This paper focuses on the study of environmental risk assessment and comprehensive index model of disaster loss for COVID-19 transmission. Considering the five environmental vectors of carrier vulnerability, environmental instability of pregnancy and disaster, intensity of disaster-causing factors, disaster prevention and mitigation capacity and emergency prevention and control capacity and its 38 indicators, the correlation coefficient matrix and principal component expressions of each vector are established by principal component analysis, respectively, and the index model of each vector is established on the basis. Then, considering the index models of these five vectors, we established the disaster loss composite index model, which was used to conduct environmental risk assessment and disaster loss composite index analysis of the transmission of COVID-19 in Hubei Province during the period of January 21, 2020 to March 18, 2020. The empirical study showed that: (1) the risk index peaked from January 21 to January 23; (2) the risk index was at a low but volatile level from January 24 to March 14; (3) the risk index rose again slightly from March 15 and rose to another peak on March 16. These fluctuating, smooth and fluctuating processes of the comprehensive index of disaster losses of COVID-19 in Hubei Province are basically stable and consistent with the actual situation of the virus outbreak in the early stage, isolation and prevention and control in the middle stage, and resumption of work and production in the late stage. The study in this paper provides a scientific decision-making reference for the prevention and control of COVID-19 as well as emergency prevention and control measures.