Cinnamon Extract Research Articles

Clinical Aspects on the Toxicity of Cinnamon Extracts: A Mini Review

Clinical Aspects on the Toxicity of Cinnamon Extracts: A Mini Review

Psidium guajava, Phalaenopsis sp., Syzygium aromaticum e Cinnamomum verum como inibidores naturais do crescimento de Streptococcus mutans

Currently, an increase on research on plant extracts seeking therapeutic action in the control of diseases of the oral cavity are observed, especially dental caries. Several plant extracts are already incorporated into toothpastes and mouthwashes. The objective of this study was to evaluate in vitro the antibacterial action of Psidium guajava (guava), Phalaenopsis sp. (orchid), Syzygium aromaticum (clove) and Cinnamomum verum (Ceylon cinnamon) extracts. The tests were carried out with the oral cavity bacteria Streptococcus mutans. The antibacterial activity of plant extracts was evaluated by the disk diffusion method in agar and by minimal inhibitory concentration (MIC). The tests showed the effectiveness of the extracts through inhibition zones of bacterial growth (from 5 to 20 mm in diameter) and MIC of 100 mg. mL-1 Phalaenopsis sp. extract and 50 mg. mL-1 P. guajava extract. Complementary studies will be needed to evaluate other pharmacological actions in order to use these plant extracts in different dental specialties and mainly in the treatment and prophylaxis of dental caries.

Powder shampoo formulation with antioxidant activity: in vitro perspectives

PurposeThe purpose of the study was to develop a powder shampoo with antioxidant attributes.Design/methodology/approachDry shampoo compositions were formulated containing alpha olefin sulfonate (AOS), sodium cocoyl isethionate (SCI), microcrystalline cellulose, mannitol, carboxymethyl cellulose, maltodextrin and sodium benzoate with or without extract of Cinnamomum zeylanicum bark. Cinnamon extract was chosen for this study owing to its ubiquitously known antioxidant attributes. The formulations were tested for detergency action and antioxidant potential in vitro.FindingsCinnamomum zeylanicum extract exhibited noticeable antioxidant activity in vitro. The authors observed that addition of the bark extract to the shampoo formulation was associated with remarkable increase in total phenolic content, total antioxidant activity and radical scavenging activity without any effect on detergency action.Research limitations/implicationsThis preliminary study provides a powder shampoo formulation which exhibits antioxidant attributes as a result of incorporation of cinnamon bark extract. Clinical efficacy of the formulation remains to be tested.Practical implicationsOwing to the powder format of the shampoo, the formulation can be manufactured with ease and economically. Functionalizing the formulation with enhancement of antioxidant activity by incorporation of cinnamon bark extract may be associated with beneficial clinical outcomes, which remains to be tested.Social implicationsThe proposed formulation may be stored and sold in eco-friendly packing material, thus could pave the way for reducing the burden of plastic consumption by the shampoo industry.Originality/valueThe present work demonstrates that incorporation of cinnamon bark extract to a powder shampoo formulation, containing AOS and SCI as principle surfactants, significantly enhances its antioxidant attributes.

Weakening of Virulence Factors and Biofilm in Salmonella Typhi by Medicinal Plants Extracts

Objective(s): Salmonella typhi, is a serious global health threat because it causes typhoid fever, a severe systemic infection. According to the World Health Organization, millions of cases of typhoid are recorded annually, and thousands of people die from it. To combat this pathogen, new medications are required. The current study aims to study the ability of medicinal plants (thyme and cinnamon) to modulate the properties of Salmonella typhi isolates instead of killing them. Materials and Methods: The plants were extracted with the help of solvents (ethanol and ethyl acetate) and to find out the minimum inhibitory concentration, the different concentrations were used. The biofilm and expression of genes (invA & fliC) of the bacterium were studied when exposed to sub-inhibitory concentrations of the plant extracts. Results: MIC values ranging between 20-25 mg/ml and 10-15 mg/ml for ethanol and ethyl acetate extracts of Thyme respectively. While the MIC values of cinnamon were 18-25 and 10-15 mg/ml for both ethanol and ethyl acetate extracts respectively. The examinations revealed a significant decrease in the composition of biofilms by isolates when treated with SICs from plant extracts. The transcription expression profile of invasion (invA) and flagellar (fliC) genes were downregulated when treated with the plant extracts. Conclusion: The findings indicate that both thyme and cinnamon extracts may have promising activity against the biofilm and virulence of S. typhi. Thus, they could be used as potential as an antibacterial drug.

Antifungal Effectiveness Test of Cinnamon Extract (Cinnamomum Burmannii) Against Candida Albicans

Background: Candida albicans, is a normal flora that lives on the oral mucosa, digestive tract and vagina. Candida albicans can cause infection such as oral candidiasis. A number of antifungal agents are widely used in the treatment of Candida infections, but some antifungal drugs sometimes have unpleasant side effects. This prompted researchers to examine the contents of natural ingredients that have antifungal activity, one of which is cinnamon. Cinnamon (Cinnamomum burmannii) contains several chemical compounds including cinnamaldehyde and eugenol which are components that have antifungal effects. Objective: to analyze the effectiveness of cinnamon (Cinnamomum burmannii) antifungal against Candida albicans. Materials and Methods: The research was performed as laboratory experiment that calculates the diameter of inhibition using the agar-well diffusion method. 25 samples tested were Candida albicans cultured in SDA (Saboroud Dextrose Agar) medium. Variations in treatment concentrations were cinnamon extract (Cinnamomum burmannii) 25%, 50%, 75%, nystatin oral suspension (positive control), and aquades (negative control). Results: The average inhibition of 75% cinnamon extract (Cinnamomum burmannii) was 16.8 mm, whereas in the positive control nystatin oral suspension was 13.4 mm. The hypothesis test has a value of p=0.000 (p<0.05). Conclusion: There is an antifungal effectiveness of cinnamon (Cinnamomum burmannii) against Candida albicans at a concentration of 75%.

Enrichment of cinnamaldehyde from Cinnamomum cassia by electroosmotic coupled particle-assisted solvent flotation

Cinnamaldehyde has been widely applied in various fields due to its special flavor and various pharmacological activities, such as antioxidant, anti-inflammatory and antibacterial properties. The strategy of quick and efficient enrichment for cinnamaldehyde is imperative. In this study, an electroosmotic coupled particle-assisted solvent flotation (ECPASF) system was designed for the cinnamaldehyde enrichment from cinnamon. The response surface method was used to optimize extraction parameters. Under optimal operating conditions, its yield was 9.33 ± 0.11 mg/g. Such high yield of cinnamaldehyde using the ECPASF might be because electroosmosis effectively alters the permeability of plant cells, which facilitates the release of cinnamaldehyde. In addition, both the crude extract of cinnamon and pure cinnamaldehyde showed good antioxidant activity. The results demonstrated that the ECPASF system is a sustainable and effective method for the extraction of cinnamaldehyde from cinnamon. It also has the prospect of being extended to the extraction of other natural products.

Chinese Herbal Extracts Mitigate Ammonia Generation in the Cecum of Laying Hens: An In Vitro Study.

The objectives of the study were to screen one or several Chinese herbal extracts with good ammonia emission reduction effects using an in vitro gas production study. The study consisted of a control (without Chinese herbal extract), and 11 experimental groups with added cinnamon extract (CE), Osmanthus extract (OE), tangerine peel extract (TPE), dandelion extract (DE), Coptis chinensis extract (CCE), honeysuckle extract (HE), Pulsatilla root extract (PRE), yucca extract (YE), licorice extract (LE), Ginkgo biloba extract (GBE), or astragalus extract (AE). The results showed that HE, PRE, YE, LE, GBE, and AE significantly reduced ammonia production (p ≤ 0.05). The most significant ammonia inhibition was achieved via AE, resulting in a 26.76% reduction. In all treatments, Chinese herbal extracts had no significant effect on pH, conductivity, or uric acid, urea, and nitrate-nitrogen concentrations (p > 0.05). However, AE significantly reduced urease activity and the relative activity of uricase (p ≤ 0.05). AE significantly increased the relative abundance of Bacteroides and decreased the relative abundance of Clostridium, Desulfovibrio, and Prevotell (p ≤ 0.05). Astragalus extract inhibited ammonia emission from laying hens by changing the gut microbial community structure, reducing the relative abundance of ammonia-producing bacteria, and reducing microorganisms' uricase and urease activities.

Effect of cinnamon extract combined with Ɛ-polylysine infusion treatment on the sensory, physicochemical and biological quality of Brassica rapa L. (Chinensis Group)

The effects of cinnamon extract and Ɛ-polylysine on microorganisms and storage quality of fresh Brassica rapa L. (Chinensis Group) stored at 4 °C for 12 d were investigated. The results showed that 0.062% cinnamon extract combined with 0.057% Ɛ-polylysine was superior to 0.062% cinnamon extract or 0.057% Ɛ-polylysine treatment alone in microbiological and physico-chemical properties. Cinnamon extract combined with Ɛ-polylysine reduced the weight loss and total color difference, declined polyphenol oxidase and peroxidase, maintained the higher level of ascorbic acid, chlorophyll and total phenolic content, as well as significantly inhibited the growth of microorganisms during storage compared to any single-factor. Therefore, cinnamon extract combined with Ɛ-polylysine treatment could be an effective preservation technique for fresh Brassica rapa L. (Chinensis Group).

The Antimicrobial of Selenium Nanoparticles and Combination with Cinnamon Oil Against Salmonella Typhi Which Cause Diarrhea in Human

Many bacterial species can cause diseases in humans, such as the bacteria that cause diarrhea as a result of having genetic characteristics that can form pathogenic factors, which help the bacterium to produce harmful effects in the host's body. From (60) fecal samples of diarrheal cases of human, Salmonella spp.42(70%) where Salmonella typhi consist29(48.33%) isolates and Salmonella paratyphi consist13(21.67%) isolates, E. coli 10(16,66%), Enterobacter 4(6,66%) and Shigella 4(6,66%). On Congo red agar (CRA) plates, among (29) S. typhi bacterial isolates from human, all the isolates (100%) were showed biofilm formation through formation of brown colonies with a dry crystalline quality. Antibiotic susceptibility profile of Salmonella typhi. isolated from fecal sample of human were determined by using Vitek2 system, the results revealed that Salmonella typhi were100% resistant to Ticarcillin and 89.7% to Aztreonam while the rest of the antibiotics were less resistant. Selenium nanoparticles (Se-NPs) are green synthesized using cinnamon extract. The antibacterial activity of the cinnamic ethanolic extract and synthesized SeNPs was investigated against isolates of human source Salmonella typhi by using the agar well diffusion method and tested by using different concentrations (25,50,100 μg/mL).According to the data, cinnamon extract only produced an inhibition of 10.66 mm at the same dose of 100 mg/ml, but Se-NPs produced a good inhibition at that concentration of 14.33 mm.

ANTIOXIDANT ACTIVITY ON SARRABBA IS BASED ON THE PROPORTION OF RED GINGER EXTRACT (ZINGIBER OFFICINALE ROSCOE) AND CINNAMON EXTRACT (CINNAMOMUM VERUM J. PRESL)

This study aims to evaluate the antioxidant activity, total phenol, yield and evaluation of the panelists' preference level including color, taste and aroma of instant sarabba. Sarabba is processed into an instant drink to extend the shelf life of the sarabba drink and is practical. The research method used was a completely randomized design (CRD) method with 4 treatment levels of the proportions of red ginger extract and cinnamon extract namely A (100% : 0%), B (95% : 5%), C (90% : 10%) ) and D (85% :15%) with 3 repetitions. The analytical method used in this research is the Folin Chiocalteau method for the total phenol test, the DPPH (1,1-diphenyl, -2 picrylhydrazyl) method for the antioxidant activity test. The results showed that the IC50 of instant sarabba ranged from 662.13 - 886.93 ppm and total phenol ranged from 2.21 - 6.75 mgGAE/100 g sample. Treatment of the proportion of 100% red ginger extract and 0% cinnamon extract had the strongest antioxidant activity with IC50 of 662.13 ppm and total phenol with a value of 6.75 mgGAE/100 g simple

Effect of Cinnamon Extract on Ovarian Torsion Detorsion Damage in Rats

Effect of Cinnamon Extract on Ovarian Torsion Detorsion Damage in Rats

High-performance CPES nanofiltration membrane decorated by cinnamon extract with efficient antibacterial/anti-fouling property for post treatment of biologically treated industrial wastewater

In this work, cinnamon extract/ coupling modified polyether sulfone (CiE/CPES) mixed matrix membrane with excellent anti-fouling and antibacterial properties was synthesized by the phase inversion method. To characterize the modified membrane, SEM, AFM, ATR – FTIR, EDX, WCA and porosity measurements were performed. SEM images showed the wider finger-like pores compared to the unfilled-CPES membrane. AFM images exhibited that with the addition of CiE to the polymer matrix the surface of CiE/CPES membranes has been significantly smoothed. BSA was used as a foulant to evaluate the anti-fouling properties and the results showed excellent flux recovery ratio (more than 95%) in all weight percentages of CiE, which indicates the significant improvement of self-cleaning property of fabricated membranes. To confirm the antibacterial properties of CiE, agar diffusion test was performed. A clear large halo around the CiE was observed for both model bacteria. The average halo radius was 41.63 mm for E. coli and 47.25 mm for S. aureus, which showed better performance compared to other routine studies. Also, the bacteria suspension immersion test and SEM analysis were investigated. The results showed a significant reduction of bacteria on the membrane surface compared to the control sample, which confirmed the excellent performance of CiE in the membrane. Besides, to measure the separation performance of the membranes, the biologically treated soft drink industrial wastewater (BTW) rejection was evaluated. The results provided very good efficiency in BTW purification. For further study, the desalination performance of the membranes was evaluated by examining the rejection of different salt solutions, and the order of rejection in all prepared membranes followed MgSO4 > MgCl2 > NaCl.

Effectiveness of botanical insecticides on larval stage of red palm weevil Rhynchophorous ferrugineus and survival of entomopathogenic nematodes

Botanical oils are considered ecofriendly compounds with insecticidal characteristics. In this study, the effects of basil (Ocimum basilicum), camphor (Cinnamomum camphora), cinnamon (Cinnamomum verum), lemon (Citrus limon), clove (Syzygium aromaticum), ginger (Zingiber officinale), black pepper (Piper nigrum), and orange (Citrus sinensis var balady) oil extracts on the survival of four entomopathogenic nematode strains belonging to the Steinernema and Heterorhabditis genera, as well as their impacts on Rhynchophorus ferrugineus egg hatching and larvae, were assessed. The results for the camphor, lemon, black pepper, and orange oils were promising as 50 μL/mL of each resulted in 0%, 0%, 16%, and 0% hatchability for the R. ferrugineus eggs, respectively. Furthermore, the mortality of R. ferrugineus larvae was up to 95% with the similar concentrations and an exposure time of 48 h, for the other investigated oils. Various morphohistopathological alterations were found in the cuticle; outer cuticle folds swelling or shrinkage and subcuticular muscle degeneration, as well as midgut; fat globules in the epithelial lining with marked degeneration and/or necrosis, of the R. ferrugineus larvae when compared with those of controls replicates. Mortality percentage of infective juveniles (IJs) of Steinernema carpocapsae (S2) was significantly lower than Heterorhabditis marelatus (D1), Steinernema riobravae (Sr) and Steinernema carpocapsae (All) when using camphor oil compared to the other oils (50%). From the obtained observations on oils lethal effects, the target of developing integral biocontrol product formulated from combinations of essential oils and nematode with insecticidal properties against R. ferrugineus (not nematode survival) is possible; a sustainable and ecofriendly product for pest management.

Antimicrobial activity of dietary supplements based on bacterial lysate of Lactobacillus rhamnosus DV.

According to WHO, antibiotic resistance is increasing to hazardous levels worldwide. Candidiasis often occurs after taking antibiotics. Therefore, antibiotic resistance is a global problem and searching for antibacterial agents is necessary. To determine the antimicrobial activity of bacterial lysate of Lactobacillus (L.) rhamnosus DV separately and with plant extracts against bacterial and yeast test cultures. Antimicrobial activity of Del-Immune V® (cell wall and DNA fragments from a L. rhamnosus DV) separately and with cinnamon, beetroot, and blackcurrant extracts was determined by the minimum inhibitory concentration (MIC). Twofold serial dilutions determined the MIC in previously prepared meat-peptone broth (MPB) for bacteria and liquid wort for yeast. In the study, gram-negative (Escherichia coli IEM-1, Proteus vulgaris PА-12, Pseudomonas sp. MI-2, L. rhamnosus 13/2) and gram-positive (Bacillus (B.) subtilis BТ-2, Staphylococcus aureus BМС-1) bacteria, as well as yeast (Candida (C.) albicans D-6, C. tropicalis PE-2, C. utilis BVS-65) were used as test cultures. The MIC for the studied bacterial test cultures after application of L. rhamnosus DV bacterial lysates was from 1.0 ± 0.05 mg/mL to 12.5 ± 0.63 mg/mL, which was significantly less than that of the thermally inactivated control (MIC from 125.0 ± 6.25 mg/mL to 250.0 ± 12.5 mg/mL). B. subtilis BT-2 culture was the least sensitive to the action of the bacterial lysate (MIC-12.5 ± 0.63 mg/mL). It showed the best antibacterial and antifungal effect bacterial lysate with the phytonutrient blackcurrant. It was demonstrated that bacterial lysate of lactic acid bacteria L. rhamnosus DV exhibits antibacterial and antifungal properties during direct contact with pathogenic agents.

In vitro antimicrobial activity of extracts and essential oils of Cinnamomum, Salvia, and Mentha spp. against foodborne pathogens: A meta-analysis study.

Essential oils (EOs) are a class of natural products that exhibit potent antimicrobial properties against a broad spectrum of bacteria. Inhibition diameters (IDs) and minimum inhibitory concentrations (MICs) are the typical measures of antimicrobial activity for extracts and EOs obtained from Cinnamomum, Salvia, and Mentha species. This study used a meta-analytical regression analysis to investigate the correlation between ID and MIC measurements and the variability in antimicrobial susceptibility tests. By utilizing pooled ID models, this study revealed significant differences in foodborne pathogens' susceptibility to extracts, which were dependent on both the plant species and the methodology employed (p<.05). Cassia showed the highest efficacy against Salmonella spp., exhibiting a pooled ID of 26.24mm, while cinnamon demonstrated the highest efficacy against Bacillus cereus, with a pooled ID of 23.35mm. Mint extract showed the greatest efficacy against Escherichia coli and Staphylococcus aureus. Interestingly, cinnamon extract demonstrated the lowest effect against Shiga toxin-producing E. coli, with a pooled ID of only 8.07mm, whereas its EOs were the most effective against this bacterial strain. The study found that plant species influenced the MIC, while the methodology did not affect MIC measurements (p>.05). An inverse correlation between ID and MIC measurements was identified (p<.0001). These findings suggest that extracts and EOs obtained from Cinnamomum, Salvia, and Mentha spp. have the potential to inhibit bacterial growth. The study highlights the importance of considering various factors that may influence ID and MIC measurements when assessing the effectiveness of antimicrobial agents.

P03 Effects of a dietary supplement containing probiotics, cinnamon and cranberry extracts in the prevention of recurrent cystitis

Abstract Objectives A study was conducted to evaluate the effects of a dietary supplement containing two probiotic strains (Lactobacillus helveticus LA201 and Lactobacillus plantarum BL3706, 5×109 cfu per two tablets) and extracts of cinnamon (320 mg) and cranberry (100 mg) in the prevention of recurrent cystitis. Methods A total of 80 women (18–65 years) were included who reported at least two episodes of cystitis in the past 6 months, at least one of which was a bacterial cystitis confirmed by a urine cytobacteriological examination or a physician, and for whom the episodes of cystitis had a strong impact on their quality of life (QoL; Acute Cystitis Symptom Score [ACSS] QoL questionnaire &amp;gt;2). Participants took two tablets of the supplement per day for 6 months (n=37; Group 1) or no supplement (n=38; Group 2). The ACSS questionnaire was completed every 15 days, or in case of cystitis, for 8 months (total score ranged from 0 [no urinary discomfort] to 39 [maximum discomfort]). The two groups were comparable at baseline, with a higher proportion of postmenopausal women in Group 1. Results During the 6 months, 2/3 of the women in Group 1 had no recurrence of cystitis (0 symptomatic cystitis episodes [SCE]) while 2/3 of the women in Group 2 had at least one SCE (P=0.03 Fisher test). The total ACSS score during SCE was significantly lower in Group 1 (8.4±5.1 versus 12±5.9, P&amp;lt;0.0001 ANOVA), with results in favour of Group 1 for dimensions assessing typical symptoms of acute cystitis and QoL. Compliance and tolerance were excellent. Conclusions These results suggest that the supplement may help prevent recurrence of cystitis, particularly in postmenopausal women who are at high risk.

Effect of cinnamon (Cinnamomum verum) extracts on the growth and protection ability of tilapia (Oreochromis spp.) against Streptococcus agalactiae

This study was conducted to investigate the effect of cinnamon (Cinnamomum verum) extract mixed to feed on growth parametersand the ability to protect tilapia against Streptococcus agalactiae isolated from infected tilapia (Oreochromis spp.) in Cu Chi district, Ho Chi Minh city. Cinnamon extract was mixed to feed with doses of 10, 20, and 40 g/kg feed. Fish were intraperitoneally injected with 0.1 ml of 1.8x104 CFU/ml of S. agalactiae. The negative control was injected with 0.1 ml of physiological saline. The results showed that the cinnamon extract (C. verum) mixed at the three above levels was shown to be safe for the growth and survival rate of tilapia. Moreover, cinnamon extracts well mixed at 20 g/kg feed proved the highest protection (with the relative percent survival (RPS) value being 51.4%). The cinnamon extract can be considered a potential herbal extract for the prevention of disease caused by S. agalactiae in tilapia.

Ultrasonic-assisted green synthesis of silver nanoparticles through cinnamon extract: biochemical, structural, and antimicrobial properties

ABSTRACT Ultrasonic-assisted green synthesis of silver nanoparticles is gaining more attention owing to its benefits over conventional synthesis process. The main objective of this study was to synthesize silver nanoparticles with aqueous cinnamon extract using ultrasound-assisted extraction and their physico-chemical characterization. Total phenolic content, DPPH, FRAP of cinnamon aqueous extract were 315 mg GAE/g, 89% scavenging activity and 9.5 mmol Trolox eq/100 g reducing power respectively. The synthesized silver nanoparticles were characterized by UV-visible spectroscopy, X-rays Diffraction (XRD), Scanning Electron Microscopy (SEM) with Energy Dispersive X-rays (EDX), Fourier transform infrared (FTIR) and Nuclear Magnetic Resonance (NMR). XRD spectra depicted that the nanoparticles were crystallite in structure and 50 nm in size. SEM micrographs showed that nanoparticles were spherical in shape. EDX, FTIR and NMR spectra indicated that the phenolic compounds present in cinnamon aqueous extract played their role in capping and reducing the silver ions. Cinnamon-based silver nanoparticles showed potential antimicrobial activity against Gram negative and Gram-positive bacteria. Thus, cinnamon extract obtained through ultrasonic-assisted extraction could be a valuable source of polyphenols, which actively participated in the reduction and stabilization of silver nanoparticles.

Modification of Polycaprolactone with Plant Extracts to Improve the Aging Resistance.

Natural extracts of plant origin are used as anti-aging compounds of biodegradable polymers. Coffee, cocoa, or cinnamon extracts in amounts from 0.5 to 10 wt.% were added to the polycaprolactone matrix. The manufactured materials were aged at elevated temperatures with increased relative humidity and continuous exposure to UV radiation for 720, 1440, or 2160 h. The performance of the proposed extracts was compared with the retail anti-aging compound, butylated hydroxytoluene. Visual assessment, FTIR analysis, melt flow rate, tensile strength, impact tensile strength, thermogravimetry, and differential scanning calorimetry tests were conducted. Results showed that the use of lower contents of the tested extracts is particularly advantageous. When the content of the extract did not exceed 1 wt.%, no unfavorable influence on the properties of the materials was observed. The stabilizing performance during accelerated aging was mostly similar to or greater than that of the reference compound used.

Enhancing the Shelf Life of &lt;i&gt;Psidium guajava&lt;/i&gt; during Post Harvesting storage by Coating with &lt;i&gt;Cinnamomum verum&lt;/i&gt; Formulations

Guava is a nutritious fruit that could decompose during storage. In this study, (GCE F1 and GCPE F2) two formulations of cinnamon extract, Guar gum, and glycerol coating were prepared. The guavas (Psidium guajava L.) were selected at the stage of maturity and coated with formulations along with controls such as water and sodium benzoate. Further physiological and biochemical attributes of the quality of guava fruits were analyzed during the storage at 4°C for 5, 10 and 15 days. The results revealed that the coated guavas (GCE F1) exhibited a significant reduction in weight and firmness, low pH, and reduced usage of organic acids which contributes to high TA values, less sugar content, high antioxidant and free radical scavenging activity, with less microbial growth during the storage period. Further, the presence of bioactive compounds in the ethanolic extract of cinnamon was identified by GCMS and cytotoxicity analysis confirmed no toxic effect on L929 cell lines. The results suggest that compared to coated guavas of GCPE F2, water, and sodium benzoate, GCE F1 exhibited superior quality and enhanced shelf life during post-harvest storage.