SummaryTargets withstanding high beam power for production of68Ge by proton irradiation of Ga were developed using electrodeposition of Ga/Ni alloy (70/30%) on thick Cu backings. Cross sections for reactions, induced by protons (up to 36MeV) and deuterons (up to 50MeV), producing γ-emitting radioisotopes with half-lives longer than 2 h were measured in a stacked-foil irradiation using thin Ga/Ni targets produced with this technique. Excitation functions for68,69Ge are discussed, relative to the monitor reactionsnatCu(p, x)62Zn ornatAl(d, x)24,22Na. The results are compared to the scarce literature values. From derived thick target yields, optimal energy domain and batch yields for68Ge production were calculated and contamination (from69Ge and71Ge) is discussed. A PC-controlled, automated dissolution and separation chemistry set-up for delivery of nca69Ge was developed (yield about 90%) and implemented in an industrial system ready to be mounted in a hot cell.