Agricultural heritage systems are receiving increasing attention due to their multifunctional role, their capability to provide ecosystem services, and for representing sustainable development models for rural areas. At the international level, the Food and Agriculture Organization (FAO) of the United Nations launched in 2002 the Globally Important Agricultural Heritage Systems (GIAHS) Program to identify and safeguard traditional agro-silvo-pastoral systems that are the result of the adaptation of rural communities to the surrounding environments. Following this approach, similar national programs have been developed, among which the Italian National Register of Historical Rural Landscapes and the China Nationally Important Agricultural Heritage Systems (China-NIAHS) initiative stand out. This research compares the China-NIAHS initiative and the Italian Register of Historical Rural Landscapes, highlighting similarities and differences and identifying strengths and weaknesses, to contribute to the development of proper tools for the conservation and valorization of agricultural heritage systems. Both initiatives were established in 2012 and share similar aims and inscription criteria, including historical and current significance, knowledge system and social structure, economic and productive framework, and causes of vulnerability. The main differences are related to the delimitation of the boundaries of the proposed sites and to the inscription process; in addition, while for the Italian National Register spatial analyses of land-use changes and landscape structure are mandatory according to a precise methodology, for the China-NIAHS no specific landscape analyses are required. The main critical issues are the lack of public participation and the lack of a monitoring plan after the inscription. The absence of monitoring is also the main vulnerability of the FAO GIAHS Programme. This research can offer important information for different stakeholders at the international, national, and local levels dealing with agricultural heritage conservation and valorization. In particular, it highlights the need of developing a multidisciplinary monitoring system with a standard methodology based on different indicators that can contribute to maximizing the impact of these initiatives. This research also provides useful information for the countries that are interested in developing a national initiative for agricultural heritage systems’ identification and valorization/conservation or for countries that intend to improve their national programs.