Effective Rate Of Treatment Group Research Articles

The clinical efficacy of external application of mirabilite and rhubarb combined with intrathoracic chemotherapy in treating malignant pleural effusion: A prospective, randomized, controlled clinical trial.

Background:Malignant pleural effusion (MPE) is one of the commonest causes of an exudative pleural effusion. Breathlessness, dyspnea and other symptoms often seriously distress and affect the quality of life. The external application of mirabilite and rhubarb (EAMR) combined with intrathoracic infusion of cisplatin, as an alternative treatment for MPE, is popular in China. The study aims to assess its effectiveness and safety combined with intrathoracic chemotherapy.Methods:This study is a prospective, randomized controlled clinical trial. Patient visits were performed at baseline and days 14 and 28 after treatment. Clinical outcomes were measured after chest drain placement using the criterion of efficacy refer to WHO standard, and QLQ-C30 questionnaire.Results:Database records of patients treated in our institution for MPE between October, 2016 and March, 2019. The study included 84 eligible patients. They were categorized with a randomization schedule into treatment group (N = 42) and control group (N = 42). There is statistical significance in the comparison of the total effective rate between these 2 groups (66.67% vs 54.76%, P < .05). Furthermore, there is statistical significance in the comparison of items of Physical (1.95 ± 0.50 vs 2.19 ± 0.58%, P < .05), Pain (1.98 ± 0.42 vs 2.07 ± 0.32, P < .05), and Global Health (1.23 ± 0.64 vs 1.13 ± 0.23%, P < .05) between these 2 groups. None of the patients had adverse reactions such as skin allergy and chest tightness.Conclusions:The total effective rate of treatment group using extra external application of mirabilite rhubarb powder is significantly higher than that of control group. The improvement of patients’ clinical symptoms is greater in treatment group and no adverse reactions is found. Therefore, external application of mirabilite and rhubarb combined with intrathoracic infusion of cisplatin is an effective method for the treatment of MPE, which is worth popularizing.

Influence on orbicularis oculi muscle in the patients with facial neuritis treated with the penetra-ting needling at Cuanzhu (BL2) and Yuyao (EX-HN4) combined with the perpendicular needling at Shenmai (BL62)

To explore the therapeutic effect on incomplete eyelid in the patients with facial neuritis treated with the penetrating needling at Cuanzhu (BL2) and Yuyao (EX-HN4) combined with the perpendicular needling at Shenmai (BL62). A total of 64 patients with facial neuritis, in compliance with the inclusion criteria, were randomized into a treatment group and a control group, with 32 cases in each. In the treatment group, the penetrating needling was applied to BL2 and EX-HN4 on the affected side, combined with the perpendicular needling at bilateral BL62. Besides, on the affected side, the penetrating needling was applied from Yangbai (GB14) toward four directions, named Shangxing (GV23), Touwei (ST8), Cuanzu (BL2) and Sizukong (TE23), the mutual penetrating needling was adopted between Dicang (ST4) and Jiache (ST6). Between Yingxiang (LI20) and Xiaguan (ST7), a row-arranged needling technique was applied. All of the needles were retained for 10 to 30 min in each treatment. The treatment was given once daily and the treatment for 10 days was as 1 course. A total of 2 courses of treatment were required. In the control group, prednisone acetate （30 mg/d）, was administered consecutively for 5 days. Afterward, the dose was reduced to be 10 mg/d and the medication stopped after taking consecutively for 1 week. Muscular injection with vitamin B12 （0.5 mg） and B1 （0.1 mg） was given, once daily. 10 days later, vitamin B1 was taken for oral administration, 10 mg each time, three times a day, for 10 days totally. Before and after the treatment, the clinical effect was compared between the two groups in terms of the analysis on the Hourse-Brackman (H-B) grade of facial nerve function, the distance between the upper and the lower eyelids, muscle strength, degree of eyelid closure and electromyogram (EMG). The total effective rate of treatment group was 96.9 % (31/32), better than 84.4%（27/32） in the control group (P<0.05). After treatment, in the treatment group, the distance between the upper and lower eyelids, the muscle strength, the degree of eyelid closure, the wave amplitude of motor nerve conduction and the latent period, as well as the blink reflex were all improved as compared with those before the treatment (P<0.01, P<0.05). In the control group, the distance between the upper and lower eyelids, the muscle strength, the degree of eyelid closure, the latent period of motor nerve conduction and the blink reflex were all improved as compared with those before the treatment (P<0.01, P<0.05). After the treatment, the results of the distance between the upper and lower eyelids, the muscle strength, the degree of eyelid closure, the wave amplitude of motor nerve conduction and the latent period, as well as the blink reflex in the treatment group were all better than those in the control group (P<0.05，P<0.01). The treatment with the penetrating needling at Cuanzhu (BL2) and Yuyao (EX-HN4) combined with the perpendicular needling at Shenmai (BL62) greatly promotes the recovery of orbicularis oculi muscle in the patients with facial neuritis, reduces the complications and presents the satisfactory clinical effect.

Salmon calcitonin combined with vitamin D3 in the treatment of hyperparathyroidism secondary to chronic renal insufficiency

Objective To explore the efficacy of salmon calcitonin combined with vitamin D3 in the treatment of chronic renal insufficiency and secondary hyperthyroidism and its effects on bone calcium metabolism. Methods A total of 40 patients with chronic renal failure who underwent hemodialysis in our blood purification center from September 2017 to December 2017 were selected for the study and were divided into treatment group (20 cases) and control group (20 cases) according to the random number table method. Patients in control group were given conventional treatment + calcitriol orally, and patients in treatment group were given subcutaneous injection of salmon calcitonin on the basis of control group. The course of treatment in both groups was 12 weeks. The clinical efficacy and clinical symptoms improvement, serum calcium, serum phosphorus and parathyroid hormone (iPTH) as well as the adverse reactions were compared between the two groups. The Kidney Disease Targeted Areas (KDTA) and Visual Analogue Pain Score (VAS) were used to evaluate the patients' quality of life and bone pain. Results The effective rate in treatment group was significantly higher than that in control group (95.00% vs 65.00%) (P 0.05). Conclusions The treatment effect of salmon calcitonin combined with vitamin D3 on chronic renal insufficiency secondary hyperthyroidism is obvious, and the clinical symptoms such as bone pain are improved obviously. It is believed that salmon calcitonin is related to the regulation of calcium, phosphorus and bone metabolism. Key words: Renal insufficiency, chronic; Hyperparathyroidism, secondary; Salmon calcitonin; Vitamin D3

The clinical research on the efficacy of Tanreiqing injection combined with routine western medicine in treating chronic obstructive pulmonary disease at acute and aggravating period with syndrome of phlegm-heat obstructing lung

Objective To evaluate effect of Tanreqing injection combined conventional western medicine therapy on acute exacerbation of chronic obstructive pulmonary disease (AECOPD) of Phlegm heat obstructing Lung. Methods A total of 112 patients with AECOPD were randomly divided into two groups with digital table method from February 2015 to February 2018, 56 cases in each group. The control group was treated byconventional western medicine therapy, and treatment group was treated by Tanreqing injection based on control group. Both groups' treatment lasted for 2 weeks. The modified version of British Medical Reseach Council respiratory questionnaire (mMRC) was used for severity evaluation in breath difficulty. The COPD assessment test (CAT) was used for the assessment of symptoms, activity ability, psychological, social impact and sleep. The FEV1% and FEV1/FVC were recorded. The SaO2, PaO2 and PaCO2 were recorded. The phlegm heat obstructing lung symptom scores were detected. The adverse reactions were recorded. Results The total effective rate of treatment group was 94.4% (51/54), and the control group was 77.3% (41/53). There was statistically significant difference between two groups (χ2=5.138, P=0.023). After treatment, the mMRC and CAT scores in the treatment group were significantly lower than those in the control group (t value were 17.233, 17.111, respectively, all Ps<0.01); the cough, wheezing, shortness of breath, fever, dry mouth, constipation scores were significantly lower than the control group (t value were 27.717, 29.387, 27.227, 30.268, 28.430, 29.738, respectively, all Ps<0.01). After treatment, the FEV1% (52.34% ± 5.79% vs. 46.98% ± 5.72%, t=4.817), FEV1/FVC (61.36 ± 6.52 vs. 56.93 ± 5.94, t=3.675) in the treatment group were significantly higher than the control group (P<0.01); SaO2 (90.11% ± 9.53% vs. 83.56% ± 8.84%, t=3.684); the PaO2 (91.22 ± 9.79 mmHg vs. 85.18 ± 8.80 mmHg, t=3.354) significantly higher than the control group (P<0.01), and PaCO2 (44.75 ± 4.94 mmHg vs. 51.05 ± 5.46 mmHg, t=6.261) significantly lower than the control group (P<0.01). The incidence of adverse reactions in the treatment group was 11.1% (6/54), and the control group was 7.5% (4/53). There was no statistically significant difference between two groups (χ2=0.091, P=0.763). Conclusions Tanreiqing injection combined with conventional western medicine therapy can take effectsimprove levels of SaO2 and PaO2, reduce PaCO2 level of the AECOPD patients. Key words: Pulmonary disease, chronic obstructive; Acute disease; Phlegm heat obstructing Lung; Tan Re Qing Zhu She Ye; Integrated Chinese traditional and western medicine therapy; Drug-related side effects and adverse reactions

Clinical research of acupuncture combined with metformin or the treatment of diabetes at the early stage

Objective To investigate the clinical application of acupuncture combined with metformin or the treatment of diabetes at the early stage. Methods According to the random table method, 123 patients with diabetes at the early stage were divided into control group (n=61) and the treatment group (n=62). The patients in the control group were treated with metformin, while the patients in the treatment group were treated with acupuncture combined with metformin. Two groups of patients were treated for 12 weeks. The clinical total effective rate of two groups of patients after treatment was counted. The FPG, HbA1c, FINS, FCP, TG, TC, LDL-C, HDL-C, LEP, GLP-1, RETN, HOMA-IR and ISI of the two groups before and after treatment were compared. Results The total effective rate of treatment group was 91.9% (57/62), while the control group was 65.6% (40/61), and the difference between two groups was statistically significant (χ2=12.818, P<0.01). After treatment, the FPG, HbA1c, FINS. FCP, HOMA-IR, ISI, TG, TC, LDL-C, LEP, RETN of treatment group were significantly lower than those of the control group (t were 14.149, 14.301, 4.254, 7.552, 9.470, 11.032, 9.993, 12.000, 11.802, 5.385, 9.121, P<0.01), while the HDL-C, GLP-1 of treatment group were significantly higher than those of the control group (t were 3.402, 14.680, P<0.01). Conclusions Acupuncture combined with metformin or the treatment of diabetes at the early stage has a good efficacy, can correct the disorder of glucose and lipid, improve the insulin resistance. Key words: Prediabetic state; Acupuncture therapy; Metformin; Integrated Chinese traditional and western medicine therapy

Effect of butylphthalide combined with edaravone on cerebral hemodynamics, vascular endothelial function and cytokines in elderly patients with acute cerebral infarction

Objective To investigate the effects of butylphthalide combined with edaravone on cerebral hemodynamics, vascular endothelial function and cytokines in elderly patients with acute cerebral infarction. Methods From May 2017 to May 2018, 82 elderly patients with acute cerebral infarction admitted to the First People's Hospital of Wenling were selected and randomly divided into two groups according to the digital table, with 41 cases in each group.The patients in the control group were treated with edaravone, while the patients in the treatment group were treated with butylphthalide on the basis of the control group.The two groups were treated for 2 weeks.The neurological deficit scale (NIHSS), cerebral hemodynamics, vascular endothelial function and cytokines were compared between the two groups before and after treatment. Results The NIHSS score of the treatment group was (18.49±1.87)points, which was lower than (22.17±1.32)points of the control group at 2 weeks after treatment (t=10.294, P<0.05). The mean flow velocity [(31.70±3.25)cm/s], vascular resistance index (0.79±0.12) and maximum peak flow velocity [(54.21±2.65)cm/s] in the treatment group were higher than those in the control group [(26.91±4.39)cm/s, (0.61±0.05) and (43.76±3.10)cm/s] (t=5.615, 8.866, 16.407, all P<0.05). The contents of NO [(71.27±6.58)μmol/L] and eNOS [(66.37±3.65)U/mL] in the treatment group were higher than those in the control group [(62.30±2.71)μmol/L and (57.89±4.08)U/mL] (t=8.071, 9.919, all P<0.05). After 2 weeks of treatment, the contents of IL-6 [(27.36±2.71)pg/mL], CRP [(2.87±0.76)mg/L] and TNF- α[(98.24±10.48)ng/mL] in the treatment group were lower than those in the control group [(43.25±4.10)pg/mL, (4.59±0.91)mg/L and (160.27±15.42)ng/mL] (t=20.702, 9.289, 21.303, all P<0.05). The total effective rate of treatment group (90.24%) was higher than that of control group (68.29%) (χ2=6.011, P<0.05). Conclusion Butylphthalide combined with edaravone can improve cerebral hemodynamics, vascular endothelial function and alleviate cellular inflammatory reaction in elderly patients with acute cerebral infarction, and the curative effect is significant, which is worthy of clinical study. Key words: Infarction, middle cerebral artery; Vascular resistance; Blood flow velocity; Nitric oxide; Nitric oxide synthase; Interleukin-6; Tumor necrosis factor-alpha; Butylphthalide; Edaravone; Aged

Clinical efficacy of Tongfei-Huatan-Huoxue decoction for the treatment of acute cerebral infarction

Objective To investigate therapeutic effect of Tongfei-Huatan-Huoxue decoction for the treatment of acute cerebral infarction. Methods According to the random table method, 103 patients with acute cerebral infarction were divided into the control group (n=51) and the treatment group (n=52). The patients in the control group were treated with conventional medicine, while the patients in the treatment group were treated with Tongfei-huatan-huoxue decoction on the basis of control group. Two groups were treated for 30 consecutive days. The clinical total effective rate of two groups after treatment was counted. The NIHSS scores, Brrthal were determined respectively before and after treatment, at the same time, the levels of serum IL-6, TNF-α, hs-CRP and plasma TXB2, AT-Ⅲ, 6-keto-PGF1α were detected before and after treatment. Results The total effective rate of treatment group was 88.5%, while the total effective rate of control group was 70.6%. The difference between two groups was statistically significant (χ2=5.067, P=0.024). After treatment, the NIHSS (9.15 ± 1.25 vs. 12.21 ± 2.05, t=9.166), plasma TXB2 (140.12 ± 16.58 ng/L vs. 168.49 ± 22.18 ng/L, t=7.362), IL-6 (32.02 ± 2.54 ng/L vs. 44.15 ± 3.17 ng/L, t=21.452), TNF-α (8.05 ± 1.71 g/L vs. 11.14 ± 2.03 g/L, t=8.361), hs-CRP (12.16 ± 5.34 mg/L vs. 20.08 ± 6.06 mg/L, t=7.041) of treatment group were significantly lower than those of the control group (P<0.05), while the Brrthal (90.05 ± 16.37 vs. 79.36 ± 15.22, t=3.431), plasma AT-Ⅲ (82.57% ± 4.83% vs. 76.64% ± 4.29%, t=6.583), 6-keto-PGF1α (65.07 ± 9.26 ng/L vs. 39.91 ± 8.38 ng/L, t=14.450) of the treatment group were significantly higher than those of the control group (P<0.05). Conclusions The clinical curative effect of Tongfei-Huatan-Huoxue decoction for the treatment of acute cerebral infarction is significantly, which can significantly improve the patient's nerve function and daily life ability,speculated that the mechanism of action relevant to correct high blood coagulation state,inhibit thrombosis and reduce the serum levels of inflammatory cytokines. Key words: Brain infarction; Stroke; Tongfei-Huatan-Huoxue decoction; Neural function defect; Quality of life; Therapies, investigational

Clinical research of Tongqiao-Huoxue decoction for the treatment of vertebrobasilar artery insufficiency vertigo with stasis orifice type

Objective To investigate the clinical application of Tongqiao-Huoxue decoction for the treatment of vertebrobasilar artery insufficiency vertigo with stasis orifice type. Methods According to the random table method, 93 vertebrobasilar artery insufficiency vertigo patients with stasis orifice type were divided into the control group (n=46) and the treatment group (n=47). The patients in the control group were treated with fluoguizine hydrochloride, while the patients in the treatment group were treated with Tongqiao-Huoxue decoction on the basis of control group. Two groups were treated for 4 weeks. The clinical total effective rate of two groups of patients after treatment was compared. The LVA mean blood flow velocity, RVA mean blood flow velocity, BA mean blood flow velocity, total blood viscosity, plasma viscosity, erythrocyte aggregation index, fibrinogen, TC, TG, LDL-C and HDL-C were detected respectively before and after treatment. In addition, the adverse reaction incidence of two groups of patients were observed. Results The total effective rate of treatment group was 93.6% (44/47), while the total effective rate of control group was 78.3% (36/46). The difference between two groups was statistically significant (χ2=4.559, P=0.033). After treatment,the LVA mean blood flow velocity (38.34 ± 3.72 cm/s vs. 29.73 ± 3.11 cm/s, t=12.096), RVA mean blood flow velocity (41.12 ± 4.05 cm/s vs. 34.11 ± 3.86 cm/s, t=8.541),BA mean blood flow velocity (48.92 ± 5.24 cm/s vs. 40.75 ± 4.63 cm/s, t=7.962), HDL-C (2.13 ± 0.64 mmol/L vs. 1.54 ± 0.53 mmol/L, t=4.836) of treatment group were significantly higher than the control group (P<0.05), while the total blood viscosity, plasma viscosity, erythrocyteaggregation index, fibrinogen, TC, TG, LDL-C of treatment group were significantly lower than the control group (t value were 5.457, 8.875, 3.661, 6.549, 3.838, 6.369, 5.201, all Ps<0.05). No serious adverse reactions occurred during the treatment of the two groups. Conclusions The clinical curative effect of Tongqiao-Huoxue decoction for the treatment of vertebrobasilar artery insufficiency vertigo with stasis orifice type is significantly, and it can increases blood flow to the brain, improve hemorheology and lipid levels. It has the high security of the forward curative effect. Key words: Vertigo; Vertebrobasilar insufficiency; Tongqiao-Huoxue decoction; Flunarizine hydrochloride capsules; Syndrome of static blood blocking orifices

Clinical observation of Qihuang-Juantong decoction combined with morphine sulfate sustained-release tabletsin treatment for cancer pain

Objective To study the clinical efficacy of Qihuang-Juantong decoction combined with morphine sulfate sustained-release tablets in treatment of cancer pain. Methods A total of 107 patients with cancer pain were divided into the control group (n=53) and the treatment group (n=54) randomly. The control group were treated with morphine sulfate sustained-release tablets, and the treatment group were treated with Qihuang-Juantong decoction combined with morphine sulfate sustained-release tablets. The two groups were treated for 14 days. The clinical efficacy of the two groups after treatment was compared. The kamofsky performance status (KPS) score of the two groups before and after treatment were compared. The initial dose and dose after two periods of treatment of morphine sulfate sustained-release tablets of the two groups were compared. The CD4+, CD8+ and CD4+/CD8+of the two groups before and after treatment were compared. The adverse reactions rates of the two groups during the treatment were compared. Results Total effective rate of treatment group was 92.59% (50/54), which was significantly higher than the control group 71.70% (38/53), and the difference was statistically significant (χ2=7.996, P<0.05). After treatment, the KPS score (70.3 ± 6.4 vs. 63.4 ± 6.0, t=5.711) in the treatment group were significantly higher than that in the control group (P<0.05), the dose after two periods of treatment of morphine sulfate sustained-release tablets (42.20 ± 5.31 mg vs. 47.08 ± 6.23 mg, t=4.364) in the treatment group were significantly lower than that in the control group (P<0.01). After treatment, the CD4+(45.58% ± 6.17% vs. 31.06% ± 4.87%, t=13.496), CD4+/CD8+(1.26 ± 0.15 vs. 0.69 ± 0.10, t=23.083) in the treatment group were significantly higher than those in the control group (P<0.05), the CD8+(36.18% ± 3.36% vs. 44.96% ± 5.04%, t=10.621) in the treatment group were significantly lower than those in the control group (P<0.01). The adverse reactions rate of the treatment group during the treatment was 11.11% (6/54), which was significantly lower than the control group 35.85% (19/53), and the difference was statistically significant (χ2=9.142, P<0.05). Conclusions The Qihuang-Juantong decoction combined with morphine sulfate sustained-release tabletshas a good efficacy and low adverse reaction rates for the cancer pain, can improve the quality of life and cellular immune function, reduce the dose of opioid, and it was worthy clinical application. Key words: Cancer pain; Qihuang-Juantong decoction; Analgesic agents (TCD); Analgesics, opioid

Clinical observation of Wumeiwan combined with triple therapy for treatment of chronic atrophic gastritis

Objective To explore clinical efficacy and safety of Wumeiwan combined with triple therapy for treatment of chronic atrophic gastritis (CAG). Methods According to the random indicator method, 113 patients with CAG were divided into control group (n=56) and treatment group (n=57). Patients of control group were treated with triple therapy, while treatment groupwere treated Wumeiwan combined with triple therapy. The two groups were treated for 3 months. Clinical effect was evaluated after treatment. The helicobacter pylori (Hp) conversion to negative of the two groups was compared and recorded. The Hp overcast conditions of the two groups were compared. The serum TNF-α, IL-6, IL-8 and peripheral blood CD3+, CD4+, CD8+, CD4+/CD8+ of the two groups before and after treatment were compared. The adverse reactions of the two groups during the treatment were compared. Results Total effective rate of treatment group was 94.7% (54/57), which was significantly higher than the control group 82.14% (46/56), and the difference was statistically significant (χ2=4.401, P=0.036). Hp overcast rate of treatment group was 88.2% (45/51), which was significantly higher than the control group 48.0%(24/50), and the difference was statistically significant (χ2=18.883, P=0.000). After treatment, the serum TNF-α (1.43 ± 0.17 mg/L vs. 1.97 ± 0.22 mg/L, t=14.615), IL-6 (30.79 ± 3.65 ng/L vs. 41.13 ± 4.10 ng/L, t=14.166), IL-8 (7.52 ± 1.32 ng/L vs. 9.60 ± 1.77 ng/L, t=7.090) in the treatment group were lower than those in the control group (P<0.05). After treatment, the peripheral blood CD3+ (75.12% ± 16.44% vs. 67.33% ± 14.37%, t=2.680), CD4+ (39.02% ± 11.41% vs. 33.49% ± 10.61%, t=2.667), CD4+/CD8+ (1.58 ± 0.35 vs. 1.19 ± 0.32, t=6.179) in the treatment group were higher than those in the control group (P<0.05), the peripheral blood CD8+ (24.75% ± 9.69% vs. 28.12% ± 11.29%, t=1.704) in the treatment group were higher than those in the control group (P<0.05). There was no significantly difference of the adverse reaction rates of the two groups during treatment (χ2=0.134, P=0.714). Conclusions The Wumeiwan combined with triple therapy for treatment of CAG has a good efficacy and low adverse reactions, has serious anti-inflammatory effects, can improve the body immunity, and it was worthy clinical application. Key words: Gastritis, atrophic; Wu Mei Wan; Triple therapy; Efficacy; Safety

Comparison of the effects of mesalazine oral plus enema and only oral administration in the treatment of ulcerative colitis

Objective To compare the efficacy and safety of mesalazine oral plus enema or only oral administration in the treatment of ulcerative colitis. Methods 114 patients with ulcerative colitis were selected, and they were randomly divided into the observation group and treatment group according to random number table, with 57 cases in each group.The observation group was given mesalazine oral treatment, and the treatment group was given mesalazine oral plus enema.The changes of CRP, Fid, MPV after treatment were compared between the two groups.The situation of mucosa under colonoscopy, effective rate and the incidence of adverse reactions were compared between the two groups. Results After treatment, the CRP, Fid levels in the treatment group were lower than those in the observation group[(3.17±1.48)mg/L vs.(6.14±2.53)mg/L, (2.14±0.17)g/L vs.(2.91±0.27)g/L], the MPV in the treatment group was higher than that in the observation group[(10.93±0.59)fL vs.(10.21±1.21)fL], the differences were statistically significant (t=7.650, 18.220, 4.038, all P<0.05). The total remission rate of the treatment group was higher than that of the observation group (100.00% vs.78.95%) (χ2=13.412, P<0.001). The total effective rate of treatment group was higher than that of the observation group (89.47% vs.75.44%) (χ2=3.881, P=0.049). The incidence rate of adverse reactions in the treatment group was lower than that in the observation group (3.51% vs.26.32%) (χ2=11.683, P=0.001). Conclusion Mesalazine oral plus enema in the treatment of ulcerative colitis has good effect, minor adverse reactions, high safety, which is worthy of clinical application. Key words: Mesalazine; Enema; Colitis, ulcerative; Comparative effectiveness research

Impact of prostaglandin F2α and endothelin, pulsation index and resistance index of uterine artery blood flow on dysmenorrhea patients of cold stagnation and blood stasis syndrome with Dingkun Dan

This research apply Dingkun Dan to treat patients with dysmenorrhea of cold stagnation and blood stasis syndrome. This study observed its effectiveness and safety of the treatment of the disease and its influence on the serum prostaglandin F2α, endothefin, pulsatility index and resistant index of uterine artery blood, to explore the possible mechanism of effect of Dingkun Dan in the treatment of dysmenorrhea and provide scientific basis for clinical application. The 75 patients with dysmenorrhea of cold stagnation and blood stasis who met the inclusion criteria, were divided into treatment group (n=37) and control group (n=38) by using random number remainder grouping method. In the treatment group patients were treated with Dingkun Dan, the other group were given Fuke Zaizao Jiaonang. Two groups have same time to take the medicine, three days prior to the menstruation for ten days. Medication for three menstrual cycles was seen as a course of treatment. To observe and compare the two groups of patients before and after treatment VAS score, syndrome integral, serum levels of prostaglandin F2α and endothelin, pulsation index and resistance index of uterine artery blood flow and related safety index changes. Finally makes statistical analysis. It has been identified that, Treatment group and control group can reduce pain symptom of dysmenorrhea patients and improve the syndromes scores, compare with control group, effect of the treatment group is more significant(P<0.01). VAS pain curative effect: the treatment group and control group total effective rate respectively were, 97.22%, 69.44%, markedly effective rate were 83.33%, 30.56%, comparison between two groups, treatment group is better than that of control group(P＜0.01). Syndromes curative effect: the treatment group and control group total effective rate respectively were 97.22%, 94.44%, markedly effective rate was 66.67%, 2.78%, respectively. The comparison between two groups, the total effective rate has no obvious difference, but markedly effective rate of treatment group is better than that of control group(P＜0.01). The treatment group can significantly reduce the patients' serum level of prostaglandin F2α(P<0.01), but no obvious difference was found in the control group before and after treatment. Both groups can significantly reduce the serum level of endothelin(P<0.01), comparison between two groups, the treatment group is more significant(P<0.01).Both treatment group and control group were significantly lower left and right pulsation index and resistance index of uterus artery blood flow(P<0.01). Between groups to compare the effect, the treatment group is more significant(P<0.01). Both treatment group and control group in the security check before and after treatment found no significant anomalies. Dingkun Dan in treating dysmenorrhea with cold stagnation and blood stasis syndrome seems to have remarkable clinical curative effect and safety, which may be achieved by significantly reducing the serum level of prostaglandin F2αand endothefin of the patients, and reducing the pulsation index and resistance index of uterine artery blood flow of the patients, to improve uterine artery condition of blood, and correcting local tissue ischemia to relieve pain.

The clinical effect of acupoint application for the patients with the chronic insomnia with liver-stagnation and Spleen-deficiency syndrome

Objective To observe the clinical effect on sleep improvement about acupoint application in treating the chronic insomnia of Liver-stagnation and Spleen-deficiency Syndrome. Methods A total of 68 patients with chronic insomnia with Liver-stagnation and Spleen-deficiency Syndrome were randomly and blindly divided into treatment group and control group by registration order. In the treatment process, 1 was eliminated and 33 were completed in the treatment group, 2 were eliminated and 32 were completed in the control group. The treatment group underwent An Mian Tie therapy half an hour before bed and the control group underwent placebo therapy in the same way of treatment group. Two groups were treated for 40 days and followed-up visit six months. The change of Pittsburgh Sleep Quality (PSQI), Index Insomnia Severity Index (ISI) and TCM Syndromes Scale were detected. Results The clinical total effective rate of treatment group was 72.7% and the control group was 9.4%, and the difference was statistically significant (χ2=46.977, P<0.01). The PSQI scores after treatment (7.55 ± 1.52 vs. 13.90 ± 2.44, t=148.165), and follow up 1 month (8.97 ± 2.51 vs. 13.17 ± 2.79, t=37.926) in the treatment group were significantly lower than those in the control group (P<0.01). The ISI scores after treatment (7.03 ± 3.37 vs. 20.89 ± 4.40, t=73.75), and follow up 1 month (9.81 ± 3.16 vs. 19.41 ± 3.66, t=40.79) in the observation group were significantly lower than those in the control group (P<0.01). The TCM Syndromes Scale scores after treatment (2.05 ± 1.09 vs. 6.98 ± 1.23, t=17.116), and follow up 1 month (4.06 ± 1.59 vs. 6.83 ± 0.91, t=68.055) and follow up 6 month (5.12 ± 1.84 vs. 7.19 ± 1.07, t=27.716) in the observation group were significantly lower than those in the control group (P<0.01). Conclusions Acupoint application could obviously change the sleep quality and Chinese medicine symptom in chronic insomnia of Liver-stagnation and Spleen-deficiency Syndrome. Key words: Insomnia; Liver-Qi stagnation and spleen deficiency; Acupoint sticking therapy; Clinical study

Acupuncture for 40 cases of spasmodic torticollis

ObjectiveTo evaluate the clinical effectiveness of professor WU Lian-zhong's “resuscitation and regulating muscle” acupuncture method for spasmodic torticollis (ST) based on syndrome differentiation, and to compare the efficacy of acupuncture treatment between the patients with spasmodic torticollis who were not given botulinum toxin A by injection and the patients given botulinum toxin A by injection. MethodsForty patients were divided into treatment group (not given botulinum toxin A by injection) and control group (given botulinum toxin A by injection), with 20 patients in each group. “Resuscitation and regulating muscle” acupuncture method was adopted in both two groups, and the treatment lasted for 6 months. The clinical efficacy in both two groups was compared after treatment. Tsui's Scale was applied to evaluate the overall effect, the abnormal posture of cervical spine and dystonic tremor. Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS) was used for scoring the severity of torticollis, quality of life and pain. ResultsAfter treatment, the markedly effective rate and the total effective rate in treatment group were 35.0% and 90.0%, respectively, which were superior to those in control group, namely 20.0% and 75.0%, and the efficacy difference was statistically significant for the total effective rate (P<0.05). It was shown according to the Tsui's Scale and TWSTRS that the differences were statistically significant when compared the two groups before and after treatment (all P<0.01); the difference of intergroup comparison after treatment was statistically significant (P<0.05). No adverse effect was found in both two groups during acupuncture treatment. Conclusion“Resuscitation and regulating muscle” acupuncture method can effectively improve the clinical symptoms of ST patients, and better efficacy is found in the patients not given botulinum toxin A by injection. The course of treatment of acupuncture treatment for torticollis patients is longer, and the patients should insist on treatment, and keep a good attitude.

Clinical study on the treatment of psoriasis vulgaris with the medicated thread moxibustion of Zhuang medicine

Objective To study the clinical effect of Zhuang medicine line point moxibustion in the treatment of psoriasis vulgaris. Methods 60 psoriasis vulgaris patients qualified subjects were randomly divided into observation group and control group.The control group was given routine treatment of psoriasis.The treatment group was given Zhuang medicine line points on the basis of the control group.The patients in two groups were treated for four courses.The clinical efficacy of the two groups were compared, and the changes of PASI score and DLQL score at different time periods were compared. Results The total effective rate of treatment group was 76.7%, which was higher than 50.0% in the control group (χ2=3.125, P<0.05). After 2, 3 and 4 courses of treatment, the PASI scores and DLQL scores between the observation group and the control group at the same time point had statistically significant differences (all P<0.05). Conclusion In this study, the use of Zhuang medicine line point moxibustion treatment for psoriasis vulgaris patients has significant curative effect, which can be used as the treatment for psoriasis vulgaris. Key words: Psoriasis vulgaris; Zhuang medicine; Medicated thread moxibustion; Curative effect observation

香菇多糖联合顺铂、地塞米松经胸腔中心静脉导管注入治疗老年肺癌恶性胸腔积液的临床观察

目的：观察香菇多糖联合顺铂、地塞米松经胸腔中心静脉导管注入治疗老年肺癌恶性胸腔积液的临床应用，评估其近期疗效及不良反应。方法：对36例老年肺癌恶性胸腔积液患者，采用胸腔留置中心静脉导管充分引流胸腔积液后，随机分治疗组(n = 19)及对照组(n = 17)，治疗组胸腔内注射香菇多糖、顺铂、地塞米松，对照组胸腔内注射顺铂、地塞米松，均为7天一次，连续最多4次。评价两组的近期疗效和不良反应。结果：治疗组有效率为84.2%，不良反应轻。对照组有效率为64.7%。结论：香菇多糖联合顺铂、地塞米松经胸腔中心静脉导管注入治疗老年肺癌恶性胸腔积液疗效肯定，不良反应少，是有效治疗老年肺癌恶性胸腔积液的方法之一。 Objective: To observe the clinical use of lentinan plus cisplatin and dexamethasone in elderly lung cancer with malignant pleural effusions by central venous catheters drainage, appraise its recent effect and adverse reactions. Methods: 36 elderly lung cancer patients with malignant pleural effusions by central venous catheters drainage were random divided into treatment group (n = 19) and control group (n = 17). The treatment group was injected into pleural cavity with lentinan Plus cisplatin and dexamethasone, and the control group was injected into pleural cavity with cisplatin and dexamethasone. They were respectively given seven days once, and continuous at most four times to evaluate recent effect and adverse reactions of two groups. Results: The total effective rates of treatment group were 84.2%, and adverse reactions were less. The total effective rate of control group was 64.7%. Conclusion: The clinical effect of lentinan plus cisplatin and dexamethasone in elderly lung cancer with malignant pleural effusions by central venous catheters drainage is certain and adverse reactions are less. It is one of the effective methods to control the elderly lung cancer with malignant pleural effusions.

Clinical observation of Yubaisang-Zhikefang decoction on treating 128 patients with chronic bronchitis

Objective To observe effects of the Yubaisang-Zhikefang decoction on chronic bronchitis. Methods A total of 128 patients were randomly divided into two groups. The control group was given the conventional therapy, and the treatment group was added the Yubaisang-Zhikefang decoction based on the conventional therapy. Results The total effective rate of treatment group was significantly better than the control group (92.58% vs . 79.37%; χ 2 =4.434, P =0.035). The treatment group significantly improved the symptoms of time of cough disappearance(3.28 ± 1.21 d vs . 5.77 ± 1.45 d; t =10.562, P <0.05), time of asthma stop (8.02 ± 3.29 d vs . 10.83 ± 7.17 d; t =2.864, P <0.05), time of sputum disappearance (3.27 ± 1.18 d vs . 5.18 ± 1.16 d; t =9.232, P <0.05), time of moist sounds disappearance(4.53 ± 1.27 vs . 7.96 ± 1.45 d; t =14.249, P <0.05). And the treatment group significantly improved the results of blood tests and lung imaging, like the WBC (5.9×10 9 /L ± 2.7×10 9 /L vs . 8.1×10 9 /L ± 2.6×10 9 /L; t =4.693, P <0.05), N% (63.3% ± 6.1% vs . 69.2% ± 6.5%; t =-4.68, P <0.05), CRP (14.5 ± 5.9 mg/L vs . 18.4 ± 4.8 mg/L; t =5.297, P <0.05). Conclusion The integrated treatment of Yubaisang-Zhikefang decoction plus convertional the rapy showed good effects on the patients with chronic bronchitis.

Research on the clinical efficacy of Shexiang Baoxin Pill in the treatment of chronic heart failure in patients with maintenance hemodialysis

Objectives To analyze the clinical efficacy of Shexiangbaoxin pill in the treatment of chronic heart failure in patients with maintenance hemodialysis. Methods Totally 58 chronic heart failure in patients with manitenace hemodialysis from August 2013 to August 2014 in the hospital were selected as the study objects, who were randomly divided into a control group and an observation group eauqlly.The control group was treated with conventional treatment methods(calcium antagonists, angiotensin converting enzyme inhibitors, beta blockers, digoxin and weekly hemodialysis 3 times, each lasting for four hours), the observation group was treated with conventional therapy and Shexiang Baoxin Pill .The cardiac output (SV), left ventricular ejection fraction(LVEF), left ventricular end systolic volume index(LVESVI) and left ventricular end diastolic volume index (LVEDVI) were compared with two groups after 8 weeks. Results After treatment, All indexes of observation group were significantly improved the effective rate of treatment group was significantly much better than that of the control group(P<0.05). Conclusions Shexiang Baoxin Pills could reduce the myocardial oxygen consumption, enhance myocardial contractility, reduce inflammation, improve the symptoms of heart failure.Shexiangbaoxin pill is used in maintenance hemodialysis patients with heart failure, which cansignificantly reduce the clinical symptoms, improve the quality of life, and is worthy of promotion. Key words: Renal Dialysis; Heart Failure; SHEXIANG BAOXIN PILL

颞下颌关节弹响与咀嚼肌功能紊乱相关性研究

目的：比较咀嚼肌功能锻炼和超短波理疗治疗颞下颌关节弹响的效果。探讨颞下颌关节弹响发生的可能机制。方法：选择128例弹响患者，随机分为实验组和对照组，每组64例。实验组行咀嚼肌功能锻炼，对照组行超短波理疗，疗程两周，随访3个月。比较两种方法的治疗效果。结果：2周后，实验组的64例患者弹响全部消失，总有效率100%；对照组的64例患者33例弹响消失，20例弹响次数减少，11例弹响次数无改变，总有效率82.81%，两组结果有显著性差异(P < 0.05)，3个月后，治疗组随访率95.31%，对照组随访率93.75%，治疗组总有效率100%，对照组总有效率66.67%，两组结果有显著性差异(P < 0.05)，3月后对照组治疗总有效率下降(P < 0.05)。结论：咀嚼肌功能锻炼治疗颞下颌关节弹响的效果优于超短波理疗，咀嚼肌功能锻炼治疗颞下颌关节弹响的疗效显著。 Objective: To compare the clinical therapeutic efficacy of masticatory muscles functional exercise and ultra-short wave therapy, and investigate a possible pathological mechanism about articulation mandibularis clicking. Methods: 128 patients with articulation mandibularis clicking were selected and divided into two groups (experimental group and control group) of 64 patients each randomly. Patients in experimental group were taught to do masticatory muscles functional exercise for 2 weeks. Patients in control group were treated with ultra-short wave therapy for 2 weeks and 3-month follow-up. The therapeutic effects of the two methods were compared. Results: After 2 weeks, symptoms of articulation mandibularis clicking disappeared in 64 patients of experimental group and 33 patients of control group; the total effective rate was 100%; 20 patients in control group showed improvement of their symptoms and 11 patients in control showed no improvement. The total effective rate was 82.81%. There were significant differences between the two groups (P < 0.05). After 3 months, the follow-up rate of the treatment group and the control group was 95.31% and 93.75%, respectively; the total effective rate of treatment group and the control group was 100% and 66.67%, respectively. There were significant differences between the two groups (P < 0.05), and we could see lower therapeutic effect in control group after 3 months (P < 0.05). Conclusions: Masticatory muscles functional exercise could cure articulation mandibularis clicking effectively and it’s a more effective way when compared with ultra-short wave therapy.

Clinical effect of oxaliplatin, calcium tolinate and tegafur in the chemotherapy of rectal cancer patients

Objective To observe the effect and toxicity of oxaliplatin combined with calcium folinate and tegafur in the treatment of rectal cancer patients, in order to provide a safe and effective clinical program for rectal cancer treatment. Methods 117 rectal cancer patients conforming to the selection criteria were randomly divided into treatment group 59 cases and control group 58 cases by using random number method, treatment group were received chemotherapy of Oxaliplatin, calcium folinate and tegafur; control group were received FOLFOX4 program. After implementation of two treatment plans, solid tumor curative effect evaluation standard from WHO was referenced to evaluate the curative effect. And toxicity classification was reached according to the WHO cancer drug toxicity assessment standard. Results Total effective rate of treatment group was 27.1%, total effective rate of control group was 29.3%,the comparative difference of two rates was not statistically significant(χ2=0.069,P>0.05). The main symptoms of adverse reactions of two treatment plans were decreased of leukopenia, hemoglobin and thrombocytopenia of the blood system; nausea, vomiting, weak and abnormal liver function of the digestive system;,and limb numbness or pain of the nervous system.Adverse reactions difference in two groups was not significant(χ2=0.106,0.158, 0.000,0.563,0.001,0.284,0.068,0.000,all P>0.05).After treatment,the median surial time was 15.5 months in treatment group and 16.5 months in control group,the difference of the median surial time in two groups was not statistically significant(P=0.781,P>0.05). Conclusion Combination of Oxaliplatin, calcium fluoride and tegafur is another safe and effective plan after the FOLFOX4 program in the treatment of rectal cancer drug application. Key words: Rectal neoplamsms; Oxaliplatin; Tegafur; Calcium Fluoride; FOLFOX4 program