Effect Of Drainage Research Articles

Single Institution Experience with Lumbar Drainage and Subarachnoid Hemorrhage

Abstract Introduction In our article, we evaluate the effect of lumbar drainage on delayed cerebral ischemia and requirements for permanent cerebrospinal fluid diversion in patients with aneurysmal subarachnoid hemorrhage. Methods We performed a retrospective cohort study from 2014 to 2023 at the University of Arkansas for Medical Sciences (UAMS) examining factors associated with patients (n = 150) who had aneurysmal subarachnoid hemorrhage and a lumbar drain placed. The main outcomes examined were incidence of delayed cerebral ischemia, need for permanent cerebrospinal fluid diversion, and neurologic outcomes at discharge that were compared to currently published standards. Results We failed to appreciate a reduced occurrence of delayed cerebral ischemia (37.3% with the current literature supporting rates of 20–30%); however, we did find a low rate of requiring permanent cerebrospinal fluid diversion (12% compared to 10–20% in the current literature) with overall good neurologic outcomes at discharge (∼69% of patients had a Glasgow Outcome Scale [GOS] of 4–5 at discharge). Patients with GOS ≥ 4 at discharge were noted to be more likely to have more days or lumbar drainage and less likely to be older than 65 years, have had an external ventricular drain placed, and have experienced delayed cerebral ischemia. Conclusion Lumbar drainage is a potentially useful adjunct in the management of secondary neurologic injury in subarachnoid hemorrhage.

Enhancing gas drainage and ventilation efficiency in underground coal mines: A hybrid expert decision approach for booster fan prioritization

Expanding mining operations in goaf zones heightens gas production potential, posing challenges in maintaining adequate ventilation within development panels, consequently impacting coal production. Various strategies have been explored to enhance mine ventilation and gas drainage effectiveness. However, deficiencies persist in the proposed ventilation system for the Okaba underground coal mine, prompting this study’s necessity. Addressing these concerns, the study evaluates the feasibility of employing booster fans to mitigate the identified drawbacks. Prioritizing booster fans for airflow distribution in underground mines is a complex decision-making process, requiring an advanced expert system approach. To address this, the study proposes an intuitionistic-based fuzzy TOPSIS (IFT) method for booster fan prioritization in the Okaba mine. Results indicate that booster fan 4 (BF4) ranks highest, followed by booster fan 3 (BF3), consistent with fuzzy TOPSIS findings. Sensitivity analysis supports the predicted importance order, affirming the efficacy of the hybrid expert decision method in selecting a booster fan capable of enhancing the overall efficiency of gas drainage and ventilation systems in underground mines. This study introduces a Hybrid Expert Decision Approach that integrates IFT and traditional fuzzy TOPSIS methodologies. This hybrid approach is particularly novel because it combines the strengths of both methods to prioritize booster fans in underground coal mines.

Simulating controlled drainage and hydrological connections in a cultivated peatland field

AbstractCultivated peatlands are increasingly regarded as hot spots due to climate change and other environmental concerns. Flexible water management, such as controlled drainage, is proposed to optimize cultivation and reduce environmental risks in peatland fields. The hydrological and environmental implications of controlled drainage depend on site‐specific variables, and it is unclear how controlled drainage should be implemented in various conditions. Simulation models are a promising approach to systemically study the field hydrology, as models can capture the complete water balance, which is difficult through experimental studies alone. We calibrated and validated the spatially distributed model FLUSH to describe the hydrology of a field block with a shallow peat cover and controlled drainage in central western Finland. The objectives were to analyze the hydrological effects of controlled drainage and detect hydrological connections between the field and an adjacent upslope forest area. The results showed how inflow from the forest can induce high observed drain discharge but impacted the block groundwater tables only in the proximity of the forest (distance <25 m). The effect of controlled drainage on groundwater tables was on average 0.15 m and seasonally varying. Controlled drainage reduced drain discharge, and the reduction was larger with the forest area included in the model. While controlled drainage effects on groundwater levels and soil moisture were insensitive to groundwater influxes from adjacent areas, the water balance impact highlights the role of hydrological connections in the hydrology of cultivated peatlands under controlled drainage.

A Comparative Study for Evaluating the Groundwater Inflow and Drainage Effect of Jinzhai Pumped Storage Power Station, China

Various hydrogeological problems like groundwater inflow, water table drawdown, and water pressure redistribution may be encountered in the construction of hydraulic projects. How to accurately predict the occurrence of groundwater inflow and assess the drainage effect during construction are still challenging problems for engineering designers. Taking the Jinzhai pumped storage power station (JPSPS) of China as an example, this paper aims to use different methods to calculate the water inflow rates of an underground powerhouse and evaluate the drainage effect caused by tunnel inflow during construction. The methods consist of the analytical formulas, the site groundwater rating (SGR) method, and the Signorini type variational inequality formulation. The results show that the analytical methods considering stable water table may overestimate the water inflow rates of caverns in drained conditions, whereas the SGR method with available hydro-geological parameters obtains a qualitative hazard assessment in the preliminary phase. The numerical solutions provide more precise and reliable values of groundwater inflow considering complex geological structures and seepage control measures. Moreover, the drainage effects, including a seepage-free surface, pore water pressure redistribution, and hydraulic gradient, have been accurately evaluated using various numerical synthetic cases. Specifically, the faults intersecting on underground caverns and drainage structures significantly change the groundwater flow regime around caverns. This comparative study can not only exactly identify the capabilities of the methods for cavern inflow in drained conditions, but also can comprehensively evaluate the drainage effect during cavern construction.

Numerical simulation analysis of effect of borehole gas extraction under fluid‐structure interaction

AbstractTo study the effect of coal pressure on gas extraction under fluid‐solid coupling, the effect of gas extraction radius under different pore sizes and treatment methods was simulated by using COMSOL Multiphysics software, the time evolution law of gas pressure on coal surface was obtained, and the numerical simulation results were verified by the observation of flow rate and concentration in experimental mine combined with fluid‐solid interaction. The results show that the distance of extraction radius increases with the increase of borehole diameter, and the relation between extraction time and extraction radius is a power function, but the increase gets smaller and smaller until it becomes zero. For Φ98 mm borehole and Φ120 mm borehole, hydraulic treatment can increase the efficiency of gas extraction by 31.3% and 22.7%, respectively. For hydraulic treatment and conventional treatment, the ratio of gas drainage effect by enlarging hole size is 6.3% and 13.8% respectively. Compared with the areas without gas extraction under the four conditions, the descending speed of gas pressure from fast to slow is Φ120 mm hydraulic flushing treatment, Φ98 mm hydraulic flushing treatment, Φ120 mm conventional treatment, Φ98 mm conventional treatment. Compared with four different conditions, after 180 days of extraction the coal gas pressure decreased by 75.3% within reasonable hole spacing. At the same time, in multi‐hole pumping, the influence area of adjacent borehole is larger than that of single‐hole pumping, and the spacing of borehole should be less than twice the radius of pumping.

Technology and application of through layer borehole ultra-high pressure hydraulic slotting in soft coal seam to pressure relief and permeability enhancement

ABSTRACT It is a vital method that controls outburst disasters through gas drainage to reduce gas pressure. But the permeability of coal seam in China is low. Therefore, technologies that can decrease pressure and increase permeability such as ultra-high pressure hydraulic slotting (UPHS) are widely applied. Based on the technology of UPHS, the principle of coal breaking and mechanism of pressure relief and permeability enhancement (PRPE) were first analyzed. The effects of PRPE between contrast borehole and UPHS were compared through numerical simulation. Finally, combined with the field test, the parameters of UPHS were determined, and difference in gas drainage effect between contrast borehole and UPHS was investigated. It is found that the exposed area of coal increased due to macroscopic slotting formed by hydraulic slotting, which provide space for coal deformation. The stress of coal relieved the permeability enhanced, resulting in the gas drainage efficiency increasing. The simulated results showed the pressure relief area and plastic deformation caused by UPHS are significantly increased compared with contrast borehole. The average concentration and total of gas drainage in UPHS are 1.49 and 3.13 times than that of contrast borehole. And radius of gas drainage of UPHS 1.77 times than that of contrast borehole under reduce the 46% engineering quantities.

Using noninvasive imaging to assess manual lymphatic drainage on lymphatic/venous responses in a spaceflight analog

This retrospective case series (clinicaltrials.gov NCT06405282) used noninvasive imaging devices (NIID) to assess the effect of manual lymphatic drainage (MLD) on dermal/venous fluid distribution, perfusion, and temperature alterations of the head, neck, upper torso, and legs while in the 6-degree head-down tilt validated spaceflight analog. A lymphatic fluid scanner measured tissue dielectric constant levels. Near-infrared spectroscopy assessed perfusion, by measuring tissue oxygenation saturation. Long-wave infrared thermography measured tissue temperature gradients. Fifteen healthy, university students participated. NIID assessments were taken 1 minute after assuming the HDT position and then every 30 minutes, with MLD administered from 180 to 195 minutes. Subjects returned to the sitting position and were assessed at post-225 min NIID demonstrated significant changes from baseline (p < 0.01), although these changes at areas of interest varied. MLD had a reverse effect on all variables. NIID assessment supported the potential use of MLD to mitigate fluid shifts during a spaceflight analog.

Mediastinal drainage combined with upper mediastinal re-tunneling vs. mediastinal drainage alone in McKeown esophagectomy of esophageal cancer: a retrospective study.

Although mediastinal drainage may lower the risk of anastomotic leakage, the incident rate of anastomotic leakage is still high. The current study aimed to compare the effects of mediastinal drainage combined with upper mediastinal re-tunneling with mediastinal drainage only on anastomotic leakage after McKeown esophagectomy for esophageal cancer. From October 2018 to March 2021, 52 patients diagnosed as esophageal carcinoma were included in the study. 21 patients received mediastinal drainage combined with upper mediastinal re-tunneling (re-tunneling group) and 31 received mediastinal drainage only (standard group) after McKeown esophagectomy. The incidence rate of anastomotic leakage, mediastinal infection, chylothorax, thoracic infection, the peak value of leukocyte count and the mortality related to anastomotic leakage were compared between the two groups. One (4.8%) patient in the re-tunneling group developed anastomotic leakage, and no patient experienced mediastinal infection or thoracic infection. Four (12.9%) patients in the standard group developed anastomotic leakage, and all these patients experienced mediastinal infection and thoracic infection (p < 0.05). The drainage volumes of patients in the re-tunneling group and the standard group were (170 ± 60) ml and (155 ± 45) ml, respectively, with no significant difference between the two groups (p > 0.05). The peak values of leukocyte count and temperature in the re-tunneling group were (14.28 ± 1.12) × 109/L and (38.6 ± 1.1) °C, both lower than that of the standard group[ (16.48 ± 1.15) × 109/L and (38.9 ± 1.2) °C, respectively]. But the difference was not statistically significant (p > 0.05). No anastomotic leakage related death occurred in both groups. Mediastinal drainage combined with upper mediastinal re-tunneling after McKeown esophagectomy for esophageal cancer may decrease the risk of anastomotic leakage, mediastinal and thoracic infection, reduce the inflammatory response of patients, but did not increase the mortality related to anastomotic leakage. The study was retrospectively registered.

RETRACTION: Effect of passive versus active abdominal drainage on wound infection after pancreatectomy: A meta-analysis.

Retraction: Y. Han, Z. Wu, J. Song, Q. Zhang, L. Wei, and H. Lu, "Effect of Passive Versus Active Abdominal Drainage on Wound Infection after Pancreatectomy: A Meta-Analysis," International Wound Journal 21, no. 3 (2024): e14755, https://doi.org/10.1111/iwj.14755. The above article, published online on 07 March 2024, in Wiley Online Library (http://onlinelibrary.wiley.com/), has been retracted by agreement between the journal Editor in Chief, Professor Keith Harding; and John Wiley & Sons, Ltd. It came to the publisher's attention from a third party that a number of articles shared concerning similarities in format and structure. Following an investigation by the publisher, the retraction has been agreed on as the peer review and publishing process for this article were found to be manipulated. The authors did not respond to the notice of retraction.

Intraperitoneal Gas Drain to Reduce Postsurgical Shoulder Tip Pain in Gynecological Laparoscopy

Abstract Background Operative gynecologic laparoscopy has become the preferred method for treating benign gynecologic diseases due to its minimally invasive nature and faster recovery compared to laparotomy. However, post-laparoscopic shoulder pain (PLSP) is a common complaint following laparoscopic surgeries, affecting patients' satisfaction and recovery. Various methods have been proposed to alleviate PLSP, but consensus on their effectiveness remains elusive. Aim of the Work This randomized controlled clinical trial aims to investigate the effect of gas drainage by intraperitoneal drain on shoulder pain in women after laparoscopic surgery in comparison to no drain use. Patients and Methods A randomized controlled clinical trial involving 120 female patients undergoing laparoscopic surgery was conducted to investigate the effect of intraperitoneal drainage on postoperative shoulder pain. The patients were divided into two groups: the study group (n = 60) with intraperitoneal drain placement, and the control group (n = 60) with routine technique and no drain use. Visual Analog Scale (VAS) scores were used to assess shoulder and abdominal pain at different postoperative time points. Results The study demonstrated that intraperitoneal drainage significantly reduced postoperative shoulder pain in the first 12 hours after surgery compared to the control group (p &amp;lt; 0.001 at 3 and 6 hours, p = 0.038 at 12 hours). However, no significant difference in shoulder pain was observed between the two groups at 24 hours post-surgery (p = 0.451). The need for postoperative analgesia was also lower in the drainage group (p &amp;lt; 0.001). These findings align with previous studies suggesting the efficacy of drainage in reducing shoulder pain after laparoscopic surgery. Conclusion This study demonstrates the effectiveness of intraperitoneal drainage in reducing post- laparoscopic shoulder pain during the first 24 hours after surgery, consequently reducing the need for postoperative analgesics. These findings support the outcomes of previous investigations, indicating that drain placement may be a valuable strategy to alleviate postoperative shoulder pain in women undergoing gynecologic laparoscopy.

Effectiveness of endoscopic ultrasound-guided biliary drainage in patients experiencing obstructive jaundice due to unsuccessful endoscopic retrograde cholangiopancreatography

Objective: To assess the treatment outcomes of endoscopic ultrasound-guided biliary drainage (EUS-BD) in patients with obstructive jaundice due to unsuccessful endoscopic retrograde cholangiopancreatography (ERCP). Methods: The clinical data of patients with obstructive jaundice who underwent EUS-BD due to ERCP failure at the Gastrointestinal Endoscopy Center of Beijing Friendship Hospital from September 2018 to November 2023, was retrospectively collected and analyzed. We explored the technical success, clinical success, and adverse events associated with EUS-BD. Results: In total, 43 EUS-BD procedures were performed in 39 patients with a technical success rate of 86.0% (37/43). The clinical success rate was 81.1% (30/37). Biliary drainage was not effectively achieved in seven cases, including two fatal cases and five cases of recurrent postoperative biliary obstruction. The incidence of adverse events was 21.6% (8/37), including two cases of postoperative bile leakage peritonitis, two cases of stent displacement, one case of stent dislocation, one case of perforation, and two cases of death. Conclusion: EUS-BD is a relatively safe and effective method for bile duct drainage, serving as a dependable alternative therapeutic option for patients with obstructive jaundice due to unsuccessful ERCP.

Prophylactic intra-abdominal drainage during pancreaticoduodenectomy: A systematic review and meta-analysis

Background: Prophylactic abdominal drainage during pancreaticoduodenectomy (PD) is a common treatment strategy for pancreatic fistula. However, its benefits and safety have been the subject of debate. The objective of this meta-analysis and system review is to assess the effects of prophylactic drainage, various types of drainage (active and passive), and the timing of drainage removal (early and late) on the postoperative outcomes of PD. Methods: A systematic literature search was conducted in the PubMed, Web of Science, and Cochrane Library databases as of April 28, 2024. Randomized controlled trials (RCTs) comparing prophylactic abdominal drainage, different drainage patterns, and the timing of drainage removal after PD were included, and the postoperative outcomes were evaluated. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated to aggregate dichotomous outcomes. Meta-analysis was performed using the Mantel-Haenszel fixed- and random-effects models. Results: Nine RCTs, including a total of 1638 patients, were incorporated in our study. The meta-analysis showed no statistically significant differences in postoperative outcomes between the closed-suction drain (CSD) group and the passive drain to gravity (PDG) group. Compared to the late drain removal (LDR) group, the early drain removal (EDR) group had a significant reduction in the incidence of Clinically relevant postoperative pancreatic fistula (CR-POPF) (OR=0.39, 95% CI=0.20 to 0.79; P=0.009), morbidity (OR=0.41, 95% CI=0.20 to 0.84; P=0.01) and intra-abdominal infection (OR=0.40, 95% CI=0.22 to 0.75; P=0.004). For the group of present of drainage and the group of absent of drainage, the patient inclusion criteria of the included studies were too heterogeneous, making meta-analysis inappropriate. Conclusion: The existing evidence is insufficient to negate the necessity of prophylactic drainage after PD. The meta-analysis did not show superiority of any specific approaches of drainage tube. But this review did indicate that patients benefit from EDR in terms of CR-POPF, morbidity and intra-abdominal infection. EDR was recommended for low/intermediate risk patients.

The impact of closed suction wound drainage on chronic pain and health-related quality of life after posterior spinal fusion in patients with adolescent idiopathic scoliosis.

Closed suction subfascial drainage is widely used after instrumented posterior spinal fusion in patients with a spinal deformity. The aim of this study was to determine the effect of this wound drainage on the outcomes in patients with adolescent idiopathic scoliosis (AIS). This was a further analysis of a randomized, multicentre clinical trial reporting on patients after posterior spinal fusion using segmental pedicle screw instrumentation. In this study the incidence of deep surgical site infection (SSI) and chronic postoperative pain at two years' follow-up are reported. We conducted a randomized, multicentre clinical trial on adolescents undergoing posterior spinal fusion for AIS using segmental pedicle screw instrumentation. A total of 90 consecutive patients were randomized into a 'drain' or 'no drain' group at the time of wound closure, using the sealed envelope technique (1:1). The primary outcomes in the initial study were the change in the level of haemoglobin in the blood postoperatively and total blood loss. A secondary outcome was the opioid consumption immediately after surgery. The aim of this further study was to report the rate of deep SSI and persistent postoperative pain, at two years' follow-up. As previously reported, the mean 48-hour opioid consumption was significantly higher in the no drain group (2.0 mg/kg (SD 0.8) vs 1.4 mg/kg (SD 0.7); p = 0.005). There were no delayed deep SSIs. At two years' follow-up, the mean Scoliosis Research Society 24-item questionnaire (SRS-24) total score did not differ between the groups (4.11 (SD 0.47) vs 4.16 (SD 0.33); p = 0.910). The mean SRS-24 pain score was 4.28 (SD 0.48) in the no drain group compared with 4.33 (SD 0.66) in the drain group (p = 0.245). Seven patients (19%) in the no drain group and six in the drain group (14%) reported moderate to severe pain (numerical rating scale ≥ 4) at two years' follow-up (p = 0.484). The general self-image domain score was significantly higher in the no drain group compared with the drain group (4.02 (SD 0.74) vs 4.59 (SD 0.54); p < 0.001). The main finding in this study was that more severe pain immediately after surgery did not result in a higher incidence of chronic pain in the no drain group compared with the drain group. Back pain and health-related quality of life at two years' follow-up did not differ between the groups. The patient-reported self-image domain was significantly better in the no drain group compared with the drain group.

Investigating the influence of climate on the evolution of fold-and-thrust belts in Chinese Tianshan: A 2D doubly vergent numerical model approach

In most analogue and numerical modelling studies for investigating the evolutionary mechanisms of fold-and-thrust belts, the initial models are typically designed as “sandboxes” with one side fixed in the horizontal direction. However, such model setup has neglected the potential effects of drainage divide migration. To address this issue, in this study we developed a 2D doubly vergent numerical model that accounts for drainage divide migration to investigate the structural evolution in Tianshan fold-and-thrust belts since the late Cenozoic, with an emphasis on the influences of climatic forcing on rock deformation. The deformation styles of northern and southern Tianshan fold-and-thrust belts exhibit significant differences, with the northern Tianshan fold-and-thrust belt characterized by deep isoclinal anticlines, whereas the southern Tianshan fold-and-thrust belts are dominated by thrust faults and minor shallow-level tight anticlines. Our modelling results suggest that such differences in deformation style may be attributed to the north–south precipitation gradient across Tianshan mountain. The results also show that unilateral climatic perturbations can lead to migration of the drainage divides towards the side with lower precipitation, thereby impacting the structural evolution on the opposite side of the mountain range. Such impact mainly manifests as an increased tendency to develop more thrust faults in the direction toward which the drainage divide is shifting. This provides a new perspective for reevaluating the patterns of tectonic evolution in the global orogenic belts since the late Cenozoic.

Optimization of Velocity String Drainage and Gas Recovery Process for Sour Gas Wells in Jingbian Gas Field

Abstract In view of the gradual attenuation of gas well energy during the development of Jingbian gas field, the liquid carrying effect of some gas wells with small gas production becomes worse, the drainage effect of 60 % gas wells is not ideal, and the H2S content of the lower paleo-sulfur gas wells is high, the salinity is high, there is a certain corrosion, and most of the drainage measures cannot be implemented. The optimization of sulfur-resistant velocity string was carried out from the aspects of velocity string size and pipe material, and the appropriate pipe diameter and pipe material were selected. A new type of broken disc speed string plug was developed, which successfully solved the problem that the existing plug could not be broken or returned after construction. The field application results show that compared with the 27/8 “ string, the liquid carrying flow rate is reduced by 82 %. After 2.5 years of service, the anti-corrosion performance of the pipe is good. The cumulative increase of the well is 445.4 thousand cubic meters, and the effective rate of the measures is 97.45 %. The stable and continuous liquid carrying of the gas well is realized, which has a good application effect. It has certain reference significance for the implementation of the drainage gas recovery technology of the velocity string in the lower ancient sulfur gas well.

Combined Effects of Mechanical Ventilation and Postural Drainage in Acute Respiratory Distress Syndrome

Background: Acute Respiratory Distress Syndrome (ARDS) is a severe condition impacting lung function, often requiring mechanical ventilation. Postural drainage may improve oxygenation and airway clearance in ARDS patients, particularly in those with burn injuries and inhalation trauma.Objective: This study aimed to evaluate the combined effects of mechanical ventilation and postural drainage on oxygen saturation and airway clearance in burn patients with ARDS.Methods: A randomized controlled trial was conducted with 50 burn patients, aged 20-50, admitted to the ICU. Patients were divided into two groups: Group A received postural drainage with mechanical ventilation, and Group B received only mechanical ventilation. Data were collected daily using the APACHE II scale. FiO2, PO2, pH, and HCO3 levels were measured pre- and post-treatment. Data were analyzed using SPSS version 25.Results: The post-treatment FiO2 in Group A increased from 48.80 ± 18.92% to 85.40 ± 13.69%, while PO2 increased from 66.40 ± 17.22 mmHg to 77.40 ± 15.08 mmHg. Statistically significant improvements were observed in oxygenation (p &lt; 0.05), with no significant changes in pH and PCO2.Conclusion: Postural drainage combined with mechanical ventilation significantly improves oxygenation in burn patients with ARDS.

Characteristics of Open-Graded Friction Course Macrotexture and Macrostructure and Its Effect on Skid Resistance under Rainfall.

An Open-Graded Friction Course (OGFC) presents a rough surface and a porous structure and provides skid resistance under wet conditions, differing from that of a dense graded mixture. This study explored the distribution of surface macrotexture with depth in OGFC. Using cross-sectional images and semantic image segmentation techniques, the internal structure, porosity, and void size distribution were analyzed to assess the effectiveness of rainfall drainage. Skid resistance was evaluated with a British Pendulum Tester, focusing on the influence of surface macrotexture and internal macrostructure, particularly with regard to contact depth. Results show that finer gradations increase surface roughness peaks, which are concentrated near the top surface. In contrast, coarser mixtures exhibit a greater effective contact depth and more peaks with higher curvature. Finer gradations also result in lower porosity, greater void dispersion, and smaller average void diameters. During heavy rainfall, OGFC-13 exhibits the highest friction coefficient due to its effective contact, surface roughness, and internal voids, which facilitate water expulsion. This research provides insights into the skid resistance mechanism of OGFC in wet conditions and offers practical guidance for selecting the optimal gradation.

Insights into catalytic co-pyrolysis of spent coffee grounds and high density polyethylene (HDPE) using acid mine drainage (AMD) treated sludge based catalyst: Analysis of kinetics, mechanism and thermodynamic properties

The present study aims to investigate the catalytic effect of acid mine drainage (AMD) treated sludge based catalyst on the co-pyrolysis of spent coffee grounds and HDPE. The sludge was generated during the treatment of AMD using eggshell and hydrogen peroxide. Theromogravimetric analysis of pyrolysis of spent coffee grounds (SC), HDPE (High density polyethylene), blend of spent coffee grounds and HDPE (SC+HDPE) in the ratio of 1:1, and blended feedstock with sludge derived catalyst (SC+HDPE_AMDC) (1:1 wt. ratio) was conducted at various heating rates of 10 °C/min, 20 °C/min, 30 °C/min and 40 °C/min respectively. Iso-conversional models such as Ozawa Flynn Wall (OFW), Kissinger Akahira Sunose (KAS), Friedman, and Starink were utilized for the determination of activation energy (Ea) of the process. The results showed that using AMD treated sludge based catalyst to the pyrolysis process, enhances its overall efficacy by lowering the activation energy (Ea) (OFW- Ea: 209.11 to 177.14 KJ/mol, KAS-Ea: 208.30 to 173.06 KJ/mol, Friedman- Ea:210.54 to 176.28 KJ/mol, and Starink- Ea:208.60 to 173.44 KJ/mol). Criado's z-master plot (CZMP) method was utilized to analyze the mechanism of the reaction. The pre-exponential factor and thermodynamic parameters were also evaluated. It is concluded that the incorporation of sludge based catalyst (AMDC) lowered enthalpy and randomness of system. Catalytic co-pyrolysis requires less energy, making it more environmental friendly choice for the sustainable processing of biomass and plastics. The present investigation will aid in the design, optimization and scalability.

Effect of Biliary Drainage on the Prognosis of Patients with Hepatocellular Carcinoma and Bile Duct Invasion.

Bile duct invasion (BDI) is rarely observed in patients with advanced hepatocellular carcinoma (HCC), leading to hyperbilirubinemia. However, the efficacy of pretreatment biliary drainage for HCC patients with BDI and obstructive jaundice is currently unclear. Thus, the aim of this study was to assess the effect of biliary drainage on the prognosis of these patients. We retrospectively enrolled a total of 200 HCC patients with BDI from multicenter cohorts. Patients without obstructive jaundice (n=99) and those who did not undergo HCC treatment (n=37) were excluded from further analysis. Finally, 64 patients with obstructive jaundice (43 subjected to drainage and 21 not subjected to drainage) were included. Propensity score matching was then conducted. The biliary drainage group showed longer overall survival (median 10.13 months vs 4.43 months, p=0.004) and progression-free survival durations (median 7.00 months vs 1.97 months, p<0.001) than the non-drainage group. Multivariate analysis showed that biliary drainage was a significantly favorable prognostic factor for overall survival (hazard ratio, 0.42; p=0.006) and progression-free survival (hazard ratio, 0.30; p<0.001). Furthermore, in the evaluation of first response after HCC treatment, biliary drainage was beneficial (p=0.005). Remarkably, the durations of overall survival (p=0.032) and progression-free survival (p=0.004) were similar after propensity score matching. Biliary drainage is an independent favorable prognostic factor for HCC patients with BDI and obstructive jaundice. Therefore, biliary drainage should be contemplated in the treatment of advanced HCC with BDI to improve survival outcomes.

Optimization of Advance Drainage Borehole Layout Based on Visual Modflow

It is an effective measure to prevent water damage in coal mines in order to construct drainage boreholes in water-filled aquifers of a working face roof. The hydrogeological parameters of the roof water-filled aquifer and the parameters of the drainage borehole are closely related to the underground drainage effect. Taking the 3085 working face of the Donghuantuo Mine in Kailuan as an example, the influence degree of hydrogeological parameters and hydrophobic borehole parameters on the amount of drainage water was analyzed using the generalized gray correlation degree. Based on Visual Modflow, the 3D groundwater visualization model was established and the dredging borehole was generalized into the pumping borehole. By changing the main influencing factors, the design optimization of the advanced hydrophobic borehole was discussed. The results showed that the aquifer thickness had a great influence on the amount of water discharged, and the influence degree of the sharp angle between the formation and the direction of drilling, the depth of the final hole, the azimuth angle of drilling, the dip angle of drilling, the elevation of the final hole and the elevation of the borehole on the amount of water discharged decreased successively. Based on the simulation calculation, it could be observed that the hydrophobic borehole should be placed in a position with a larger accumulated thickness of the aquifer to have a better effect of hydrophobic depressurization.