To achieve sustainability, industrial systems need to be modernized to improve resource efficiency while optimizing environmental and social performance. The implementation of environmental and technological projects is a complex management process and requires sufficient innovative potential and serious investments, which not every company can provide. Network integration of companies, providing synergy of resources and potentials, is an effective tool for the development and implementation of innovative technologies that allow achieving optimal resource efficiency indicators. An integrated complex approach to the formation of a cross- industrial system on the principles of network integration and partnerships ensures technological interaction between companies, optimizes the methods and forms of their economic activities, allows integration participants to achieve strategic goals and ensure environmental and social effects for the territory of presence. The sustainability of such a system is expressed in its ability to withstand internal threats and external challenges. Approaches to balancing environmental and technological effects while simultaneously analysing social efficiency have not received sufficient development in scientific research. This article discusses an approach to the selection of environmental-technological projects based on criteria for assessing the sustainability and resilience of industrial systems. The authors’ approach has been tested using two industrial symbioses of advanced socio-economic development territories in the city of Novotroitsk (Orenburg region, Russian Federation). The authors presented calculated indicators of resource efficiency before and after the formation of a cross-sectoral industrial system in order to identify social and environmental effects in Novotroitsk. This approach to the assessment of environmental and technological projects allows to concentrate government support measures on the general priorities of the implementation of regional economic and industrial policies.