Double Bridge Research Articles

Arthroscopic Fixation of Posterior Cruciate Ligament Tibial Bony Avulsion Fractures: The Double Suture Bridge Technique and Evaluation of Results

Background: Surgical fixation is required for displaced posterior cruciate ligament (PCL) tibial bony avulsion fractures or with fractures having grade 2 or more posterior instability. The purpose of this study is to evaluate the results of arthroscopic fixation of PCL tibial bony avulsion fractures using the double suture bridge technique. Methods: A retrospective study was done involving 24 patients having displaced PCL tibial bony avulsion fractures. The arthroscopic double suture bridge technique was used to fix these fractures. Patients were followed up for three years and assessed for knee-related symptoms, signs, Lysholm Knee Score, and satisfaction. Results: The study group consisted of 21 men and three women. Fracture union was achieved in all cases two months postoperatively. The mean Lysholm Knee Score at follow-ups of three months, six months, one year, two years, and three years was 86.6, 96.5, 98.8, 99.1, and 99.4, respectively. At the latest follow-up, all the patients were satisfied with their knee function with respect to pain, range of motion (ROM), stability, and resumption of pre-injury activity level. Conclusion: The arthroscopic double suture bridge technique is an effective method for the fixation of PCL tibial bony avulsion fractures with respect to knee stability, ROM, and resumption of pre-injury activity level.

Excellent clinical and radiological outcomes after arthroscopic reduction and double row-suture bridge for large-sized greater tuberosity fractures of the humerus.

Currently, there is limited information on the clinical outcomes of arthroscopic reduction and double-row suture bridge fixation for large greater tuberosity fractures of the proximal humerus. This study aimed to evaluate the radiological and clinical outcomes of arthroscopic reduction and double-row suture bridge fixation for these fractures, hypothesizing that arthroscopic reduction and double-row suture bridge fixation is a safe, effective and minimally invasive treatment for large greater tuberosity fractures. This retrospective study analysed patients with large greater tuberosity fractures (fracture fragment ≥30 mm in diameter) who underwent arthroscopic reduction and double-row suture bridge fixation and had a follow-up period exceeding 2 years. The anatomic reduction was confirmed by assessing the step-off on radiographs immediately after surgery, and the radiologic union time was recorded. At the final follow-up, range of motion and functional outcome scores were evaluated. Additionally, any surgery-related complications were evaluated. Fifteen patients with a mean follow-up of 57.7 ± 23.1 months were included in the study. The mean fracture fragment size was 32.5 ± 2.4 mm, with a mean displacement of 5.1 ± 1.6 mm. Immediately postsurgery, 13 of 15 patients (86.7%) had a fracture step-off of <3 mm, with an average union time of 3 months. At the final follow-up, patients demonstrated excellent outcomes, with an average forward flexion of 167 ± 9.7° and external rotation of 70 ± 16.3. Functional outcome scores showed significant improvement compared with preoperative scores (p < 0.001). No major surgery-related complications were reported. Arthroscopic reduction and double-row suture bridge fixation for large-sized greater tuberosity fractures is safe and shows good fracture reduction and excellent clinical outcomes. Therefore, this surgical method can be considered an alternative to open reduction for large greater tuberosity fractures. Level IV.

DNA Damage, Cell Death, and Alteration of Cell Proliferation Insights Caused by Copper Oxide Nanoparticles Using a Plant-Based Model.

The speedy growth of copper oxide nanoparticle (CuO NP) manufacturing due to their wide application in industries has caused concerns due to their increased discharge into the environment from both purposeful and accidental sources. Their presence at an elevated concentration in the environment can cause potential hazards to the plant kingdom, specifically to staple food crops. However, limited research is available to determine the consequences of CuO NPs. The present study aimed to assess the morphological and cytological changes induced by CuO NPs on Pisum sativum L., a key staple food crop. Seeds of Pisum sativum were exposed to various concentrations of CuO NPs (0, 25, 50, 75, 100, and 125 ppm) for 2 h, and their effects on seed germination (SG), radicle length (RL), cell proliferation kinetics (CPK), mitotic index (MI), cell death (CD), micronucleus frequency (MNF), and chromosomal aberration frequency (CAF) were studied. The results indicate a significant reduction in SG, RL, CPK, and MI and a significant dose-dependent increase in CD, MNF, and CAF. CuO NP treatment has led to abnormal meiotic cell division, increased incidence of micronucleus frequency, and chromosomal aberration frequency. Additionally, the CuO NP-treated groups showed an increase in the percentage of aberrant meiotic cells such as laggard (LG), double bridge (DB), stickiness (STC), clumped nuclei (CNi), precocious separation (PS), single bridge (SB), and secondary association (SA). CuO NP treatment led to reductions in SG as follows: 55% at 24 h, 60.10% at 48 h, and 65% at 72 h; reductions in RL as follows: 0.55 ± 0.021 cm at 24 h, 0.67 ± 0.01 cm at 48 h, and 0.99 ± 0.02 cm at 72 h; reductions in CPK as follows: 34.98% at prophase, 7.90% at metaphase, 3.5% at anaphase, and 0.97% at telophase. It also led to a 57.45% increase in CD, a 39.87% reduction in MI, and a 60.77% increase in MNF at a higher concentration of 125 ppm. The findings of this study clearly show that CuO NPs have a genotoxic effect on the food crop plant Pisum sativum.

Cobalt Ferrite@Barium titanate core-shell nanoparticles empowered triboelectric electromagnetic coupled nanogenerator for self-powered electronics

In pursuing sustainable energy solutions for wearable technology and Internet of Things (IoT) devices, achieving high power in self-powered electronics is a significant challenge. This study introduces a novel hybrid nanogenerator by integrating a triboelectric nanogenerator (TENG) and an electromagnetic generator (EMG) to achieve both high voltage and high current outputs simultaneously. The cobalt ferrite barium titanate (CoFe2O4@ BaTiO3) core–shell nanoparticles (NPs) were chosen for their unique ability to enhance the system’s performance by combining triboelectric, piezoelectric, and electromagnetic properties. The BaTiO3 shell exhibited robust triboelectric and piezoelectric properties essential for TENG operation, while the CoFe2O4 core, influenced by the EMG’s magnetic field, induces additional static charges, significantly boosting overall energy conversion efficiency. The TENG and EMG in the combined system operate together in a contact-separation mode, where their in-phase output signals are seamlessly combined via a double bridge rectifier, resulting in a robust power output of 37.7 mW and a power density of 1.86 mW/cm2, with cycling stability of over 10,000 cycles. The uniquely designed TENG-EMG combined nanogenerator (C-TENG) exhibited striking adaptability, effectively operating across different low-to-high frequencies and load situations while constantly powering portable electronic devices. This innovative approach meets the high energy demands of modern self-powered electronics with exceptional efficiency, durability, and high-power density, positioning it as a versatile solution for wearable biomechanical energy harvesting.

Facile Preparation of A−D−A Type Through‐Space Charge Transfer Molecules Utilizing Indoloindoles

AbstractThis study presents a straightforward synthetic pathway for the preparation of through‐space charge transfer (TSCT) molecules, utilizing an IDID core as the donor, connected to double bridges. The IDID core, known for its enhanced donor properties, incorporates two sites that facilitate a concise synthetic approach for the introduction of bridges in the acceptor‐donor‐acceptor design. Computational studies played a pivotal role in guiding our design, predicting favorable energy levels and TSCT characteristics. Experimental validation of TSCT characteristics was achieved through measurements of photophysical properties.

Enhanced catalytic performance for CO2 cycloaddition and Knoevenagel condensation reactions via stable Eu3+ modified Mn-MOF

The construction of MOF-based catalysts containing simultaneous Lewis acid and Lewis base sites has been considered as an efficient approach to enhance chemical fixation of CO2 into value-added products and Knoevenagel condensation reaction. Herein, one novel Eu3+-modified Mn-MOF (Eu3+@Mn-MOF-1) was successfully synthesized by solvothermal synthesis and post-synthesis modification. In Mn-MOF-1, the alternating chains with single and double carboxylate bridges are connected by H2L4− ligands to form a three-dimensional framework with 1D channels along a axis. Interestingly, the activated state of Eu3+@Mn-MOF-1 (noted as Eu3+@Mn-MOF-1a) with the removal of coordinated and lattice H2O molecules displayed excellent thermal stability. Furthermore, it is worth emphasizing that the inner surfaces of Eu3+@Mn-MOF-1a are functionalized by pentiful Lewis acid sites (tri- and penta-coordinated Mn2+ ions and modified Eu3+ ions) and Lewis base sites (uncoordinated Ocarboxylate and Npyridine). By virtue of the abundant co-existing Lewis acid-base sites, Eu3+@Mn-MOF-1a exhibited high catalytic performance for the cycloaddition of CO2 with epoxides and Knoevenagel condensation of aldehydes and malononitrile with preferable repeatability under mild conditions without the requirement of any solvent. Moreover, Eu3+@Mn-MOF-1a performed much higher activity for the cycloaddition of CO2 with epoxides than Mn-MOF-1a under the same conditions. In addition, Eu3+@Mn-MOF-1a also shows the yield of benzylidenemalononitrile can reach 99.9 % at room temperature within 1 h, representing about 1.3-fold increase compared to that of Mn-MOF-1a (76.0 %). The improvement of catalytic performance suggested the contribution of Eu3+ ions to the reaction. Hence, this work provides an efficient approach for the construction of MOFs with Lewis base sites by elaborately designing organic ligands and Lewis acid sites by post-synthetic modification to expose and/or introduce more unsaturated metal sites.

Asymmetric Intramolecular Amination Catalyzed with Cp*Ir-SPDO via Nitrene Transfer for Synthesis of Spiro-Quaternary Indolinone.

An asymmetric intramolecular spiro-amination to high steric hindering α-C-H bond of 1,3-dicarbonyl via nitrene transfer using inactive aryl azides has been carried out by developing a novel Cp*Ir(III)-SPDO (spiro-pyrrolidine oxazoline) catalyst, thereby enabling the first successful construction of structurally rigid spiro-quaternary indolinone cores with moderate to high yields and excellent enantioselectivities. DFT computations support the presence of double bridging H-F bonds between [SbF6]- and both the ligand and substrate, which favors the plane-differentiation of the enol π-bond for nitrenoid attacking. These findings open up numerous opportunities for the development of new asymmetric nitrene transfer systems.

High-Nuclear Co-Added Polyoxometalate-Based Chain: Electrocatalytic Oxygen Production.

A high-nuclear Co-added polyoxometalate (CoAP) was synthesized via a hydrothermal reaction: H14.5K9Na7.5-{[Co8(μ2-OH)(μ3-OH)2(H2O)2(Co(H2O)GeW6O26)(B-α-GeW9O34)2][BO(OH)2][Co12(μ2-OH)(μ3-OH)5(H2O)3(Co(H2O)GeW6O26)(GeW6O26)(B-α-GeW9O34)]}·46H2O (1). The polyoxoanion of 1 contains a large Co20 cluster gathered by lacunary GeW6O26 and GeW9O34 subunits. 1 represents a one-dimensional (1D) chain formed by adjacent polyoxoanions coupling through a CoO6 double bridge, showing the first example of a high-nuclear CoAP-based inorganic chain. 1 served as an efficient electrocatalyst in oxygen evolution reactions (OERs).

Structural Investigation of Schiff Base Ligand and Dinuclear Copper Complex: Synthesis, Crystal Structure, Computational, and Latent Fingerprint Analysis.

The structural studies of the fluorinated Schiff base ligand and its copper complex were synthesized and characterized by Fourier transform infrared, UV-visible, and photoluminescence spectroscopy. Single-crystal X-ray diffraction analysis unveils a dinuclear copper complex arising from double bridging acetate anions to copper ions that are chelated by the tridentate Schiff base ligand Cu(LS). The trigonality index τ5 of 0.080 indicates a distorted square pyramidal coordination geometry for the metal. The SL ligand and complex exhibit intra- and intermolecular interactions, leading to unique supramolecular architectures. The structural changes between the free halogenated Schiff base ligand and upon coordination with the metal were extensively studied by experimental and theoretical approaches. The intra- and intermolecular interactions have been analyzed by Hirshfeld surface and quantum theory of atoms in molecules analysis, and the enrichment ratio highlights the most favored interactions in the formation of molecular packing. The chemical and physical properties, such as the HOMO - LUMO energy gap, chemical reactivity, and electron density topology, are studied using density functional theory studies. In addition, the Schiff base ligand compound is used to study the latent fingerprint analysis.

Bridge effect on charge transfer and energy transfer in fullerene-chromophore dyads.

Fullerene-chromophore dyads have attracted a great deal of research interest because these complexes can be potentially designed as nanoscale artificial photosynthetic centers, in which the chromophore and fullerene function as the electron donor and acceptor, respectively. The basic operation of this dyad-type artificial reaction center is photoinduced electron transfer from the donor to the acceptor. The fullerene and chromophore are usually covalently linked so that sufficient electronic coupling between these two moieties can facilitate the electron transfer. However, other deactivation pathways for the chromophore excited state, such as energy transfer to the fullerene, may reduce the quantum yield of the photoinduced electron transfer. Here, a series of C60-perylene dyads is exploited to interrogate the effect of the linkage on deactivation mechanisms of the chromophore excited state. For the C60-perylene dyads with a single or double bond bridge, we find that the decay of the singlet state of the chromophore is dominated by the electron transfer, and the corresponding time constant is determined to be 45ps. On the other hand, for the dyad with a triple bond bridge, the singlet state of the chromophore is quickly quenched through energy transfer to fullerene, and the time constant is as short as 7.9ps. Our finding suggests that the bond order of the bridge in the fullerene-chromophore dyads can be utilized to control the deactivation pathways of the excited state.

Glucoconjugated monoterpene indole alkaloids with xanthine oxidase inhibitory activity from Ophiorrhiza japonica

Continued interest in the bioactive alkaloids led to the isolation of five undescribed alkaloids (1–5), ophiorglucidines A-E, and seven known analogues (6–12) from the water-soluble fraction of Ophiorrhiza japonica. The structures were elucidated based on spectroscopic data and quantum calculations as well as X-ray crystallographic analysis. The structure of 1 was characterized as a hexacyclic skeleton including a double bridge linking the indole and the monoterpene moieties, which is the first report of a single crystal with this type of structure. Moreover, the inhibitory effect of zwitterionic indole alkaloid glycosides on xanthine oxidase was found for the first time. The alkaloids 2 and 3, both of which have a pentacyclic zwitterionic system, were more active than the reference inhibitor, allopurinol (IC50 = 11.1 μM) with IC50 values of 1.0 μM, and 2.5 μM, respectively. Structure-activity relationships analyses confirmed that the carbonyl group at C-14 was a key functional group responsible for the inhibitory effects of these alkaloids.

Механизм влияния электрического поля на процесс модифицирования серого чугуна

A diagram of an experimental installation for measuring the electrical resistance of a gray cast iron melt is presented, where a gauge based on a Kelvin double bridge is used. It is shown that the value of the specific electrical resistance of gray cast iron varies depending on the type of conditioning agent. Experimental data on the difference in specific resistivity values for various gray cast iron nucleating agents are presented. Changes in the values of electrical resistance under the influence of electric field treatment of inoculated cast iron melt are also given. Comparison of the strength values of gray cast iron with its values of the electrical resistivity of the cast iron melt after the electrical field exposure showed their simultaneous change. The decrease in the values of the electrical resistance of hot iron due to the electric field exposure is shown and it corresponds to an increment in the strength of inoculated cast iron. The effectiveness of the electric field exposure on the process of inoculation is determined by thermal ionization of the chemical elements included in the conditioning agent. The maximum increase of these parameters after electric field exposure when using FS75 nucleating agent is shown. The mechanism of the influence of an electric field on the cast iron solidification for the inoculation process of FS75, containing 75 % silicon in its composition, is described. The dependence of the efficiency of electric field exposure on the composition of the nucleating agent for gray cast iron is shown. A physical model of the effect of an electric field exposure on the process of cast iron inoculation is found. The possibility of influencing the hydrodynamic situation in the melt of gray cast iron and changing the rate of dissolution of nucleating agent particles by means of electric field exposure is given

The Optimal Control Method of Test Power Supply for DC Distribution Network

Background:: The test power supply is one of the key devices in the DC distribution network, which is necessary to supply power with high quality for testing other devices' performance. The double active bridge (DAB) converter is a common circuit topology for test power supply, which has the advantages of high-frequency electrical isolation, bi-directional power flow, and high power density. For the converter, control methods, such as single-phase-shift (SPS) control, and single-current stress or single-return power optimization under extended-phase-shift (EPS) control, have their limitations, which influences efficiency. Objective:: This paper aims to propose a dual-objective optimal control method, which can effectively improve efficiency of the test power supply. Methods:: This paper addresses the limitations of SPS control, and single-current stress or singlereturn power optimization under EPS control of the DAB converter, and proposes a dual-objective optimal control method based on the idea of using objective planning in the full power range under the condition of satisfying soft switching, which effectively improves efficiency of the test power supply. Results:: With the proposed dual-objective optimal control method, the converter achieves a smaller current stress similar to that with the single-current stress optimal control, and the return power is also reduced by 29.51%. Efficiency of the test power supply reaches 86.9%, which is better than 82.5% with SPS control and 85.3% with single-current stress optimization under EPS control. The experimental results fully verify the effectiveness of the proposed control method. Conclusion:: A dual-objective optimal control method is proposed. By using the presented method, current stress and return power are both optimally designed, so the efficiency of the test power supply can be effectively improved.

Arthroscopic suture bridge fixation for acute bony Bankart with anterior glenohumeral instability: a case report and narrative review.

Anterior shoulder dislocations can result in acute glenoid rim fractures that compromise the bony stability of the glenohumeral joint. Adequate fixation of these fractures is required to restore stability, decrease shoulder pain, and facilitate return to activity. The double-row suture bridge is a relatively novel fixation technique, first described in 2009, that accomplishes internal fixation with sufficient stability using an all-arthroscopic technique to restore the glenoid footprint. A 40-year-old female with recurrent anterior shoulder instability in the setting of seizure disorder was found to have a bony Bankart lesion of 25% to 30% with a concomitant superior labral tear. The patient was treated with a double-row bony Bankart bridge and labral repair. At six months follow-up, she has progressed to a full recovery with no recurrence. A search was conducted in May 2023 in PubMed, EMBASE, and CINAHL with the search terms bony Bankart, bone Bankart, osseous Bankart, acute, bridge, suture bridge, double row. Double-row suture bridge repairs result in improvement in shoulder function as determined by ASES (93.5), QuickDASH (4.5), SANE (95.9), and SF-12 (55.6). The overall recurrence rate of anterior instability after a bony Bankart bridge repair is 8%. When examining the return to prior level of function, 81.4% of patients were able to do so with only 7.9% of patients reporting significant modifications to their activity level. In mid-term results, double row suture bridge demonstrates similar outcomes to other all-arthroscopic fixation methods of bony Bankart injuries. Importantly, bony Bankart bridge remains a viable option for critical glenoid lesions over the 20% cutoff used in other all arthroscopic techniques. Biomechanically, the double-row suture bridge offers distinct benefits over its single-row counterpart including increased compression, reduced displacement, and reduced step-off. Although there is limited data, the studies discussed and the demonstrative case show the potential benefit of all-arthroscopic double-row suture bridge fixation including increased compression, decreased displacement, and a lower complication rate in patients with large bony Bankart lesions traditionally requiring bony augmentation. However, more robust studies are necessary to determine the long-term success of the double-row suture bridge.

(1199) - Double Bridge Approach for Treatment of Acute Mitral Regurgitation from Ruptured Chordae

(1199) - Double Bridge Approach for Treatment of Acute Mitral Regurgitation from Ruptured Chordae

(66) - Double Bridge to Heart Transplantation: Outcomes of Early vs Delayed ECMO Crossover in the Pediatric Population - An Analysis of the ACTION Registry

(66) - Double Bridge to Heart Transplantation: Outcomes of Early vs Delayed ECMO Crossover in the Pediatric Population - An Analysis of the ACTION Registry

Aggregation of graphene oxide upon the stripping of oxidized debris: An experimental and molecular dynamics simulation study

The most recent structural study of graphene oxide (GO) indicates that the oxidized debris (ODs) adhered to as-prepared GO will strip in certain aquatic settings. The impact of ODs stripping on the characteristics of GO has been widely reported, but its effects on GO aggregation have received less attention. Here, the influence of OD stripping on the GO aggregation property was identified, and the aggregation of as-prepared GO and GO upon OD stripping was compared. Upon ODs stripping, the pKa values of GO shifted from 3.91, 6.25, and 9.84 to 4.54, 6.65, and 10.21, respectively. Further analysis indicated the removal of ODs reduced the net negative charge and improved the hydrophobicity of GO, hence promoting the aggregation of GO. The acceleration of GO-Ca2+-OD aggregate formation was facilitated by the collective effects of ODs stripping, functional group deprotonation, double layer compression, OD bridging, and charge neutralization. The metal ions and stripped ODs attach to GO edges and link GO, which perform like bridges and contribute to further aggregation. In general, the existence of ODs adds complexity to the constructions and characteristics of GO, and it is important to take this into account while evaluating the aggregation characteristic of GO-based materials.

Blood Flow Restriction Training for Meniscus Repair Surgery

Background: Blood flow restriction (BFR) is a training tool that involves wearing a tourniquet or occlusive device during exercise. Data support that low-load training with BFR may produce muscle hypertrophy similar to standard high-load training. Because of the weight-bearing and range of motion (ROM) restrictions after meniscal repair, patients encounter substantial atrophy of lower extremity musculature. We perform BFR for these patients to limit atrophy postoperatively with the goal of facilitating their return to prior function and sports. Indications: We incorporate BFR in the postoperative rehabilitation protocol for patients undergoing meniscal repair not involving the root. Patients with the following are excluded: acute or severe cardiac disease, peripheral vascular disease, blood pressure over systolic 180 mm Hg or diastolic 100 mm Hg, hemophilia, thrombophlebitis or history of deep vein thrombosis, severe anemia, and sickle cell disease. Technique Description: An automated BFR device calculates the patient’s limb occlusion pressure (LOP) and titrates to 50% to 80% of LOP for lower extremity exercises. Exercise parameters typically consist of 4 sets of each exercise, totaling 75 repetitions, with 30-second interset rest. Patients undergo a standard 3-phase postoperative rehabilitation protocol. Phase I (weeks 0-6): Patients are nonweightbearing, may be either footflat weightbearing or partial weightbearing at the surgeon’s, with ROM restricted 0 to 90 in a hinge knee brace throughout the phase. Exercises include quadriceps sets with neuromuscular electrical stimulation and straight leg raises and short/long arcs quadriceps. Phase II (weeks 7-8): Patients progress to weightbearing and ROM as tolerated and begin exercises including double mini squats, hamstring curls, double leg press, and double leg heel raises. Phase III: (weeks 9+): Patients perform double and single leg bridges, double leg bridges on ball with knee band, squats, single leg press, and single leg heel raises, all with the goal of returning to sports. Results: Prior systematic review data demonstrate low-load training with BFR increases muscle strength and induces hypertrophy relative to low-load training alone. No significant differences for Knee Injury and Osteoarthritis Outcome Score (KOOS) subscales between BFR training group and control group. Discussion: BFR training may facilitate postoperative recovery in patients undergoing meniscal repair surgery by helping mitigate muscular atrophy. Patient Consent Disclosure Statement: The author(s) attests that consent has been obtained from any patient(s) appearing in this publication. If the individual may be identifiable, the author(s) has included a statement of release or other written form of approval from the patient(s) with this submission for publication.

Coupled Rotary Motion in Molecular Motors.

Biological molecular machines play a pivotal role in sustaining life by producing a controlled and directional motion. Artificial molecular machines aim to mimic this motion, to exploit and tune the nanoscale produced motion to power dynamic molecular systems. The precise control, transfer, and amplification of the molecular-level motion is crucial to harness the potential of synthetic molecular motors. It is intriguing to establish how directional motor rotation can be utilized to drive secondary motions in other subunits of a multicomponent molecular machine. The challenge to design sophisticated synthetic machines involving multiple motorized elements presents fascinating opportunities for achieving unprecedented functions, but these remain almost unexplored due to their extremely intricate behavior. Here we show intrinsic coupled rotary motion in light-driven overcrowded-alkene based molecular motors. Thus far, molecular motors with two rotors have been understood to undergo independent rotation of each subunit. The new bridged-isoindigo motor design revealed an additional dimension to the motor's unidirectional operation mechanism where communication between the rotors occurs. An unprecedented double metastable state intermediate bridges the rotation cycles of the two rotor subunits. Our findings demonstrate how neighboring motorized subunits can affect each other and thereby drastically change the motor's functioning. Controlling the embedded entanglement of active intramolecular components sets the stage for more advanced artificial molecular machines.

Study on the aerodynamic performances and the operational safety of the vehicle-bridge system under the crosswind

The train operates in special environments such as large bridges and elevated viaducts. The fluctuations of the aerodynamic loads of the high-speed train (HST) are more intense and the possibility of the train derailment and overturning will increase when the train is running on the bridge under the crosswind. Thus, it is of utmost importance to study both the aerodynamic characteristics and the running safety of the train in this situation. This study uses the IDDES method to investigate the aerodynamic characteristics of the train running on the double track bridge in both up and down train directions at different speeds. The differences in the impact of aerodynamic loads on the train’s dynamic response indicators are discussed using the wind-vehicle coupling dynamic response calculation method. Based on these researches, the operational safety of the train under different operating conditions is evaluated from both flow field and dynamic perspectives. The results show that large-scale vortices fall off from the nose of the train and form a larger vortex structure on the leeward side and when the train is running under the crosswind. Its aerodynamic loads fluctuate intensely with time due to the complex wake flow of the train. The dominant frequencies of the unsteady aerodynamic loads are mostly concentrated in the range of 0–5Hz, which is close to the natural modal frequencies of the train. This will lead to the overturning of the train due to vehicle resonance. The derailment coefficient and wheel load reduction rate of the train increase with the speed. Their peak values exceed the limit of 0.8 while the peak duration of the derailment coefficient is less than 0.05s, which means the state of the leeward wheel will recover from a short derailment. However, the duration of derailment increases with speed. Therefore, appropriate measures should be taken to prevent accidents when the train is running at higher speed on the bridge to guarantee the operational safety of the HST.