ABSTRACT: The economic costs of tobacco use are substantial particularly in developing countries. While much has been written on healthcare costs from tobacco use related diseases, little is known on the macro-economic impacts of tobacco-related productivity loss. The objective of the current research is to understand the macroeconomic burden of tobacco use in developing countries. Using World Bank's development indicators database for 44 low-and lower-middle-income countries, most of which are African, this paper assesses the relationship between tobacco consumption and economic growth. Specifically, using the fixed effect regression approach, we examined whether tobacco prevalence affects long-run growth rate in the real gross domestic product (GDP) per capita. We adopted an empirical framework from the growth literature by including the national tobacco prevalence rate as one of the determinants of long-run growth in the real GDP per capita. The tobacco prevalence rate varies across countries ranging from 5% in Ethiopia to almost 50% in Myanmar. The prevalence rate is much higher among males than females in almost all countries, with Myanmar males having above 70%. The regression results indicate the existence of a statistically significant negative relationship between the prevalence of tobacco and economic growth after controlling for other determinants of growth, including the initial level of GDP per capita, gross fixed capital formation, trade, resource revenues, institutional quality, a human capital indicator, and infrastructure capacity. A 1% increase in the total tobacco prevalence rate reduces the economic growth rate by almost 2%, all else equal. These findings are robust even after running separate models for male and female tobacco prevalence rates. The results on the other determinants of growth are consistent with the previous empirical studies on economic growth in the context of developing countries. The findings of this study provide additional support to the existing body of empirical economic research on the role of better health, as a form of human capital, in increasing economic output. Thus, actively targeting tobacco control interventions, both in and outside of the workplace, can likely improve workers' productivity and hence economic growth.