Dynamics Of Clinical Parameters Research Articles

EFFECTIVENESS OF DIFFERENTIAL DRUG CORRECTION IN GENERALIZED PERIODONTITIS AGAINST THE BACKGROUND OF VARIOUS BODY REACTIVITY IN THE SHORT TERM

The aim of this study was to evaluate the effectiveness of the proposed differential drug correction in generalized periodontitis of the II and III severity degrees depending on the initial state of the body's response in the short term.
 Material and methods. We examined 216 people aged 45 to 55 years with a diagnosis of generalized periodontitis. Depending on the state of the body's reactivity, patients were divided into three groups with normal, hyperand hyporeactivity. All patients received comprehensive conventional treatment. After surgery, the proposed differential drug correction was additionally performed. The effectiveness of the treatment was monitored by cytological and clinical examination on days 2, 4 and 6.
 Research results and their discussion. The results of the evaluation of the effectiveness of the complex treatment of generalized periodontitis of II and III severity in the short term showed that the proposed differential drug correction in the postoperative period optimizes the wound healing process by bringing the phases of the cellular reaction periods closer to those of normal body reactivity in terms of duration and intensity. Namely: the period of initial degenerative changes (1st day), the period of intense inflammation with active granulocyte and macrophage reactions (4th day) and the period of increasing reparative processes (6th day). The results of the cytological study are complemented and confirmed by the corresponding dynamics of clinical parameters, characterized by their normalization during differential drug correction.
 Conclusion. In patients with generalized periodontitis with hyperand hyporeactivity of the body, the proposed differential drug correction leads to normalization of the periods of cellular reaction during postoperative wound healing and clinical parameters in the short term.

Bioregulatory therapy for chronic abacterial prostatitis

BACKGROUND: Chronic abacterial prostatitis/chronic pelvic pain syndrome (CAP/CPPS) is the most common form of chronic prostatitis.
 AIM: The aim of the study was to evaluate the effectiveness and tolerability of complex therapy in patients with CAP/CPPS using the bioregulatory peptide drug Uroprost-D.
 MATERIALS AND METHODS: The study included 47 men aged 23 to 54 years (mean 38.1 7.2 years) with CAP/CPPS (category III according to the NYHA classification, 1995). Patients of the 1st group (n = 24) were prescribed alpha-blocker tamsulosin 0.4 mg for 30 days and rectal suppositories Uroprost-D one per day for 15 days. Patients of the 2nd group (n = 23) were also prescribed tamsulosin 0.4 mg per day for 30 days and rectal suppositories indomethacin 100 mg, one per day for 15 days. The dynamics of clinical parameters was assessed on the 15, 30 and 60th day from the start of the study.
 RESULTS: By the 15th day of the study, there was a significant positive dynamics of symptoms in patients of both groups. By the 30th day of the study in patients of the 1st group the treatment effect persisted, while in patients of the 2nd group pain increased, which was expressed in an increase in the scores for the Pain domains and the total score of the NIH-CPSI questionnaire. This trend is even more pronounced by the 60th day of observation, when a significant difference was found both in the total score of the NIH-CPSI questionnaire and separately in the domains Pain, Dysuria and Quality of life. During the study, there were no statistically significant changes in the maximum urine flow rate, prostate volume and residual urine volume. Tolerability of treatment was satisfactory, the frequency of negative manifestations was slightly higher in patients of the 2nd group.
 CONCLUSIONS: The use of the bioregulatory peptide drug Uroprost-D in the complex therapy of patients with CAP was accompanied by a decrease in the severity of pain syndrome and dysuria. The appointment of Uroprost-D seems to be a pathogenetically justified alternative to the use of NSAIDs in this category of patients.

Застосування лікувально-профілактичного комплексу при карієсі та гінгівіті у дітей шкільного віку

Актуальність. Єдність найбільш значущих патогенетичних механізмів розвитку карієсу та захворювань тканин пародонту обґрунтовує сучасну концепцію профілактики цих захворювань, що включає розробку лікувально-профілактичних програм з урахуванням клінічних особливостей поєднаного перебігу карієсу та захворювань пародонту в дітей та основних патогенетичних механізмів розвитку цих захворювань. Мета дослідження: оцінити вплив розробленого лікувально-профілактичного комплексу в дітей шкільного віку при поєднаному перебігу карієсу та хронічного катарального гінгівіту з урахуванням основних патогенетичних механізмів розвитку цих захворювань. Матеріали та методи. Клінічні дослідження проводили за участю 138 дітей віком від 7 до 10 років, у яких визначали індекс кп + КПУ, приріст інтенсивності карієсу зубів, редукцію та карієспрофілактичний ефект, ТЕР-тест, індекс Greenn — Wermillion, спрощений індекс зубного нальоту О’Leary, індекс ефективності гігієни порожнини рота (РНР), індекс РМА, Basic Periodontal Examination-Simplified (BPES) перед проведенням лікувально-профілактичного комплексу (ЛПК) та через 18 місяців після його триразового застосування. Результати. Результати клінічного дослідження показали, що при позитивній динаміці клінічних показників у дітей всіх досліджуваних груп, у підгрупах, де ми застосовували розроблений і запропонований ЛПК, ми визначили добрий стан гігієни порожнини рота (0,37 ± 0,03; 0,46 ± 0,04) та добру ефективність проведення гігієнічних заходів (0,58 ± 0,05; 0,60 ± 0,03); низький рівень приросту інтенсивності карієсу (0,11–0,18) із редукцією 67,27–80,70 % при карієспрофілактичній ефективності 66,53–76,79 % на відміну від контрольних груп дітей, в яких рівень приросту інтенсивності карієсу становив 0,35–0,57, гігієнічний стан порожнини рота залишився на задовільному рівні. Серед дітей із хронічним катаральним гінгівітом повне усунення основних клінічних ознак запалення з подальшою довготривалою ремісією при застосуванні ЛПК ми спостерігали в більшому відсотку випадків на відміну від дітей, при лікуванні яких використовували стандартні підходи. Висновки. Отримані результати клінічних досліджень, а саме запобігання подальшому розвитку карієсу та усунення основних клінічних проявів запалення ясен із тривалою ремісією, свідчать про позитивний вплив та ефективність розробленого ЛПК.

Observações clínicas, hematologia e características do fluido ruminal de bovinos de corte recebendo dieta "Max Beef" grão inteiro

Este estudo propôs caracterizar os efeitos da alimentação baseada na dieta do grão de milho inteiro na dinâmica de parâmetros clínicos e metabólitos bioquímicos de bovinos confinados. Foram utilizados 20 bovinos, sem raça definida, adultos, com peso médio de 300 kg, divididos em dois grupos experimentais. O grupo experimental (G1; n=15), composto por animais alimentado somente dieta “Max Beef” Grão Inteiro e o grupo controle (G2; n=5), composto por animais, alimentado com bagaço de cana e a dieta “Max Beef” Grão Inteiro, na proporção 30:70. Todos os animais foram submetidos às observações clínicas, colheita de sangue por venopunção jugular e fluido ruminal. Os animais do grupo G1 (Dieta “Max Beef” Grão Inteiro) apresentaram movimentos ruminais incompletos, timpania ruminal branda e diarreia com grãos de milho inteiro. Não foram registradas alterações hematológicas nem na concentração de fibrinogênio. Apresentaram menor valor de pH ruminal durante todo o período experimental, com comprometimento da população de infusórios, diminuição da prova de redução do azul de metileno e tempo de sedimentação e flotação ausente. Conclui-se que dietas para bovinos de corte contendo “Max Beef” Grão Inteiro provoca acidose crônica ruminal e compromete as características físico-químicas e microbiológicas do fluido ruminal.

Impact of different methods of treatment of hip osteoarthritis on the clinical manifestations during short- and long-term observation

The course of coxarthrosis, its short-term and long-term prognosis remains sufficiently unknown, and the influence of one or another method of treatment on the course of the disease and the time of onset of irreversible changes is still the subject of scientific research. The aim of the study is to evaluate the dynamics of clinical data in patients with the initial stages of coxarthrosis in the observation interval of 1–5 years with various treatment regimens that include both medical therapy and arthroscopic intervention. The analysis of the dynamics of clinical parameters (using the modified Harris scale) in the course of various treatment methods (non-steroidal anti-inflammatory drugs with / without chondroprotector or hyaluronic acid) with a group of arthroscopically operated patients was carried out after 1, 3 and 5 years from the diagnosis of 225 patients with initial stages coxarthrosis. All quantitative data obtained are processed by variational statistics methods (Wilkoxon test for 2 groups of dependent populations and Mann-Whitney U-test for 2 groups of independent populations). It has been established that the combination of NSAID therapy with symptom-modifying delayed-action drugs contributes to the solution of individual therapeutic problems in patients with coxarthrosis during the short and medium term observation period. Reception of chondroprotectors improves the effectiveness of pain control, intra-articular administration of hyaluronic acid contributes to a longer preservation of the motor function of the affected joint. The most effective method in overcoming the progression of loss of motor function of the hip joint and increasing the intensity of the pain syndrome is arthroscopic treatment. The obtained data allow us to state that arthroscopy has a pathogenetic and preventive orientation, slows the progression of the disease and, as a consequence, improves the patient's quality of life.

Minimally invasive dorsal decompression-stabilization surgery in patients with overweight and obesity

The study aim was to assess the efficacy of a new low-invasive rigid fixation technique and traditional open spinal fusion in surgical treatment of degenerative lumbar spine diseases in patients with overweight and obesity. The study included 73 patients (49 males and 24 females, aged 53 (42; 65) years) with a BMI of more than 25 kg/m2. Two study groups were allocated: group I (MIS-TLIF, n=32) included patients operated on using an original technique of spinal canal reconstruction, interbody spinal fusion, and combined transpedicular stabilization; group II (O-TLIF, n=41) included patients who underwent single-level rigid stabilization through the median approach. The mean follow-up period was 34 months in group I and 40 months in group II. Comparative analysis assessed clinical parameters, intraoperative indicators, postoperative period specificity, instrumental data, and complications. Compared to the O-TLIF group, the MIS-TLIF group was characterized by a shorter time of surgery, X-ray exposure, activation, and hospital stay as well as by a smaller amount of blood loss. A comparative analysis of the pain severity (visual analogue scale) and performance status (ODI) in the follow-up period revealed significantly better results in group I, which was associated with smaller intraoperative injury to soft tissues. The total rate of postoperative complications was 9% in group I and 17% in group II (p=0.01). In this case, the interbody bone block formed in the long-term postoperative period in 88% of group I patients and in 83% of group II patients (p=0.15). According to the instrumental data, there was statistically significant greater muscular atrophy in the group after O-TLIF (p<0.001). The original technique of minimally invasive rigid stabilization is safe and highly effective in surgical treatment of degenerative lumbar spine diseases in patients with overweight and obesity. MIS-TLIF has a number of significant advantages over O-TLIF in the dynamics of clinical parameters and a low number of perioperative complications, which is confirmed by smaller injury to paravertebral tissues and a better performance status in the long-term postoperative period.

ИЗУЧЕНИЕ КАЧЕСТВА ЖИЗНИ У ПАЦИЕНТОВ С ГАЛЬВАНОЗОМ ДО И ПОСЛЕ ПОВТОРНОГО ПРОТЕЗИРОВАНИЯ СПЛАВОМ КХС С ЗАГОТОВКАМИ В ВИДЕ ГРАНУЛ И ПРУТКОВ

Currently, the fairly widespread use in prosthetic dentistry KHS alloy. Its main application – frames arc prosthesis and metal constructions. Recently a number of manufacturers to reduce the adverse effects on the patients components of dental alloys began to produce billet in the form of pellets. This type of blanks has a homogeneous structure and higher physical- mechanical and anti-corrosion properties that had previously been shown in studies the authors of this article. 70 patients aged from 26 to 62 years old with a history of oral or galvanosis toxic stomatitis, due to exposure to the components of metal alloys, metal vkolyucheny after removal and rehabilitation of the oral cavity have been re prosthetic alloy KHS. Patients were divided into two groups. The main group (30 people), metal-ceramic prosthetic designs from KHS, having a workpiece in the form of pellets. The control group (40 people) of the prosthetic KHS having traditional harvesting in the form of rods or bars. To evaluate the efficacy of a new kind of KHS alloy billets both groups of patients using a questionnaire «Profile influence dental health» OHIP-49 RU. The results of the clinical and social research, in general, allowed the complex to prove the effectivenessand benefits of prosthetic treatment with KHS alloy billets casting into pellets before conventional prosthetics like the dynamics of clinical parameters, and from the standpoint of quality of life.

SAT0308 Efficacy and toxicity of leflunomide monotherapy versus leflunomide combination therapy with non-biological disease-modifying antirheumatic drugs in psoriatic arthritis

BackgroundAbout 7% of patients (pts) with arthritis are patients with psoriatic arthritis (PsA). After 10 years of PsA 55% of pts have deformity more than 5 joints. Only one trial...