3D Dosimetry for Electron Flash Radiotherapy: Assessment of Radiochromic Dosimeter Phantoms with Optical CT Scanning as a 3D Dosimetry System

Abstract

Many of the dosimeters used in conventional radiation therapy exhibit dose rate dependence which prohibits their use in ultra-high-dose-rate (FLASH) radiation therapy. Radiochromic plastic dosimeter PRESAGE® has been used for 3D dosimetry for many years. We hypothesized that these phantoms would show dose-rate independence throughout both the conventional and FLASH RT regimes, indicating these phantoms exhibit qualities useful for relative 3D dosimetry in FLASH electron beams. FLASH experiments were performed using a commercially available linear accelerator, converted to deliver an ultra-high-dose-rate 10 MeV electron beam. The LINAC delivered approximately 0.7 Gy/pulse for FLASH irradiations. Dose rate was varied from about 40 Gy/s to 240 Gy/s by changing the repetition rate. PRESAGE phantoms were irradiated en face at six FLASH dose rates: 40 Gy/s, 80 Gy/s, 120 Gy/s, 160 Gy/s, 200 Gy/s, and 240 Gy/s. EBT film and scintillator measurements were used to verify dose delivered. The optical response of the PESAGE phantom versus delivered dose was evaluated with various known doses. A novel parallel-beam optical CT scanner, utilizing fiber optic taper for collimated images, was developed for fast, high resolution, and accurate readout of 3D dosimeters. Percent depth dose curves for various FLASH dose rates and conventional dose rate beams were generated and compared based on the optical response versus dose measurements. Percent depth dose curves from Monte Carlo calculation of the presage phantom were also compared. As shown in Table 1, the percent depth dose as a function of depth for six FLASH dose rates (240-40 Gy/s) are nearly identical, indicating that optical response of PRESAGE is dose-rate independent. The optical density of PRESAGE phantom was confirmed to be linear with absorbed dose for all FLASH dose rates, consistent with the observation at regular treatment dose rates. PRESAGE phantoms show dose-rate independence in electron beams for a wide range of dose rates from conventional to ultra-high-dose-rates, indicating these phantoms can be useful for relative 3D dose measurements in FLASH electron beams. Future experiments will be undertaken as part of the commissioning of a commercially available FLASH radiotherapy unit.