Spatial response is a feature of rock deformation in regions surrounding large-scale underground caverns and includes significant vertical components due to the construction method of layered excavation. This vertical response is different to the longitudinal response of excavation deformation surrounding shallow tunnels. The study of longitudinal deformation profiles (LDPs), which describe the spatial response of longitudinal tunnel excavation and surrounding rock deformation, is a mature field. However, there has been no independent discussion of the relationship between vertical excavation and the spatial response of deformation in large-scale underground caverns nor the incremental characteristics of layered excavation. In this paper, we define the attenuation function λ x of unloading strength based on theoretical analyses and numerical simulations. We also propose the concept and form of the vertical deformation profile (VDP) curve for the first time and apply it to the Baihetan and Lianghekou Hydropower Stations. After fitting the complete VDP curve with a Levenberg-Marquardt algorithm, we verify its validity by comparing predicted data with in situ monitoring data. The curve can be used to quantitatively analyze the relationship between layered excavation and incremental deformation of surrounding rock, providing a basis for the rapid evaluation of staged deformation during the excavation of large underground caverns. This study has practical significance for the control of deformation in rock surrounding excavations and decision-making during the construction progress.