Electron Beam Dosimetry Research Articles

AAPM WGTG51 Report 385: Addendum to the AAPM's TG-51 protocol for clinical reference dosimetry of high-energy electron beams.

An Addendum to the AAPM's TG-51 protocol for the determination of absorbed dose to water is presented for electron beams with energies between 4MeV and 22MeV ( ). This updated formalism allows simplified calibration procedures, including the use of calibrated cylindrical ionization chambers in all electron beams without the use of a gradient correction. New data are provided for electron beams based on Monte Carlo simulations. Implementation guidance is provided. Components of the uncertainty budget in determining absorbed dose to water at the reference depth are discussed. Specifications for a reference-class chamber in electron beams include chamber stability, settling, ion recombination behavior, and polarity dependence. Progress in electron beam reference dosimetry is reviewed. Although this report introduces some major changes (e.g., gradient corrections are implicitly included in the electron beam quality conversion factors), they serve to simplify the calibration procedure. Results for absorbed dose per linac monitor unit are expected to be up to approximately 2% higher using this Addendum compared to using the original TG-51protocol.

Curvature correction factors for the independent verification of monitor units of electron treatment plans calculated in Eclipse.

Electron beam dosimetry is sensitive to the surface contour of the patient. Over 10% difference between Treatment Planning System (TPS) and independent monitor-unit (IMU) calculations have been reported in the literature. Similar results were observed in our clinic between Radformation ClearCalc IMU and Eclipse TPS electron Monte Carlo (eMC) algorithm (v.16.1). This paper presents data measured under 3D printed spherical and cylindrical phantoms to validate the eMC algorithm in the presence of curved geometries. Measurements were performed with multiple detectors and compared to calculations made in Eclipse for the 6, 9 and 12MeV electron energies. This data is used to create curvature correction factors (CCFs), defined as the ratio of the detector reading with the curved-surface phantom to a flat phantom at the same depth. The mean difference between the TPS calculated and measured CCFs using the NACP, Diode E, microSilicon, and microDiamond detectors were 1.3, 0.9, 0.7 and 0.7% respectively, with maximum differences of 4.5, 2.3, 1.9, and 1.8% respectively. Applying CCFs to previous failing patient IMU calculations improved agreement to the TPS. CCFs were implemented in our clinic for patient-specific IMU calculations with the assistance of a ESAPI script.

Simulation Dosimetry Studies for FLASH Radiation Therapy (RT) with Ultra-High Dose Rate (UHDR) Electron Beam

FLASH-radiotherapy (RT) presents great potential as an alternative to conventional radiotherapy methods in cancer treatment. In this paper, we focus on simulation studies for a linear particle accelerator injector design using the ASTRA code, which permits beam generation and particle tracking through electromagnetic fields. Space charge-dominated beams were selected with the aim of providing an optimized generated beam profile and accelerator lattice with minimized emittance. The main results of the electron beam and ultra-high dose rate (UHDR) simulation dosimetry studies are reported for the FLASH mode radiobiological treatment. Results for the percentage depth dose (PDD) at electron beam energies of 5, 7, 15, 25, 50, 100 MeV and 1.2 GeV for Poly-methyl-methacrylate (PMMA) and water phantom vs. the penetration depth are presented. Additionally, the PDD transverse profile was simulated for the above energies, delivering the beam to the phantom. The simulation dosimetry results provide an UHDR electron beam under the conditions of the FLASH-RT. The performance of the beam inside the phantom and the dose depth depends on the linear accelerator beam’s energy and stability.

State-of-the-art silicon carbide diode dosimeters for ultra-high dose-per-pulse radiation at FLASH radiotherapy

Objective. The successful implementation of FLASH radiotherapy in clinical settings, with typical dose rates >40 Gy s−1, requires accurate real-time dosimetry. Approach. Silicon carbide (SiC) p–n diode dosimeters designed for the stringent requirements of FLASH radiotherapy have been fabricated and characterized in an ultra-high pulse dose rate electron beam. The circular SiC PiN diodes were fabricated at IMB-CNM (CSIC) in 3 μm epitaxial 4H-SiC. Their characterization was performed in PTB’s ultra-high pulse dose rate reference electron beam. The SiC diode was operated without external bias voltage. The linearity of the diode response was investigated up to doses per pulse (DPP) of 11 Gy and pulse durations ranging from 3 to 0.5 μs. Percentage depth dose measurements were performed in ultra-high dose per pulse conditions. The effect of the total accumulated dose of 20 MeV electrons in the SiC diode sensitivity was evaluated. The temperature dependence of the response of the SiC diode was measured in the range 19 °C–38 °C. The temporal response of the diode was compared to the time-resolved beam current during each electron beam pulse. A diamond prototype detector (flashDiamond) and Alanine measurements were used for reference dosimetry. Main results. The SiC diode response was independent both of DPP and of pulse dose rate up to at least 11 Gy per pulse and 4 MGy s−1, respectively, with tolerable deviation for relative dosimetry (<3%). When measuring the percentage depth dose under ultra-high dose rate conditions, the SiC diode performed comparably well to the reference flashDiamond. The sensitivity reduction after 100 kGy accumulated dose was <2%. The SiC diode was able to follow the temporal structure of the 20 MeV electron beam even for irregular pulse estructures. The measured temperature coefficient was (–0.079 ± 0.005)%/°C. Significance. The results of this study demonstrate for the first time the suitability of silicon carbide diodes for relative dosimetry in ultra-high dose rate pulsed electron beams up to a DPP of 11 Gy per pulse.

A dose rate independent 2D Ce-doped YAG scintillating dosimetry system for time resolved beam monitoring in ultra-high dose rate electron “FLASH” radiation therapy

Preclinical studies have shown that radiotherapy treatments benefit from ultra-high dose rate (UHDR) irradiations. These trigger the FLASH-effect, resulting in a strong decrease in normal tissue toxicity with conserved tumor control probability, compared with conventional irradiations. However, the beam parameters to trigger the FLASH-effect and the radiobiological mechanisms behind it remain to be elucidated. A limiting factor in many studies is the lack of accurate real time dosimetry. In this work an innovative solution for 2D real time dosimetry in UHDR electron beams is presented and characterized.The in-house developed ImageDosis system consists of a scientific camera, with high temporal resolution, and a coating, containing 12% of Y3Al5O12:Ce3+ as scintillating material. Reference dosimetry was performed by means of radiochromic film, and a (C38H34P2)MnBr4 point scintillator was used to validate the pulse discrimination properties of the ImageDosis system. Irradiations were performed in two centers (Antwerp and Orsay), with an ElectronFlash accelerator. The ImageDosis system was tested with varying number of pulses, pulse length, pulse repetition frequency (PRF) and energy. In addition, its temporal resolution and 2D properties were investigated.The ImageDosis system showed negligible dose, dose rate and energy dependence for doses up to 13 Gy and average dose rates up to 140 Gy/s, with a dose per pulse up to 2 Gy and a PRF up to 300 Hz. The system is capable of discriminating and measuring the dose of individual pulses and shows promising 2D characteristics that need further optimization.

Development of a device to improve the precision of water surface identification for MeV electron beam dosimetry

The study aimed to develop a laser-based distance meter (LDM) to improve water surface identification for clinical MeV electron beam dosimetry, as inaccurate water surface determination can lead to imprecise positioning of ionization chambers (ICs). The LDM consisted of a laser ranging sensor, a signal processing microcontroller, and a tablet PC for data acquisition. I50 (the water depth at which ionization current drops to 50 % of its maximum) measurements of electron beams were performed using six different types of ICs and compared to other water surface identification methods. The LDM demonstrated reproducible I50 measurements with a level of 0.01 cm for all six ICs. The uncertainty of water depth was evaluated at 0.008 cm with the LDM. The LDM also exposed discrepancies between I50 measurements using different ICs, which was partially reduced by applying an optimum shift of IC's point of measurement (POM) or effective point of measurement (EPOM). However, residual discrepancies due to the energy dependency of the cylindrical chamber's EPOM caused remained. The LDM offers straightforward and efficient means for precision water surface identification, minimizing reliance on individual operator skills.

Monte Carlo calculated beam quality correction factors for high energy electron beams

Purpose:As the dosimetry protocol TRS 398 is being revised and the ICRU report 90 provides new recommendations for density correction as well as the mean ionization energies of water and graphite, updated beam quality correction factors kQ are calculated for reference dosimetry in electron beams and for independent validation of previously determined values. Methods:Monte Carlo simulations have been performed using EGSnrc to calculate the absorbed dose to water and the dose to the active volumes of ionization chambers SNC600c, SNC125c and SNC350p (all Sun Nuclear, A Mirion Medical Company, Melbourne, FL). Realistic clinical electron beam spectra were used to cover the entire energy range of therapeutic electron accelerators. The Monte Carlo simulations were validated by measurements on a clinical linear accelerator.With regards to the cylindrical chambers, the simulations were performed according to the setup recommendations of TRS 398 and AAPM TG 51, i.e. with and without consideration of a reference point shift by rcav/2. Results:kQ values as a function of the respective beam quality specifier R50 were fitted by recommended equations for electron beam dosimetry in the range of 5 MeV to 18 MeV. The fitting curves to the calculated values showed a root mean square deviation between 0.0016 and 0.0024. Conclusion:Electron beam quality correction factors kQ were calculated by Monte Carlo simulations for the cylindrical ionization chambers SNC600c and SNC125c as well as the plane parallel ionization chamber SNC350p to provide updated data for the TRS 398 and TG 51 dosimetry protocols.

Optically stimulated luminescence system as an alternative for radiochromic film for 2D reference dosimetry in UHDR electron beams

Radiotherapy is part of the treatment of over 50% of cancer patients. Its efficacy is limited by the radiotoxicity to the healthy tissue. FLASH-RT is based on the biological effect that ultra-high dose rates (UHDR) and very short treatment times strongly reduce normal tissue toxicity, while preserving the anti-tumoral effect. Despite many positive preclinical results, the translation of FLASH-RT to the clinic is hampered by the lack of accurate dosimetry for UHDR beams. To date radiochromic film is commonly used for dose assessment but has the drawback of lengthy and cumbersome read out procedures. In this work, we investigate the equivalence of a 2D OSL system to radiochromic film dosimetry in terms of dose rate independency. The comparison of both systems was done using the ElectronFlash linac. We investigated the dose rate dependence by variation of the (1) modality, (2) pulse repetition frequency, (3) pulse length and (4) source to surface distance. Additionally, we compared the 2D characteristics by field size measurements. The OSL calibration showed transferable between conventional and UHDR modality. Both systems are equally independent of average dose rate, pulse length and instantaneous dose rate. The OSL system showed equivalent in field size determination within 3 sigma. We show the promising nature of the 2D OSL system to serve as alternative for radiochromic film in UHDR electron beams. However, more in depth characterization is needed to assess its full potential.

3D Dosimetry for Electron Flash Radiotherapy: Assessment of Radiochromic Dosimeter Phantoms with Optical CT Scanning as a 3D Dosimetry System

Many of the dosimeters used in conventional radiation therapy exhibit dose rate dependence which prohibits their use in ultra-high-dose-rate (FLASH) radiation therapy. Radiochromic plastic dosimeter PRESAGE® has been used for 3D dosimetry for many years. We hypothesized that these phantoms would show dose-rate independence throughout both the conventional and FLASH RT regimes, indicating these phantoms exhibit qualities useful for relative 3D dosimetry in FLASH electron beams. FLASH experiments were performed using a commercially available linear accelerator, converted to deliver an ultra-high-dose-rate 10 MeV electron beam. The LINAC delivered approximately 0.7 Gy/pulse for FLASH irradiations. Dose rate was varied from about 40 Gy/s to 240 Gy/s by changing the repetition rate. PRESAGE phantoms were irradiated en face at six FLASH dose rates: 40 Gy/s, 80 Gy/s, 120 Gy/s, 160 Gy/s, 200 Gy/s, and 240 Gy/s. EBT film and scintillator measurements were used to verify dose delivered. The optical response of the PESAGE phantom versus delivered dose was evaluated with various known doses. A novel parallel-beam optical CT scanner, utilizing fiber optic taper for collimated images, was developed for fast, high resolution, and accurate readout of 3D dosimeters. Percent depth dose curves for various FLASH dose rates and conventional dose rate beams were generated and compared based on the optical response versus dose measurements. Percent depth dose curves from Monte Carlo calculation of the presage phantom were also compared. As shown in Table 1, the percent depth dose as a function of depth for six FLASH dose rates (240-40 Gy/s) are nearly identical, indicating that optical response of PRESAGE is dose-rate independent. The optical density of PRESAGE phantom was confirmed to be linear with absorbed dose for all FLASH dose rates, consistent with the observation at regular treatment dose rates. PRESAGE phantoms show dose-rate independence in electron beams for a wide range of dose rates from conventional to ultra-high-dose-rates, indicating these phantoms can be useful for relative 3D dose measurements in FLASH electron beams. Future experiments will be undertaken as part of the commissioning of a commercially available FLASH radiotherapy unit.

Modified calibration protocols in electron beam dosimetry: comparison with IAEA TRS-398 and AAPM TG-51

This study aimed to compare absolute calibration outputs based on the protocols of the International Atomic Energy Agency (IAEA) Technical Report Series (TRS)-398, the American Association of Physicists in Medicine (AAPM) Task Group (TG)-51, and modified calibration approach. The electron beam output calibration followed the IAEA TRS-398 and AAPM TG-51 protocols, both of which required cylindrical chambers and parallel plates. However, the use of cylindrical chambers is not recommended at low energies because of the large fluence-correction factor. TG-51 recommended cross-calibration of the parallel-plate chamber against the cylindrical chamber in a high-energy electron beam. In 2020, an electron beam dosimetry modification was introduced that used a cylindrical ionisation chamber at all energies and updated the data for beam quality conversion factors. This modification provided a lower deviation than that reported in AAPM TG-51. Thus, the modified calibration based on TRS-398 was applied in the present study, which yielded results below the permissible tolerance. The beam calibration at 6, 8, 10, 12, and 15 MeV energies was carried out for two Elekta linear accelerators.. Electron beam dosimetry followed the AAPM TG-51 and TRS-398 protocols, and modified calibration were performed to measure the dose at the maximum depth expressed in dose/monitor units (cGy/MU). Charge-reading measurements were measured using ionisation chambers PTW 30013, IBA CC13, and Exradin A11. The average absorbed dose ratios were 1.004 and 1.009 using the modified calibration and TRS-398 and modified calibration and TG-51, respectively. Therefore, based on IAEA TRS-398, the results were below the tolerance limit (±2%).

Investigation of TL and OSL detectors in ultra-high dose rate electron beams

Objective. This work aims at investigating the response of various thermally stimulated luminescence detectors (TLDs) and optically stimulated luminescence detectors (OSLDs) for dosimetry of ultra-high dose rate electron beams. The study was driven by the challenges of dosimetry at ultra-high dose rates and the importance of dosimetry for FLASH radiotherapy and radiobiology experiments. Approach. Three types of TLDs (LiF:Mg,Ti; LiF:Mg,Cu,P; CaF2:Tm) and one type of OSLD (Al2O3:C) were irradiated in a 15 MeV electron beam with instantaneous dose rates in the (1–324) kGy s−1 range. Reference dosimetry was carried out with an integrating current transformer, which was calibrated in absorbed dose to water against a reference ionization chamber. Additionally, dose rate independent BeO OSLDs were employed as a reference. Beam non-uniformity was addressed using a matrix of TLDs/OSLDs. Main results. The investigated TLDs were shown to be dose rate independent within the experimental uncertainties, which take into account the uncertainty of the dosimetry protocol and the irradiation uncertainty. The relative deviation between the TLDs and the reference dose was lower than 4 % for all dose rates. A decreasing response with the dose rate was observed for Al2O3:C OSLDs, but still within 10 % from the reference dose. Significance. The precision of the investigated luminescence detectors make them suitable for dosimetry of ultra-high dose rate electron beams. Specifically, the dose rate independence of the TLDs can support the investigation of the beam uniformity as a function of the dose rate, which is one of the challenges of the employed beam. Al2O3:C OSLDs provided high precision measurements, but the decreasing response with the dose rate needs to be confirmed by additional experiments.

Analysis of different protocols using an Exradin A12 cylindrical chamber for electron beam reference dosimetry

The Technical Report Series 398 (TRS-398), Electron Dosimetry Working Party (EWDP), and Task Group 51 (TG 51) are the most important protocols for reference dosimetry. In the case of electron beam reference dosimetry, these protocols recommend using parallel-plate ionization chambers for beams with R50 values below specific thresholds. However, recent papers suggested using cylindrical chambers for reference dosimetry of all electron beam energies. Here we compared different protocols using a cylindrical chamber with the recommendations of using a parallel-plate chamber and the TRS-398 formalism for the dosimetry of several electron beam energies. We employed electron beams with nominal energies of 4, 6, 9, 12, and 15 MeV of a Varian 2100C linear accelerator, an Exradin A12, and an Exradin P11 chamber for the analysis. The results showed differences below 3% when comparing the cylindrical chamber and alternative protocols with the parallel-plate chamber and the TRS-398 formalism for electron beams reference dosimetry. These results can bring confidence in using a cylindrical chamber for reference electron beam dosimetry, which can make the electron beam dosimetry procedure simpler and faster.

Current Approach of Small Field Electron Beam for Head and Neck Cases

Regarding the increasing use of small-field photons in clinical treatment, in this study, we investigate the use of small-field electron beams in clinical treatment. This study aimed to evaluate small-field electron beam dosimetry of the nasopharyngeal, thyroid, and ethmoid sinus carcinoma cases. Dose measurement was done using EBT3 film. In nasopharyngeal cases with a homogenous area and irregular surface, the dose discrepancies for 6 MeV energy were unpredictable except for the 5×5 cm2 field size. For all energies in 5×5 cm2 field size, the dose discrepancies were less than 3%. In these cases, we found that a smaller electron beam field will increase the percentage of the dose discrepancy. This is caused by the effect of the lateral scatter disequilibrium in a small field electron beam. For ethmoid sinus cases, dose discrepancy depends on the field size and inhomogeneity of bone and tissue organ. Based on the evaluation of doses on the spinal cord, chiasm, and larynx (OAR), it can be seen that these organs received a very small dose. From this result, a small field electron beam is recommended for cases with a homogeneous target. However, in cases with a heterogenous target, further investigation is needed.

Experimental investigation of the effective point of measurement for plane-parallel chambers used in electron beam dosimetry.

In this study, the effective point of measurement (EPOM) for plane-parallel ionization chambers in clinical high-energy electron beams was determined experimentally. Previous studies have reported that the EPOM of plane-parallel chambers is shifted several tens of millimeters downstream from the inner surface of the entrance window to the cavity. These findings were based on the Monte Carlo (MC) simulation, and few experimental studies have been performed. Thus, additional experimental validations of the reported EPOMs were required. In this study, we investigated the EPOMs of three plane-parallel chambers (NACP-02, Roos and Advanced Markus) for clinical electron beams. The EPOMs were determined by comparing the measured percentage depth-dose (PDD) of the plane-parallel chambers and the PDD obtained using the microDiamond detector. The optimal shift to the EPOM was energy-dependent. The determined EPOM showed no chamber-to-chamber variation, thereby allowing the use of a single value. The mean optimal shifts were 0.104±0.011, 0.040±0.012, and 0.012±0.009cm for NACP-02, Roos, and Advanced Markus, respectively. These values are valid in the R50 range from 2.40 to 8.82cm, which correspond to 6-22 MeV. Roos and Advanced Markus exhibited similar results to those of the previous studies, but NACP-02 showed a larger shift. This is probably due to the uncertainty of the entrance window of NACP-02. Therefore, it is necessary to carefully consider where the optimal EPOM is located when using this chamber.

Comparison of effective atomic number, output factor, and glow curve of fabricated Ge-doped optical fibers (FGDOFs) for electron beams dosimetry

The present study is extended from a previous study on advanced characteristics for Fabricated Ge-Doped Optical Fibers (FGDOFs) in electron beam dosimetry with comparison in terms of Effective Atomic Number (Zeff), Output Factor (OF), and Glow Curve Analysis. Other than that, the different shapes and germanium dopant concentrations of FGDOFs were studied. Regarding Zeff, Flat Fiber (FF) showed lower Zeff than Cylindrical Fiber (CF) at a difference of ±7%. No significant difference at p > 0.05 for the of 6, -9, and 12 MeV electron energies. WinGCF software was used to deconvolute the glow curve, with the best fitting for FF and CF. Results from Glow Curve Analysis showed that the Maximum Temperature (Tmax) was energy independent for all CFs and FFs. Peak 3 (P3) was for the significantly deep holes for FF (2.3% mol; 643 μm × 356 μm), CF (2.3% mol; 481 μm), and CF (6.0% mol; 486 μm) while peak 4 (P4) for FF (6.0% mol; 620 μm × 165 μm) and CF (6.0% mol; 616 μm), respectively. Both FF (2.3% mol and 6.0% mol) have the greater sensitivity with the highest thermoluminescence (TL) signal due to the highest activation energy compared to CFs.

On the measurement of scaling factors in the RW3 plastic phantom during high energy electron beam dosimetry.

Ionometric electron dosimetry inside water-equivalent plastic phantoms demands special considerations including determination of depth scaling and fluence scaling factors (cpl and hpl) to shift from in-phantom measurements to those relevant to water. This study evaluates these scaling factors for RW3 slab phantom and also introduces a new coefficient, k(RW3), for direct conversion from RW3 measurements to water without involving scaling factors. The RW3 solid phantom developed by the PTW Company was used and the corresponding scaling factors including cpl, hpl, and k(RW3) were measured for conventional electron energies of 4, 6, 9, 12, and 16MeV. Separate measurements were performed in water and the RW3 slab phantom using the Advanced Markus chamber. The validity of the reported scaling factors was confirmed by comparing the direct and indirect percentage depth dose (PDD) measurements in water and in the RW3 phantom. The cpl values for the RW3 phantom were respectively equal to 0.915, 0.927, 0.934, 0.937, and 0.937 for 4, 6, 9, 12, and 16MeV electron energies. The hpl and k(RW3) values were dependent on the depth of investigation and electron energy. Application of the cpl-hpl factors and k(RW3) coefficients to measured data inside the RW3 can reliably reproduce the measured PDD curves in water. The mean difference between the PDDs measured directly and indirectly in water and in the RW3 phantom was less than 1.2% in both approaches for PDD conversion (cpl-hpl coupling and the use of k(RW3)). The measured scaling factors and k(RW3) coefficients are sufficiently relevant to mimic water-based dosimetry results through indirect measurements inside the RW3 slab phantom. Nevertheless, employing k(RW3) is more straightforward than the cpl-hpl approach because it does not involve scaling and it is also less time-consuming.

Characteristics Performance of Newly Developed Parallel Plate Chamber in Electron Beams.

To investigate the dosimetric performance of newly developed parallel plate chamber in electron beams. Rosalina Instruments India Private Limited (Mumbai, Maharashtra, India) has designed and fabricated PRATT2 parallel plate chamber. The various dosimetric characteristics, including pre- and post-irradiation leakage, stability, polarity effect, chamber response with bias voltage, dose linearity, dose rate effect, and chamber absorbed dose calibration, were performed for the developed chamber. The electron beam energies of 4, 6, 8, and 15MeV were used in this study. The pre- and post-irradiation leakage of the developed chamber was within the acceptable limit. The chamber shows good stability over the electron beams used in this study. The maximum error in polarity effect was 0.7% for the developed chamber. The chamber shows the good linear response with dose, and its response is independent of the dose rate for all electron beams. The beam quality correction factor (kQ, Q0) was determined for the all electron beam energies, which was used for determination absorbed dose in electron beams. The developed parallel plate chamber (PRATT2) is suitable for dosimetry of electron beams in radiotherapy. The chamber is cost effective and shows precise and reproducible response. The study carried out confirms that the newly designed and fabricated ion chamber can be used in the measurement of absorbed dose for therapeutic electron beams.

Comparison of commercially available detectors used for the dosimetry of the High Energy Electron Beams.

In modern radiotherapy, electron beams are used less and less often. However, there are still techniques where this type of particles is irreplaceable, like intraoperative radiotherapy (IORT) or total skin electron irradiation (TSEI). Due to low range of electrons penetrating the medium, dosimetric measurements and beam characteristics are challenging. One of the most important steps during this process is to select the right detector in order to collect reliable data. The purpose of this work was to perform beam characteristics using six commercially available detectors: Semiflex 3D (Type 31021), Advanced Markus (Type 34045), Markus (Type 23343), Roos (Type 34001), microDiamond (Type 60019), Diode E (Type 60017). Collected data shows various parameters describing electron beams, depending on the used detector. Obtained results showed that the most useful detector for beam characteristics is microDiamond Type 60019. Thanks to the very small effective volume, microDiamond showed a superior spatial resolution, which is especially handful during the measurements of dose profiles, allowing estimating beam parameters very precisely.

AAPM WGTG51 Report 374: Guidance for TG-51 reference dosimetry.

Practical guidelines that are not explicit in the TG-51 protocol and its Addendum for photon beam dosimetry are presented for the implementation of the TG-51 protocol for reference dosimetry of external high-energy photon and electron beams. These guidelines pertain to:(i)measurement of depth-ionization curves required to obtain beam quality specifiers for the selection of beam quality conversion factors, (ii)considerations for the dosimetry system and specifications of a reference-class ionization chamber, (iii)commissioning a dosimetry system and frequency of measurements, (iv)positioning/aligning the water tank and ionization chamber for depth ionization and reference dose measurements, (v)requirements for ancillary equipment needed to measure charge (triaxial cables and electrometers) and to correct for environmental conditions, and (vi)translation from dose at the reference depth to that at the depth required by the treatment planning system. Procedures are identified to achieve the most accurate results (errors up to 8% have been observed) and, where applicable, a commonly used simplified procedure is described and the impact on reference dosimetry measurements is discussed so that the medical physicist can be informed on where to allocateresources.

Polymer-Gel Radiation Dosimetry of Laser-Based Relativistic Electron Sources for Biomedical Applications: First Qualitative Results and Experimental Challenges

The generation of laser based relativistic electron sources involves impressive basic science as well as innovative applications. This study reports first novel qualitative results on polymer-gel radiation dosimetry of ultrafast laser-based relativistic electron beams. The fabricated polymer-gels are irradiated by the ultra-high dose rate (FLASH) laser-generated electron beams and then are analysed using magnetic resonance imaging. The reading of the irradiated dosimeters is performed using a clinical 1.5 T Magnetic Resonance Imaging system. Three-dimensional colour parametric T2 maps are then constructed from the original PD-T2 weighted images obtained from the clinical MRI scanner. For comparison, the gels are also irradiated with standard electron beams of various energies utilizing a radiotherapy clinical linear accelerator system. For the calibration measurements of the gel dosimetry method, special calibrated dosimetric films are also implemented. The preliminary results demonstrate the potential of polymer gel dosimetry for 3D-dose-distribution of FLASH type irradiation of laser generated electron beams. Furthermore, they illustrate potential issues related to the polymer gel based dosimetry in challenging irradiation arrangements, such as the oxygen sensitivity and necessity for oxygen impermeable container material.