Evaluation Of Safety Indicators Research Articles

The Novel Antipsychotic Lumateperone (Iti-007) in the Treatment of Schizophrenia: A Systematic Review.

Lumateperone (also known as ITI-007 or ITI-722) represents a novel second-generation medication characterized by a favorable safety and tolerability profile. This is attributed to its notable selectivity for D2 receptors within specific regions of the brain. The U.S. Food and Drug Administration (FDA) granted approval for the treatment of schizophrenia in adults in December 2019. Additionally, it gained approval for addressing depressive episodes associated with bipolar I and II disorders in adults, either as a standalone therapy or in conjunction with lithium or valproate, in December 2021. The objective of this investigation is to systematically review the existing literature to assess the safety, tolerability, and efficacy of lumateperone in the treatment of schizophrenia. Lumateperone has demonstrated effectiveness in addressing positive, negative, and cognitive symptoms associated with schizophrenia. The evaluation of safety indicators in the reviewed studies indicates that lumateperone is deemed to be a well-tolerated and safe antipsychotic. Additional research is warranted to explore lumateperone's efficacy in managing major depressive disorders, behavioral issues in Alzheimer's disease and dementia, sleep maintenance insomnia, bipolar disorders, and personality disorders.

Оценка качества и безопасности продуктов убоя косули из Уральского региона

The article presents the results of veterinary and sanitary examination and evaluation of safety indicators of roe deer slaughter products (carcass and internal organs) obtained during hunting in the Chelyabinsk and Kurgan regions Ural region of the Russian Federation. According to organoleptic and physico-chemical parameters, the carcasses were recognized as fresh and obtained from healthy animals. The hydrogen acidity index (pH) was 5,7–5,9. The degree of exsanguination corresponded to the requirements for carcasses of wild commercial animals. The defeat of helminths was not registered. As a result of microbiological examination, bacteria of the genus Proteus were isolated in 12,5 % of samples (intercostal muscles), bacteria of the E. coli group (Escherichia coli) were isolated in 25 % of samples («soup set» and kidneys), bacteria of the Bacillus subtilis group were isolated in 12,5 % of samples (heart). According to the specific activity of caesium-137, all samples met the safety requirements. However, the content of strontium-90 exceeded the recommended level (according to CODEX STAN 193-1995 (1)) by 2,48 (in muscles) to 6,45 times (in kidneys).

MEDA and its use in data collecting and evaluating

Article discusses the use of the Maintenance error decision aid (MEDA) methodology in the investigation of events and subsequent data collection and assessment which is needed for the collection and evaluation of safety indicators. The first part describes the methodology of MEDA, the second outlines the use of factors for the purposes of collecting safety indicators and evaluation of the safety performance of the organization in terms of implementation of risk factors contributing to the realization of unwanted events.

Processes on Uncontrolled Aerodromes and Safety Indicators - Part II

<p>This article follows on the Part I, where the basic processes on uncontrolled aerodromes were introduced. The uncontrolled aerodromes face with the growing traffic and from that result the higher workload on AFIS officer. This means a higher potential for dangerous situations.</p><p>The article describes some models of sub-processes and creates several safety indicators related to the operation at uncontrolled aerodromes. Thanks to monitoring and evaluation of safety indicators can be adopted targeted safety measures and thus increase safety on small uncontrolled aerodromes.</p>

The Methodology for Evaluating the Safety of Operations at the Uncontrolled Aerodromes

<span style="line-height: 115%; font-family: 'Times New Roman','serif'; font-size: 9pt; mso-fareast-font-family: Calibri; mso-ansi-language: EN-GB; mso-fareast-language: EN-US; mso-bidi-language: AR-SA; mso-fareast-theme-font: minor-latin;" lang="EN-GB">The objective of this methodology is to determine the general procedure for the evaluation of safety indicators for operation at uncontrolled aerodromes. The basis of this assessment is to determine the processes that take place at the aerodrome and finding critical points in these processes. They are determined on the basis of observations at aerodromes and are based on current legislation. The result of applying this methodology to aerodrome operations is the identification of several indicators, which monitoring and the adoption of safety measures can enhance safety at these uncontrolled aerodromes in the Czech Republic.</span>