On 6 February 2023, two independent earthquake pairs on the East Anatolian Fault Zone, with epicenters in Pazarcık (Mw = 7.7) and Elbistan (Mw = 7.6) districts of Kahramanmaraş province, caused great destruction. Adıyaman and Gölbaşı districts of this city are among the settlements most affected by the earthquake. Especially in the district where geotechnical damages are most observed, the destructive effects of earthquakes have been clearly observed in buildings with different structural systems. In this study, information is given about the earthquakes that hit the region and the fault zone where the earthquakes occur. Geotechnical and structural damages occurring in the villages and center of the district were evaluated within the scope of earthquakes and structural engineering. It can be stated that damages observed in the district center are generally caused by soil–structure interaction problems. The fact that masonry structures, which are widely used in rural areas, do not benefit from any engineering services has an impact on the level of damage. The main reason for the damages occurring in the reinforced concrete structures in the district is the reinforced concrete system that is not designed properly or not built in accordance with the design. This case study demonstrated the importance of earthquake–soil–structure interactions in line with earthquake-resistant building design principles.