Cultivation of some herbal medicinal plants was made by irrigation with distillery spentwash of different concentrations. The spentwash i.e., primary treated spentwash (PTSW), 50% and 33% spentwash were analyzed for their plant nutrients such as nitrogen, phosphorous, potassium and other physical and chemical characteristics. Experimental soil was tested for its chemical and physical parameters. Seeds of herbal medicinal plants were sown in the prepared land and irrigated with raw water (RW) 50% and 33% spentwash. The influence of spentwash on the yields of herbal medicinal plants at their respective maturity was investigated. It was found that the yields of all herbal medicinal plants were more in 33% spentwash irrigation than raw water and 50% spentwash irrigations.