The development of computer technology has promoted the processing technology of large data, meanwhile, the upsurge of college students’ innovation and entrepreneurship has also been promoted. Therefore, it is very meaningful to study the way of innovation and entrepreneurship by using large data technology. Firstly, the research status and development trend of innovation entrepreneurship are analyzed. The development of large data is introduced, and then the coupling point of innovative entrepreneurship and Internet technology is analyzed, and the large data algorithm suitable for the research of innovative startups is designed. Finally, by using the distributed Blackboard Control algorithm in the large data technology, the innovation and entrepreneurship approach of university is analyzed. Through experimental analysis and verification, the proposed improved large data technology, compared to other algorithms, in some performance has a certain advantage.