Aiming at solving the effective data delivery and energy hole problem in multi-hop cognitive radio sensor networks (CRSNs), a weighted energy consumption minimization-based uneven clustering (ECMUC) routing protocol is proposed in this paper. For the first time, the impact of control overhead on the network performance is taken into consideration, to be specific, the energy consumption of control overhead is integrated with that of data communication to model the network energy consumption. Through effective transformation and theoretical analysis, cluster radius of each ring is derived by minimizing the network energy consumption and balancing the residual energy among nodes in different rings. Distributed cluster heads (CHs) selection and cluster formation are carried out within this range to control the cluster size and the corresponding energy cost. Expected times for being CHs metric is defined to measure nodes’ energy and spectral potential and help select powerful CHs. Simulation results show that ECMUC protocol is superior to most clustering protocols designed for CRSNs in terms of network surveillance capability and network lifetime, and it is also demonstrated that taking control overhead into consideration is beneficial for improving the network performance.