The current paper deals with the study of magneto-convective and chemically reactive Casson nanofluid flow along an inclined permeable stretching surface embedded in a fluid-saturated uniform porous medium. As a novelty of the work, entropy generation analysis in the presence of multiple slips at the surface and a nonuniform heat source/sink is carried out. Moreover, viscous dissipation, Arrhenius activation energy, Joule dissipation and thermal radiation are included in the investigation. To the best of authors’ knowledge, no such study on Casson nanofluid is reported yet in the literature. Dimensionless similarity transformations have been introduced to convert the regulating model PDEs into ODEs in dimensionless form. As the model equations are highly nonlinear in nature, shooting technique based on the Runge-Kutta Cash-Karp method is used to solve those equations numerically. The updated values of the initial guesses are computed with the help of secant iteration. Profiles for fluid velocity, temperature, nanoparticle concentration and entropy generation have been drawn to explain the impacts of several important parameters on momentum, thermal and mass fields. However, the surface drag force, heat and mass transport rates at the solid wall are illustrated using numerical data displayed in tabular form. Also, a linear regression model is derived for the local Nusselt number and the related physical parameters. Moreover, a comparison table is presented to confirm the correctness of the obtained results. A fantastic correlation of the present results with the existing results is reported. Graphical results reveal that for the rising values of the angle of inclination parameter and magnetic parameter velocity profiles are declined, but for the growing values of Eckert number and thermal radiation parameter temperature profiles are enhanced.