Fe3O4 Chitosan Research Articles

Synthesis of CS/Fe3O4/TiO2@MXene nanocomposite photocatalyst with excellent degradation and bacteriostatic properties by one-step hydrothermal method

With the rapid development of global economy and industrialization, the management and protection of water resources have become increasingly important. In this paper, a novel three-dimensional Chitosan/Fe3O4/TiO2@MXene photocatalyst with excellent degradation and bacterial inhibition properties was prepared by a simple one-step hydrothermal method using FeCl3·6H2O, Chitosan (CS) and MXene (Ti3C2) as main raw materials. TiO2 was generated in-situ on the surface of Ti3C2 nanosheets and modified by loading Fe3O4 nanoparticles and CS films. The conformations and band gaps of the composites were modified, and then photocatalytic mechanisms, phase compositions, morphological structures, magnetic properties and photoelectrochemical properties of the photocatalysts were systematically analyzed. The degradation efficiency of the CS/Fe3O4/TiO2@Ti3C2 composite photocatalyst can reach 95.9 % when the ration of CS to FeCl3·6H2O is 1:3 and the hydrothermal temperature is 180 °C, which showing excellent photocatalytic performance. Meanwhile, the inhibition rate of Staphylococcus aureus (S. aureus) is close to 98.91 % under the light condition. This study further reveals that visible light is a cost-effective way to treat pollution in terms of degradation and bacteriostatic inhibition, and the composite photocatalysts can be efficiently recycled and reused under the action of a magnetic field.

Chitosan-iron oxide nanoparticle preparation and performance as a lipid-lowering agent in serum patients with nephrotic syndrome

Objective: The main objectives of this study was to Prepare and study the structural features of chitosan/iron oxide nanoparticles CS-FeO NPs and to examine the applications of chitosan nanoparticles as a lipid-lowering agent in children with nephrotic syndrome
 Method: The preparation processes for nanoparticles are described in depth. Chitosan nanoparticle applications are shown. X-ray diffraction patterns (XRD) indicated that the magnetic Fe3O4 nanoparticles were pure Fe3O4 with a spinel structure and the coating of chitosan did not result in a phase change.
 Results: The coating of CTS onto the Fe3O4 nanoparticles was also demonstrated by the measurement of Fourier transform infrared (FTIR) spectra. Magnetic measurement revealed that the saturated magnetization of the Fe3O4–chitosan nanoparticles reached +18.3 mV and the nanoparticles showed the characteristics of superparamagnetic.
 Conclusion: Magnetic Fe3O4–chitosan nanoparticles were prepared successfully by the covalent binding of CTS on the Fe3O4 nanoparticles. These microspheres was apply to the magnetic-field-assisted lipid lowering processes.

Green synthesis of sustainable magnetic nanoparticles Fe3O4 and Fe3O4-chitosan derived from Prosopis farcta biomass extract and their performance in the sorption of lead(II)

The sustainable processes are now in tremendous demand for nanomaterial synthesis as a result of their unique properties and characteristics. The magnetic nanoparticles comprised of Fe3O4 and its conjugate with abundant and renewable biopolymer, chitosan, were synthesized using Prosopis farcta biomass extract, and the resulting materials were used to adsorb Pb (II) from aqueous solution. Thermodynamic parameters revealed that the sorption of lead (II) on Fe3O4 as well as Fe3O4-Chitosan (Fe3O4-CS) has been an endothermic and self-regulating procedure wherein the sorption kinetics was defined by a pseudo-second-order pattern and the sorption isotherms corresponded to the Freundlich pattern. A multivariable quadratic technique for adsorption process optimization was implemented to optimize the lead (II) adsorption on Fe3O4 and Fe3O4-chitosan nanoparticles, the optimal conditions being pH 7.9, contact time of 31.2 min, initial lead concentration of 39.2 mg/L, adsorbent amount of 444.3 mg, at a 49.7 °C temperature. The maximum adsorption efficiencies under optimal conditions were found to be 69.02 and 89.54 % for Fe3O4 and Fe3O4-CS adsorbents, respectively. Notably, Fe3O4 and Fe3O4-CS can be easily recovered using an external magnet, indicating that they are a viable and cost-effective lead removal option.

A magnetically recyclable carboxyl-functionalized chitosan composite for efficiently removing methyl orange from wastewater: Isotherm, kinetics, thermodynamic, and adsorption mechanism

In this study, a kind of magnetically recyclable adsorbent for dyes was synthesized by grafting diethylenetriamine pentaacetate acid (DTPA) to the composite of Fe3O4 microspheres and crosslinked chitosan (CS). The microstructures, molecular structure, crystal structure, and magnetic hysteresis loops of the chitosan matrix adsorbent before and after grafting was characterized. The results suggested that DTPA was covalent bonded with the composite of Fe3O4 microspheres and chitosan. The modified composite has larger specific surface area and can realize rapid solid-liquid separation. Batch experiments were conducted to optimize the parameters affecting the adsorption of methyl orange (MO). The adsorption process could be better described by pseudo-second-order kinetics model and Langmuir isotherm equation, and its saturated adsorption capacity of the modified adsorbents was 1541.5 mg·g−1 at 25 °C, which was 1.40 times of that the unmodified adsorbent (1104.1 mg·g−1). The obtained values of the thermodynamic parameters indicated that the adsorption was a spontaneous process. The regeneration experiment proved the stability and reproducibility of the adsorbent even after five cycles of adsorption-desorption. The primary adsorption mechanism was electrostatic interaction and hydrogen bonding. The adsorbent could be potentially applied for removing dyes from wastewater in wide pH of range, especially acid wastewater.

Effect of Chromium (VI) on the Oxidation of Methylene Blue Dye by Fe3O4/ Chitosan Composite

Heavy metal ion removal from industrial wastewater treatment systems is still difficult because it contains organic contaminants. In this study, functional composite hydrogels with photo Fenton reaction activity were used to decompose organic contaminants. Fe3O4 Nanoparticle, chitosan (CS), and other materials make up the hydrogel. There are different factors that affected Photo-Fenton activity including (pH, H2O2 conc., temp., and exposure period). Atomic force microscopy was used to examine the morphology of the composite and its average diameter (AFM). After 60 minutes of exposure to UV radiation, CS/ Fe3O4 hydrogel composite had degraded methylene blue (M.B.) dye by 92 percent. In the meantime, following an 1hour of visible irradiation, COD (Chemical Oxygen Demand) dropped to 6.1 mg/l.

Development of an Fe3O4 Surface-Grafted Carboxymethyl Chitosan Molecularly Imprinted Polymer for Specific Recognition and Sustained Release of Salidroside

The choice of carrier material is critical in the study of natural drug release preparations and glycosylated magnetic molecularly imprinted materials. The stiffness and softness of the carrier material affect the efficiency of drug release and the specificity of recognition. The dual adjustable aperture-ligand in molecularly imprinted polymers (MIPs) provides the possibility of individualized design for sustained release studies. In this study, a combination of paramagnetic Fe3O4 and carboxymethyl chitosan (CC) was used to enhance the imprinting effect and improve drug delivery. A combination of tetrahydrofuran and ethylene glycol was used as a binary porogen to prepare MIP-doped Fe3O4-grafted CC (SMCMIP). Salidroside serves as the template, methacrylic acid acts as the functional monomer, and ethylene glycol dimethacrylate (EGDMA) serves as the crosslinker. Scanning and transmission electron microscopy were used to observe the micromorphology of the microspheres. The structural and morphological parameters of the SMCMIP composites were measured, including the surface area and pore diameter distribution. In an in vitro study, we found that the SMCMIP composite had a sustained release property of 50% after 6 h of release time in comparison to the control SMCNIP. The total amounts of SMCMIP released at 25 °C and 37 °C were 77% and 86%, respectively. In vitro results showed that the release of SMCMIP followed Fickian kinetics, meaning that the rate of release is dependent on the concentration gradient, with diffusion coefficients ranging from 3.07 × 10-2 cm2/s to 5.66 × 10-3 cm2/s. The results of cytotoxicity experiments showed that the SMCMIP composite did not have any harmful effects on cell growth. The survival rates of intestinal epithelial cells (IPEC-J2) were found to be above 98%. By using the SMCMIP composite, drugs may be delivered in a sustained manner, potentially leading to improved therapeutic outcomes and reduced side effects.

Dihydroflavonol 4-reductase immobilized on Fe3O4-chitosan nanoparticles as a nano-biocatalyst for synthesis of anthocyanidins

Dihydroflavonol 4-reductase (DFR) is a crucial enzyme involved in anthocyanidin biosynthesis pathway in plants. Here, we successfully immobilized the recombinant DFR protein onto Fe3O4-Chitosan (Fe3O4-CS) nano-carrier based on covalent bonding. The Fe3O4-CS-immobilized DFR enzyme were characterized and its catalytic function for anthocyanidins synthesis in vitro was confirmed. The immobilized enzyme enhanced thermal and acid stabilities and tolerances to the inhibitions of Zn2+, Cu2+, Fe2+and several organic solvents, remained 75 % initial activities after 25 days of storage, other than relatively lower catalytic yield of anthocyanidins. In this work, we developed a new recyclable nano-immobilized biocatalyst for the catalytic synthesis of anthocyanidins.

Synthesis and characterization of mussel-inspired nanocomposites based on dopamine–chitosan–iron oxide for wound healing: In vitro study

There are many challenges faced the soft tissue adhesives in the medical application field. For example, there is a limited effective binding between the medical adhesive and different types of soft tissues. Chitosan (CS) and dopamine (DA) were used as structural units for synthesizing nanocomposites utilized as a wet tissue adhesive. To produce dopamine–chitosan–iron oxide nanocomposites (DA–CS–Fe3O4 NCs), DA was loaded onto chitosan–iron oxide nanocomposites. The nanocomposites have been prepared using ionic gelation method under vigorous homogenization and characterized by different techniques. Fourier-transform infrared spectroscopy (FTIR) have shown that DA–CS– Fe3O4 NCs could attach to the tissue through two possible functional groups, namely, the catechol and amine groups. The results of in vitro scratch wound-healing assay suggested that the prepared DA–CS– Fe3O4 NCs facilitate cell migration (the wound-closure percentage reached 96% at 72 h). All experimental results confirm that DA–CS– Fe3O4 NCs are strongly recommended for use as a soft medical tissue adhesive in wound healing and surgeries such as vascular surgery. In addition, the results of the whole blood clotting, antibacterial assessment, live and dead assay, cytotoxicity test, and wound-healing assay indicate that DA-CS–Fe3O4 NCs can be used as a multifunctional biomedical adhesive.

Improvement of the bladder perfusion curative effect through tight junction protein degradation induced by magnetic temperature-sensitive hydrogels.

Postoperative intravesical instillation of chemotherapy is a routine procedure for non-muscular invasive bladder cancer (NMIBC). However, traditional bladder perfusion methods have insufficient exposure time, resulting in unsatisfactory therapeutic effects. In the present study, a chitosan (CS)-based in situ forming depot (ISFD) delivery system, including Fe3O4 magnetic nanoparticles (Fe3O4-MNP), CS, and β-glycerophosphate (GP) as main components, was synthesized. Pirarubicin (THP), as a chemotherapeutic drug, was loaded into the new system. Results showed that our carrier system (Fe3O4-THP-CS/GP) was converted into gel and attached to the bladder wall, possessing loose network structures with magnetic targeting and sustained release properties. Moreover, its retention time in bladder was more than 72 h accompanied by a suitable expansion rate and good degradation characteristics. The antitumor activities of Fe3O4-THP-CS/GP were more effective both in vitro and in vivo than the free THP solution. In the study of its mechanism, results showed that Fe3O4-THP-CS/GP suppressed the expression of occludin (OCLN) and affected tight junctions (TJ) between urothelial cells to promote THP absorption.

Preparation and performance study of a reactive polyurethane hot-melt adhesive/CS-Fe3O4 magnetic nanocomposite film/fabric.

Magnetic nanoparticles are attracting significant attention for their wide application as biomaterials and magnetic storage materials. As an environmentally friendly adhesive, reactive polyurethane hot-melt adhesive (PUR) is a biocompatible polymer with a wide range of applications. In this paper, chitosan (CS)-surface-modified magnetic Fe3O4 nanoparticles were synthesized by the sol–gel method. Surface modification of the Fe3O4 nanoparticles with CS enhanced their mechanical properties in PUR. The nanoparticles were characterized by Fourier transform infrared (FTIR) and X-ray diffraction (XRD) analyses, while their surface morphology was elucidated using scanning electron microscopy (SEM) and projection electron microscopy (TEM) techniques. Subsequently, PUR/CS–Fe3O4 magnetic nanocomposite films were prepared using an in situ method, wherein different amounts of CS–surface-modified magnetic Fe3O4 nanoparticles were doped into the PUR and coated on the films. The thermal, UV resistance and mechanical properties of the PUR/CS–Fe3O4 magnetic nanocomposite films were investigated by TGA, UV spectrometer and tensile testing. CS–Fe3O4 nanoparticles were successfully prepared using the sol–gel method and CS to modify the surface of the Fe3O4 nanoparticles. The results show that the mechanical properties and UV resistance of PUR/CS–Fe3O4 magnetic nanocomposites are improved by almost 50%, so the constructed PUR/CS–Fe3O4 magnetic nanocomposites have good UV-resistant properties and mechanical properties. The as-synthesized CS–Fe3O4 magnetic nanocomposites show great potential for application to mechanical and textile development.

Development of chitosan decorated Fe3O4 nanospheres for potential enhancement of photocatalytic degradation of Congo red dye molecules

Fe3O4 nanospheres (Nsps) and chitosan (Cts)/Fe3O4 Nsps were prepared using a one-pot hydrothermal method and subsequently used as photocatalysts against the degradation of Congo red (CR) dye molecules. The sphere-shaped Fe3O4 nanoparticles were heterogeneously decorated by the Cts matrix, which was confirmed by powder X-ray diffraction, scanning and transmission electron microscopies. The Cts/Fe3O4 Nsps demonstrated 98% efficient photocatalytic activity against CR dye molecules upon 60 min exposure to visible light compared to Fe3O4 Nsps (77% for 60 min). When compared to Fe3O4 Nsps, the visible light photocatalytic efficiency of Cts/Fe3O4 Nsps against CR dye molecules was significantly improved.

Synthesis of polypyrrole – chitosan magnetic nanocomposite for the removal of carbamazepine from wastewater: Adsorption isotherm and kinetic study

A polypyrrole–chitosan–Fe3O4 magnetic nanocomposite (PPy–CS–Fe3O4 MNC) was prepared by in situ coprecipitation of iron salts in the presence of chitosan followed by chemical oxidative polymerization of pyrrole on the magnetic chitosan. Afterward, the nanocomposite was applied as a magnetic nanosorbent for the removal of carbamazepine (CBZ) from the wastewater samples. The prepared adsorbent was characterized by various modern surface and microstructure analyzing methods. Several operating parameters affecting the removal efficiency of the CBZ including sample pH, amount of sorbent, initial concentration and adsorption time were investigated and adjusted. However, under the optimal conditions, the PPy–CS–Fe3O4 MNCs showed prominent removal performance compared to the bare Fe3O4 magnetic nanoparticles. According to the results, the PPy–CS–Fe3O4 MNCs could eliminate the CBZ from water medium with an efficiency of 94.5% in the 25 min. In contrast, it took about an hour to remove 65% of the CBZ using bare Fe3O4 magnetic nanoparticles. The experimental results revealed that the CBZ sorption on the PPy–CS–Fe3O4 MNCs was fitted well with the pseudo-second-order kinetic model (R2 = 0.9901). Moreover, the adsorption model was in accordance with the Langmuir isotherm with the adsorption capacity of 121.95 mg g−1. It was found that PPy–CS–Fe3O4 MNCs could be frequently applied for CBZ removal up to five times without noticeable decrease in its adsorption efficiency. The adsorption results established the high potential of synthesized MNCs as a robust and promising adsorbent for water treatment.

Chitosan-Grafted Halloysite Nanotubes-Fe3O4 Composite for Laccase-Immobilization and Sulfamethoxazole-Degradation.

A surface-engineered nano-support for enzyme laccase-immobilization was designed by grafting the surface of halloysite nanotubes (HNTs) with Fe3O4 nanoparticles and chitosan. Herein, HNTs were magnetized (HNTs-M) by a cost-effective reduction-precipitation method. The synthesized HNTs-M were grafted with 0.25%, 0.5%, 1%, and 2% chitosan (HNTs-M-chitosan), respectively. Synthesized HNTs-M-chitosan (0.25%), HNTs-M-chitosan (0.5%), HNTs-M-chitosan (1%) and HNTs-M-chitosan (2%) were linked with glutaraldehyde (GTA) for laccase immobilization. Among these formulations, HNTs-M-chitosan (1%) exhibited the highest laccase immobilization with 95.13% activity recovery and 100.12 mg/g of laccase loading. The optimized material was characterized thoroughly by scanning electron microscopy (SEM), high-resolution transmission electron microscopy (HR-TEM), X-ray powder diffraction (XRD), thermal gravimetric analysis (TGA), and vibrating sample magnetometer (VSM) analysis. The immobilized laccase (HNTs-M-chitosan (1%)-GTA-Laccase) exhibited higher pH, temperature, and storage stabilities. The HNTs-M-chitosan (1%)-GTA-Laccase possesses excellent reusability capabilities. At the end of 10 cycles of the reusability experiment, HNTs-M-chitosan (1%)-GTA-Laccase retained 59.88% of its initial activity. The immobilized laccase was utilized for redox-mediated degradation of sulfamethoxazole (SMX), resulting in 41%, 59%, and 62% degradation of SMX in the presence of 2,2′-Azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS), guaiacol (GUA), and syringaldehyde (SA), respectively. Repeated SMX degradation (57.10% after the sixth cycle) confirmed the potential of HNTs-M-chitosan (1%)-GTA-Laccase for environmental pollutant degradation. Thus, we successfully designed chitosan-based, rapidly separable super-magnetic nanotubes for efficacious enhancement of laccase biocatalysis, which can be applied as nano-supports for other enzymes.

Analysis ofin vitrocorrosion behavior and hemocompatibility of electrophoretically deposited bioglass–chitosan–iron oxide coating for biomedical applications

Abstract

Magnetic Porous Controlled Fe3O4-Chitosan Nanostructure: An Ecofriendly Adsorbent for Efficient Removal of Azo Dyes.

In this work, chitosan/magnetite nanoparticles (ChM) were quickly synthesized according to our previous report based on co-precipitation reaction under ultrasound (US) irradiation. Besides ChM was in-depth structurally characterized, showing a crystalline phase corresponding to magnetite and presenting a spheric morphology, a “nanorod”-type morphology was also obtained after increasing reaction time for eight minutes. Successfully, both morphologies presented a nanoscale range with an average particle size of approximately 5–30 nm, providing a superparamagnetic behavior with saturation magnetization ranging from 44 to 57 emu·g−1. As ChM nanocomposites have shown great versatility considering their properties, we proposed a comparative study using three different amine-based nanoparticles, non-surface-modified and surface-modified, for removal of azo dyes from aqueous solutions. From nitrogen adsorption–desorption isotherm results, the surface-modified ChMs increased the specific surface area and pore size. Additionally, the adsorption of anionic azo dyes (reactive black 5 (RB5) and methyl orange (MO)) on nanocomposites surface was pH-dependent, where surface-modified samples presented a better response under pH 4 and non-modified one under pH 8. Indeed, adsorption capacity results also showed different adsorption mechanisms, molecular size effect and electrostatic attraction, for unmodified and modified ChMs, respectively. Herein, considering all results and nanocomposite-type structure, ChM nanoparticles seem to be a suitable potential alternative for conventional anionic dyes adsorbents, as well as both primary materials source, chitosan and magnetite, are costless and easily supplied.

Magnetic graphene/chitosan nanocomposite: A promising nano-adsorbent for the removal of 2-naphthol from aqueous solution and their kinetic studies

In this study, magnetic/graphene/chitosan nanocomposite (MGCH) is prepared through facile solvothermal process and employed as an adsorbent for the removal of 2-naphthol from aqueous solution. The physico-chemical characteristic results of FESEM, Raman, FTIR, XRD and VSM confirms that the MGCH nanocomposite is effectively prepared. The FESEM and EDS analysis reveals that the high density of spherical-like Fe3O4 nanoparticles and chitosan are successfully assembled on the surfaces of the graphene sheets. VSM result of MGCH composite exhibited higher saturation magnetization of 46.5 emu g−1 and lower coercivity (Hc) of 50 Oe. This result discloses that MGCH possesses enough response required for the separation from aqueous solution. The batch mode adsorption studies demonstrates that MGCH based adsorbent showed almost 99.8% adsorption of 2-naphthol with a maximum adsorption capacity of 169.49 mg g−1 at pH 2. Moreover, the kinetic studies of the samples are performed by fitting adsorption models to ensure the nature of the adsorption system. This work proves that MGCH nanocomposite can be used as high-performance adsorbent for removing of phenolic pollutants from contaminated wastewater.

Cobalt-Tetraamide-Phthalocyanine Immobilized on Fe3O4/Chitosan Microspheres as an Efficient Catalyst for Baeyer-Villiger Oxidation.

Cobalt-Tetraamide-Phthalocyanine (CoTaPc) immobilized onto magnetic Fe3O4 chitosan microspheres (Fe3O4/CTO) was synthesized via a simple immersion method, which is an efficient catalyst for the oxidation of cyclic ketones to lactones with O2/benzaldehyde as the oxidant. The CoTaPc-Fe3O4/CTO catalyst was applied for the first time in the Baeyer–Villiger (B–V) oxidation reaction. Characterization results obtained from X-ray diffraction, UV–vis, Fourier transform infrared, and scanning electron microscopy showed that the combination of CoTaPc and magnetic Fe3O4/CTO microspheres was achieved. The catalyst could be easily separated from the reaction system with an external magnet and reused several times without the remarkable loss of activity. In addition, a possible radical mechanism for the B–V oxidation in this catalytic system is proposed and verified by controlled experiments.

Chitosan–Fe3O4 nanoparticle enzymatic electrodes on paper as an efficient assay for glucose and uric acid detection in biological fluids

In this study, two important biomarkers, namely glucose and uric acid, were detected in different biological fluids using a highly sensitive and selective chitosan-/nano-based electrochemical microfluidic paper-based analytical device (µPAD). A graphite/chitosan/polyethylene glycol (PEG) mixture was used as bare working electrode and counter electrode with silver ink being used as quasi-reference electrode. Graphene, multiwall carbon nanotubes, and Fe3O4 nanoparticles were used to improve sensitivity as well as selectivity of the working electrodes. The developed chitosan-/nano-based microfluidic analytical system showed apparent redox peaks, and all the three types of nanomaterials improved the performance of the bare graphite/chitosan/PEG electrode with the Fe3O4-modified electrode exhibiting the sharpest signals with the highest selectivity. The linear ranges of glucose and uric acid were 0.01–30 mM and 0.05–15 mM, respectively, where the limits of detection (LOD) were 5 µM and 20 µM for glucose and uric acid, respectively. In comparison with most of previous data reported on μPADs and due to high surface area/volume ratio of NPs and faster electron transfer promoted by chitosan and NPs, the better LODs were found in the current study. The fast, efficient, and low-cost µPADs were successfully applied to highly sensitive and selective detection of glucose and uric acid in serum and urine samples and noninvasive glucose detection in tear samples.

Fructo-oligosaccharides production by an Aspergillus aculeatus commercial enzyme preparation with fructosyltransferase activity covalently immobilized on Fe3O4–chitosan-magnetic nanoparticles

Pectinex Ultra SP-L, a commercial enzyme preparation with fructosyltransferase activity, was successfully immobilized by covalent binding to Fe3O4–chitosan- magnetic nanoparticles. Immobilization carried out according to a 23-full factorial design where glutaraldehyde concentration, activation time and time of contact between enzyme and support were selected as the independent variables and immobilization yield as the response. The highest immobilization yield (94.84%) was obtained using 3.0% (v/v) glutaraldehyde and activation and contact times of 180 and 30 min, respectively. The immobilized biocatalyst, which showed for both hydrolytic and transfructosylating activities optimum pH and temperature of 7.0 and 60 °C, respectively, retained 70 and 86% of them after 6 cycles of reuse. A kinetic/thermodynamic study focused on thermal inactivation of the immobilized construct indicated high thermostability at temperatures commonly used for fructo-oligosaccharides (FOS) production. Maximum FOS concentration obtained in lab-scale experiments was 101.56 g L−1, with predominant presence of 1-kestose in the reaction mixture. The results obtained in this study suggest that the immobilized-enzyme preparation may be effectively exploited for FOS production and easily recovered from the reaction mixture by action of a magnetic field.

Novel Fe3O4 chitosan–quince-seed mucilage polymeric composite to enhance protein release

This work aimed at evaluating the ability of chitosan (CS)–quince-seed mucilage (QSM) polymeric matrix in biomedical applications. Hence, bovine albumin serum (BSA) was selected as a sample protein and the potential of this polymeric composite in both protein encapsulation and controlled protein release was investigated. To recognize the effect of magnetism on the performance of this biomaterial, CS–BSA–QSM–magnetite NPs were fabricated and the experiment was repeated in the presence and absence of alternating magnetic field. As a result, over 63% of BSA loading into chitosan was achieved using QSM in the absence of any crosslinker. Also the results confirmed the positive effect of magnetite NPs on BSA encapsulation efficiency and the ability of magnetite NPs in controlling protein release. Also, the kinetics of protein release from all three samples was explored and some mechanisms were suggested.