Abstract A theoretical model for segmental contractions of the small intestine is developed using lubrication method. Here, the nonlinear partial differential equations governing the fluid flow were normalized in viscous regime and solved semi-analytically for a power law fluid under long wavelength approximation on a MatlabTM platform. The segmental contraction was defined as a sinusoid with choice for variation in the wavelength, occlusion and frequency of luminal closure to study the effects of parametric variation (base values of the parameters were chosen as – n = 1.0, f*=6 wave•min-1, t*=T*3/4 sec, L*=20 cm, R*=1 cm, λ*=2 cm, and pocc, max*=0.5) on the flow for fluid of different viscosity, and flow behavior index of 0.5 (pseudo-plastic), 1.0 (Newtonian), 1.2 (dilatants) and 1.5 (dilatants). Pressure was specified as Dirichlet boundary conditions at the ends of the intestinal segment and velocity as no-slip boundary condition on the wall. Flow was characterized by determining the spatial distribution of the pressure, shear stress and flow rate along the length of the intestine during luminal closure at its maximal radial velocity. Study indicates that segmentation leads to the pressurization of the lumen (with a formation of a plateau at the middle) during closure and generation of vacuum during opening of the lumen. For four-wave segmentation, shearing is highest at the 1st and 4th mid-occlusion in comparison to 2nd and 3rd mid-occlusion. Parametric study indicates that the flow is sensitive to – the span of segmentation or wavelength of the wave, occlusion of the wave and frequency of the contraction; with shearing being highest for dilatants. Wavelength has an effect of altering the flow to within the span of the wavelength of the wave with no change in magnitude of shearing. However, contractions show preference for an optimal value of wavelength; above and below this values leads to inefficiency. Shearing is more prominent at higher occlusion (>50%) and frequency (>6Hz). Further, mixing is more prominent at the steep regions of the wave; having intensity of mixing highest for the outer waves in comparison to waves at mid-region of the segmentation. The degree of friction offered to the non-Newtonian fluids increases for increase in frequency, wavelength and occlusion; but less sensitive to flow behavior index. Simulation indicate that the power demand is more when peristalsis is driven at higher frequency (f = 12wpm) in comparison to lower frequency (f = 1wpm). The power demand is found to be greater in segmentation and has the following precedence - frequency, wavelength, flow behavior index, and occlusion (up to 80%). The spatial variation of the mixing parameter, Rm, indicates that the mixing is confined, majorly, at the steep edges of the wave. Further, multiplicity of the wave gives rise to multiple zones of mixing which increases the rate of mixing of the contents. Suggesting that, the segmentation primarily serves the purpose of mixing. In conclusion, we speculate that the segmentation facilitates digestion of the contents by enhancing the mixing, developing to-and-fro motion of the contents during events of periodic opening and closing of the lumen, increasing the enzymatic breakdown by increasing the surface area of solutes and delivering them within the proximity of the enzymes, and absorption.
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