Internet-of-Things (IoT) is the technical backbone of smart cities which are envisioned to cope up with rapid urbanization of human population with limited resources. IoT provides three key features of smart cities such as intelligence, interconnection, and instrumentation. IoT is essentially a system-of-systems which can be considered as a configurable dynamic global network of networks. The main components of IoT include the following: 1) The Things; 2) Internet; 3) LAN; and 4) The Cloud. IoT is built by various diverse components including electronics, sensors, actuators, controllers, networks, firmware, and software. However, the existing electronics, controllers, and processors do not meet IoT requirements, such as multiple sensors, communication protocols, and security requirements. The existing computer-aided design (CAD) or electronic design automation tools are not enough to meet diverse challenges such as time-to-market, complexity, and cost of IoT. The required electronic circuits and systems need to be developed by handling and solving specific requirements. Real-time and ultralow power plays a major role since mobile devices in the IoT have to provide a long availability with a relative small energy budget. At the same time, reliability, availability, real-time constraints, and performance requirements pose significant challenges, and therefore, lead to a high interest in research. In this special issue, different approaches to design novel devices, circuits, and systems for solving the challenges with IoT are targeted. Various novel design automation components including modeling, design flows, simulation methods, and optimizations for designing of modern IoT are targeted, from system level down to device level. The current special issue was envisioned with the above technical considerations. After a rigorous review process, a set of articles were selected for this special issue. These papers are briefly discussed in the rest of the editorial.