We present a comprehensive study of the production of top quark pairs in association with one hard jet in the di-lepton decay channel at the LHC. Our predictions, accurate at NLO in QCD, focus on the LHC Run II with a center-of-mass energy of 13 TeV. All resonant and non-resonant contributions at the perturbative order ${\cal O}(\alpha_s^4 \alpha^4)$ are taken into account, including irreducible backgrounds to $t\bar{t}j$ production, interferences and off-shell effects of the top quark and the $W$ gauge boson. We extensively investigate the dependence of our results upon variation of renormalisation and factorisation scales and parton distribution functions in the quest for an accurate estimate of the theoretical uncertainties. Additionally, we explore a few possibilities for a dynamical scale choice with the goal of stabilizing the perturbative convergence of the differential cross sections far away from the $t\bar{t}$ threshold. Results presented here are particularly relevant for searches of new physics as well as for precise measurements of the top-quark fiducial cross sections and top-quark properties at the LHC.