Streptomyces, known primarily for their prolific production of antibiotics, have recently garnered attention for their antioxidant properties. Antioxidants play a vital role in neutralizing harmful free radicals, thus protecting cells from oxidative damage and ultimately reducing the risk of various diseases. This review aims to comprehensively explore the antioxidant capabilities of Streptomyces spp., shedding light on their mechanisms of action, bioactive compounds involved, and potential applications in medicine and food industries. Streptomyces is a widely studied genus of bacteria that is known for its diverse metabolic capabilities and production of bioactive compounds. In recent years, there has been increasing interest in the antioxidant properties of Streptomyces and their potential applications in various industries, including pharmaceuticals, food, and cosmetics. Ulcerative diseases, particularly gastric and duodenal ulcers, pose a significant burden on public health worldwide. The search for effective therapeutic agents with anti-ulcer properties has led to the exploration of various natural sources, including Streptomyces. Streptomyces is a diverse genus of bacteria known for its ability to produce bioactive compounds with diverse biological activities. This review article aims to provide a comprehensive overview of the anti-ulcer properties of Streptomyces, the antioxidant properties of Streptomyces, including the mechanisms of action, bioactive compounds involved, and the potential therapeutic applications.