Family CARD Research Articles

Protocatechuic acid and quercetin attenuate ETEC-caused IPEC-1 cell inflammation and injury associated with inhibition of necroptosis and pyroptosis signaling pathways

BackgroundNecroptosis and pyroptosis are newly identified forms of programmed cell death, which play a vital role in development of many gastrointestinal disorders. Although plant polyphenols have been reported to protect intestinal health, it is still unclear whether there is a beneficial role of plant polyphenols in modulating necroptosis and pyroptosis in intestinal porcine epithelial cell line (IPEC-1) infected with enterotoxigenic Escherichia coli (ETEC) K88. This research was conducted to explore whether plant polyphenols including protocatechuic acid (PCA) and quercetin (Que), attenuated inflammation and injury of IPEC-1 caused by ETEC K88 through regulating necroptosis and pyroptosis signaling pathways.MethodsIPEC-1 cells were treated with PCA (40 μmol/L) or Que (10 μmol/L) in the presence or absence of ETEC K88.ResultsPCA and Que decreased ETEC K88 adhesion and endotoxin level (P < 0.05) in cell supernatant. PCA and Que increased cell number (P < 0.001) and decreased lactate dehydrogenases (LDH) activity (P < 0.05) in cell supernatant after ETEC infection. PCA and Que improved transepithelial electrical resistance (TEER) (P < 0.001) and reduced fluorescein isothiocyanate-labeled dextran (FD4) flux (P < 0.001), and enhanced membrane protein abundance of occludin, claudin-1 and ZO-1 (P < 0.05), and rescued distribution of these tight junction proteins (P < 0.05) after ETEC infection. PCA and Que also declined cell necrosis ratio (P < 0.05). PCA and Que reduced mRNA abundance and concentration of tumor necrosis factor-α (TNF-α), interleukin (IL)-6 and IL-8 (P < 0.001), and down-regulated gene expression of toll-like receptors 4 (TLR4) and its downstream signals (P < 0.001) after ETEC infection. PCA and Que down-regulated protein abundance of total receptor interacting protein kinase 1 (t-RIP1), phosphorylated-RIP1 (p-RIP1), p-RIP1/t-RIP1, t-RIP3, p-RIP3, mixed lineage kinase domain-like protein (MLKL), p-MLKL, dynamin- related protein 1 (DRP1), phosphoglycerate mutase 5 (PGAM5) and high mobility group box 1 (HMGB1) (P < 0.05) after ETEC infection. Moreover, PCA and Que reduced protein abundance of nod-like receptor protein 3 (NLRP3), nod-like receptors family CARD domain-containing protein 4 (NLRC4), apoptosis-associated speck-like protein containing a CARD (ASC), gasdermin D (GSDMD) and caspase-1 (P < 0.05) after ETEC infection.ConclusionsIn general, our data suggest that PCA and Que are capable of attenuating ETEC-caused intestinal inflammation and damage via inhibiting necroptosis and pyroptosis signaling pathways.

PEMBUATAN VIDEO PELAYANAN KANTOR DESA SEKURA BERBASIS ANIMASI 2D

Sekura Village Office does not yet have the media to deliver the services at Sekura Village Office. The services at Sekura Village Office are in the form of population administration such as ID cards, family cards, birth certificates, marriages, deaths, and business permits. Information about services at Sekura Village Office has not been visualized properly. Currently, the information can be obtained by coming directly to the village office. Therefore, a 2D animated video was made entitled Keluarge Pak Wawan di Kantor Desa Sekura, which can provide information for the community about services at Sekura Village Office. This study aims to provide information about the services of Sekura Village Office so that it is better known to the public, especially the Sekura Village area in the form of 2D animation. The development method that will be used in making 2D animation is the Villamil-Molina method. This development method consists of 3 stages, namely Pre Production, Production, and Post Production. The results of this study are 2D animation in MP4 format.

Public Service Procedures (Case Study of Handling Services for Making Cover Letters for Birth Certificates in Bareng Village, Klojen District, Malang City)

This research was conducted at the Bareng Village office. The purpose of this study was to determine public service procedures at the Bareng Village Office, Klojen District, Malang City. The results of this study indicate that 1) Procedures for handling birth certificate delivery services at the Bareng Village office, Klojen District, Malang City include: a) submitting a birth certificate application and providing the application form by the service officer. Submission of requests by the community is not difficult and not complicated. b) Examination of files by service officers. There were no problems with examining the files, the officers carried out according to the existing procedures, namely checking one by one the completeness of the requirements starting from birth certificates, family cards, ID cards, and diplomas. c) Filling out the register book and expedition book. During the process of filling out the registration book and expedition book, the officers did not experience any problems. d) Preparation of an application letter signed by the village head. There is no problem in preparing a cover letter for making a birth certificate introduction. 2) the inhibiting factor that many officers face is the community, which lacks participation in the awareness to complete the requirements in making an introduction to a birth certificate. Supporting factors in the service procedure for making birth certificate introductions are the existence of clear laws, the officers who handle them are by the SOPs that have been set in the Village

Full-length transcriptome sequencing analysis reveals differential skin color regulation in snakeheads fish Channa argus

Albinism is a genetic disorder caused by a series of genetic abnormalities that result in a decrease in melanin. Golden yellow snakehead fish (GCAS) has been discovered while the Channa argus (CAS) breeding, but the genetic mechanism that causes its albinism is not known. Transcriptome sequencing and comparison of CAS and GCAS skin using Oxford Nanopore Technologies (ONT) technology to elucidate the molecular mechanisms of snakehead albinism.27.1 G clean reads and 26,198 full-length non-redundant sequences were generated via ONT sequencing. Overall, 8079 new transcripts and 7231 genes were identified by comparing and analyzing redundant removed transcripts and known reference genome annotations. The results of DEGs analysis showed that a total of 59 transcripts were differentially expressed in the two groups, including 22 up-regulated transcripts and 37 down-regulated transcripts. Five causative genes associated with albinism have been identified, including TYR (Tyrosinase) and SOX10 (SRY-box transcription factor 10) (tyrosinase synthesis and metabolism), S-100 (S100 calcium binding protein A1) (melanin production), NLRC3 (NLR family CARD domain containing 3) (disease immunity) are significantly down-regulated in GCAS, while RhoGEFs expression (melanin synthesis) is up-regulated. Protein interaction analysis revealed that GAPDH (Glyceraldehyde-3-phosphate dehydrogenase) is the top hub gene in the regulation of skin color in C.argus. In addition, the skin of snakehead fish is regulated by metabolic (GAPDH), immune [(Tumor protein p53 (TP53), C-X-C motif chemokine ligand 8 (CXCL8), SRC proto-oncogene, non-receptor tyrosine kinase (SRC), CD274] and neural [(Notch receptor 1 (NOTCH1), C-X-C motif chemokine ligand 12 (CXCL12)] related genes to achieve differences in skin color. These findings in understanding the process by which albinism in fish develops.

Perancangan Sistem Informasi Perdesaan Berbasis Android

The research objective was to design an android-based rural information system at the Montasik Aceh Besar sub-district office, as a service in rural storage and services and it is hoped that it can be used as a reference for making a faster and more accurate android-based rural information system. The method used in designing an Android-based rural information system is using the waterfall method. The design results consist of service features for the community. services for making letters, searching for population data and village information by village officials, thereby increasing the work efficiency of village officials and village administration to become more orderly and regular. The Android-based rural information system for Montasik District is software that was built to help manage website and Android-based, with correspondence making services starting from requests for Family Cards, Resident Cards, Certificates of Inability, Death Certificate, Birth Certificate, Versatile Certificate, Transfer Certificate, Marriage Certificate, Business Certificate, and Certificate of Good Conduct, as well as information about the Village (vision and mission, Profile, History, Village Potential). Thus this system can be used as a tool to support the performance of village officials as well as a media for village promotion to make Montasik District Village an icon of a tourism village, especially in the Aceh Besar District area.

MEKANISME PEMBUKAAN DAN PENUTUPAN REKENING TABUNGAN PADA ANAK USIA DINI DI BANK SYARIAH(Studi pada PT Bank Muamalat Kabupaten Bone)

A bank is a financial institution whose main business is to raise funds, distribute funds, and provide services in payment traffic and money circulation. Islamic banking as an institution that collects and distributes funds has various types of businesses that offer various conveniences for the public to meet the needs of business capital, consumptive needs, future savings, and just meet entertainment needs. Mechanism is a process of carrying out an activity carried out by a person or several people using orders and rules as well as the flow of communication and division of tasks in accordance with professionalism. This study aims to find out how the mechanism for opening and closing savings accounts in early childhood in Islamic banks, and to find out how savings law in early childhood is in an Islamic economic perspective. Based on the purpose of the study, this research is a type of qualitative research using a grounded theory approach. This technique is used to describe the data that researchers collect, both data from interviews, observations and documentation during research at "PT. Bank Muamalat Bone Regency". The results of this study show that the mechanism for opening and closing accounts in early childhood savings is on the condition that the identity of the child who wants to open a savings account must already have a birth certificate and have been recorded in the family card, and the contract system used in this savings is to use a wadiah contract in the form of a entrustment

PERILAKU MASYARAKAT TERHADAP PENYIMPANAN ARSIP KELUARGA

The family is the first organization where a person socializes and gets education. In one family creates an archive of everyone in the family. The archives produced in a family are important documents in the phase of human life, ranging from marriage certificates, birth certificates, family cards, and other documents. Maintenance of archival documents in a family is an important thing that must be done, to maintain the integrity of the documents and information contained therein. In rural communities, the management and maintenance of family records is still very minimal in information, so it is not uncommon for family records to be neglected and lost, due to the lack of awareness of family members to maintain their archives. The focus of the research in this study is to look at how to manage digital-based family records and the factors that influence the management of digital-based family records. The method used in this research is a case study. Data were obtained from surveys and literature studies. The results of this study can be seen that people in Indonesia are not fully aware of backing up data from their family archives to anticipate the risk of loss or damage to archives.

Response to Immune Checkpoint Inhibitors Is Affected by Deregulations in the Antigen Presentation Machinery: A Systematic Review and Meta-Analysis.

Immune checkpoint inhibitors (ICI) targeting programmed death 1 (PD-1), its ligand (PD-L1), or cytotoxic T-lymphocyte antigen 4 (CTLA-4) have shown promising results against multiple cancers, where they reactivate exhausted T cells primed to eliminate tumor cells. ICI therapies have been particularly successful in hypermutated cancers infiltrated with lymphocytes. However, resistance may appear in tumors evading the immune system through alternative mechanisms than the PD-1/PD-L1 or CTLA-4 pathways. A systematic pan-cancer literature search was conducted to examine the association between alternative immune evasion mechanisms via the antigen presentation machinery (APM) and resistance towards ICI treatments targeting PD-1 (pembrolizumab and nivolumab), PD-L1 (durvalumab, avelumab, and atezolizumab), and CTLA-4 (ipilimumab). The APM proteins included the human leucocyte antigen (HLA) class I, its subunit beta-2 microglobulin (B2M), the transporter associated with antigen processing (TAP) 1, TAP2, and the NOD-like receptor family CARD domain containing 5 (NLRC5). In total, 18 cohort studies (including 21 original study cohorts) containing 966 eligible patients and 9 case studies including 12 patients were reviewed. Defects in the APM significantly predicted poor clinical benefit with an odds ratio (OR) of 0.39 (95% CI 0.24−0.63, p < 0.001). The effect was non-significant, when considering complete and partial responses only (OR = 0.52, 95% CI 0.18−1.47, p = 0.216). In summary, the APM contains important targets for tumorigenic alterations which may explain insensitivity towards ICI therapy.

Rancang Bangun Sistem Informasi Administrasi Publik Berbasis Website di Desa Panyadap

Panyadap Village which are Village Government Agencies whose duties are to collect population data, Make Family Cards, Birth Certificates, Death Certificates, Certificates Moving, Business Certificate and others. The public administration system in the Panyadap village administration is still manual or semi-computerized, not yet making full use of Information Technology. So that the process of public service becomes difficult and slow. With the creation of a Website-Based Public Administration Information System Design, it can make it easier for staff or officers to do their work. Make it easier for members of the public to know and be more thorough about the requirements when submitting correspondence so that services become more effective and efficient.

Inclusive Finance in Sembako Program: An Overview From Proper Governance Perspective

The Sembako program is one of the social protection programs launched by the Government of Indonesia to overcome poverty by providing food assistance. The sembako program is also expected to increase financial inclusion by using the prosperous family card as an electronic money and savings feature. This study uses a proper governance perspective with the research location in Banyumas Regency, Central Java Province, Indonesia. The results showed that the implementation of the Sembako program went well. However, the recipients complain that the types, quantities, and goods received are different from the instructed provisions, so they are not in accordance with the principles of proper governance. The sembako program contributes little to increasing financial inclusion because the KKS Card can only be used to take assistance from the sembako program and cannot access other banking services. It was found that the KKS Card was not held by the recipient of the basic food program, and the recipient did not memorize the KKS Card Pin. This study recommends that all shops and stalls carry out the distribution of the sembako program without being limited to certain stalls. The sembako program is not packaged so that beneficiaries are free to take basic food assistance according to the needs of their families.

Legal Protection For Children Born In Unrecorded Marriages (Research Study In Nisam Antara District, North Aceh District)

This study aims to determine legal protection for children born of unregistered marriages in Nisam Antara District, to determine the juridical impact on children born of unregistered marriages, and to find out what efforts can be made so that these children receive legal protection. &#x0D; Based on the results of this study, namely to obtain legal protection for children born from unregistered marriages, one of them is by registering marriages (Isbat nikah) which is carried out at the Office of Religious Affairs (KUA) and at the local Sharia Court. So that the legal protection that can be given by parents to these children can be done through making birth certificates, being registered on the family card (KK), and getting equality before the law.

HAK KONSTITUSIONAL PENDUDUK DALAM PERNIKAHAN YANG TIDAK TERCATAT MENURUT HUKUM DI INDONESIA

The development of legal norms in Indonesia related to the existence of space for citizens in managing population rights, especially related to unregistered marriages, which so far has been based on legal norms in the Marriage Law and the KHI does not have room for its existence to be recognized. However, with the issuance of Presidential Regulation Number 96 of 2018 concerning Requirements and Procedures for Population Registration and Civil Registration and its derivatives in the form of Permendagri, it is possible for unregistered marriages to obtain birth certificates and family cards as basic rights in population administration. The approach in writing this is a normative juridical approach which is carried out based on the main legal material by examining theories, concepts, legal principles and laws and regulations related to registration of population and unregistered marriages. This research reveals that unregistered marriages have no legal force even though they can be recorded on a family card or birth certificate. The existence of Perpres and Permendagri which regulates the registration of population for marriage actors is not recorded only to protect administratively but does not give legal force because this registered marriage can only become legal by way of itsbat marriage.

IMPLEMENTASI PENDAFTARAN DOKUMEN ADMINISTRASI KEPENDUDUKAN DENGAN SISTEM ONLINE SEBAGAI UPAYA TERTIB ADMINISTRASI DI DINAS KEPENDUDUKAN DAN PENCATATAN SIPIL KABUPATEN DEMAK

&lt;p&gt;&lt;em&gt;Registration of population administration documents as an effort to orderly administration is carried out by the government with an online system to provide convenience for the community, so this study seeks to examine the implementation of registration of the population administration documents with an online system as an effort to orderly administration at the Department of Population and Civil Registration of Demak Regency, obstacles and efforts overcome it. The research methods used are: type of sociological juridical research, analytical descriptive specifications. The data used is primary data supported by secondary data with qualitative data analysis. The results showed that the registration of family card population administration documents with an online system as an effort to orderly administration at the Demak Regency Population and Civil Registration Office in January 2017 - February 2021 was based on the Republic of Indonesia Law Number 24 of 2013 concerning Population Administration changes. on Law Number 23 of 2006 concerning Population Administration, and Regulation of the Minister of Home Affairs of the Republic of Indonesia Number 7 of 2019 concerning Online Population Administration Services with the mechanism starting with register, login, select menu, upload, send, finish. For the implementation of the registration, there were 5,472 documents. The orderliness of administrative documents after using the online system before using the online system shows that it is more orderly to use the online system, as indicated by the increasing number from year to year. The obstacles include 2 things, first, the public's lack of understanding to access online services, in this case it can be attempted by means of socialization, namely through brochures, websites, Instagram and Youtube; Second, the absence of a strong network/signal in some areas, in this case it can be attempted by serving reporters who wish to register documents directly.&lt;/em&gt;&lt;em&gt;&lt;/em&gt;&lt;/p&gt;

Implementasi Kebijakan Pelayanan Administrasi Terpadu Kecamatan (PATEN) di Kantor Kecamatan Katapang Kabupaten Bandung

The problem studied is the implementation of the policy of the District Integrated Administrative Service (PATEN) at the Katapang District Office, Bandung Regency in the service of making Identity Cards and Family Cards that have not been running optimally. The purpose of the research is to determine the implementation of the policy by using a qualitative approach through descriptive analysis that describes the situation according to the facts that occurred in the research process without manipulation. Analyzed based on four factors that influence the success or failure of implementation, namely communication, resources, disposition, and bureaucratic structure. Informants as data sources include three elements including structural ranks of officials at the Katapang District Office, functional staff serving as operators, representatives from village level government and the general public. The results of the study indicate that the implementation of the District Integrated Administrative Service (PATEN) policy at the Katapang District Office, Bandung Regency in the service of making Identity Cards and Family Cards in general has achieved quite good results. Communication based on aspects or distribution of information through policy socialization has been carried out in accordance with the provisions but has not achieved optimal results, the clarity is quite clear through appeals, announcements through letters and information boards and Whatsapp Group, and consistency covers the entire service process. Resources include aspects of competent human resources at work because they were prepared in advance, financial resources are adequate, facility resources are adequate even though there are some shortcomings and damages, and authority resources are already available based on regional regulations and Regent regulations. Disposition based on the aspect of bureaucratic appointments is in accordance with the needs and incentives in accordance with policy provisions. The bureaucratic structure based on the SOP aspect is already available through the District Head's decision letter and is linked to the Service SOP and the fragmentation is well established.

Implementasi Kebijakan Pelayanan Administrasi Terpadu Kecamatan (PATEN) di Kantor Kecamatan Katapang Kabupaten Bandung

The problem studied is the implementation of the policy of the District Integrated Administrative Service (PATEN) at the Katapang District Office, Bandung Regency in the service of making Identity Cards and Family Cards that have not been running optimally. The purpose of the research is to determine the implementation of the policy by using a qualitative approach through descriptive analysis that describes the situation according to the facts that occurred in the research process without manipulation. Analyzed based on four factors that influence the success or failure of implementation, namely communication, resources, disposition, and bureaucratic structure. Informants as data sources include three elements including structural ranks of officials at the Katapang District Office, functional staff serving as operators, representatives from village level government and the general public. The results of the study indicate that the implementation of the District Integrated Administrative Service (PATEN) policy at the Katapang District Office, Bandung Regency in the service of making Identity Cards and Family Cards in general has achieved quite good results. Communication based on aspects or distribution of information through policy socialization has been carried out in accordance with the provisions but has not achieved optimal results, the clarity is quite clear through appeals, announcements through letters and information boards and Whatsapp Group, and consistency covers the entire service process. Resources include aspects of competent human resources at work because they were prepared in advance, financial resources are adequate, facility resources are adequate even though there are some shortcomings and damages, and authority resources are already available based on regional regulations and Regent regulations. Disposition based on the aspect of bureaucratic appointments is in accordance with the needs and incentives in accordance with policy provisions. The bureaucratic structure based on the SOP aspect is already available through the District Head's decision letter and is linked to the Service SOP and the fragmentation is well established.

Identification of pyroptosis‑related genes in neuropathic pain based on bioinformatics analysis.

Pyroptosis is defined as inflammation-induced programmed cell death. However, gene expression levels related to pyroptosis and their role in neuropathic pain (NP) remain unclear. The present study aimed to develop and validate an NP-predictive signature based on the genes associated with pyroptosis. Gene expression level profiles were downloaded from the Gene Expression Omnibus database. Weighted gene co-expression network analysis was used to identify the pyroptotic genes most highly associated with NP. NP-related pyroptosis gene signature was constructed using multivariate logistic regression. A rat model of neuropathic pain was established through chronic constriction injury to analyse the inflammatory infiltration and myelin damage around the sciatic nerve, and examine the expression levels of macrophage markers S100 calcium-binding protein β (S100β) and ionized calcium-binding adapter molecule 1 (Iba-1). Finally, flow cytometry analysis was used to examine the lipopolysaccharide (LPS)-induced cell death ratio of RSC96 cells (Schwann cells), while the expression levels of LPS-induced pyroptosis-related genes in RSC96 cells were measured via reverse transcription-quantitative PCR. The results demonstrated that pyroptosis-related genes (gasdermin D, NLR family pyrin domain containing 3, neuronal apoptosis inhibitory protein and NLR family CARD domain containing 4) were identified to increase the risk of NP. NP-related pyroptosis signatures were constructed based on these four genes. Moreover, the high-risk group had a higher level of macrophage infiltration compared with the low-risk group, as determined by the CIBERSORT algorithm. H&E staining results showed that the myelin structure of the sciatic nerve tissue of chronic constriction injury (CCI) rats was destroyed and inflammatory cells infiltrated around neurons. The results of immunohistochemistry showed that compared with in the sham group, the expression levels of Iba-1 and sS100β in the sciatic nerve of the CCI group were increased. Furthermore, the expression levels of cell death and pyroptosis-related genes in Schwann cells induced by LPS were increased compared with in the control group. In conclusion, an NP-related pyroptosis gene signature was constructed based on four pyroptosis-related genes and it was found that the expression of pyroptosis-related genes was upregulated in the early steps of the neuroinflammatory process in RSC96 cells.

Vise Kriterijumska Optimizacija I Kompromisno Resenje (VIKOR) Algorithm for Analysis as Supporting System

In the event of a coronavirus (covid-19) pandemic, those in need will be helped through a government aid program known as the Village Cash Direct Assistance beneficiary fund (abbreviated BLT). Because of the COVID-19 pandemic, which has spread to nearly every corner of the globe, citizens’ activities around the world have been hindered, especially those involving employment to support life’s basic needs. The local economy suffers as a result of people losing their jobs. They have no idea how they will pay for the necessities of life. So, in order to help the locals, the government set up a Village BLT fund support program. Limag Village is one of the settlements that plans to ask for help. When the final decision is made, the village head will choose from the list of households that fit the criteria. A decision support system is one option for achieving clear and exact findings based on the strategy utilized. For a ranking-based decision-support system, the VIKOR approach (Vise Kriterijumska Optimizacija I Kompromisno Resenje) is an excellent choice. In order to reduce the amount of time spent on guesswork when choosing which communities will benefit from BLT Desa money, this study aims to examine and quantify the results of decisions made using criteria that match those criteria. With the use of the following five criteria: profession (K1), number of dependents (K2), social safety net (K3), medical history (K4), and family card (K5): (K5). The results show that the VIKOR approach is able to obtain ranking values from the ten samples it was applied to..

Quantitative proteomics reveals potential anti-inflammatory protein targets of radial extracorporeal shock wave therapy in TNF-α-induced model of acute inflammation in primary human tenocytes

Tendinopathy refers to a type of tendon disease with a multifactorial spectrum. Recent research has begun to reveal the effects of inflammation on the tendinopathic process, especially in the first stage of tendinopathy. Radial extracorporeal shock wave therapy (rESWT) has been successfully used to treat orthopedic diseases. However, the molecular mechanisms underlying the anti-inflammatory effects of rESWT on tumor necrosis factor-α treated tenocytes have not been fully elucidated. In this study, we applied total protein tandem mass tag-labeled quantitative proteomics with liquid chromatography-mass spectrometer/mass spectrometer technology to identify differentially expressed proteins (DEPs) among inflammatory tenocytes, rESWT inflammatory tenocytes, and controls using three biological replicates. Human tenocytes were used and they were cultured in vitro. In total, 1028 and 40 DEPs were detected for control versus inflammatory tenocytes and for inflammatory tenocytes versus rESWT inflammatory tenocytes, respectively. Further, we identified integrin α2, selenoprotein S, and NLR family CARD domain-containing protein 4 as pivotal molecular targets of the anti-inflammatory effects of rESWT. This is the first study to provide a reference proteomic map for inflammatory tenocytes and rESWT inflammatory tenocytes. Our findings provide crucial insight into the molecular mechanisms underscoring the anti-inflammatory effects of rESWT in tendinopathy.

Implementasi Prinsip Good Governance Dalam Pelayanan E-Ktp Dan Kartu Keluarga Di Kecamatan Benda Kota Tangerang

The purpose of this research is to know the implementation of the principles of good governance in the service of E-KTP and Family Cards in Benda District, Tangerang City, Benda District in the E-KTP and Family Card services. To obtain data in this study, the method used is a qualitative research method. The data collection techniques are observation, interviews and documentation. The results of this study indicate that the Implementation of Good Governance Principles in E-KTP and Family Card Services in Benda District, Tangerang City has not gone well, there are still some things that are still not appropriate, such as the existence of services that prioritize people who have positions and kinship , as well as service employees who still serve with unfriendly looks. The results of this study found that the implementation of the principle of Good Governance in the E-KTP and Family Card services was not in accordance with the principles of Good Governance because there was still injustice in providing services by prioritizing one's position and when performing services if people who had families working there the service would be faster. , but behind that there are several principles of Good Governance that have been in accordance with such as Participation, Rule of Law, Transparency, Responsiveness, Consensus Oriented, Effectiveness and Efficient, Accountability, Strategic Vision.

APLIKASI E-GOVERNMENT PELAYANAN ADMINISTRASI KEPENDUDUKAN PADA DESA SUMBER MULYA KABUPATEN MUARO JAMBI

Desa Sumber Mulya is a village located in the North Bahar District, Muaro Jambi Regency. The population continues to grow every year in Desa Sumber Mulya along with the demands of the community both inside the village and outside the village for population administration services which of course demand to switch from a manual data collection system and population administration service to a more advanced administrative service system efficient and effective administrative data collection of its citizens. The purpose of this research is to make the population administration service system better and easier in terms of data processing. The input requirements include population data, social assistance data, and certificate data. The process needs are population data processing, social assistance data processing, and certificate data processing. Meanwhile, the output needs are in the form of population data reports and reports of certificates that have been processed previously. This web-based application is built to assist the Desa Sumber Mulya government in serving the activities of recording births, deaths, marriage certificates, and statements of introduction for family cards, identity cards, temporary resident certificates, residents moving in and out and collecting data on social assistance. So that the expected results in this study are to facilitate the population administration service system so that it is effective and efficient.