Crișana Region is one of the most representative and wide historical regions of Romania, which encompasses several “lands” and ethnographic areas, each of them being defined by a series of features, among which those of demographic nature (ethnicity, religion) and ethno-cultural features stand out. In this context, the aim of the current study is to identify, assess and emphasize the relationship between the demographic features and those related to the ethno-cultural heritage. The accomplishment of this work required the use of the multi-criteria analysis method, successfully applied in various activity areas, a method which is characterized by a high level of complexity. The obtained results emphasized the spatial distribution on ‘territorial administrative unit’ (TAU) level of the aggregated synthetic values and of the relationship types which were determined between population and ethno-cultural heritage in Crișana Region, Romania.