Aim . To confirm association between sudden cardiac death (SCD) and single nucleotide polymorphisms rs6582147 rs 10010305, rs2136810, rs17797829, identified as the most likely candidate markers. Material and methods . The SCD group (n=360, mean age 53,0±9,2 years, men — 76,9%, women — 23,1%) was formed using the SCD criteria of the European Society of Cardiology. The control group (n=402, mean age 52,9±9,1 years, men — 69,7%, women — 30,3%) was selected by gender and age from the DNA bank of international studies MONICA, HAPIEE. DNA is separated by phenol-chloroform extraction. Genotyping was performed by polymerase chain reaction followed by analysis of restriction fragment length polymorphism. Results . The GT rs6582147 genotype is associated with a protective effect on SCD (OR=0,671, 95% CI 0,496-0,909, p=0,011), and the GG genotype with an increased risk of SCD (OR=1,598, 95% CI 1,195-2,135, p=0,002). The greatest effect was in the group of men over 50 years old (p<0,05). The CT rs10010305 genotype is associated with SCD in the group of men (OR=1,773, 95% CI 1,085-2,897 p=0,027), in the group of men over 50 years old (p<0,05) and in the group of people over 50 years old without separation according to sex (OR=1,719, 95% CI 1,038-2,847 p=0,041). The GG rs2136810 genotype is associated with an increased risk of SCD (OR=1,372, 95% CI 1,005-1,871, p=0,049); in the group of people over 50, the GA rs2136810 genotype is associated with a protective effect against SCD (OR=0,642, 95% CI 0,422-0,976, p=0,045). In the group of women, the GG rs17797829 genotype is protective for SCD (OR=0,392, 95% CI 0,203-0,760, p=0,007), in the group of women over 50, except for the GG genotype, the AA genotype of the same polymorphism is associated (OR=2,739, 95% CI 2,176-3,448, p=0,020). Conclusion . According to the results of study, single nucleotide polymorphisms rs6582147 rs10010305, rs2136810, rs17797829 confirmed the association with SCD.