Objective: comprehend the stigmatization of the homeless population, its relationship with drug use, gender and its consequences from the perspective of the assistance personnel in Medellin. Methods: qualitative research with a descriptive-interpretative scope. Data were generated through focus groups. The information was analyzed with grounded theory techniques and contrasted with the scientific literature on the subject. Results: two conceptions of the homeless person emerged: disposable and citizen. About gender, the multiple stigmas towards women and the LGBTI population living on the streets were highlighted, and the consequences of stigmatization were described. Conclusion: Living on the street and having a lifestyle contrary to the dominant values, makes homeless people to be discriminated, dehumanized and corrected by society, which is worse when belong to non-hegemonic genders, this situation limits the guarantee of fundamental human rights, especially the right to health.