Digestive System Disorders Research Articles

In-Hospital Mortality in Patients with and without Dementia across Age Groups, Clinical Departments, and Primary Admission Diagnoses.

Studies have reported higher in-hospital mortality rates in patients living with dementia (PlwD) with limited evidence across age groups, clinical departments, and admission diagnoses. The aim of this study was to compare the in-hospital mortality rate of PlwD with patients without dementia across groups, clinical departments, and admission diagnoses. This case-control study included patients aged ≥ 60 years hospitalized in 1 of 14 German hospitals between January 2019 and July 2023. PlwD were matched to patients without dementia. The associations between dementia and in-hospital mortality across groups were assessed using univariable logistic regression analyses. 15,956 patients with and 15,956 without dementia were included (mean age: 83.9 years, 60.7% female). PlwD had a significantly higher in-hospital mortality rate (14.0% vs. 11.7%; OR 1.24, 95% CI: 1.16-1.32) than non-dementia controls. The highest excess mortality rate was observed in the youngest age group (60-70 years: 10.9% vs. 5.7%; OR: 2.05, 95% CI: 1.30-3.24), decreased with age, and became non-significant in the oldest age group (≥90 years: 16.2% vs. 17.3%; OR: 0.93, 95% CI: 0.80-1.08). Significant differences were found for digestive system disorders (OR: 1.59; 95% CI: 1.15-1.89), cardiovascular and cerebrovascular disorders (OR: 1.51; 95% CI: 1.30-1.75), endocrine, nutritional, and metabolic diseases (OR: 1.42; 95% CI: 1.06-1.90), and pneumonia (OR: 1.20; 95% CI: 1.04-1.37), as well as for all clinic departments except for geriatric departments. The excess mortality rate was highest in younger age groups, where the general mortality and complication rate is relatively low in the general population. Appropriate approaches are needed, especially in non-geriatric wards.

Kandungan Fitokimia Daun Asam Jawa dan Potensinya sebagai Bioagen Antibakteri untuk Pengobatan Alami

Indonesia is known as a country that is abundant in various biological riches and their potential as medicines, so a review of natural antidiarrheal treatment methods using tamarind leaves was carried out. Diarrhea is a digestive disorder with a high prevalence rate, especially in developing countries. Diarrhea is a digestive system disorder characterized by stomach cramps, a liquid stool consistency, and an increase in the frequency of defecation more than 3 times in 24 hours. The research method used is to use literature review through online publications based on the Web, ResearchGate, Google Scholar and Scopus. The research sample used in this literature review was 22 articles. The research results show that the phytochemical content of tamarind consists of tannins, flavonoids, saponins, alkaloids, phenols and triterpenoids. The results of the analysis in the literature review show that tamarind leaves are an alternative natural treatment and are effective in inhibiting the growth of bacteria, for example the Escherichia coli bacteria that causes diarrhea.

The effects of gastrointestinal diet therapy for chronic pathologies of the digestive system in cats

Gastroeintestinal diseases are one of the most common groups of diseases among small domestic animals. The gastro-intestinal tract includes the oral cavity, pharynx, esophagus, stomach, pancreas, small intestine and large intestine. General signs of digestive system disorders in cats with diseases of the digestive tract are vomiting, regurgitation, capricious appetite, as well as various defecation disorders: diarrhea, coprostasis, various inclusions in feces (blood, mucus). Diseases of the gastrointestinal tract of a chronic nature often involve the manifestation of symptoms on an ongoing basis or are recur-rent in nature. Chronic gastritis, enteropathy, pancreatitis require specialized diets that normalize the functioning of the digestive tract and help improve digestive function. These therapeutic complete diets are presented in ready-made feeds in dry (pellets) and wet (pates, pouches) variations from many manufacturers of industrial feeds. Dietary therapy is required long-term or lifelong; during remission it is the basis in the treatment of chronic patients. The compositions of these diets take into account the physiological and specific needs of the animal, and are also developed on the basis of easily digestible ingredients and a reduced amount of fat, but completely replenishing the required amount of calories.

Supplementation of Crataegi fructus alleviates functional dyspepsia and restores gut microbiota in mice.

Functional dyspepsia (FD), also known as non-ulcerative dyspepsia, is a common digestive system disorder. In this study, an FD model was established using hunger and satiety disorders combined with an intraperitoneal injection of L-arginine. Indices used to evaluate the efficacy of hawthorn in FD mice include small intestinal propulsion rate, gastric residual rate, general condition, food intake, amount of drinking water, gastric histopathological examination, and serum nitric oxide (NO) and gastrin levels. Based on the intestinal flora and their metabolites, short-chain fatty acids (SCFAs), the mechanism of action of Crataegi Fructus (hawthorn) on FD was studied. The fecal microbiota transplantation test was used to verify whether hawthorn altered the structure of the intestinal flora. The results showed that hawthorn improved FD by significantly reducing the gastric residual rate, increasing the intestinal propulsion rate, the intake of food and drinking water, and the levels of gastrointestinal hormones. Simultaneously, hawthorn elevated substance P and 5-hydroxytryptamine expression in the duodenum, reduced serum NO levels, and increased vasoactive intestinal peptide expression in the duodenum. Notably, hawthorn increased the abundance of beneficial bacteria and SCFA-producing bacteria in the intestines of FD mice, decreased the abundance of conditional pathogenic bacteria, and significantly increased the SCFA content in feces. The mechanism by which hawthorn improves FD may be related to the regulation of intestinal flora structure and the production of SCFAs.

32 Hypermobile Ehlers-Danlos Syndrome: Phenotypic Presentation, Comorbidity Risk, and Medical Service Utilization in the United States

OBJECTIVES/GOALS: Hypermobile Ehlers-Danlos syndrome (hEDS) is a heritable connective tissue disorder with no known genetic etiology. Its complex phenotypic presentation with multi-system involvement delays proper diagnosis and treatment, especially for females. This study examines the risk for common hEDS comorbidities and medical service utilization. METHODS/STUDY POPULATION: Electronic health records from over 150 million patients across 92 American healthcare servers were queried using the TriNetX database to determine phenotypic presentation of hEDS and risk of receiving comorbid diagnoses. Contingency tables were created with hEDS as the condition and postural orthostatic tachycardia syndrome (POTS) or gastroparesis as the grouping variables. Advanced analytics were conducted to compare outcomes of two cohorts: (1) patients diagnosed with hEDS and both POTS and gastroparesis, and (2) patients with a sole diagnosis of hEDS. After propensity score matching, differences in medical service utilization and mental health diagnoses were assessed between these two cohorts. All analyses restricted age (12-70 years) and employed established exclusion criteria (e.g., diabetes). RESULTS/ANTICIPATED RESULTS: TriNetX national health records (N = 1,968) reveal that hEDS predominantly affects females (87%) and is diagnosed at a mean of 35 years of age. People diagnosed with hEDS have a high prevalence of comorbid nervous system (81%), mental health (76%), and digestive system (69%) disorders. They are 29.7 times more likely to be diagnosed with POTS [95% CI: 27.1, 32.6] and 66.3 times more likely to be diagnosed with gastroparesis [95% CI: 56.5, 77.9], compared to people without hEDS. After propensity score matching for sex, race, and ethnicity, people diagnosed with hEDS and both POTS and gastroparesis have significantly greater service utilization (72.2% vs. 56.7%; z = 2.18, p < .05) but not a greater incidence of mental health disorders (34.4% vs. 24.4%; z = 1.47, p = .14) than people diagnosed with hEDS alone. DISCUSSION/SIGNIFICANCE: This study reveals the phenotypic presentation of hEDS and the elevated risk of co-occurring POTS and/or gastroparesis diagnosis. hEDS and its comorbidities are associated with more frequent medical encounters but not with a greater incidence of mental illness. Findings have implications for both clinical practice guidelines and further research.

Environmental virology linked to waterborne diseases and foodborne pathogens: Human and animal food viruses

Foodborne illnesses constitute a serious global one health issue. The transmission of foodborne viruses can occur due to inadequate hygiene of food, lack of basic sanitation, poor personal hygiene and consumption of raw or undercooked food. This study aims overview about environmental virology linked to waterborne diseases and foodborne pathogens in human and animal food viruses. Thus, epidemiological studies have proposed some emerging pathogens as possible transmitters of contaminated water ingestion based on biochemical properties and viral structures such as: Picornaviridae (polioviruses, enteroviruses, coxsakiviruses, hepatitis A viruses and echoviruses), Adenoviridae (adenoviruses), Caliciviridae (noroviruses, caliciviruses, astroviruses), and Reoviridae (reoviruses and rotaviruses). These viruses can cause gastrointestinal, liver and central nervous system disorders. In controlling foodborne infections, accurately identifying sources of contamination is a significant challenge, given the complexity of the food production chain. The lack of adequate monitoring and neglect of good health practices contribute to the spread of these infections. Large-scale immunization has contributed to the reduction of enteric outbreaks and eradication of cases in many regions of the world as a prevention of hepatitis A and poliomyelitis. However, challenges such as the lack of effectiveness in inspecting viruses in food increase the risk of outbreaks and epidemics, with emphasis on Noroviruses as the main causes of these infections today. Investment in vaccine research and development has been a fundamental strategy to reduce these statistics, especially in vulnerable groups. Moreover, the implementation molecular-based tools and wastewater-based epidemiology studies to high-throughput for aquatic biomonitoring should be up to date to avoid the risk and impact on public health and aquatic environments. Novel perspectives to control of waterborne viruses has been introduced in continuous surveillance programs for ecosystems monitoring.

Obesity and Gastrointestinal Regulation of Food Intake

The aim in this review is to explain the role of the gastrointestinal system in obesity and related complications by focusing on the biological mechanisms between obesity and the gastrointestinal system, based on the latest evidence in the literature. A systematic search of the literatures in the PubMed and ScienceDirect databases was conducted. Factors such as inflammation, mechanical space-occupying effect, microbiota, and adipocyte peptides are involved the development of obesity-related gastrointestinal system comorbidities. However, obesity occurs when the connection between the gastrointestinal tract and the brain changes. Signaling dysfunction disrupts the brain-gut axis, leading to increased frequency of food intake and excessive fat accumulation. Obesity increases the risk of developing gastrointestinal system disorders. However, the gastrointestinal tract and its pathophysiology play a key role the regulation of food intake and subsequent progression to obesity.

Unraveling the immunological landscape in acute pancreatitis progression to sepsis: insights from a Mendelian randomization study on immune cell traits.

Acute pancreatitis (AP) is a severe digestive system disorder with a significant risk of progressing to sepsis, a major cause of mortality. Unraveling the immunological pathways in AP is essential for developing effective treatments, particularly understanding the role of specific immune cell traits in this progression. Employing a bidirectional two-sample Mendelian Randomization (MR) approach, this study first examined the causal relationship between AP and 731 immune cell traits to identify those significantly associated with AP. Subsequently, we explored the causal associations between 731 immune cell traits and sepsis. The analysis utilized extensive genome-wide association studies (GWAS) summary datasets, with a focus on identifying common immune cell traits with statistically significant causal associations between AP and sepsis. Our investigation identified 44 immune cell traits unidirectionally associated with AP and 36 traits unidirectionally associated with sepsis. Among these, CD127 on CD28+ CD45RA- CD8+ T cells emerged as a common mediator, accounting for 5.296% of the increased risk of sepsis in AP patients. This finding highlights the significant role of specific memory CD8+ T cells in the pathophysiology of AP and its progression to sepsis. This study elucidates the critical role of specific immune cell traits, particularly CD127hi memory CD8+ T cells, in the progression of AP to sepsis. Our findings provide a foundation for future research into targeted immune-modulatory therapies, potentially improving patient outcomes in AP-related sepsis and offering new insights into the complex immunological dynamics of this condition.

Analisis Asuhan Keperawatan Pada Pasien Dengan Gangguan Sistem Pencernaan

According to data released by the Ministry of Health of the Republic of Indonesia regarding the incidence of appendicitis in Indonesia in 2016, the number of patients with appendicitis in Indonesia reached 591,819 people and increased in 2017 by 596,132 people (Soewito, 2017). The incidence of appendicitis in 2018 reached 7 of the world's population. In 2018 the incidence of appendicitis in most parts of Indonesia is still high. In Indonesia, the number of patients suffering from appendicitis is about 7% of the total population or about 179,000 people (Depkes, 2018). The author's goal is to be able to provide nursing care for post-operative appendectomy patients with acute pain nursing problems. Appendicitis is a painful swelling of the appendix with the management of appendectomy, namely surgery to remove the appendix, surgery is indicated when the diagnosis of appendicitis has been established. The research method used is a case study. Samples were taken according to the inclusion criteria of patients with post-appendectomy digestive system disorders with acute pain problems. The care was carried out for 3 days at the Bekasi District Hospital. Data was collected by: interviews, observations, physical examinations, and documentation studies. Data were analyzed narratively based on a comparison of two patients. Patient data 1 and 2 have been supportive to raise the problem of acute pain and its implementation has been implemented and there are no obstacles.

Evaluation of functional gastrointestinal disorders in children aged 4-10 years with autism spectrum disorder.

Gastrointestinal system disorders are known to be prevalent among children with autism spectrum disorder (ASD). Some ASD-associated comorbidities are abdominal pain, constipation, diarrhea, gastroesophageal reflux, sleep disturbances, epilepsy, and psychiatric problems. Nonetheless, there is still limited information about the presence of functional GI disorders (FGIDs) among children with ASD, especially in Türkiye. Using the Rome criteria, we aimed to investigate FGIDs in children with ASD. The sample of the study consisted of 68 children aged 4-10 years, diagnosed with ASD according to the DSM-5 diagnostic criteria and had scores greater than 30 on the Childhood Autism Rating Scale (CARS-2) and an age-sex matched control group (n=78). The Rome III criteria were used to evaluate FGIDs. The frequency of FGIDs in the ASD group was higher (76.5%) compared to the control group (p < 0.001). Compared to the control group, abdominal migraine frequency increased 10 times (p=0.012), functional constipation 7 times (p < 0.001), and fecal incontinence 6 times (p < 0.001) in the ASD group. Stool retention was not present in most children in the ASD group who were found to have fecal incontinence. In this study, the most common FGIDs in the ASD group were abdominal migraine, functional constipation, and non-retentive fecal incontinence. The finding that most children with ASD who had fecal incontinence did not show stool retention implicated social, psychological, and behavioral factors as the causes of incontinence. Raising awareness of healthcare professionals about the frequency of FGIDs in children with ASD will improve many areas in the daily lives of these children.

Ethnobotanical survey of plant species in folkloric medicine in Hawul Local Government Area, Borno State

Area of Borno State was conducted with a view to document the indigenous knowledge of some medicinal plant species found in the area. The information was obtained through semi-structured questionnaire. The benefits, importance and coverage of ethnomedicine were expressed through several quantitative indices including Informant Consensus Factor (ICF), Use Value (UV) and Fidelity Level (FL). The agreement of homogeneity between the present and previous studies and among the indigenous communities was evaluated using the Jaccard Index (JI). A total of fifty-five (55) medicinal plant species, which were distributed in twenty-nine (29) families were documented from one hundred (100) informants. Majority of documented species were trees, and leaves were the most utilised plant parts for the preparation of ethnomedicines. The highest ICF value was 0.77 for digestive system disorders. The information retrieved from the questionnaires revealed that the most common ailments were pile and ulcer. Based on UVs, the two most commonly cited ethnomedicinal plant species in the study area were Khaya senegalensis (0.40) and Piliostigma thonningii (0.35) . The most common method of preparation was by decoction and the major route of administration was oral. Phytochemical profiles showed that flavonoids, alkaloids, phenols, saponins and tannins were the major phytochemical components in Khaya senegalensis and Piliostigma thonningii leaves. This justified the frequent use of these plants in folklore medicine by the traditional herbal practitioners to treat different illnesses.

Assessment of Knowledge and Attitudes of Physicians and Pharmacists on Probiotics: A Cross-Sectional Survey.

Probiotics have been gaining increased attention from the public recently, which originates concerns about their rationale use among healthcare professionals. Although there is evidence on the efficacy and safety of probiotics in certain gastrointestinal disorders, it is important to identify healthcare professionals' opinions on probiotics. This study aimed to identify the opinions of pharmacists and physicians on the use of probiotics. This cross-sectional study was conducted between November, 2017 and August, 2018 among pharmacists and physicians practicing in Ankara, Türkiye. An electronic survey was designed and sent to the participants via e-mail. A total of 361 pharmacists (74.5% female) and 356 physicians (42.4% female) participated in the study. Approximately two-thirds of pharmacists and physicians were familiar with the mechanism of action and indications of probiotics. Most pharmacists and physicians recommended probiotics to be used in gastrointestinal system disorders (99.7% and 97.7%). Other areas that probiotics are commonly recommended was genitourinary system (29.3%) by pharmacists and dermatological symptoms (15.1%) by phycisians, respectively. Considering patient advice regarding the probiotics, pharmacists (63.3%) seemed to receive more requests compared to physicians (30.9%); and with regard to the probiotic recommendation, 70.7% and 38.2% of pharmacists and physicians, respectively, indicated that they have no concerns, but 61% of physicians have concerns on reimbursement policy when prescribing. Pharmacists and physicians are healthcare providers commonly asked about probiotics by patients. Therefore, it is important to address healthcare professionals' concerns and increase their knowledge of the use of probiotics for different health conditions. Given that probiotic products can be purchased without a prescription, healthcare professionals in primary care settings should be more vigilant about the rational use of probiotics.

The Potential of Algae in Treating Celiac Disease

Compounds found in algae, such as bioactive substances, sulfated polysaccharides, and polyunsaturated fatty acids, have been found to have positive effects on the immune system. Previous research has shown that algae can also benefit digestive system disorders. They possess antioxidant and anti-inflammatory properties and can influence the balance of gut microbiota and maintain the integrity of the intestinal lining. Celiac disease (CD), a disorder caused by an abnormal immune response to gluten, results in inflammation and damage to the intestinal lining, leading to problems with nutrient absorption. Although a lifelong gluten-free diet is the only treatment option for this disease, it is challenging to adhere to. Therefore, recent studies have focused on finding supplementary or alternative therapies for celiac disease patients. Traditional medical treatments, like anti-inflammatory and biological drugs, are associated with significant side effects and are not suitable for supplementary therapy for this group of patients. Algae shows promise as a potential research area for treating CD; however, their specific effects on this condition have not been widely studied. The aim of this study was to gather current information and draw attention to the potential use of algae extracts in treating CD to encourage further research in this field.

Risks of digestive diseases in long COVID: evidence from a population-based cohort study

BackgroundIn the post-pandemic era, a wide range of COVID-19 sequelae is of growing health concern. However, the risks of digestive diseases in long COVID have not been comprehensively understood. To investigate the long-term risk of digestive diseases among COVID patients.MethodsIn this large-scale retrospective cohort study with up to 2.6 years follow-up (median follow-up: 0.7 years), the COVID-19 group (n = 112,311), the contemporary comparison group (n = 359,671) and the historical comparison group (n = 370,979) predated the COVID-19 outbreak were built using UK Biobank database. Each digestive outcome was defined as the diagnosis 30 days or more after the onset of COVID-19 infection or the index date. Hazard ratios (HRs) and corresponding 95% confidence intervals (CI) were computed utilizing the Cox regression models after inverse probability weighting.ResultsCompared with the contemporary comparison group, patients with previous COVID-19 infection had higher risks of digestive diseases, including gastrointestinal (GI) dysfunction (HR 1.38 (95% CI 1.26 to 1.51)); peptic ulcer disease (HR 1.23 (1.00 to 1.52)); gastroesophageal reflux disease (GERD) (HR 1.41 (1.30 to 1.53)); gallbladder disease (HR 1.21 (1.06 to 1.38)); severe liver disease (HR 1.35 (1.03 to 1.76)); non-alcoholic liver disease (HR 1.27 (1.09 to 1.47)); and pancreatic disease (HR 1.36 (1.11 to 1.66)). The risks of GERD were increased stepwise with the severity of the acute phase of COVID-19 infection. Even after 1-year follow-up, GERD (HR 1.64 (1.30 to 2.07)) and GI dysfunction (HR 1.35 (1.04 to 1.75)) continued to pose risks to COVID-19 patients. Compared to those with one SARS-CoV-2 infection, reinfected patients were at a higher risk of pancreatic diseases (HR 2.57 (1.23 to 5.38)). The results were consistent when the historical cohort was used as the comparison group.ConclusionsOur study provides insights into the association between COVID-19 and the long-term risk of digestive system disorders. COVID-19 patients are at a higher risk of developing digestive diseases. The risks exhibited a stepwise escalation with the severity of COVID-19, were noted in cases of reinfection, and persisted even after 1-year follow-up. This highlights the need to understand the varying risks of digestive outcomes in COVID-19 patients over time, particularly those who experienced reinfection, and develop appropriate follow-up strategies.

Increasing the effectiveness of complex influence on the condition of parodontal tissue in patients with diseases of the digestive system and having fixed dentures

The study is dedicated to analyzing the effectiveness of comprehensive treatment of periodontal tissues in patients with digestive system diseases who use non-removable prostheses. The work considers the connection between periodontal diseases and digestive system disorders, emphasizing the importance of an integrated approach to treatment. A significant number of patients were included in the study, various clinical and biochemical parameters were evaluated, and a comprehensive methodological approach was used, including statistical analysis. The results of the study showed that a combined approach to treatment significantly improved the oral cavity and periodontal condition in these patients, suggesting greater effectiveness of such integrated strategies for treating periodontal diseases in individuals with digestive system disorders and non-removable dental prostheses. The findings of the study are significant for developing more effective methods of treating periodontal diseases, especially for patients with concurrent digestive system diseases. Objective: to develop and evaluate new methods of comprehensive treatment of the periodontium in patients with digestive system diseases who use non-removable prostheses. Materials and Methods: The study was conducted at the Department of Dentistry of Bukhara State Medical Institute in the years 2020–2023. Participants: 138 patients, aged 18–60, including 101 men and 37 women. Age group distribution: 78 people aged 18–39, 39 people aged 40–49, 21 people aged 50–65. All patients suffered from chronic generalized periodontitis of varying severity, had digestive system diseases, and used non-removable prostheses. The main group included 108 patients with gastrointestinal tract exacerbations: 52 with metal bridge prostheses, 28 with metal-ceramic prostheses, and 28 with dental prostheses on dental implants. The control group consisted of 30 patients: 12 with metal bridge prostheses, 10 with dental prostheses on dental implants, and 8 with metal-ceramic prostheses. Results: The treatment improved clinical-hygienic indicators in patients, reducing OHI-S and PMA indices. The microbial population in the oral cavity significantly decreased, particularly the levels of Lactobacillus and Streptococcus mutans. The effectiveness of the treatment was higher in the first group, with improved microflora and a reduction in pathogens. The use of Traumeel-S, HelboBlue, and ALT-Vostok model 03 contributed to the improvement of periodontal health. Patients experienced a restoration of metabolic processes in periodontal tissues, an increase in the levels of L-arginine and citrulline, and a decrease in nitrates and urea. The integrated approach proved effective in correcting the condition of the periodontium in patients with gastrointestinal diseases and non-removable prostheses.

Ocimum Basilicum (basil/tulsi): a herbal sustainable treasure and its therapeutic potency

Basil is a good source of free radical scavenging compounds that have their traditional medicinal applications that may be successful for future modern medical applications and personal care as well. Ocimum basilicum (Basil) has long been revered for its culinary allure, but its medicinal benefits are equally remarkable. Ocimum basilicum is known for its bioactive therapeutic metabolites. Basil is used in Ayurveda and in traditional medicine to treat digestive system disorders like stomach ache, fever and diarrhoea, kidney infections. Various vegetative parts of Ocimum species were explore by researchers to test their anti-inflammatory and antinociceptive potential. Holy basil is also found to contain eugenol oil that may helpful to treat hypertension. Basil essential oils and its phytochemical compounds were found to exhibit excellent antimicrobial activity against a wide range of Gram-negative and Gram-positive bacteria, yeast, and mold. The analysis of antimicrobial properties was also confirmed that Ocimum basilicum essential oils have excellent inhibiting activity by showing growth inhibition zones ranged from 9.67 to 15.33 mm in Gram-positive microbes and Gram-negative microbes including inhibition zone ranging from 5.33 to 7.33 mm in yeast. Observed lowest minimal inhibition concentration (MIC) of Ocimum basilicum essential oils was 3.21 µL/mL against Gram -negative Azotobacter chrococcum and Gram -positive Micrococcus luteus. Notable highest insecticidal activity was also found against Pyrrhocoris apterus that caused the death of 80% of individuals globally. As a result, Ocimum basilicum essential oils have potent broad spectrum of activity, so that its various extracts can become safe and sustainable herbal choice to preserve fruit and vegetables against plant pathogenic infections.. Hence, this discrete review is strived to explore basil's safe and sustainable therapeutic approaches in combating microbial and viral infections, oxidative stress including improving metabolic disorders, cognitive improvement, strengthening the immune system, oral health and skin wellness.

Regulation of lipids and inflammation by vaisvanara churnam in hypercholesterolemia

Conventional ayurvedic herbal formulations exhibited enormous potential effects to ameliorate hypercholesterolemia. Vaisvanara Churnam (VC), a classic conventional ayurvedic formulation useful to correct digestive system disorders. Hypercholesterolemia is induced by oral administration of 1.5% of cholesterol along with cholic acid (0.5%) and treated with VC (450mg/kg) for 60 days in rats. The objective is to decipher the lipid metabolism regulation via reverse cholesterol transport (RCT) and Toll like receptor, (TLR) signalling pathway in high cholesterol diet fed rats. VC for 60 days in cholesterol co-administered rats tapered off the elevated lipid profile, decreased lipogenic enzymes, enhanced RCT and decreased TLR-NFқB expression, maintains the balance of pro and anti-inflammatory cytokines and boost up the excretion of bile acids. VC thus effectively abolished the established hypercholesterolemia and had a conspicuous protective role against atherogenesis.

استخدام الاعشاب في العلاجات البيطرية لمواشي المربين المحليين

The herbs have a huge role in development of pharmacology besides the role of veterinary medicine in development of human medicine The study aimed to evaluate the therapeutic efficacy of pomegranate peel and leaves of both thuja and tobacco in 5 cows, 15 sheep and 15 goats were brought to veterinary clinics on the outskirts of Baghdad suffering from health problems in the skin, upper respiratory tract and digestive system. Cases were treated topically or orally as a powder, aqueous solution, or ointment. The results showed that 66% of cases were cured. The cure rate was related to the severity of the infection or lesion, course of treatment, routes of administration and herbal formula. Also, the results did not show any side effects of the herbal during the treatment period. Pour- on using of tobacco leaf infusion for lice-infected goats gave a better result than in sheep. The thuja and peels of pomegranate have proven to healing as an ointment for wounds, sores and blisters. Also, the aqueous solution or powder of thuja and peel of pomegranate have proven effective in reducing symptoms in the digestive system and upper respiratory disorders. Both ointments of thuja and pomegranate gave acceptable results for the treatment of warts (papilloma). Therefore, the farmer can use these herbs in emergencies. Recommendation is conducting more clinical veterinary studies on pomegranate, thuja, and tobacco leaves and their medicinal propriety. Thus, the field of veterinary medicine is the best field for reviving biopharmaceutical research and comparative medicine.

PROGNOSTIC SIGNS OF HEPATOPATHY FORMATION IN ADOLESCENTS WITH TYPE 1 DIABETES MELLITUS

Introduction. The incidence of diabetes mellitus in the world among children is steadily increasing. The main striking factor in type 1 diabetes mellitus (T1DM) is hyperglycemia, which affects the formation of liver complications such as glycogenic hepatopathy and non-alcoholic fatty liver disease (NAFLD).&#x0D; The aim of the study is to determine the prognostic signs of hepatopathy formation in adolescents with type 1 diabetes mellitus.&#x0D; Materials and methods. Clinical-anamnestic and laboratory-instrumental examination: glycosylated hemoglobin (HbA1c), aspartate aminotransferase (AST), alanine aminotransferase (ALT), total bilirubin and its fractions, lipidogram. According to the results of ultrasound of the hepatobiliary system, girls and boys with T1DM were divided into groups taking into account the size of the liver. The study included 87 girls and 86 boys aged 8-18 years. Methods of mathematical statistics, system-information analysis, Wald’s heterogeneous sequential statistical procedure with Kulbak’s information measure were used.&#x0D; Results. A comprehensive examination of adolescents with T1DM revealed that 70% of patients had digestive system disorders in the form of pain and dyspeptic syndromes. In 88% of boys and 68% of girls, palpation and ultrasound revealed liver enlargement (χ2 &lt; 0,05). Atherogenic orientation of lipidogram was determined in all adolescents with T1DM. In girls, the difference in β-lipoprotein level and atherogenicity coefficient reached statistical significance compared with boys. In most adolescents, the content of high-density lipoprotein cholesterol was within normal limits, but the frequency of its decrease in boys with liver enlargement was greater compared with girls with liver enlargement (32% and 24%, respectively, χ2 &lt; 0,05). ALT activity significantly exceeded the upper limit of normal only in the group of girls with liver enlargement. Increased ALT activity in girls with enlarged liver appeared 1.5 times more often than in boys of the similar group (respectively 68% and 43%, χ2 &lt; 0,05).&#x0D; Conclusions. In boys with T1DM, significant informative prognostic factors for the formation of hepatopathy are the duration of the disease, increased levels of HbA1c, atherogenic lipoprotein fractions, and ALT activity. In girls with T1DM, the most significant prognostic factor was an increase in ALT activity; the overall informativeness of lipid profile parameters in girls was three times lower compared with boys. The duration of the disease and the degree of compensation were less significant for the formation of hepatopathy in girls.

Effects of Earthquake on Children's Health and Responsibilities of Nurses

Abstract The earthquake, which is one of the natural disasters whose time cannot be determined and causes negative consequences such as the death of many living things, financial losses, and psychological problems, has great effects especially on children. Earthquake has many negative effects on children physically, socially and psychologically. Children have negative consequences such as sleep and eating problems due to fear and anxiety, lack of hygiene, deterioration in family earthquakes, disruption of squinting, drinking, and post-traumatic stress disorder. Apart from these, musculoskeletal system problems, respiratory problems, digestive system disorders are among the health problems that occur due to earthquakes. Every year, hundreds of children are affected by earthquakes in our country. Children are the future of a country and they are vulnerable to the events and people around them. Because they are vulnerable, their rights should be protected by adults. In order to maintain the sibling and family relations of the children affected by the earthquake, to continue their treatment and education; Professionals such as nurses, physicians, teachers, psychologists and physical therapists have great responsibilities. Nurses have important duties in the process of determining the physical, mental and social needs of children affected by the earthquake and meeting these needs. The aim of this study is to evaluate and compile the data on the effects of the earthquake on children's health and the responsibilities of nurses in reducing these effects, and to inform the interested reader about the situation of children being affected by the earthquake and the roles of nurses in reducing these effects. The fact that our country is an earthquake country and children are greatly affected by this situation has revealed the necessity of compiling this article. Keywords: Child health; child mental health; natural disaster; nursing