In this study, a crosslinked poly(vinyl alcohol) (CPVA) was synthesized using glutaraldehyde as the cross-linking agent. Subsequently, the CPVA was sulfonated with chlorosulfonic acid to yield SCPVA. The SCPVA was then used in the in situ coprecipitation method to create a magnetic nanocomposite named SCPVA@CuFe2O4. Characterization of the SCPVA@CuFe2O4 nanocatalyst was conducted through EDX, XRD, TGA, FTIR, VSM, and SEM analyses. The catalytic activity of SCPVA@CuFe2O4 was evaluated through studies on synthesizing imidazoles and amino naphthoquinones. Using 0.08 g of the catalyst, yields of amino naphthoquinones and imidazoles reached 88–94 % and 89–95 %, respectively. The synthesized derivatives showed high antioxidant and antibacterial activity close to the DPPH solution and tested bacteria, correspondingly. The synthesized derivatives exhibited high toxicity against breast cancer cell lines and demonstrated promising antioxidant and antibacterial activities.