Exposure Values Research Articles

Health burden of unbalanced fatty acids intake from 1990 to 2019: A global analysis

Unbalanced fatty acids intake is associated with a range of health outcomes; however, the impact on human health remains unclear globally. We aim to provide a comprehensive assessment of the health effect of unbalanced fatty acids intake on a global scale. We analyzed the trends of summary exposure value (SEV) and the attributable burden of unbalanced fatty acids intake, including diet low in polyunsaturated fatty acids (low PUFAs), diet low in seafood omega-3 fatty acids (low seafood-(ω-3)-PUFAs), and diet high in trans fatty acids (high TFAs) from 1990 to 2019 using data from Global Burden of Disease Study 2019. The global fatty acids intake was far from the optimal level. High-income North America had the highest SEV of diet of high TFAs, while less-developed regions located in Saharan Africa had the highest SEVs of low PUFAs and low seafood-(ω-3)-PUFAs. The attributable burden was unequally distributed to less-developed regions. Males had lower SEVs but higher attributable burden than females and this gender gap was particularly pronounced before the age of 59. The young population had a higher SEV of diet of low PUFAs, comparable SEV of low seafood-(ω-3)-PUFAs but lower SEV of high TFAs than the elderly population. This study underpinned the high prevalence of unbalanced fatty acids intake worldwide and provided evidence-based guidance for identifying at-risk populations and developing effective strategies to improve fatty acids intake in the future. The study was funded by Shanxi Province "136" Revitalization Medical Project Construction Funds and the Fundamental Research Funds for the Central Universities.

A novel ecological risk assessment approach applied to Jiangsu coastal zone, China

Natural and anthropogenic risk factors contribute to ecological risks in coastal zones; however, the response of ecological entities (receptors) to disturbances varies with the risk source. We used the risk causal law as a guide to construct an ecological risk assessment method for Jiangsu coastal zone, China, with different ecological receptors as the research subjects. We screened the evaluation indicators for natural and anthropogenic risks, validated the evaluation results, and designed a method to map the integrated coastal ecological risk. The five typical ecological receptors exhibited different risk responses when faced with different disturbances. Among the natural risks, invasive species and seawater pollution had the largest differences in risk values. Of the anthropogenic risks, the largest differences in risk values were for reclamation sea farming and industry. The results of the habitat risk assessment model, which were based on the exposure–consequence framework, and those of the hazard–vulnerability–damage model showed a strong positive correlation. Furthermore, the T-test results were tested with P values of less than 0.05, and were not significantly different at the 95% confidence level; thus, the results were valid. The variability in the evaluation results of different ecological receptors was used to map the integrated ecological risk. High- and very-high-risk areas were distributed along the coastline and the edge of the radiating sand ridge, and moderate-risk areas were distributed within the high-risk mudflat areas. The ecological risk values were quantified for each shore section; very-high-risk areas were mainly distributed in the central and estuaries shore sections, and moderate-risk areas were mainly distributed in the southern shoreline sections. The exposure and consequence values calculated using InVEST-HRA model were used to select ten primary factors represented by coastal erosion and sewage discharge as well as five secondary factors represented by green tides and coastal engineering. Finally, we suggested future ecological protection and risk prevention measures based on the shore sections and primary and secondary factors. This study takes the causal relationship of the risk occurrence process as a guideline, and combines the reflected difference characteristics among the risk elements to provide scientific support for the practice of ecological risk prevention and governance in the coastal zone.

The occurrence and probabilistic risk assessment of 3-MCPDEs and GEs in infant formulas from Chinese market employing Monte Carlo simulation technique.

3-monochloropropane-1,2-diol esters (3-MCPDEs) and glycidyl esters (GEs) are food contaminants and have arisen continuous attention due to their toxicity, especially towards infants. Current risk assessment of these contaminants was mostly employing deterministic approaches, lacking quantitative characterization of the likelihood, incidence, or severity of the risks involved. Herein, 3-MCPDE and GE levels in 46 representative infant formulas (IFs) from Chinese market were determined by GC-MS/MS. Then, combining the occurrence data and consumption data from China National Food Consumption Survey, the Monte Carlo simulation-based probabilistic model for risk assessment of 3-MCPDEs and GEs in IFs from Chinese market was established. The results showed that all P90 (90th percentiles) hazard quotient values were below 1, demonstrating 3-MCPDEs didn't pose health risks to most populations aged 0-36 months old. However, for 0-12 months old groups, P10 (10th percentiles) margin of exposure values were all below 25000, indicating GEs may pose potential risks to 10% of this group. Uncertainty analysis revealed that the probabilistic model had considered uncertainties of model input and distribution, and realized refined assessment. This study is the first report on probabilistic assessment of 3-MCPDEs and GEs in IFs, which also provided references for the formulation of related regulatory limits in China.

Risk Potency of Lead Exposure to Decrease Cognitive Ability of Productive Age Community in Indonesia Emas 2045

Lead (Pb) can decrease children’s IQ and cognitive abilities. This study aims to analyze the risk characteristics of lead exposure in children aged 4-5 years related to the risk of low IQ as an obstacle in realizing “Indonesia Emas” of 2045 and to analyze the role of medical intelligence to anticipate these potential risks. This study was conducted in Tangerang Industrial Area. The Pb concentrations in food, urine, water, and rice were tested using Flame Atomic Absorption Spectrometry (FAAS). The results showed that Pb levels in food were lower than the Limit of Quantification (LOQ) method, thus, censored data rule was used for data processing. Overall results indicate a risk of causing long term cognitive impairment. However, The results of the calculation of exposure and Margin of Exposure (MOE) are based on the assumption of 50% and 100% of LOQ value. The obtained exposure and MOE values can not be used to said that the status of Pb exposure occurs. The resulting data is still useful as a basis for further research.

Occurrence and risk characterization of aflatoxin M1 in milk samples from southeastern Iran using the margin of exposure approach.

This study aimed to investigate Aflatoxin-M1 (AFM1) contamination in pasteurized and raw milk samples consumed in Kerman and Rafsanjan in southeastern Iran. In this cross-sectional study, a total of 100 samples of raw (n = 67) and pasteurized (n = 33) milk were randomly collected from retail stores, supermarkets, and milk transport tankers in the winter of 2020 and the summer of 2021. The level of AFM1 contamination in the collected samples was evaluated by high-performance liquid chromatography with fluorescence detection (HPLC-FD). AFM1 was detected in 95% of samples and its median concentration was 17.38 ng/L. The median concentration of AFM1 in the pasteurized milk samples (24.89 ng/L) was significantly higher than in the raw milk samples (13.54 ng/L). The AFM1 contamination level in 20% (raw = 13% and pasteurized = 7%) of the samples was higher than the maximum permitted level (MPL) recommended by the European Union (i.e., 50 ng/L), whilst 4% (raw = 3% and pasteurized = 1%) of the samples was higher than the Iranian maximum standard limit (i.e., 100 ng/L). The hazard index (HI) was higher than 1 in 16%, 18%, and 35% of total milk samples for men, women, and children, respectively. The AFM1 contamination level in the milk samples collected in southeastern Iran was worrying. The margin of exposure (MoE) values were lower than 10,000 for children. Because aflatoxins are among the most potent carcinogens known, prevention of milk contamination in all stages from the farm to the table can considerably reduce the community's exposure to AFM1 and its consequent health risks.

Exposure to airborne polychlorinated biphenyls and type 2 diabetes in a Danish cohort

BackgroundPrevious research indicates an association between higher-chlorinated polychlorinated biphenyls (PCBs) and type 2 diabetes (T2D). However, less is known about the extent to which PCB exposure in indoor air, composed primarily of lower-chlorinated PCBs, affects T2D risk. We assessed the association between indoor air exposure to PCBs in residential buildings and T2D incidence. MethodsThe register-based ‘Health Effects of PCBs in Indoor Air’ (HESPAIR) cohort comprises 51,921 Danish residents of two residential areas with apartments built with and without PCB-containing materials (reference apartments). We assessed exposure status by combining register-based information on relocation history with extrapolated values of exposure based on PCB-measurements in indoor air from subsets of the apartments. T2D cases were identified in the Danish registers during 1977–2018. We estimated adjusted hazard ratios (HR) and 95% confidence intervals (CI) using Cox regression analyses with time-varying exposure. ResultsWe identified 2737 incident T2D cases during the follow-up. Exposure to ≥3300 ng/m3 PCB × year (3rd tertile of PCByear) was associated with higher risk of T2D (HR 1.15, 95% CI 1.02–1.30) compared with exposure to <300 ng/m3 PCB × year (reference). However, among individuals with lower cumulated PCByear, the risk was similar to residents with exposure <300 ng/m3 PCB × year (300–899 ng/m3 PCB × year: HR 0.98, 95% CI 0.87–1.11; 900–3299 ng/m3 PCB × year: HR 0.96, 95% CI 0.83–1.10). DiscussionWe observed a marginally higher risk of T2D, but there was no evidence of an exposure-response relationship. The results should be interpreted with caution until confirmed in other independent studies of PCB exposure in indoor air.

The Occurrence and Health Risk Assessment of Aflatoxin M1 in Raw Cow Milk Collected from Tunisia during a Hot Lactating Season.

Milk is a staple food that is essential for human nutrition because of its high nutrient content and health benefits. However, it is susceptible to being contaminated by Aflatoxin M1 (AFM1), which is a toxic metabolite of Aflatoxin B1 (AFB1) presented in cow feeds. This research investigated AFM1 in Tunisian raw cow milk samples. A total of 122 samples were collected at random from two different regions in 2022 (Beja and Mahdia). AFM1 was extracted from milk using the QuEChERS method, and contamination amounts were determined using liquid chromatography (HPLC) coupled with fluorescence detection (FD). Good recoveries were shown with intra-day and inter-day precisions of 97 and 103%, respectively, and detection and quantification levels of 0.003 and 0.01 µg/L, respectively. AFM1 was found in 97.54% of the samples, with amounts varying from values below the LOQ to 197.37 µg/L. Lower AFM1 was observed in Mahdia (mean: 39.37 µg/L), respectively. In positive samples, all AFM1 concentrations exceeded the EU maximum permitted level (0.050 µg/L) for AFM1 in milk. In Tunisia, a maximum permitted level for AFM1 in milk and milk products has not been established. The risk assessment of AFM1 was also determined. Briefly, the estimated intake amount of AFM1 by Tunisian adults through raw cow milk consumption was 0.032 µg/kg body weight/day. The Margin of Exposure (MOE) values obtained were lower than 10,000. According to the findings, controls as well as the establishment of regulations for AFM1 in milk are required in Tunisia.

Arsenic source analysis of rice from different growing environments and health risk assessment in Hunan Province, China

Rice is an important pathway for arsenic dietary intake. Hunan Province is the major rice-producing region in China and is rich in mineral resources. To evaluate the sources of arsenic contamination in rice and health risks associated with rice consumption, the arsenic content in rice, paddy soils, and irrigation water in Hunan Province was analyzed. The results showed that the mean values of total arsenic (tAs) were 132 ± 42, 198 ± 95, 521 ± 390, and 2050 ± 3300 μg/kg in milled rice, brown rice, rice bran, and rice husk, respectively. Inorganic arsenic (iAs) was the dominant species in rice, accounting for 78.1% and 85.9% of tAs in milled rice and brown rice, respectively. Moreover, the contents of iAs in rice husk, bran, and brown rice were 19.7, 4.81, and 1.65 times higher than that in milled rice. Arsenic accumulation rice was mainly from irrigation water, and high tAs in soil may not necessarily cause increased concentrations in rice. Based on the target hazard quotient (THQ) and margin of exposure (MOE) values, residents will not encounter a significant noncarcinogenic risk (THQ < 1) through rice consumption; however, contaminated rice poses a potential carcinogenic risk in Hunan Province (MOE < 100).

Assessing Social Vulnerability to Climate Change in a Fishery-Dependent Village in South Central Vietnam

Fishery-dependent communities are highly susceptible to the impacts of climate change due to their proximity to vulnerable coastal areas and reliance on ecosystem services for their livelihoods. The study assessed the effects of climate change on the socioeconomic livelihoods and adaptive capacity of Xuan Tu, a community located in South Central Vietnam. The assessment employed the social vulnerability index (SVI) and adaptive capacity index (ACI). A hybrid data collection approach was utilized to gather information from households, and a composite method was employed to aggregate the data, enabling an assessment of community vulnerability. The findings indicated exposure, sensitivity, and adaptive capacity index values of 0.16, 0.34, and 0.26, respectively. The community exhibited a moderate vulnerability to climate change, with a social vulnerability index of 0.43. Notably, economic sufficiency, access to social groups, and level of education emerged as significant factors in reducing social vulnerability. To adapt to climate change, the community modified their fish feeding practices, fish culture methods, increased technology usage, and diversified their sources of income. However, the study identified a lack of institutional support as a significant obstacle to the community's autonomous adaptation. Based on these results, the study recommends livelihood diversification and the implementation of planned adaptation strategies to enhance preparedness for climate emergencies in South Central Vietnam.

Health protection and climate change require ambitious limit values for air pollutants in Europe : Opinion on the revision of the Directive on Air Quality and Clean Air for Europe of the Environmental Public Health commission of the Robert Koch Institute and the Federal Environment Agency

Based on scientific findings, the World Health Organization (WHO) has recommended stricter guideline values for air quality in 2021. Significant reductions in the annual mean values of particulate matter (particle size 2.5 µm or smaller, PM2.5) and long-term exposure to nitrogen dioxide (NO2) and ozone (O3) were put forward. The risk of mortality already increases above the WHO guideline values, as shown in studies investigating low concentrations of air pollutants. In Germany, the 2021 WHO guideline values for PM2.5 and NO2 were clearly exceeded in 2022.In this position paper we give the following recommendations for the European Air Quality Directive: (1)set binding limit values according to WHO 2021, (2)apply the limit values to the whole of Europe, (3)continue and expand the established country-based monitoring networks, (4)expand air quality measurements for ultrafine particles and soot particles, and (5)link air pollution control and climate protection measures.Stricter limits for air pollutants require societal and political changes in areas such as mobility, energy use and generation, and urban and spatial planning. Implementation according to WHO 2021 would lead to anet economic benefit of 38billion euros per year.Ambitious limit values for air pollutants also have an impact on climate change mitigation and its health impacts. The Environmental Public Health commission concludes that more ambitious limit values are crucial to enable effective health protection in Germany and calls for air pollutant limit values in line with the 2021 WHO recommendations to become binding in Europe.

Inter-individual exposure variability interpretation through reflection of biological age algorithm in physiologically based toxicokinetic model: Application to human risk assessment of di-isobutyl-phthalate

Age-related changes and interindividual variability in the degree of exposure to hazardous substances in the environment are pertinent factors to be considered in human risk assessment. Existing risk assessments remain in a one-size-fits-all approach, often without due consideration of inter-individual toxicokinetic variability factors, such as age. The purpose of this study was to advance from the existing risk assessment of hazardous substances based on toxicokinetics to a precise human risk assessment by additionally considering the effects of physiologic and metabolic fluctuations and interindividual variability in age. Qualitative age-associated physiologic and metabolic changes in humans, obtained through a meta-analysis, were quantitatively modeled to produce the final biological age algorithm (BAA). The developed BAAs (for males) were extended and applied to the reported testicular reproductive toxicity-focused di-isobutyl-phthalate (DiBP)−mono-isobutyl-phthalate (MiBP) physiologically based toxicokinetic (PBTK) model in males. The advanced PBTK model combined with the BAA was applied to the human risk assessment based on MiBP biomonitoring data. As a result, the specialized DiBP external exposure values for each age could be estimated. Additionally, by applying the Monte Carlo simulation, the distribution of internal exposure diversity among individuals according to the same external exposure dose could be estimated. The contributions of physiologic and metabolic factors to the age-dependent toxicokinetic changes were approximately 93.41–99.99 and 0.01−6.59%, respectively. In addition, the relative contribution of metabolic factors was major in infants and continued to decrease as age increased (up to about age 30 years). This study provides a step-by-step platform that can be widely applied to overcome the limitations of existing toxicokinetic models that still require interindividual pharmacokinetic variability explanations. This will be important for the rationalization and explanation of inter-individual variability in the pharmacokinetics of many substances.

Trend in global burden attributable to low bone mineral density in different WHO regions: 2000 and beyond, results from the Global Burden of Disease (GBD) study 2019.

We aimed to document the current state of exposure to low bone mineral density (BMD) and trends in attributable burdens between 2000 and 2019 globally and in different World Health Organization (WHO) regions using the Global Burden of Disease (GBD) study 2019. We reviewed the sex-region-specific summary exposure value (SEV) of low BMD and the all-ages numbers and age-standardized rates of disability-adjusted life years (DALYs), years lived with disability (YLDs), years of life lost (YLLs), and deaths attributed to low BMD. We compared different WHO regions (Africa, the Eastern Mediterranean Region, Europe, Region of the Americas, Southeast Asia, and Western Pacific), age categories, and sexes according to the estimates of the GBD 2019 report. The global age-standardized SEV of low BMD is estimated to be 20.7% in women and 11.3% in men in 2019. Among the WHO regions, Africa had the highest age-standardized SEV of low BMD in women (28.8% (95% uncertainty interval 22.0-36.3)) and men (16.8% (11.5-23.8)). The lowest SEV was observed in Europe in both women (14.7% (9.9-21.0)) and men (8.0% (4.3-13.4)). An improving trend in the global rate of DALY, death, and YLL was observed during 2000-2019 (-5.7%, -4.7%, and -11.9% change, respectively); however, the absolute numbers increased with the highest increase observed in global YLD (70.9%) and death numbers (67.6%). Southeast Asia Region had the highest age-standardized rates of DALY (303.4 (249.2-357.2)), death (10.6 (8.5-12.3)), YLD (133.5 (96.9-177.3)), and YLL (170.0 (139-197.7)). Overall, the highest-burden attributed to low BMD was observed in the Southeast Asia Region. Knowledge of the SEV of low BMD and the attributed burden can increase the awareness of healthcare decision-makers to adopt appropriate strategies for early screening, and also strategies to prevent falls and fragility fractures and their consequent morbidity and mortality.

Assessing Lifetime Cancer Risk Associated with Population Exposure to PM-Bound PAHs and Carcinogenic Metals in Three Mid-Latitude Metropolitan Cities.

Lifetime cancer risk characterization of ambient PM-bound carcinogenic metals and polycyclic aromatic hydrocarbons (PAHs) were examined in the cities of Los Angeles (USA), Thessaloniki (Greece) and Milan (Italy), which share similar Mediterranean climates but are different in their urban emission sources and governing air quality regulations. The samples in Milan and Thessaloniki were mostly dominated by biomass burning activities whereas the particles collected in Los Angeles were primary impacted by traffic emissions. We analyzed the ambient PM2.5 mass concentration of Cadmium (Cd), Hexavalent Chromium (Cr(VI)), Nickel (Ni), Lead (Pb), as well as 13 PAH compounds in the PM samples, collected during both cold and warm periods at each location. Pb exhibited the highest annual average concentration in all three cities, followed by Ni, As, Cr(VI), Cd and PAHs, respectively. The cancer risk assessment based on outdoor pollutants was performed based on three different scenarios, with each scenario corresponding to a different level of infiltration of outdoor pollutants into the indoor environment. Thessaloniki exhibited a high risk associated with lifetime inhalation of As, Cr(VI), and PAHs, with values in the range of (0.97-1.57) × 10-6, (1.80-2.91) × 10-6, and (0.77-1.25) × 10-6, respectively. The highest cancer risk values were calculated in Milan, exceeding the US EPA standard by a considerable margin, where the lifetime risk values of exposure to As, Cr(VI), and PAHs were in the range of (1.29-2.08) × 10-6, (6.08-9.82) × 10-6, and (1.10-1.77) × 10-6, respectively. In contrast, the estimated risks associated with PAHs and metals, except Cr(VI), in Los Angeles were extremely lower than the guideline value, even when the infiltration factor was assumed to be at peak. The lifetime cancer risk values associated with As, Cd, Ni, Pb, and PAHs in Los Angeles were in the range of (0.04-0.33) × 10-6. This observation highlights the impact of local air quality measures in improving the air quality and lowering the cancer risks in Los Angeles compared to the other two cities.

Evaluation of human exposure to vibration in the hand-arm system during motorcycle riding activities.

The majority of Indians prefer to drive by two-wheeler. Hands are the most important interface between the rider and bike while riding a motorbike. The vibration is transferred to the physical structure by the handlebar as it travels. Long-term exposure to the vibrations may have an impact on various bodily structures. To measure and analyse the human exposure to vibration in the hand-arm system while riding a motorcycle using a vibrometer. The several types of bikes based on their cc's were evaluated in three different road conditions during this investigation (tar road, concrete road, and gravel road). The subjective and quantitative data of each participant were recorded. The RMS A(8) values were supported for every combination of motorcycles and road conditions, and vibration intensity was evaluated using a tri-axial vibrometer. The exposure limit value for daily vibration exposure is 5 m/s2 according to the UK Control of Vibration at Work Regulations 2005 standards.This study suggests that the bike with the least amount of vibration be used to prevent hand-arm vibration (HAV) syndrome. This study found that bike C had the least vibration across all three types of roads, which will benefit riders by reducing health issues as they ride. Therefore, it is further examined utilising the Taguchi method with various bike C age groups. Bike C with the lowest age had the least vibration when different bike C ages were compared, hence it was recommended for riding. The vibration level of each bike has a huge impact, which was measured using a tri-axial vibrometer. According to the results, bike C has the least vibration across three distinct types of roads and also provides riders with less health issues while riding bikes. As a result, a moped can drive in three different road circumstances with the least amount of vibration, delivering comfort and safety while lowering vibration levels.

PENGARUH TERPAAN MEDIA SOSIAL PADA AKUN TIKTOK @exploremajalengka TERHADAP MINAT BERKUNJUNG KE TEMPAT WISATA DI MAJALENGKA

@exploremajalengka is a TikTok account to reach users and encourage them to visit Majalengka tourist attractions. The purpose of this study is to find out how much influence social media exposure has on the @exploremajalengka account on the interest in visiting Majalengka tourism. This study uses the uses and gratification theory and uses a quantitative explanatory research method with non-probability sampling method using a purposive sampling technique of 100 respondents following the TikTok account @exploremajalengka. The results of this study indicate that exposure to the social media TikTok @exploremajalengka has a significant effect on interest in visiting Majalengka tourist attractions. Other findings reveal that the influence value of TikTok's social media exposure is quite high with a value of 59.3% and the rest is influenced by other variables that are not in this study.

Bone weathering in an Atlantic environment: preliminary results of the Global Weathering Project in Spain

Weathering constitutes one of the most investigated taphonomic processes for understanding the formation of archaeological and palaeontological assemblages. Despite being studied for decades through numerous monitoring experiments, no homogeneous methodology exists to compare the results obtained in different regions and climates. Here, we present the protocols and the preliminary results of an experimental research started four years ago in a coastal and inland location within the Cantabrian Region (northern Spain) to assess the influence of the weathering process in an Atlantic climate. This experiment allows evaluation of the preservation of faunal assemblages in regional open-air sites throughout the Middle and Upper Palaeolithic. We conduct this experiment within the Global Weathering Project of the International Council for Archaeozoologists (ICAZ), an international network of archaeozoologists and taphonomists who coordinates the same experiment worldwide. The experiment planned to last 18 years consists on recording the weathering stages suffered on the cow ribs disposed on the surface of a fenced enclosure under the protection of a cage, separated from the soil by a neutral inorganic substrate and close to a weather station where the temperature, humidity, rainfall, wind and sun exposure values are daily recorded.

Issues in Implementing Regression Calibration Analyses.

Regression calibration is a popular approach for correcting biases in estimated regression parameters when exposure variables are measured with error. This approach involves building a calibration equation to estimate the value of the unknown true exposure given the error-prone measurement and other covariates. The estimated, or calibrated, exposure is then substituted for the unknown true exposure in the health outcome regression model. When used properly, regression calibration can greatly reduce the bias induced by exposure measurement error. Here, we first provide an overview of the statistical framework for regression calibration, specifically discussing how a special type of error, called Berkson error, arises in the estimated exposure. We then present practical issues to consider when applying regression calibration, including: 1) how to develop the calibration equation and which covariates to include; 2) valid ways to calculate standard errors of estimated regression coefficients; and 3) problems arising if one of the covariates in the calibration model is a mediator of the relationship between the exposure and outcome. Throughout, we provide illustrative examples using data from the Hispanic Community Health Study/Study of Latinos (United States, 2008-2011) and simulations. We conclude with recommendations for how to perform regression calibration.

The Value of Exposure in Crowdsourcing: How Solver Participation Leads to Post-Contest Retributions

The Value of Exposure in Crowdsourcing: How Solver Participation Leads to Post-Contest Retributions

A revised concept for deriving reference values for internal exposures to chemical substances and its application to population-representative biomonitoring data in German children and adolescents 2014–2017 (GerES V)

HBM reference values, in contrast to toxicologically derived values, are statistically derived values that provide information on the exposure of the population. The exceedance frequency (if applicable for individual population groups) is often a first assessment standard for the local exposure situation for municipalities. More than 25 years have passed since the German Human Biomonitoring Commission (HBMC) formulated the first recommendations for the derivation of population-based reference values (HBM reference values, RV95) for substance concentrations based on HBM studies. A fundamental revision is timely, for several reasons. There have been considerable advances in relevant statistical methods, which meant that previously time-consuming and inaccessible procedures and calculations are now widely available. Furthermore, not all steps for the derivation of HBM reference values were clearly elaborated in the first recommendations. With this revision we intended to achieve a rigorous standardization of the entire process of deriving HBM reference values, also to realise a higher degree of transparency.In accordance with established international practice, it is recommended to use the 95th percentile of the reference distribution as the HBM reference value. To this end, the empirical 95th percentile of a suitable sample should be rounded, ensuring that the rounded value is within the two-sided 95% confidence interval of the percentile. All estimates should be based on distribution-free methods, and the confidence interval should be estimated using a bootstrap approach, if possible, according to the BCa (“bias-corrected and accelerated bootstrap”). A minimum sample size of 80 observations is considered necessary. The entire procedure ensures that the derived HBM reference value is robust against at least two extreme values and can also be used for underlying mixed distributions.If it is known in advance that certain subgroups (different age groups, smokers, etc.) show differing internal exposures, it is recommended that group-specific HBM reference values should be derived. Especially when the sample sizes for individual subgroups are too small, individual datasets with potential outliers can be excluded in advance to homogenize the reference value population.In the second part, new HBM reference values based on data of the German Environmental Survey for Children and Adolescents (GerES V, 2014–2017) were derived in accordance with the revised recommendations. The GerES V is the most recent population-representative monitoring of human exposure to pollutants in Germany on children and adolescents aged 3–17 years (N = 2294). RV95 for GerES V are reported for four subgroups (males/females and 3–11/12-17 years) for 108 different substances including phthalates and alternative plasticisers, metals, organochlorine pesticides, polychlorinated biphenyls (PCB), per- and polyfluoroalkyl substances (PFAS), parabens, aprotic solvents, chlorophenols, polycyclic aromatic hydrocarbons (PAH) and UV filter, in total 135 biomarkers. Algorithms implemented in R were used for the statistics and the determination of the HBM reference values. To facilitate a quality control of the study data, the corresponding R source code is given, together with graphical representations of results.The HBM reference values listed in this article replace earlier RV95 values derived by the HBMC for children and adolescents from data of precedent GerES studies (e.g. published in Apel et al., 2017).

Phenolic compounds—Occurrence in water, sediment and sludge, and ecological risk evaluation

AbstractTen phenolic compounds (PC) concentration levels were determined in river water, wastewater, sediments and sludge using solid phase extraction (SPE) microwave assisted extraction (MAE) and ultrasonic extraction (UE), and their ecological risk was evaluated. All the extraction methods showed good sensitivity with limit of detection and limit of quantification values at 0.01–2.00 and 0.02–6.07 µg L−1 for SPE, 0.05–1.20 and 0.17–3.17 µg kg−1 for MAE and 0.09–1.33 and 0.26–3.54 µg kg−1 for UE, correspondingly. Recovery ranges of 75.2–112% (SPE), 80.9–110% (MAE) and 79.3–119% (UE) were obtained. The PC concentrations in wastewater matrix were within the maximum allowable limit except for 2,4‐dichlorophenol at sampling point wdv4. In river water, at Camps Drift the highest concentrations compared to other sampling points was measured, however, all were within the acceptable limits. The risk quotient values exhibited high ecological risk in majority of the sites, with effects range median values indicating toxic effects to the surroundings likely to occur frequently. The probable carcinogenic risk potential was notably found to be high for adults with increment life cancer risk through dermal exposure (ILCRderm) values of 5.34 × 10−2 and 5.92 × 10−2 compared to that for children at 1.26 × 10−2 and 1.39 × 10−2 for both sludge and sediment samples.