Clinical effect of oxaliplatin, calcium tolinate and tegafur in the chemotherapy of rectal cancer patients

Abstract

Objective To observe the effect and toxicity of oxaliplatin combined with calcium folinate and tegafur in the treatment of rectal cancer patients, in order to provide a safe and effective clinical program for rectal cancer treatment. Methods 117 rectal cancer patients conforming to the selection criteria were randomly divided into treatment group 59 cases and control group 58 cases by using random number method, treatment group were received chemotherapy of Oxaliplatin, calcium folinate and tegafur; control group were received FOLFOX4 program. After implementation of two treatment plans, solid tumor curative effect evaluation standard from WHO was referenced to evaluate the curative effect. And toxicity classification was reached according to the WHO cancer drug toxicity assessment standard. Results Total effective rate of treatment group was 27.1%, total effective rate of control group was 29.3%,the comparative difference of two rates was not statistically significant(χ2=0.069,P>0.05). The main symptoms of adverse reactions of two treatment plans were decreased of leukopenia, hemoglobin and thrombocytopenia of the blood system; nausea, vomiting, weak and abnormal liver function of the digestive system;,and limb numbness or pain of the nervous system.Adverse reactions difference in two groups was not significant(χ2=0.106,0.158, 0.000,0.563,0.001,0.284,0.068,0.000,all P>0.05).After treatment,the median surial time was 15.5 months in treatment group and 16.5 months in control group,the difference of the median surial time in two groups was not statistically significant(P=0.781,P>0.05). Conclusion Combination of Oxaliplatin, calcium fluoride and tegafur is another safe and effective plan after the FOLFOX4 program in the treatment of rectal cancer drug application. Key words: Rectal neoplamsms; Oxaliplatin; Tegafur; Calcium Fluoride; FOLFOX4 program