A multicenter study of the application of the microbiological preparation Embiko® in vineyards with its introduction with drip irrigation in the Western foothill-seaside viticultural zone of Crimea was carried out. Granulometric analysis of the soil showed that in the experimental version with the use of Embiko®, the specific content of its fine fractions increased by 5%, i.e. the soil became looser. The introduction of Embico® in liquid form with drip irrigation gave an increase in yield by 1.3 kg per bush, while the sugar content of the berry juice improved by at least 8%. An antistress effect on plants under the influence of treatment with a biological preparation was also revealed, which manifests itself in a significant functional improvement of the leaf apparatus and an increase in the growth rates of grape shoots. When using the biological preparation Embico®, the profit or net income at the pilot site increased compared with the control option (without application) and, accordingly, the profitability of production increased by 79%.