Absorption-enhancing Effect Research Articles

Amphipathic KALA fusogenic peptide enhances absorption of insulin and calcitonin by pulmonary membranes of rats.

The aim was to investigate the absorption-enhancing effect (AEE) of lysine-alanine-leucine-alanine (KALA) repeating unit peptide upon pulmonary absorption of peptide and protein medicines among rats. Absorption of insulin and calcitonin in the lung was evaluated using varying concentrations of KALA peptide from 0.1% to 1.0% (w/v). The study also examined the lung damage caused by the KALA peptide. KALA peptide with various concentrations improved the absorption of insulin and calcitonin in the lungs. It also reduced glucose and calcium levels in the blood compared to the control, with the AEE increasing in a concentration-dependent manner due to the KALA peptide. In toxicity assays, test results for protein and lactate dehydrogenase (LDH) in bronchoalveolar lavage fluid (BALF) did not show a significant increase in the presence of KALA peptide at various concentrations. This implies that the KALA peptide did not cause any membrane damage to lung tissues. In transmembrane electrical resistance (TEER) and permeability detection, a decrease in TEER value and an increase in papp value by the addition of KALA peptide indicated that KALA peptide had the ability to aid the drug delivery through epithelial cells via both paracellular and transcellular pathways. KALA peptides are suitable as an absorption enhancer at lower concentrations (below 1.0%, w/v) for improving the absorption of insulin and calcitonin from the lung with no observed toxic impact.

Effect of Various Herbal and Chemical Enhancers on Skin Permeability to Cetirizine: A Study of Changes in Rat Skin Cells

Background: Cetirizine is a second-generation antihistamine with anti-allergy and anti-itching properties. The topical formulation of this medicine is used in androgenic alopecia treatment. Due to the hydrophilic nature of cetirizine, its skin absorption is negligible, so to increase its absorption, various enhancers were examined to see which can be used in the design of a topical formulation. Methods: First, the skin was exposed to enhancers, including eucalyptus, menthol, Tween 80, propylene glycol, and oleic acid, for 1 or 2 hours. Then, the permeability parameters of the cetirizine solution and the structural changes of the skin after exposure to enhancers were analyzed by differential scanning calorimetry (DSC) and Fourier-transform infrared spectroscopy (FTIR) techniques. Results: The obtained results show that all used enhancers increased the permeability of the drug cetirizine compared to water. Various mechanisms, such as liquefaction of lipids, destruction of lipid structure, and irreversible denaturation of intracellular keratin, are involved in the increase in drug penetration caused by eucalyptus, mint, Tween 80, propylene glycol, and oleic acid. Conclusions: The results showed that among the studied absorption enhancers, eucalyptus and Tween 80 had the strongest, and propylene glycol had the weakest absorption enhancement effect after 2- and 1-hour pre-contact, respectively.

Absorption enhancement of peach kernel oil on hydroxysafflor yellow A in safflower extracts and its mechanisms

Carthamus tinctorius L. (Safflower) is extensively used as a functional food and herbal medicine, with its application closely associated with hydroxysafflor yellow A (HSYA). However, the low oral bioavailability of HSYA in safflower extract (SFE) limits its health benefits and application. Our study found that co-administration of 250, 330, and 400 mg/kg peach kernel oil (PKO) increased the oral bioavailability of HSYA in SFE by 1.99-, 2.11-, and 2.49-fold, respectively. The enhanced bioavailability is attributed to improved lipid solubility and intestinal permeability of HSYA in SFE due to PKO. PKO is believed to modify membrane fluidity and tight junctions, increase paracellular penetration, and inhibit the expression and function of P-glycoprotein, enhancing the transcellular transport of substrates. These mechanisms suggest that PKO is an effective absorption enhancer. Our findings provide valuable insights for developing functional foods with improved bioavailability.

Synthesis of salcaprozate sodium and its significance in enhancing pancreatic kininogenase absorption performance.

We conducted pharmacokinetic research wherein salcaprozate sodium (SNAC) was utilized as a penetration enhancer by incorporating it into pancreatic kininogenase (PK) to improve the bioavailability of pancreatic kininogenase enteric-coated tablets. We conducted invitro studies on PK using the Caco-2 cell model and quantified PK levels using the enzyme-linked immunosorbent assay (ELISA) method. We conducted methodological verification by blending SNAC and PK powders into enteric-coated capsules, and studied the pharmacokinetic characteristics. Based on the PK transport assay, the cumulative permeation rates of the test group that employed a SNAC to PK ratio of 32:1, 16:1, 8:1, 4:1, and 2:1 were 13.574%, 7.597%, 10.653%, 3.755%, and 2.523%, respectively. We conducted a uniformity test on the powder that contained a blend of SNAC and PK. The relative standard deviations (RSDs) for both the power containing SNAC and the power not containing SNAC were less than 10%. Based on the methodological verification, invivo pharmacokinetic study of PK met the experimental requirements. As indicated by the results of invivo pharmacokinetic research on rats, the test group (This group used SNAC) had a PK AUC0-12 h of 5679.747 ng/L*h and t1/2 of 4.569 h, while the control group (This group did not use SNAC) had a PK AUC0-12 h of 4639.665 ng/L*h and t1/2 of 3.13 h. This study has established a low-cost, environmentally friendly, and safe SNAC synthesis route with high process yield suitable for industrial production. SNAC demonstrates an absorption-enhancing effect on PK, and the optimal ratio of SNAC to PK is determined to be 32:1.

High-sensitivity detection of low-concentration heavy metal ions in solution by multiple reflection enhanced absorption (MREA) spectroscopy.

Heavy metal ions (Cr6+, Co2+, Ni2+, and Cu2+) in the electroplating and electrolysis industries are significantly related to process parameters and product quality, even at lower concentrations. Absorption spectroscopy is widely used for substance qualitative and quantitative analysis, which is an analytical method with the potential for real-time monitoring of heavy metal ions concentration in industrial processes. In this paper, a low-concentration heavy metal ion analysis method based on multiple reflection enhanced absorption (MREA) is proposed. Compared with traditional absorption, MREA has the advantages of low concentration detection limit and high-sensitivity. First, a reflective film (Al-SiO2) was prepared and a multiple reflection optical structure was designed to realize multiple parallel reflections of light in the solution medium. Then absorption spectra of low-concentration Cr6+, Co2+, Ni2+ and Cu2+ solutions were measured by MREA and traditional absorption methods. Finally, spectral bandwidth and incident light spots were optimized to obtain a superior absorption enhancement effect. The results showed that MREA could effectively increase the substance absorbance compared with traditional absorption. At the same time, with the optimal spectral bandwidth (0.4 nm) and incident light spot (1 mm), the detection limit of Cr6+, Co2+, Ni2+ and Cu2+ was reduced by 81.48%, 82.52%, 80.92% and 82.93%, respectively. The sensitivity was improved by 5-6 times, which was more obvious for low-concentration detection. In addition, the MREA method can achieve ion concentration analysis when Cr6+, Co2+, Ni2+, and Cu2+ coexist, and the linear correlative coefficients of the C-A curves were all greater than 0.999. Moreover, by adjusting reflectivity of the reflective film and the number of reflections in the optical structure, the results of the MREA method can be further optimized for the low-concentration heavy metal ion analysis. The MREA method has the advantages of simplicity, rapidity and versatility, which can provide the technical foundation for real-time monitoring method development of low-concentration heavy metal ions in industrial processes.

Assessment of in Vivo Performance of Lipid-Based Formulations: Correlation between in Vitro Drug Release Profiles and in Vivo Absorption Rate Profiles.

The purpose of this study was to assess the in vivo absorption enhancement effects of lipid-based formulations (LBFs) through in vitro release studies. The type IIIA-MC (medium-chain) and type IIIA-LC (long-chain) formulations containing a Biopharmaceutics Classification System (BCS) Class II drug (dipyridamole or ketoconazole) were used as model LBFs. The type IIIA-MC formulation, but not the type IIIA-LC formulation, showed a higher initial absorption rate than the control suspension for both model drugs in rats. An in vitro side-by-side chamber system coupled with a lipid digestion model was used to measure free drugs, available for intestinal absorption, that are released from a model LBF. The profiles of free drug concentration on the donor side were determined by calculating the ratio of permeation rate (LBF/suspension) at every sampling interval. The in vitro free drug concentration was immediately supersaturated when the digestion of type IIIA-MC formulation was initiated for both drugs, which would cause the initially high absorption rate in rats. In contrast, the free concentration of the type IIIA-LC formulation became lower than the equilibrium solubility over time for both drugs. Overall, the profiles of in vitro free concentrations were consistent with those of in vivo absorption rates for both drugs and all LBFs. These findings would help predict the in vivo performance and establish an in vitro-in vivo correlation (IVIVC) of LBFs.

Anomalous absorption in TM polarization light by echelle gratings.

Echelle grating plays an essential role in spectral analysis due to its broadband blaze, high dispersion, and high resolution; however, its absorption properties have received no attention. In this paper, we investigate the effect of parameters including incident wavelength, incident angle, and blaze angle on the absorption properties of the Al echelle grating. Based on calculations by the boundary integral equation method, we observe that the Al grating with a large blaze angle has an absorption enhancement effect on TM-polarized waves, and its intensity increases as the incident angle approaches the pseudo-Brewster angle (maximum absorption over 87%). In particular, this absorption enhancement effect is present in the wideband and somewhat generalizable to other metallic materials. In addition, the potential physical mechanisms underlying the absorption enhancement of the echelle grating are analyzed in detail through the electric field distribution. The resonance between the grating anomaly and the pseudo-Brewster effect results in the appearance of surface plasmon polariton and strong absorption. These findings will bring new understanding to the study of echelle gratings in case of high energy loss when the light incidents with a high angle for high resolution and will also show potential applications in electromagnetic stealth, photothermal conversion, and photodetection.

Nanocarriers significantly augment the absorption of ocular-delivered drugs: A comparative meta-analysis study

This study presents a meta-analysis that compiles information collected from several studies aiming to prove, by evidence, that nanocarriers out-perform conventional formulations in augmenting the bioavailability of ocular topically administered drugs. Data was further categorized into two subgroups; polymeric-based nanocarriers versus their lipid-based counterparts, as well as, naturally-driven carriers versus synthetically-fabricated ones. After normalization, the pharmacokinetic factor, area under the curve (AUC), was denoted as the “effect” in the conducted study, and the corresponding Forest plots were obtained. Our meta-analysis study confirmed the absorption enhancement effect of loading drugs into nanocarriers as compared to conventional topical ocular dosage forms. Interestingly, no significant differences were recorded between the polymeric and lipidic nanocarriers included in the study, while naturally-driven nanoplatforms were proven superior to the synthetic alternatives.

PS-b-PMMA templated ITO electrodes for improving the performance of non-fullerene organic photovoltaics

We have developed a block copolymer (BCP)-based patterned electrode with a periodic structure of 80 nm and investigated their application in organic photovoltaics. The indium tin oxide (ITO) electrodes with the thicknesses of 30, 50, 70, 90, and 120 nm were sputtered onto BCP-patterned templates and the morphology and optoelectronic properties were investigated. Using the finite difference in time domain method, the effect of different thickness electrodes on the light absorption of the active layer was studied. We found that the ITO thickness of 70 nm has an absorption enhancement effect in the visible wavelength band. Finally, we prepared organic photovoltaic devices based on the non-fullerene PBDB-T:ITIC system, the BCP-patterned templates enhance greatly the light absorption of the active layer through both light diffraction and coupling to surface plasmon polariton modes achieving a 12.9% increase in power conversion efficiency. • ITO electrodes with 80 nm periodic structure were developed by BCP self-assembly. • Patterned ITO greatly enhance the light absorption of the PBDB-T:ITIC active layer. • OPVs with patterned ITO achieve a 12.9% increase in power conversion efficiency.

Liquid-liquid phase separation reduces radiative absorption by aged black carbon aerosols

Black carbon aerosols absorb radiation and their absorptive strength is influenced by particle mixing structures and coating compositions. Liquid-liquid phase separation can move black carbon to organic particle coatings which affects absorptive capacity, but it is unclear which conditions favour this redistribution. Here we combine field observations, laboratory experiments, and transmission electron microscopy to demonstrate that liquid-liquid phase separation redistributes black carbon from inorganic particle cores to organic coatings under a wide range of relative humidity. We find that the ratio of organic coating thickness to black carbon size influences the redistribution. When the ratio is lower than 0.12, over 90% of black carbon is inside inorganic salt cores. However, when the ratio exceeds 0.24, most black carbon is redistributed to organic coatings, due to a change in its affinity for inorganic and organic phases. Using an optical calculation model, we estimate that black carbon redistribution reduces the absorption enhancement effect by 28–34%. We suggest that climate models assuming a core-shell particle structure probably overestimate radiative absorption of black carbon aerosols by approximately 18%.

A fiber optic communication shield based on a two-dimensional molybdenum disulfide broadband absorber

We propose a broadband absorber in the infrared band using a two-dimensional molybdenum disulfide with a patterned gold array. The light absorption enhancement effect of the local surface plasmon resonance (LSPR) is utilized to greatly enhance the light absorption of the monolayer MoS2. Our absorber has 99.62% absorption in the most important band for fiber optic communication (i.e. 1550 nm), a result calculated by the finite-difference time-domain method. Our absorber can serve as an excellent shield for fiber optic communication. At the same time, our absorber is also polarization and light incidence angle insensitive, which greatly expands the application location of our absorber. In addition, we demonstrate that our absorber structure can be widely used in absorbers based on transition-metal dichalcogenides (TMDCs), which is a guideline for the design of such absorbers. In order to solve the tuning difficulties of MoS2-based absorbers, we also propose an effective method for tuning the absorber, which is able to tune the absorber over a large wavelength range without a significant decrease in the absorber's optical absorption. We believe that our absorber can play an important role in fiber optic communication shielding systems, detection systems in the infrared band.

Effect of Different Absorption Enhancers on the Nasal Absorption of Nalmefene Hydrochloride.

The purpose of this work is to explore the effects of novel absorption enhancers on the nasal absorption of nalmefene hydrochloride (NMF). First, the influence of absorption enhancers with different concentrations and types and drug concentrations on the nasal absorption of NMF was investigated in vivo in rats. The absorption enhancers studied include n-dodecyl-β-D-maltoside (DDM), hydroxypropyl-β-cyclodextrin (HP-β-CD), and polyethylene glycol (15)-hydroxy Stearate (Solutol®HS15). At the same time, the in situ toad palate model and rat nasal mucosa model were used to assess the cilia toxicity. The results showed that all the absorption enhancers investigated significantly promote the nasal absorption of NMF, but with different degrees and trends. Among them, the 0.5% (w/v) DDM had the strongest enhancement effect, followed by 0.5% (w/v) Solutol®HS15, 0.25% (w/v) DDM, 0.25% (w/v) Solutol®HS15, 0.1% (w/v) Solutol®HS15, 0.1% (w/v) DDM, and 0.25% (w/v) HP-β-CD, with absolute bioavailability of 76.49%, 72.14%, 71.00%, 69.46%, 60.41%, 59.42%, and 55.18%, respectively. All absorption enhancers exhibited good safety profiles in nasal ciliary toxicity tests. From the perspective of enhancing effect and safety, we considered DDM to be a promising nasal absorption enhancer. And in addition to DDM, Solutol®HS15 can also promote intranasal absorption of NMF, which will provide another option for the development of nalmefene hydrochloride nasal spray.

Accelerate the Electrolyte Perturbed-Chain Statistical Associating Fluid Theory-Density Functional Theory Calculation With the Chebyshev Pseudo-Spectral Collocation Method. Part II. Spherical Geometry and Anderson Mixing.

To improve the efficiency of electrolyte perturbed-chain statistical associating fluid theory–density functional theory (ePC-SAFT-DFT) calculation of the confined system, in this work, first, the Chebyshev pseudo-spectral collocation method was extended to the spherical pores. Second, it was combined with the Anderson mixing algorithm to accelerate the iterative process. The results show that the Anderson mixing algorithm can reduce the computation time significantly. Finally, based on the accelerated ePC-SAFT-DFT program, a systematic study of the effects of the temperature, pressure, pore size, and pore shape on the CO2 solubilities in the ionic liquids (ILs) confined inside the silica nanopores was conducted. Based on the simulation results, to obtain high CO2 solubilities in the ILs confined in silica, a better option is to use the silica material with a narrow spherical pore, and the IL-anion should be selected specifically considering that it has a more significant impact on the absorption enhancement effect.

AUTOMATIC SELECTION OF XRF SPECTRAL FEATURE VARIABLES FOR SOIL HEAVY METAL BASED ON FiPLS AND BiPLS, 52-59.

When using X-ray fluorescence (XRF) spectrometry to detect heavymetal content in soil, there are several factors that affect the range ofspectral variable resolutions such as characteristic peak broadeningof heavy metal, characteristic peak overlapping of heavy metal,instrumental noise, and potential absorption enhancement effect ofelements.

Light absorption enhancement due to mixing in black carbon and organic carbon generated during biomass burning

We report the direct observation of the light absorption enhancement effect due to the mixing of black carbon (BC) and organic carbon (OC) aerosols generated during biomass combustion. The biomass fuels viz. mango tree wood (Mangifera indica) and dung cake were burned and the dry absorption of the aerosol stream was measured using the 7-wavelength aethalometer. The absorption coefficients were measured for thermally denuded and undenuded aerosols. The measurements provided an enhancement ratio for black carbon in presence of organic carbon at seven different wavelengths. The near-source enhancement ratio for wood and dung cake at 880 nm was found to be 1.35 ± 0.06 and 1.59 ± 0.08, respectively. The enhancement effect was found to increase with the decrease in wavelength for both the fuels, indicating absorption by the brown carbon. The organic coating on the black carbon was estimated using the mie theory modelling. The organic coating factor on the black carbon was found to be 1.37 and 1.69 for wood and dung cake, respectively. The enhancement ratio at 370 nm increased with the increase in the absorption angstrom exponent (AAE). The enhancement ratio depicted negative linear dependence (r = −0.91) on the logarithmic ratio of black carbon and absorption coefficients of brown carbon at 370 nm across both fuels and burn conditions.

Determination of effective concentrations of drug absorption enhancers using in vitro and ex vivo models

BackgroundAchievement of an effective concentration of the pharmaceutically active ingredient in the blood and/or at the target site is an important aspect in the formulation of drugs and therefore needs to be quantified. Any concentration above therapeutic levels can cause toxic effects whereas low concentrations can be sub-therapeutic. This paper investigated different concentrations of selected commercially sourced analytical-grade pure chemicals as potential drug absorption enhancers in vitro and ex vivo to determine the lowest effective concentrations for optimizing drug absorption in oral dosage forms. MethodsRecombinant cytochrome (CYP) 3A4 enzyme and recombinant p-glycoprotein membrane models were utilized for the investigation of in vitro inhibitory effects of drug absorption enhancers. Promega (2015) protocols were adopted for both assays. The everted porcine intestinal ex vivo model was employed for assessing effects of the drug absorption enhancers on the absorption of propranolol. ResultsThe lowest effective CYP3A4 inhibitory concentrations were observed for curcumin (75µM and 100 µM), quercetin (75 and 100 µM) and glycyrrhizic acid (50 µM) while the most effective p-glycoprotein (P-gp) inhibition concentrations were curcumin (10, 15, 25, 50, 75 and 100 µM), sinomenine (50, 75, and 100 µM), quercetin (75 and 100 µM) and naringin (50 µM). Additive effects were observed between combinations of quercetin (75 µM) and curcumin (100 µM); quercetin (75 µM) and curcumin (75 µM); quercetin (75 µM) and curcumin (50 µM), and quercetin (75 µM) with curcumin (10 µM), which increased the basal ex vivo absorption of propranolol from 1.24 ± 0.03 µg/mL to 5.19 ± 0.12 µg/mL, 4.17 ± 0.05 µg/mL, 3.86 ± 0.10 µg/mL, and 4.07± 0.05 µg/mL respectively, after 2 hours. ConclusionIncorporation of the drug absorption enhancers (e.g., curcumin and quercetin), at specific concentrations, in dosage forms could improve the bioavailability of the BCS Class III and IV drugs that are substrates of CYP3A4 and p-glycoprotein.

Toxic and carcinogenic constituents of jewelry in the Indian retail market determined using x‐ray fluorescence

The elemental composition of about 60 items of precious and non‐precious jewelry in the Indian retail market has been explored through x‐ray fluorescence (XRF) measurements using silicon drift and high‐purity germanium detectors. The proportions of various elements have been established through the use of Gaussian fitting and background subtraction routines, along with corrections for photopeak detection efficiencies at different energies. Tabulated XRF yields were accounted for in the determination of proportions however matrix correction and absorption enhancement effects, if present, could not be included. The non‐destructive characterization and quantification allowed by x‐ray spectrometric methods indicate the presence of significant amounts of toxic bromine and antimony in fashion jewelry. A disturbing trend observed in many items of non‐precious, metal imitation jewelry is that carcinogenic cadmium is the predominant constituent (around 80% w/w) which poses a significant health hazard for a large section of the population. The proportion of cadmium is found to be far greater than the minor fractions reported earlier. It has been determined that cadmium continues to be added to precious jewelry, albeit in smaller amounts, though its use is restricted by existing regulations. This pan‐Indian study underscores the urgent necessity to inspect and regulate, particularly the metal imitation and fashion jewelry business, in order to mitigate the harmful effects of some of the constituent elements on human health and the environment.

Preparation and properties of styrene ethylene butylene styrene / polypropylene thermoplastic elastomer powder for selective laser sintering 3D printing

AbstractAs one of the most important thermoplastic elastomer materials, the application of styrene ethylene butylene styrene (SEBS) in selective laser sintering (SLS) has not been reported. In this study, SEBS and polypropylene (PP) are blended and then pulverized at low temperatures. We find that SEBS with high molecular weight and styrene segment content is difficult to melt and flow under laser irradiation, which is not suitable for SLS 3D printing. SEBS with low molecular weight can be printed, and its tensile properties can reach 2.1Mpa and 134% elongation at break. We test the enhanced absorption effect of two different infrared absorbers and find that graphene (GE) can enhance absorption mainly rely on its special structure to increase the optical path of the laser. The absorption enhancement effect of each enhancer rises first and then decreases. 0.4‰ addition of GE can bring 22.5% enhancement. With the enhancement of GE, we get a product of 2.8 MPa tensile strength and 176% elongation at break.

Enhanced optical absorption of AlxGa1-xAs nanoarrays with variable Al composition structure for solar cell applications

In this study, various variable Al composition nanoarray structures are proposed and designed to achieve high-efficient light capture. The COMSOL Multiphysics package based on finite element method is utilized to investigate the optical absorption performance of cylinder, circular frustum and inverted circular frustum nanoarray structures. The effects of different geometric diameters, sub-layer thickness distribution and Al composition range on the optical properties of various nanostructures are also analyzed in detail. The results show that the designed cylinder structure can obtain optical absorption enhancement of more than 5 % and 3 % compared with the circular frustum and inverted circular frustum structure. Besides, the reasonable design of sub-layer thickness distribution can be selected to allow different nanostructures to obtain effective optical absorption enhancement performance. In addition, the larger Al composition range distribution design can effectively improve the absorption for short-wavelength photons. The design principles proposed in this work will provide a reference for selecting appropriate parameters for solar cell applications.

The efficiency and mechanism of a new absorption enhancer, malic acid, for enhancing the oral bioavailability of docetaxel

This study investigated the efficiency and the related mechanisms of a new absorption enhancer, DL-malic acid (MA), on the oral bioavailability of docetaxel (DTX). Polyethylene glycol polycarbonate (PEG-PCL) modified liposomes (PLip) were prepared for DTX, and incorporated into the pH-sensitive microspheres (MS) with sustained release. MA decreased the transepithelial electrical resistance (TEER) across a Caco-2 cell monolayer by 20% and 57% after 2 and 3 h of co-incubation with DTX-PLip and the cells, respectively, indicating that MA could open tight junctions but not instantaneously. After long enough exposure (4 h) of MA to the small intestine of rats, only the absorption rate constant (ka ) of DTX-PLip, but not Duopafei®, was increased, which could be related to the intestinal mucosal permeability of DTX. After co-administration in rats, MA significantly enhanced the oral bioavailability of DTX in DTX-PLip-MS from 44.67% to 81.27%, rather than DTX-PLip and Duopafei®, which could be related to the prolonged intestinal retention time of DTX-PLip via the MS and the promoted drug intercellular transport by MA. The absorption-enhancing effects of MA on DTX-PLip-MS were further confirmed by in vivo imaging. The above findings suggest that MA served as a new and efficient absorption enhancer for DTX-PLip-MS. HIGHlIGHTS In this study, malic acid as a new absorption enhancer for DTX in polymer-liposome (PLip) embedded in pH-sensitive microspheres (MS) was found for the first time. The malic acid could significantly enhance oral bioavailability of DTX in DTX-PLip-MS (from 44.67 % to 81.27%) rather than Duopafei® and DTX-PLip after co-administration. The absorption enhancement may be closely related to the intestinal retention time and mucosal permeability. These findings will provide an important reference for the study of absorption enhancers for promoting intercellular insoluble drug transport.