Dual Cycle Research Articles

Visible light-driven Z-scheme Bi2O3/CuBi2O4 heterojunction with dual metal ions cycle for PMS activation and Lev degradation

In this study, Bi2O3/CuBi2O4 composite was prepared by sol–gel method, which was used to degrade levofloxacin (Lev) by the synergistic effect of visible light and peroxymonosulfate (PMS). The physicochemical properties of Bi2O3/CuBi2O4 were regulated by varying the molar ratio of the raw materials. The structure and morphology of the materials were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), X-ray photoelectron spectroscopy (XPS) and ultraviolet–visible diffuse reflectance spectroscopy (UV–Vis DRS). Secondly, Bi2O3/CuBi2O4/Vis/PMS system was constructed to investigate the effects of different conditions (pollutant concentration, catalyst dosage, PMS concentration, pH and different anion concentration) on the removal effect of Lev. Benefit from the highly ordered alternating nanoparticles and nanosheets, Bi2O3/CuBi2O4 showed satisfactory PMS activation ability than single Bi2O3. The degradation rate increased from 12.98 ± 2.41% (Bi2O3) to 70.62 ± 0.07% (Bi2O3/CuBi2O4) within 120 min. Finally, the quenching experiments and electron paramagnetic resonance (EPR) results showed that radical pathways (h+, SO4-·, ·OH) and non-radical pathways (1O2) were both involved in the PMS activation process. The main reaction mechanism of Bi2O3/CuBi2O4/Vis/PMS system was predicted, the unique electron transfer pathway of Z-scheme heterojunction and Cu(II)/Cu(I), Bi(V)/Bi(III) redox-cycle on the catalyst surface effectively drove the generation of radicals, realizing the high efficiency of pollutant degradation.

Multi-aspect evaluation of a novel geothermal-driven trigeneration system for cooling, heat, and power generation

This paper presents a novel trigeneration process that utilizes geothermal fluid and a gas turbine to generate electricity, heat, and cooling. The trigeneration system comprises a gas turbine cycle, dual flash geothermal-organic Rankine cycle, cooling production unit, and heat and power generation unit. A comprehensive parametric study is conducted from energy, exergy, economic, and environmental perspectives to evaluate the proposed process. Thermodynamic analysis shows that the energy and exergy efficiencies of the system are 46% and 47%, respectively. The total exergy destruction of the process is calculated to be 147,006 kW, with the gas turbine cycle and combustor contributing the highest and second-highest exergy destruction ratios at 66% and 45%, respectively. Environmental analysis reveals that the indirect emission of the proposed structure is zero, and the total carbon dioxide emission is related to the flue gas of the gas turbine unit, amounting to 44,010 kgCO2/h. Considering the production capacity of the three products, the carbon dioxide footprint is determined to be 17.44 kgCO2/MJ. Furthermore, the economic analysis indicates that the total annual cost of the proposed scheme is 56,817,774 $. The production costs for cooling, electricity, and heating are 0.3 $/kg(CW,5℃), 0.073 $/kWhe, and 0.174 $/kgST, respectively. This comprehensive evaluation demonstrates the efficiency and feasibility of the trigeneration process, making it a promising option for sustainable power generation with minimal environmental impact.

Ce/Zr-MOF with Dual Cycle Synergistic Catalysis Pathway Enabling Enhanced Peroxidase-like Performance for Wearable Hydrogel Patch Visualization Sensing Platform.

Engineering the activity of enzyme-like catalysts should be a top priority to make them superior substitutes for natural enzymes. Herein, a Ce/Zr bimetal-organic framework (Ce/Zr-MOF) was designed and synthesized by a one-pot hydrothermal method, which has enhanced performance in mimicking peroxidase (POD) than its single-metal counterparts. To further comprehend the mechanism of activity enhancement, the role of the bimetallic synergistic catalysis process in H2O2 decomposition and reactive oxygen species formation was elucidated, and the possible dual cycle synergistic catalysis pathway of bimetallic catalysis is proposed for the first time. The enhanced POD-like activity mainly depends on the introduction of Ce, which improved the conductivity and electron-transfer capability of Ce/Zr-MOF and promoted the generation of •OH. Integrated with a hydrogel substrate, a wearable all-solid-state H2O2 sensor for early diagnosis of plant health was produced. The detection limit can be as low as 3.3 μM, which is lower than that of some instrument-based colorimetric methods and has great potential in the development of visualized sensing applications. The concept of dual cycle synergistic catalysis pathway we proposed not only deepens the comprehension regarding sensing and catalytic mechanisms but also provides novel perspectives into the design of enzyme-like catalysts for extensive usage.

Acceptorless cross-dehydrogenative coupling for C(sp3)-H heteroarylation mediated by a heterogeneous GaN/ketone photocatalyst/photosensitizer system

Alkanes are naturally abundant chemical building blocks that contain plentiful C(sp3)-H bonds. While inert, the activation of C(sp3)-H via hydrogen atom abstraction (HAT) stages an appealing approach to generate alkyl radicals. However, prevailing shortcomings include the excessive use of oxidants and alkanes that impede scope. We herein show the use of gallium nitride (GaN) as a non-toxic, recyclable, heterogeneous photocatalyst to enable alkyl C(sp3)-H in conjunction with the catalytic use of simple photosensitizer, benzophenone, to promote the desired alkyl radical generation. The dual photocatalytic cycle enables cross-dehydrogenative Minisci alkylation under mild and chemical oxidant-free conditions.

SO3 removal rate and emission test of the limestone-gypsum wet desulfurization system for coal-fired power plants

This paper studies the SO3 removal ability of dual tower wet desulfurization (in series) and adopts a combination of on-site flue gas sampling and laboratory condensation control. A dual tower (series) supported boiler is used. The SO3 content in the original and clean flue gas of the dual cycle wet desulfurization device was measured, and the removal rate of SO3 of the device was measured. Desulfurization is calculated on the basis of the influence of unit electrical load, coal sulfur content, and desulfurization (raw material flue gas) inlet particle concentration on removal rate. This paper discusses and analyzes the SO3 and SO3 emission concentrations for SO3 removal rules in desulfurization systems. The results indicate that the total sulfur content of coal is relatively high, and the concentration of SO3 is relatively high. The traditional flue gas and net flue gas content in the dual tower wet desulfurization system (series) is relatively high. When burning sulfur-containing coal, there may be “blue smoke” in the flue gas. When the unit load changes between 182 MW and 350 MW, the SO3 removal rate of dual tower wet desulfurization (in series) is between 46.7% and 65.3%, with a net flue gas SO3 concentration of 16.0 mg/m3∼20.5 mg/m3. Due to equipment layout and other reasons, the SO3 removal rate of the primary tower is lower than that of the secondary tower. The removal rate of SO3 is also affected by the concentration of original smoke particles. Due to the condensation of SO3 on the particles and the dust removal of the adsorption tower, the higher the concentration of raw flue gas particles is, the higher the removal rate is. SO3 will be higher. The study also suggests the SO3 removal ability of double tower (series) and double ring wet desulfurization, which is better adapted to changes in load and coal. The next step is to explore the SO3 removal capacity of the dual tower system by optimizing its operating parameters. In addition, due to the arrangement of a desulfurization system after dust removal, it is impossible to control the SO3 source. Subsequent research can control the production of existing SO3 through coal distribution and combustion control.

Radical Group Transfer of Vinyl and Alkynyl Silanes Driven by Photoredox Catalysis.

Radical group transfer is a powerful tool for the formation of C-C bonds. These processes typically involve radical addition to C-C π bonds, followed by fragmentation of the resulting cyclic intermediate. Despite the advantageous lability of organosilanes in this context, silicon-tethered radical acceptor groups have remained underexplored in radical group transfer reactions. We report a general photoredox-catalyzed protocol for the radical group transfer of vinyl and alkynyl silanes onto sp3 carbons, using activated and unactivated iodides as radical precursors. Our method displays high diastereoselectivity and excellent functional group tolerance, and enables direct formation of group transfer products by in situ ring opening. Mechanistic investigations revealed that the reaction proceeds via an unusual dual catalytic cycle, resulting in an overall redox-neutral process.

Advanced cobalt-ferrite layered double hydroxides sandwich-structured nanozymes for ROS-bloomed tumor therapy

Artificial-engineered nanozymes show great promise for improving cancer therapeutic outcomes. Herein, we elaborately designed the advanced cobalt-ferrite layered double hydroxides (Co-Fe LDHs) sandwich-structured architectures that can serve as superior nanozymes with Co/Fe dual catalytic cycles and also be used as nanocarriers for loading Au nanoparticles (NPs) and maleimide (MA) to achieve the “all-in-one” reactive oxygen species (ROS)-bloomed tumor therapeutic strategy. The constructed Co-Fe LDHs@Au@MA nanozymes can not only enhance the oxidative stress in tumors through cascade enzymatic reactions but also disrupt the glutathione supply and further aggravate the tilt of the established redox homeostasis. The Co/Fe active sites are optimal by manipulating the Co/Fe-doped amount for obtaining the synergistic effect of multi-metallic enzyme-like activities. Besides, the mild photothermal effect of Au NPs facilitates the enhanced catalytic efficiency of Co-Fe LDHs but also initiates tumor cell apoptosis via the hyperthermia effect. In conclusion, this study presents a typical paradigm to utilize bi-functional LDHs-based nanozymes for tumor treatment with enhanced enzyme-like activities.

Proposal and 4E analysis of an innovative integrated model based on A gas turbine cycle for the simultaneous production of power, methanol, desalinated water, and heating

Gas turbine power cycles are among the most important power plants, operating in higher temperatures. Their principal defect is huge waste heat, leading to lower exergetic performances in addition to higher carbon dioxide (CO2) emissions. In this regard, the current paper focuses on a new solution to solve these defects appropriately. For this purpose, a new thermal integration model is designed for a multigeneration purpose, which is able to decrease the CO2 emission intensity below zero (a negative emission solution). The designed model comprises a steam power cycle, a Kalina power cycle, a dual organic Rankine cycle, a water desalination unit plus, and a methanol production unit plus. Thus, the products include electricity, heating, fresh water, and methanol. This system is simulated in the Aspen HYSYS software and is studied from the energy, exergy, economic, and environmental standpoints. According to the results obtained from the thermodynamic analysis, it is demonstrated that the total energy and exergy efficiencies are 49.38% and 66.5%, respectively. Furthermore, the net CO2 emission intensity of the process is negative and equals − 1.036 kgCO2/kgMeOH. Eventually, according to the economic evaluation, the methanol production cost equals 0.136 $/kg, which is 90.87% lower than the renewable methanol production method.

Comparative performance investigation of a dual evaporator cycle using an ejector with the conventional cycle using a pressure reducing valve

The performance of a dual evaporator cycle using ejector is compared with a conventional cycle employing pressure reducing valve. In both the systems, high temperature evaporator is considered as a flooded evaporator, thus a separator is employed after the high temperature evaporator. However, low temperature evaporator is a kind of conventional dry evaporator. The comparison of both systems, i.e., conventional and ejector assisted, is done for the same cooling capacities and same dryness fraction at the exit of high temperature evaporator with R134a, R152a, and R1234yf refrigerants. The effects of varying the states of refrigerant at the exit of flooded evaporator, and temperatures of both the evaporators and the condenser are analyzed using Engineering Equation Solver. It is found that the compressor work is reduced in both the cycles with the rise in low temperature evaporator temperature; however, a little variation is observed in the total cooling effect. The cooling effect in high temperature evaporator is increased with the increase in dryness fraction at the exit of the high temperature flooded evaporator, but it is decreased in low temperature evaporator.

A Developmental Ontology for the Colonial Architecture of Salps.

AbstractColonial animals are composed of clonal individuals that remain physically connected and physiologically integrated. Salps are tunicates with a dual life cycle, including an asexual solitary stage that buds sexual colonies composed of jet-propelling zooids that efficiently swim together as a single unit by multijet propulsion. Colonies from different species develop distinct architectures characterized by their zooid arrangement patterns, but this diversity has received little attention. Thus, these architectures have never been formally defined using a framework of variables and axes that would allow comparative analyses. We set out to define an ontology of the salp colony architecture morphospace and describe the developmental pathways that build the different architectures. To inform these definitions, we collected and photographed live specimens of adult and developing colonies through offshore scuba diving. Since all salp colonies begin their development as a transversal double chain, we characterized each adult colonial architecture as a series of developmental transitions, such as rotations and translations of zooids, relative to their orientation at this early shared stage. We hypothesize that all adult architectures are either final or intermediate stages within three developmental pathways toward bipinnate, cluster, or helical forms. This framework will enable comparative studies on the biomechanical implications, ecological functions, evolutionary history, and engineering applications of the diversity of salp colony architectures.

Pengaruh Performa Quay Container Crane dan Penerapan System Single Cycle dan Dual Cycle Terhadap Bongkar Muat Peti Kemas di KSO Peti Kemas Koja Jakarta

Since 2012 Koja Jakarta Container Terminal has a target of unloading and loading 1 million containers. To get the desired target, KSO Koja Container Terminal immediately took quick steps by upgrading and adding several tools to support performance so that it could be more optimal in carrying out loading and unloading activities such as upgrading several CCs from Post Panamax grade to Super Post Panamax. Along with the many containers that are unloaded or loaded at TPK KOJA, and the market that competes between container terminals with each other. The management of Koja must increase the target size of unloading and loading containers by quay container crane (QCC) or what we often call Box Crane per Hours (BCH), but on the other hand with the demands of TPK KOJA management that unloading and loading 1 million containers, many tools in the field and at the dock are forced to work hours with maintenance that has not been scheduled properly resulting in congestion of loading and unloading equipment. The type of research used in this study is qualitative descriptive analysis, qualitative descriptive research is aimed at describing and describing existing phenomena, both natural and human engineering, which pay more attention to the characteristics, quality, relationships between activities. In addition, descriptive research does not provide treatment, manipulation or alteration of the variables studied, but describes a condition as it is. So the results of the Quay container crane performance research at TPK Koja from the author's observation, in the process of container loading and unloading activities at TPK Koja still found inhibiting factors. The effect of the Dual Cycle Operation system in loading and unloading at TPK KOJA cannot be determined the box crane unit per hour produced, because in this case the management of TPK KOJA is still in the trial stage of the system.

The direct and indirect spatial spillover effects of infrastructure on urban green and smart development

Introduction: Economic development is not simply the accumulation of elements, but the improvement of efficiency, which is supported by infrastructure construction. In particular, the urban green and smart development (UGSD) in recent years has put forward higher requirements for infrastructure, and domestic trade as well as opening-up are of great significance during the process.Methods: Based on the panel data of 221 prefecture-level cities in China from the year of 2005 to 2019, this paper adopts the undesirable SBM model and GML index to measure the level of UGSD. Then the spatial Durbin model is conducted to explore the direct spatial spillover effects and the spatial decomposition effects of energy, transportation, and information infrastructure on UGSD. Considering the context of dual cycle, the indirect effects of domestic trade and opening-up between infrastructures and UGSD are further analyzed.Results: Results show that UGSD demonstrates strong spatial agglomeration and maintains a stable spatial positive correlation with different spatial matrices. In general, energy and transportation infrastructure show positive spatial spillover effects on UGSD. By contrast, information infrastructure presents positive spatial spillover effect on UGSD on the whole, while shows insignificant and negative spatial spillover effect with geographical distance matrix. Furthermore, the mediation effect indicates that both transportation and information infrastructure mainly promote local and adjacent cities’ UGSD through domestic trade with economic distance matrix. By contrast, energy infrastructure exerts positive spatial spillover effect on UGSD through weakening the negative impact of opening-up.Discussion: The conclusions of the research show that it is necessary to construct infrastructure in a reasonable way, strengthen the positive spillover effect of intercity factors, and promote the two-wheel driving effect of domestic trade and opening-up on the relationship between infrastructure and UGSD.

Simulation of Dual Combustion Cycle in Internal Combustion Engines using MATLAB

The aim of this study is to develop a comprehensive mathematical model to accurately represent the dual combustion cycle in internal combustion engines, with a focus on improving combustion efficiency and reducing emissions. The novelty of this research lies in the integration of advanced combustion models within the mathematical framework to capture the unique characteristics of dual combustion cycles. The model will consider factors such as combustion characteristics, fuel-air mixing, heat transfer, and emissions. By accurately simulating the dual combustion cycle, valuable insights can be gained into the complex interactions occurring within the engine, leading to the development of optimized engine design and control strategies. The proposed model will be implemented using MATLAB, which offers flexibility and computational efficiency. The results obtained from the simulation can be validated against experimental data to ensure the accuracy and reliability of the model. This study is expected to contribute to the advancement of dual combustion cycle technology and provide valuable guidance for the design and optimization of future internal combustion engines.

Dual metal ions/BNQDs boost PMS activation over copper tungstate photocatalyst for antibiotic removal: Intermediate, toxicity assessment and mechanism

In the metal-based peroxymonosulfate (PMS) activation process, the sluggish surface redox cycle of metal ions generally hampered the efficiency of PMS activation for pollutant removal. Herein, Co-doped CuWO4/BN quantum dots (CW/Co/BNQDs) photocatalysts were developed to realize Cu2+/Cu+ and Co2+/Co3+ dual ions redox cycles for PMS activation, which would facilitate the tetracycline (TC) removal. CW/4Co/2BNQDs could degrade 94.8% TC within 30 min in PMS/Vis system, and the apparent rate constant of CW/4Co/2BNQDs was 2.7 times and 1.2 times higher than those of CW and CW/4Co, respectively. The improved TC degradation performance could be attributed to the synergetic effect between BNQDs and dual redox cycles. X-ray photoelectron spectroscopy (XPS) spectra of samples before and after the reaction demonstrated that BNQDs were beneficial for accelerating the Cu2+/Cu+ and Co2+/Co3+ redox cycles in CW/4Co/2BNQDs, further boosting the activation of PMS in TC degradation. Experiments of different radical scavengers revealed that the SO4·−/·OH/h+/1O2 reactive species participated in the PMS activation for the TC degradation process. The possible TC degradation pathway and intermediate toxicity were detailed investigated. In addition, CW/4Co/2BNQDs exhibited outstanding photocatalytic activity over five consecutive cycles, which illustrated that it was supposed to be a reliable PMS activator over antibiotic elimination for practical application. And this work shed new light on constructing dual redox cycles for efficient PMS activation.

The effect of gonadotrophin-releasing hormone agonist versus human chorionic gonadotrophin trigger on pregnancy and neonatal outcomes in Letrozole-HMG IUI cycles

BackgroundGnRHa and hCG are both used for oocyte maturation and ovulation triggering. However, GnRHa have a shorter half-life than hCG, which leads to luteal phase deficiency. Letrozole (LE) has been found to improve the luteal function. Thus, the choice of triggering strategy can be different in intrauterine insemination (IUI) cycles using LE and human menopausal gonadotropin (HMG). The aim of this study was to compare the pregnancy and neonatal outcomes of patients triggered with GnRHa versus hCG versus dual trigger in LE-IUI cycles.MethodsThis retrospective cohort study included 6,075 LE-HMG IUI cycles between January 2010 and May 2021 at a tertiary-care academic medical center in China. All cycles were divided into three groups according to different trigger strategies as hCG trigger group, GnRHa trigger group and dual trigger group. The primary outcome was clinical pregnancy rate. Logistic regression analysis was performed to explore other risk factors for clinical pregnancy rate.ResultsNo significant difference was observed in clinical pregnancy rate between hCG, GnRHa and dual trigger cycles in LE-HMG IUI cycles (P = 0.964). The miscarriage rate was significantly lower in the GnRHa trigger group, and higher in the dual trigger group, compared with the hCG group (P = 0.045). Logistic analysis confirmed that triggering strategy was associated with miscarriage (aOR:0.427, 95%CI: 0.183–0.996, P = 0.049; aOR:0.298, 95%CI: 0.128–0.693, P = 0.005). No significant differences were observed regarding neonatal outcomes between the three groups.ConclusionsOur findings suggested that both GnRHa and dual trigger can be used to trigger ovulation in LE-HMG IUI cycles, but dual trigger must be used with caution.

Improvement of n-Butene Yield in Dimethyl Ether-to-Olefin Reaction Using Ferrierite Zeolite Catalysts

Various ferrierite zeolites were investigated as catalysts for the dimethyl ether (DME)-to-olefin (DTO) reactions to efficiently synthesize n-butene, such as 1-butene, trans-2-butene, and cis-2-butene except for iso-butene using a fixed-bed flow reactor. Twenty P-loaded ferrierite zeolites with different structural parameters and acidic properties were prepared by the impregnation method by varying the P content and the temperature of air calcination as a pretreatment. The zeolites were characterized by X-ray diffraction (XRD), N2 adsorption-desorption, and NH3 temperature-programmed desorption (NH3-TPD). Micropore surface area, external surface area, total pore volume, micropore volume, and weak and strong acid sites affected the DTO reaction behavior. A high n-butene yield (31.2 C-mol%) was observed, which is higher than the previously reported maximum yield (27.6 C-mol%). Multiple regression analysis showed that micropore surface area and strong acid sites had a high correlation with n-butene yield. Based on our findings, we explained the reaction mechanism for selective n-butene synthesis except for iso-butene in the DTO reaction by the dual cycle model.

Hydrogen Cyanamide Causes Reversible G2/M Cell Cycle Arrest Accompanied by Oxidation of the Nucleus and Cytosol.

Hydrogen cyanamide (HC) has been widely used in horticulture to trigger bud burst following dormancy. Its use has been banned in some countries due to human health concerns, however the search for effective safe alternatives is delayed by lack of knowledge of the mechanism of HC action. Earlier studies demonstrate that HC stimulates the production of reactive oxygen species (ROS) and alters the rate of cell division. However, the relationships between HC effects on ROS, redox (reduction/oxidation) homeostasis and cell division are unknown. This study used Arabidopsis thaliana ((L.) Heynh.) seedlings expressing the redox reporter roGFP2 to measure the oxidation states of the nuclei and cytosol in response to HC treatment. The Cytrap dual cell cycle phase marker system and flow cytometry were used to study associated changes in cell proliferation. HC (1.5 mM) reversibly inhibited root growth during a 24 h treatment. Higher concentrations were not reversible. HC did not synchronise the cell cycle, in contrast to hydroxyurea. Rather, HC caused a gradual accumulation of cells in the G2/M phase and decline of G1/S phase cells, 16 to 24 h post-treatment. This was accompanied by increased oxidation of both the nuclei and cytosol. Taken together, these findings show that HC impairs proliferation of embryonic root meristem cells in a reversible manner through restriction of G2/M transition accompanied by increased cellular oxidation.

Investigating the Mechanism of Ni-Catalyzed Coupling of Photoredox-Generated Alkyl Radicals and Aryl Bromides: A Computational Study.

Photoredox catalysis has emerged as an alternative to classical cross-coupling reactions, promoting new reactivities. Recently, the use of widely abundant alcohols and aryl bromides as coupling reagents was demonstrated to promote efficient coupling through the Ir/Ni dual photoredox catalytic cycle. However, the mechanism underlying this transformation is still unexplored, and here we report a comprehensive computational study of the catalytic cycle. We have shown that nickel catalysts can promote this reactivity very efficiently through DFT calculations. Two different mechanistic scenarios were explored, suggesting that two catalytic cycles operate simultaneously depending on the concentration of the alkyl radical.

Thermodynamic analysis of a dual reverse Brayton cycle (dual-RBC) hydrogen liquefaction process precooled by mixed-refrigerant

In order to reduce hydrogen liquefaction power consumption, a dual reverse Brayton cycle (dual-RBC) process is proposed and analyzed in this paper, which consists of a mixed-refrigerant J-T cycle for precooling, a hydrogen RBC for hydrogen liquefaction, and a helium RBC for liquid hydrogen subcooling. Compared with typical dual-Claude processes, the two-phase low-pressure cycling hydrogen for liquid hydrogen product subcooling is replaced by an independent helium RBC, reducing the temperature difference and exergy loss in subcooling heat exchangers. Consequently, the specific power consumption (SPC) of dual-RBC process is 4.16% lower than dual-Claude process under the same conditions. The mixed-refrigerant J-T cycle (driven by single-stage oil-lubricated compressor, no liquid/two-phase expanders) could reduce precooling power consumption by >45% comparing with liquid nitrogen. The dual-RBC process could reach a SPC of 7.08 kWh kg−1 under typical conditions. While it is more realizable with mature technologies than novel processes.

TEAD Inhibitors Sensitize KRASG12C Inhibitors via Dual Cell Cycle Arrest in KRASG12C-Mutant NSCLC.

KRASG12C is one of the most common mutations detected in non-small cell lung cancer (NSCLC) patients, and it is a marker of poor prognosis. The first FDA-approved KRASG12C inhibitors, sotorasib and adagrasib, have been an enormous breakthrough for patients with KRASG12C mutant NSCLC; however, resistance to therapy is emerging. The transcriptional coactivators YAP1/TAZ and the family of transcription factors TEAD1-4 are the downstream effectors of the Hippo pathway and regulate essential cellular processes such as cell proliferation and cell survival. YAP1/TAZ-TEAD activity has further been implicated as a mechanism of resistance to targeted therapies. Here, we investigate the effect of combining TEAD inhibitors with KRASG12C inhibitors in KRASG12C mutant NSCLC tumor models. We show that TEAD inhibitors, while being inactive as single agents in KRASG12C-driven NSCLC cells, enhance KRASG12C inhibitor-mediated anti-tumor efficacy in vitro and in vivo. Mechanistically, the dual inhibition of KRASG12C and TEAD results in the downregulation of MYC and E2F signatures and in the alteration of the G2/M checkpoint, converging in an increase in G1 and a decrease in G2/M cell cycle phases. Our data suggest that the co-inhibition of KRASG12C and TEAD leads to a specific dual cell cycle arrest in KRASG12C NSCLC cells.