Introduction: Enhanced Recovery After Surgery (ERAS) care protocol is better in improving the quality of postoperative care which can mitigate surgical stress and accelerate postoperative recovery. Aim: To compare ERAS care protocol with conventional care in cases with major gastrointestinal surgeries. Materials and Methods: The present study was a prospective interventional study in which 56 cases undergoing elective laparotomy surgeries were recruited. Cases were randomly divided into two groups i.e., group 1 cases were managed according to ERAS care protocol and group 2 cases received conventional care. The preoperative, intraoperative and postoperative outcomes like duration of oral intake of drugs, duration of hospital stay, duration of drain tube removal and ambulatory period was recorded. The Clavien-Dindo classification system was followed for postoperative assessment. Chi-square test was used to analyse qualitative data. Results: The ERAS care group showed a better outcome than the conventional group in terms of early oral dietary intake (by 2nd day in 89.28% of ERAS and 3.57% in conventional group), less ambulatory period (on the day of surgery in 85.71% of ERAS and 7.14% of conventional group), early removal of a nasogastric and urinary catheter (92.86% in ERAS and 3.57% in conventional group). The duration of hospital stay, postoperative drain removal, incidence of postoperative complications and infections at the surgical site were statistically significant (p<0.05). Conclusion: The ERAS care protocols were effective in reducing hospital stay, postoperative complications and early oral dietary intake.