business processes regarding enterprise effectiveness, accounting expenses, accounting duration, etc. The findings indicate that implementing a PA-AIS with enhanced business PM is economically viable and successful. This system saves time, minimizes accounting risks, and enhances management control inside the firm. The implementation of a PA-AIS, along with enhanced business PM, effectively decreases the accounting expenses of firm Y. The initial accounting cost is from 100k to 200k, but the accounting expense after implementing the new system ranges from 80k to 100k. Implementing the new system resulted in a minimum 10-20% improvement in Company Y's accounting efficiency, rationality, and user convenience. The PA-AIS enhances business process administration

Design of a Novel Three-Degree-of-Freedom Piezoelectric-Driven Micro-Positioning Platform with Compact Structure

In this paper, a novel three-degree-of-freedom piezoelectric-driven micro-positioning platform based on a lever combination compound bridge-type displacement amplification mechanism is proposed. The micro-positioning platform proposed in this paper aims to solve the current problem of the large size and small travel of the three-degree-of-freedom piezoelectric-driven micro-positioning platform. In this paper, a lever combination compound bridge-type displacement amplification mechanism combined with a new biaxial flexible hinge is proposed, the structural dimensions of the lever mechanism and the compound bridge mechanism are optimized, and the amplification multiplier is determined. The maximum output simulation analysis of the micro-positioning platform is carried out by using ANSYS, and the experimental test system is built for verification. The validation results show that the maximum errors between simulation and experiment in the z-direction, rotation direction around x, and rotation direction around y are 64 μm, 0.016°, and 0.038°, respectively, and the corresponding maximum relative errors are 5.6%, 2.4%, and 6.6%, respectively, which proves the feasibility of the theoretical design.