Clinical efficacy of Tongfei-Huatan-Huoxue decoction for the treatment of acute cerebral infarction

Abstract

Objective To investigate therapeutic effect of Tongfei-Huatan-Huoxue decoction for the treatment of acute cerebral infarction. Methods According to the random table method, 103 patients with acute cerebral infarction were divided into the control group (n=51) and the treatment group (n=52). The patients in the control group were treated with conventional medicine, while the patients in the treatment group were treated with Tongfei-huatan-huoxue decoction on the basis of control group. Two groups were treated for 30 consecutive days. The clinical total effective rate of two groups after treatment was counted. The NIHSS scores, Brrthal were determined respectively before and after treatment, at the same time, the levels of serum IL-6, TNF-α, hs-CRP and plasma TXB2, AT-Ⅲ, 6-keto-PGF1α were detected before and after treatment. Results The total effective rate of treatment group was 88.5%, while the total effective rate of control group was 70.6%. The difference between two groups was statistically significant (χ2=5.067, P=0.024). After treatment, the NIHSS (9.15 ± 1.25 vs. 12.21 ± 2.05, t=9.166), plasma TXB2 (140.12 ± 16.58 ng/L vs. 168.49 ± 22.18 ng/L, t=7.362), IL-6 (32.02 ± 2.54 ng/L vs. 44.15 ± 3.17 ng/L, t=21.452), TNF-α (8.05 ± 1.71 g/L vs. 11.14 ± 2.03 g/L, t=8.361), hs-CRP (12.16 ± 5.34 mg/L vs. 20.08 ± 6.06 mg/L, t=7.041) of treatment group were significantly lower than those of the control group (P<0.05), while the Brrthal (90.05 ± 16.37 vs. 79.36 ± 15.22, t=3.431), plasma AT-Ⅲ (82.57% ± 4.83% vs. 76.64% ± 4.29%, t=6.583), 6-keto-PGF1α (65.07 ± 9.26 ng/L vs. 39.91 ± 8.38 ng/L, t=14.450) of the treatment group were significantly higher than those of the control group (P<0.05). Conclusions The clinical curative effect of Tongfei-Huatan-Huoxue decoction for the treatment of acute cerebral infarction is significantly, which can significantly improve the patient's nerve function and daily life ability,speculated that the mechanism of action relevant to correct high blood coagulation state,inhibit thrombosis and reduce the serum levels of inflammatory cytokines. Key words: Brain infarction; Stroke; Tongfei-Huatan-Huoxue decoction; Neural function defect; Quality of life; Therapies, investigational