P03 Effects of a dietary supplement containing probiotics, cinnamon and cranberry extracts in the prevention of recurrent cystitis

Abstract

Abstract Objectives A study was conducted to evaluate the effects of a dietary supplement containing two probiotic strains (Lactobacillus helveticus LA201 and Lactobacillus plantarum BL3706, 5×109 cfu per two tablets) and extracts of cinnamon (320 mg) and cranberry (100 mg) in the prevention of recurrent cystitis. Methods A total of 80 women (18–65 years) were included who reported at least two episodes of cystitis in the past 6 months, at least one of which was a bacterial cystitis confirmed by a urine cytobacteriological examination or a physician, and for whom the episodes of cystitis had a strong impact on their quality of life (QoL; Acute Cystitis Symptom Score [ACSS] QoL questionnaire >2). Participants took two tablets of the supplement per day for 6 months (n=37; Group 1) or no supplement (n=38; Group 2). The ACSS questionnaire was completed every 15 days, or in case of cystitis, for 8 months (total score ranged from 0 [no urinary discomfort] to 39 [maximum discomfort]). The two groups were comparable at baseline, with a higher proportion of postmenopausal women in Group 1. Results During the 6 months, 2/3 of the women in Group 1 had no recurrence of cystitis (0 symptomatic cystitis episodes [SCE]) while 2/3 of the women in Group 2 had at least one SCE (P=0.03 Fisher test). The total ACSS score during SCE was significantly lower in Group 1 (8.4±5.1 versus 12±5.9, P<0.0001 ANOVA), with results in favour of Group 1 for dimensions assessing typical symptoms of acute cystitis and QoL. Compliance and tolerance were excellent. Conclusions These results suggest that the supplement may help prevent recurrence of cystitis, particularly in postmenopausal women who are at high risk.