Event Abstract Back to Event A predictive coding account of MMN and brain plasticity Marta Garrido1*, J M Kilner2, S J Kiebel2, K E Stephan2, 3, Torsten Baldeweg4 and K J Friston2 1 Department of Psychology, University California Los Angeles, United States 2 Wellcome Trust Centre for Neuroimaging, University College London, United Kingdom 3 Institute for Empirical Research in Economics, University of Zurich, Switzerland 4 Developmental Cognitive Neuroscience, Institute of Child Health, University College London, United Kingdom Predictive coding models state that the brain perceives and makes inferences about the world by recursively updating predictions about sensory input. Thus, perception could result from comparing bottom-up input from the environment with top-down predictions. Predictive coding as a model of cortical organization and function has been used to frame the mismatch negativity (MMN), and supporting empirical evidence has been furnished by dynamic causal modelling (DCM), a novel tool for connectivity analysis of neuroimaging data. In the light of this framework, the generation of the MMN, an event-related response to unpredictable events, reflects prediction error, which occurs whenever the current input does not match a previously learnt rule. In brief, this talk will discuss how MMN can be framed within a predictive coding scheme, and show the usefulness of DCM in investigating the underlying cortical mechanisms of responses to unpredictable auditory events. Moreover, alternative candidate models that map onto mechanistic hypotheses for MMN generation will be discussed. These models correspond to alternative hierarchical cortical networks, which can be statistically evaluated within the Bayesian framework of DCM. Finally, it will be shown how tone repetition can induce connectivity changes over time (or plasticity), both between distant cortical areas and within an area belonging to a cortical network. This suggests that learning an auditory perceptual model from the environment is associated with repetition-dependent plasticity in the human brain. Conference: MMN 09 Fifth Conference on Mismatch Negativity (MMN) and its Clinical and Scientific Applications, Budapest, Hungary, 4 Apr - 7 Apr, 2009. Presentation Type: Oral Presentation Topic: Symposium 2: Predictive models within and of MMN Citation: Garrido M, Kilner J, Kiebel S, Stephan K, Baldeweg T and Friston K (2009). A predictive coding account of MMN and brain plasticity. Conference Abstract: MMN 09 Fifth Conference on Mismatch Negativity (MMN) and its Clinical and Scientific Applications. doi: 10.3389/conf.neuro.09.2009.05.040 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 23 Mar 2009; Published Online: 23 Mar 2009. * Correspondence: Marta Garrido, Department of Psychology, University California Los Angeles, Los Angeles, United States, migarrido@ucla.edu Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Marta Garrido J M Kilner S J Kiebel K E Stephan Torsten Baldeweg K J Friston Google Marta Garrido J M Kilner S J Kiebel K E Stephan Torsten Baldeweg K J Friston Google Scholar Marta Garrido J M Kilner S J Kiebel K E Stephan Torsten Baldeweg K J Friston PubMed Marta Garrido J M Kilner S J Kiebel K E Stephan Torsten Baldeweg K J Friston Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.