In order to investigate the bearing characteristics of inclined straight alternating pile groups under vertical and horizontal loads, the indoor model test of 2 × 2 inclined straight alternating pile groups with two layers of soil on low pile caps was carried out, the manufacturing method of inclined straight alternating pile groups was studied, and the test scheme was reasonably designed. In the test, the fast maintenance load method was used to simulate vertical loads, and the horizontal force loading frame was designed to simulate horizontal loads. The experimental data were obtained by pasting strain gauges on the pile body, and the computer was used to process the data according to the mechanical formula. The distribution of axial force, lateral friction resistance, and end resistance of each characteristic pile of the pile group foundation was obtained, and the settlement law of the pile group was analyzed. At the same time, combined with the test data and the existing theories, the interaction mechanism between pile caps, piles, and soil of inclined and straight alternating pile groups is discussed. The load sharing characteristics between piles and pile caps are analyzed, and the horizontal load is in the proportion between straight piles and inclined piles. The stress characteristics of straight piles and pile groups in the pile group system are compared and analyzed, and some valuable conclusions are obtained.