Differential Pulse Stripping Voltammetry Research Articles

Highly Selective Mercury Detection at Partially Oxidized Graphene/Poly(3,4-Ethylenedioxythiophene):Poly(Styrenesulfonate) Nanocomposite Film-Modified Electrode

Partially oxidized graphene flakes (po-Gr) were obtained from graphite electrode by an electrochemical exfoliation method. As-produced po-Gr flakes were dispersed in water with the assistance of poly(3,4-ethylenedioxythiophene)/poly(styrenesulfonate) (PEDOT:PSS). The po-Gr flakes and the po-Gr/PEDOT:PSS nanocomposite (po-Gr/PEDOT:PSS) were characterized by Raman spectroscopy, Fourier transform-infrared spectroscopy (FT-IR), UV-Vis spectroscopy, X-ray diffraction (XRD) and scanning electron microscopy (SEM). In addition, we demonstrated the potential use of po-Gr/PEDOT:PSS electrode in electrochemical detection of mercury ions (Hg2+) in water samples. The presence of po-Gr sheets in PEDOT:PSS film greatly enhanced the electrochemical response for Hg2+. Cyclic voltammetry measurements showed a well-defined Hg2+ redox peaks with a cathodic peak at 0.23 V, and an anodic peak at 0.42 V. Using differential pulse stripping voltammetry, detection of Hg2+ was achieved in the range of 0.2 to 14 µM (R2 = 0.991), with a limit of detection (LOD) of 0.19 µM for Hg2+. The electrode performed satisfactorily for sensitive and selective detection of Hg2+ in real samples, and the po-Gr/PEDOT:PSS film remains stable on the electrode surface for repeated use. Therefore, our method is potentially suitable for routine Hg2+ sensing in environmental water samples.

Electrochemistry of pertechnetate on ultramicroelectrode: A new quality control for radiopharmaceuticals manufactured at hospital in nuclear medicine

Every day, thousands of diagnostic tests in nuclear medicine are performed on patients around the world wherein pertechnetate-based solutions are taken internally, requiring time-consuming quality controls. In this paper, we demonstrate the use of platinum ultramicroelectrodes coupled to differential pulse stripping voltammetry as an advantageous alternative to conventional quality control for radiopharmaceuticals using paper or thin-layer chromatography and gamma camera. Detection limits lower than 5 nM have been achieved during fast experiments in few minutes with ready-to-use pertechnetate-based physiological solutions. This method can be generic and transposed to other radiopharmaceuticals having an electrochemical activity at a potential different from each others.

A palladium imprinted polymer for highly selective and sensitive electrochemical determination of ultra-trace of palladium ions

We report on the design of a palladium(II)-selective electrode based on the use of palladium(II) imprinted polymer nanoparticles (IP-NPs), and its application for the anodic stripping deferential pulse voltammetry determination of palladium ions. The IP-NPs were obtained by precipitation polymerization of 4-vinylpyridine (the functional monomer), ethylene glycol dimethacrylate (the cross-linker), 2,2'-azobisisobutyronitrile (the initiator), eriochrome cyanine R (the palladium-binding ligand), and palladium ions (the template ion) in methanol solution. After polymerization, the Pd2+ in the polymer nanoparticles were leached out with dilute hydrochloric acid to create cavities for hosting Pd2+. The new sensor showed high selectivity for palladium ions in the presence of common potential interferences according to the specific recognition nature of the synthesized imprinted material. A carbon paste electrode was modified with the IP-NPs, and differential pulse stripping voltammetry was applied as the detection technique after open-circuit sorption of Pd2+ ions and its reduction to the metallic form. An explicit difference in the response was observed between the electrodes modified with IP-NPs and electrodes modified with non-IP-NPs. The modified electrode responses to Pd2+ was linear in the 0.01 nmol dm−3 to 1.0 nmol dm−3 (with sensitivity of 92.25nA/nmol dm−3) and in the 1.0 nmol dm−3 to 1.0μmol dm−3 (with sensitivity of 16.12μA/μmol dm−3) concentration ranges. The limit of detection (LOD) of the sensor was 3.0pmol dm−3 (at S/N=3). The sensor was successfully applied to the trace determination of Pd2+ in spiked environmental water and soil samples.

Electro-analytical Chemistry and Chemo-metrics for Meat Products in the Quantitative Determination of Hazardous Substances

In this study, differential pulse stripping voltammetry meat tissues examined three drug residues salbutamol and ractopamine hydrochloride oxidation peak on the glassy carbon electrode serious overlapping and partially overlapping with clenbuterol, among the three components there is a strong interaction, the mixture is difficult to determine the content of each single component directly. Based on the optimization of the experimental conditions and based on the introduction Chemometrics mixing its components resolved to avoid the tedious separation and purification steps, simplifying the measurement process.

Developing electrochemical sensor for point-of-care diagnostics of oxidative stress marker using imprinted bimetallic Fe/Pd nanoparticle

A novel electrochemical-sensing platform based on imprinted bimetallic Fe/Pd (BI-Fe/Pd) nanoparticle has been fabricated for point-of-care diagnostics of oxidative stress marker (3-nitrotyrosine) in biological fluids. Herein, BI-Fe/Pd nanoparticles are used as a platform on which 3-nitrotyrosine imprinted cavities are created using acrylamide as monomer and N-N′-methylene bisacrylamide as cross-linker. The performance of the obtained imprinted sensor is investigated by cyclic, differential pulse, and square wave voltammetry in stripping mode. The imprinted sensor exhibits high recognition ability and affinity for 3-nitrotyrosine in comparison with the non-imprinted one. In addition, the proposed sensor is capable of measuring 3-nitrotyrosine in aqueous as well as in human blood serum, plasma, and urine samples within the range of 4.90–867.57µgL−1 and 9.90–867.57µgL−1 with detection limit of 1.20µgL−1 and 3.25µgL−1 by square wave and differential pulse stripping voltammetry, respectively. Imprinted BI-Fe/Pd nanoparticle modified sensor shows high affinity and no interference from blood or urine components. Modified sensor was stored for 45 days at room temperature without any detrimental effects to their binding properties. The high affinity of proposed sensor and the lack of requirement for cold chain logistics make them an attractive alternative to the enzyme-linked immunosorbent assay (ELISA) technique.

Eenhanced electrochemical sensing of Nimodipine with Sodium montmorillonite clay

Nano size surface of sodium montmorillonite was prepared via a colloidal physical approach and deposited onto glassy carbon electrodes and used as working electrode. A highly sensitive electrochemical biosensor for the detection of trace amount of calcium channel blocking drug has been designed. The cyclic voltametric behaviour of the drug was studied in media with five ranges of pH. Among the pHs studied, pH 13.0 showed good response for the drug. Differential pulse stripping voltammetry was employed and the optimum condition was arrived at. Accumulation of the substrate was ascertained from SEM analysis. A simple, sensitive and time-saving differential pulse stripping voltammetric procedure has been developed for determination of antihypertensive drug in its commercial tablet. The method was successfully applied to the determination of the drug in tablets and proved to be reliable.

Microfabricated three-electrode on-chip PDMS device with a vibration motor for stripping voltammetric detection of heavy metal ions

A microfabricated three-electrode on-chip device with a vibration motor for stripping voltammetric detection of Cd2+ and Pb2+ ions is introduced. Gold electrodes on a glass substrate are utilized as the counter electrode directly, as well as the working electrode with bismuth coating. The reference electrode is achieved by painting silver/silver chloride layer on the gold layer. Polydimethylsiloxane (PDMS) cover is bonded onto the glass substrate, organizing a compact module. A vibration motor in the device provides vibration as the alternate for stirring to improve detection limits and decrease deposition time. Cyclic voltammetry (CV) is performed with the on-chip reference electrode and a commercial liquid electrolyte Ag/AgCl electrode, showing that the potential shift is less than 20mV. Differential pulse stripping voltammetry (DPSV) is used to detect Cd2+ and Pb2+ ions. Linearity is well defined from 10µg/L to 80µg/L for both ions. Detection limits for Cd2+ and Pb2+ ions are 0.7µg/L and 1.2µg/L, respectively, at 325s deposition without vibration; the limits are 0.11µg/L and 0.25µg/L at 120s deposition with vibration. The reliability is verified by detecting Cd2+ and Pb2+ concentrations of natural water samples and comparing with the results obtained from inductively coupled plasma mass spectrometry (ICP-MS).

A metronidazole-probe sensor based on imprinted biocompatible nanofilm for rapid and sensitive detection of anaerobic protozoan

A novel and simple molecularly imprinted polymer (MIP) based electrochemical sensor is developed for indirect detection of anaerobic protozoans (Entamoeba histolytica and Giardia lamblia) using metronidazole (MDZ) as an electroactive probe molecule. Before electropolymerization, a computational approach was applied to screen functional monomers and polymerization solvents for rational design of a MDZ selective MIP. Based on the theoretical calculations, glutamic acid and water were found to be the best functional monomers and solvent for polymerization, respectively. A thin film of polyglutamic acid along with gold nanoparticles and MDZ was cast onto the surface of a pencil graphite electrode by cyclic voltammetry method for the fabrication of the electrochemical sensor. Surface morphology of the MDZ-imprinted polymer modified electrode was analyzed with a scanning electron microscope, whereas cyclic voltammetry, chronocoulometry and differential pulse stripping voltammetry were performed for qualitative and quantitative analysis of MDZ. The MDZ-imprinted sensor presented a linear response to MDZ in the concentration range from 9.87 ng L−1 to 130.0 mg L−1 with a limit of detection of 1.0 ng L−1 (S/N = 3). The MDZ-selective sensor was further successfully applied to the determination of anaerobic protozoans and showed high sensitivity and reproducibility (liner range from 1.6 to 1.6 × 107 CFU mL−1 with a detection limit of 2.0 CFU mL−1). The research in this study has offered a rapid, accurate and sensitive electrochemical method for quantitative determination of MDZ as well as anaerobic protozoans in a single format.

Evaluation of a new multi-walled carbon nanotube paste electrode modified with Alizarin Red S for the determination of tellurium by differential pulse stripping voltammetry

A new modified carbon paste electrode based on multi-walled carbon nanotube and Alizarin Red S acts as a chelating agent for tellurium(IV) ions, is described. The electrochemical responses were found to be analytically suitable to develop a method for the determination of tellurium at low concentration levels. Under optimised operational conditions, the sensor exhibited linear behaviour in the range of 2.0–300 ng mL−1 (correlation coefficient: 0.9982) with a detection limit of 0.45 ng mL−1. The results indicate that the sensor is sensitive and effective for the determination of tellurium in water samples and certified reference materials.

Synthesis, characterization and application of novel lead imprinted polymer nanoparticles as a high selective electrochemical sensor for ultra-trace determination of lead ions in complex matrixes

We report on the design of a lead(II)-selective electrode based on the use of lead(II) imprinted polymer nanoparticles (IP-NPs), and its application for the differential pulse voltammetry determination of lead ions. The IP-NPs were obtained by precipitation polymerization of 4-vinylpyridine (the functional monomer), ethylene glycol dimethacrylate (the cross-linker), 2,2’-azobisisobutyronitrile (the initiator), 4-(2-pyridylazo)resorcinol (the lead-binding ligand), and lead ions (the template ion) in acetonitrile solution. After polymerization, the Pb(II) in the polymer nanoparticles were leached out with dilute hydrochloric acid to create cavities for hosting Pb(II). The new sensor showed high selectivity for lead ions in the presence of common potential interferences according to the specific recognition nature of the synthesized material. A carbon paste electrode was modified with the IP-NPs, and differential pulse stripping voltammetry was applied as the detection technique after open-circuit sorption of Pb(II) ions and its reduction to the metallic form. An explicit difference in the response was observed between the electrodes modified with IP-NPs and electrodes modified with non-IP-NPs. The modified electrode responds to Pb(II) was linear in the 0.1nM to 10nM (with sensitivity of 49.179nA/nM) and in the 10nM to 10μM (with sensitivity of 30.305μA/μM) concentration range. The limit of detection (LOD) of the sensor was 30 pM (at S/N =3). The sensor was successfully applied to the trace determination of Pb(II) in spiked environmental water samples.

Microscopic gel–liquid interfaces supported by hollow microneedle array for voltammetric drug detection

This report describes a method for integration of a gel–liquid interface in hollow microneedles compatible with minimally invasive, electrochemical detection of drugs in vivo. The electrochemical sensor was characterised using cyclic voltammetry with tetraethyl ammonium. The experimental work demonstrated the detection of propranolol as a representative drug in physiological buffer with the microneedle system. A calibration curve for propranolol was built from measurements with differential pulse stripping voltammetry, indicating a sensitivity of 43nAμM−1, a limit of detection of 50nM and a linear range between 50 and 200nM.

Disposable Electrochemical Aptasensor Array by Using in Situ DNA Hybridization Inducing Silver Nanoparticles Aggregate for Signal Amplification

Nanomaterials as tracing tags have been widely used in biosensors with high sensitivity and selectivity. In this work, a signal amplification electrochemical aptamer sensing strategy for the detection of protein was designed by combining the hybridization-inducing aggregate of DNA-functionalized silver nanoparticles (AgNPs) and differential pulse stripping voltammetry (DPSV) detection. The multiprobes containing hybridization DNA and aptamers were anchored onto the silver nanoparticles. The protein assay was prepared through the immobilization of capture aptamer that specifically recognizes platelet-derived growth factor (PDGF-BB) on gold nanoparticles modified screen-printed electrode (SPE) array. After a sandwich-type reaction, two kinds of DNA-modified AgNPs were simultaneously added on the electrode surface for specifically recognizing PDGF-BB and forming the AgNPs aggregate caused by in situ hybridization of DNA. Compared to the signal-labeled tag, the tracing aggregate tags showed a strong electroactivity for signal amplification through stripping detection of silver after preoxidation. By using the hybridization-inducing aggregate as electrochemical readouts, the sensor showed wide linear range and low detection limit. The hybridization-inducing AgNPs aggregate were further used as tracing tags in multiplied proteins assays for PDGF-BB and thrombin by using the SPE array chip as sensing platform. The cross-talk between different aptamer-modified electrodes on the same array was avoided because of the advantage of labeled AgNPs. The array detection was also applied in the logic gate operation. The proposed method described here is ideal for multianalytes determination in clinical diagnostics with good analytical performance.

Voltammetric Studies of Cu(II) Ion Transfer Reaction with Picolinamide-phenylenevinylene across Liquid/liquid Interfaces and Their Sensing Applications

Voltammetric responses associated with the transfer reaction of Cu(II) cations assisted by picolinamide-phenylenevinylene (picolinamide-PV) across a polarized liquid/liquid interface were investigated and their sensing applications were demonstrated. The transfer process characteristics of Cu(II) ions by picolinamide-PV at the water/1,2-dichloroethane (1,2-DCE) interface was first investigated using cyclic voltammetry. The assisted transfer behavior of Cu(II) ions was then compared to that of Cu(I) ions. In order for Cu(II) ion selective sensing applications, a single microhole interface featuring the water and polyvinylchloride-1,6-dichlorohexane (PVC-1,6-DCH) gel layer incorporating picolinamide-PV was fabricated. The sensitivity for Cu(II) ions was improved by the use of differential pulse stripping voltammetry, which preconcentrates Cu(II) ions in the gel layer by means of holding the transfer potential of Cu(II) ions at 800mV (vs. Ag/AgCl) for 20 s followed by stripping the ions from the gel to the aqueous phase. The Cu(II) ion sensor exhibited a low detectable concentration of 1μM (0.13ppm) Cu(II) ions alongside a linear dynamic range of 1μM (0.13ppm) to 50μM (6.72ppm) Cu(II) cations. An excellent selectivity over Ni2+, Ba2+ and Ca2+ ions was also achieved.

Electrochemical Comparison of the Interaction of 5-Nitrouracil with Single- or Double-Stranded DNA at mercury and glassy carbon electrodes

The interaction of the 5-Nitrouracil (5NU), with ss-, and ds-DNA was investigated electrochemically in absence and presence of copper ions by using cyclic voltammetry (CV) and differential pulse stripping voltammetry (DPSV) at hanging mercury drop electrode (HMDE) and glassy carbon electrode (GCE) surfaces. It was found that, in absence of copper ions, the addition of ss- or ds-DNA to a buffered solution of 5NU results in a decrease on the 5NU redox peak current with a remarkable change in the peak potential (ca. 150 mV vs. Ag/AgCl) at both electrodes. This means that, an interaction of 5NU molecules with both ss- and ds-DNA was observed. The results also demonstrate that a distinguish between ss-, and ds-DNA can be achieved in presence of copper ion through their interaction with 5NU. The binding constants of 5NU with ds-DNA at HMDE and GCE were determined through the changes on the 5NU redox peak currents (at HMDE, 1.45x10^5 and at GCE, 2.65x10^5). The calibration plot for the DNA determination was obtained through the corresponding decreases on the DPSV peak current of 5NU to different additions of DNA (ss- or ds-DNA) concentration levels at the optimum conditions.

Design of a novel hybrid sensor with microelectrode array and LAPS for heavy metal determination using multivariate nonlinear calibration

This paper presents a novel hybrid sensor array for heavy metal determination with self-calibration process by multivariate nonlinear regression (MNLR). Microelectrode array (MEA) and light addressable potentiometric sensor (LAPS) were synchronously fabricated on the same wafer by microfabrication technology. The electrochemical behavior of gold MEAs in different sizes was characterized by cyclic voltammetry. Meanwhile, the detection and quantification of zinc, lead and copper were conducted by differential pulse stripping voltammetry. The sensitivity of zinc, lead and copper are 36.3nA/ppb, 11.2nA/ppb and 4.6nA/ppb, respectively. The electrochemical performance of pH in LAPS was studied with sensitivity of 52.1mV/pH. The reproducibility and long-term stability were investigated in which relative standard deviation of merely 1.45% was observed and less than 4mV deviation was presented in a continuous test of 2h. The acidity of solutions influences the stripping process to great extent due to hydrogen evolution, hydrolysis of heavy metal and hydroxylation of the working electrode. Therefore, a self-calibration process through MNLR was carried out to calibrate the influence of pH and to enhance the detection performance based on the outcomes of heavy metal in MEA and pH in LAPS. The results validate good capability of the hybrid sensor array for trace heavy metal analysis.

Screen-printed carbon electrodes modified with a bismuth film for stripping voltammetric analysis of platinum group metals in environmental samples

The increasing use of platinum group metals, PGMs (e.g. platinum, palladium and rhodium) in catalytic converters and the increasing mining activities for these metals in South Africa, has increased the presence of these metals in the aquatic environment. For this reason, the developments of sensitive detection techniques for metal ions in environmental samples have been investigated in this study. The work reported in this paper describes the development of an adsorptive differential pulse stripping voltammetric procedure for the determination of palladium (Pd), platinum (Pt) and rhodium (Rh) in environmental samples collected from rivers in close proximity to mining activities in South Africa. A screen-printed carbon electrode coated with a bismuth film, SPCE/BiF was constructed. The optimisation of the experimental conditions performed, included an appropriate buffer solution for coating and the supporting electrolyte solution. The voltammetric procedure included pre-concentration of the metals using dimethylglyoxime (DMG) as chelating agent, followed by adsorptive differential pulse stripping voltammetry (AdDPSV) at appropriate deposition potentials for each of Pd, Pt and Rh. Other essential stripping voltammetric parameters optimised included the DMG concentration, composition of the supporting electrolyte, pH, deposition time, and deposition potential. Interference studies in the presence of Ni and Co have also been conducted and showed promising results. The results obtained for this investigation have shown that the detection limits of 0.008μg/L, 0.006μg/L and 0.005μg/L were obtained for Pd(II), Pt(II) and Rh(III) determination respectively, using the SPCE/BiF sensor. The results obtained for Pd(II) determination of freshwater samples have shown that the concentration of Pd(II) in these samples ranged between 2.56–5.17±0.41 ppb (n=3). The results obtained for the Pt(II) concentrations ranged between 0.41–0.71±0.17 ppb (n=3). In the case of the Rh(III) determination, it was found to be 0.14–0.38±0.07 ppb (n=3). It was therefore concluded that the performance of the SPCE/BiF sensor was found to be more sensitive than the GCE/BiF sensor constructed in our laboratory in a previous study. It was further established that the SPCE/BiFE sensor delivers more sensitive results in ammonia buffer (pH=9.2) solution, compared to acetate buffer (pH=4.8) solution.

Graphene-gold Nanoparticle Composite Film Modified Electrode for Determination of Trace Mercury in Environmental Water

The graphene-gold nanoparticles composite film modified glassy carbon electrode (EG- AuNPs/GCE) was prepared by one-step coelectrodeposition and employed for determination of trace mercury in environmental water with differential pulse stripping voltammetry. Such a nanostructured composite film combined with the advantages of gold nanoparticles and graphene, can greatly promote the electron-transfer process and increase accumulation ability for Hg(II), leading to a remarkably improved sensitivity. The linear calibration curve ranged from 0.2 μg/L to 30 μg/L for Hg(II) and the detection limit (S/N=3) was found to be 0.03 μg/L at a deposition time of 300 s. Moreover, the stablity of the as-prepared electrode and interferences from other substances were evaluated. The modified electrode was successfully applied to the direct detection of Hg(II) in real water samples.

Portable Amperometric Perchlorate Selective Sensors with Microhole Array-water/organic Gel Interfaces

A novel stick-shaped portable sensing device featuring a microhole array interface between the polyvinylchloride-2-nitrophenyloctylether (PVC-NPOE) gel and water phase was developed for in-situ sensing of perchlorate ions in real water samples. Perchlorate sensitive sensing responses were obtained based on measuring the current changes with respect to the assisted transfer reaction of perchlorate ions by a perchlorate selective ligand namely, bis(dibenzoylmethanato)Ni(II) (Ni(DBM)2) across the polarized microhole array interface. Cyclic voltammetry was used to characterize the assisted transfer reaction of perchlorate ions by the <TEX>$Ni(DBM)_2$</TEX> ligand when using the portable sensing device. The current response for the transfer of perchlorate anions by <TEX>$Ni(DBM)_2$</TEX> across the micro-water/gel interface linearly increased as a function of the perchlorate ion concentration. The technique of differential pulse stripping voltammetry was also utilized to improve the sensitivity of the perchlorate anion detection down to 10 ppb. This was acquired by preconcentrating perchlorate anions in the gel layer by means of holding the ion transfer potential at 0 mV (vs. Ag/AgCl) for 30 s followed by stripping the complexed perchlorate ion with the ligand. The effect of various potential interfering anions on the perchlorate sensor was also investigated and showed an excellent selectivity over <TEX>$Br^-$</TEX>, <TEX>$NO_2{^-}$</TEX>, <TEX>$NO_3{^-}$</TEX>, <TEX>$CO{_3}^{2^-}$</TEX>, <TEX>$CH_3COO^-$</TEX> and <TEX>$SO{_4}^{2^-}$</TEX> ions. As a final demonstration, some regional water samples from the Sincheon river in Daegu city were analyzed and the data was verified with that of ion chromatography (IC) analysis from one of the Korean-certified water quality evaluation centers.

Electrochemical Behavior and Determination of Rutin at Inlaid Multi-Wall Carbon Nanotubes Modified Graphite Electrode and Reline Ionic Liquids

Inlaid multi-wall carbon nanotubes modified graphite electrode (MWCNTs-GE) was fabricated, combined with Reline Ionic Liquids which possess high conductivity and wide electrochemical window, the electrochemical behavior and determination of Rutin was investigated by cyclic voltammetry and differential pulse stripping voltammetry. The result shows that the oxidation peak current of rutin increased obviously at the inlaid multi-wall carbon nanotubes modified graphite lectrode and in the Reline Ionic Liquids compared to that at the bare graphiteelectrode (GE). In phosphate buffer solution (pH=6.3), one pair of redox peak of rutin was obtained by cyclic voltammetry with 0.32 V of Epaand 0.24 V of Epc. The oxidation peak current value was linearly related to the concentration of rutin in the range of 2×10-6~3×10-5mol·L-1and the detection limit was 9.4×10-7mol·L-1. The average RSD of rutin was 4.0%. The average recovery was 100.2%. The inlaid multi-wall carbon nanotubes modified graphite electrode and the Reline Ionic Liquids had the function of electrocatalysis to oxidation of rutin obviously.This method is reliable, fast and convenient, sensitive and can be used for the determination of the content of rutin.

A novel electrochemical sensor for paracetamol based on molecularly imprinted polymeric micelles

A novel molecular imprinted polymeric (MIP) micelle was prepared via macromolecule self-assembly of an amphiphilic photo-crosslinkable copolymer in combination with a molecular imprinting technique using paracetamol as the template molecule, and applied as a molecular recognition element to construct paracetamol (PCM) electrochemical sensor. The template molecules (PCM) were imbedded in the copolymer micelle during the self-assembly micellization of amphiphilic copolymers through the interactions between PCM and copolymer chain. A robust MIP film was formed in situ on the electrode surface by electrodeposition of the MIP micelles and subsequent photo-crosslinking, leading to successful construction of a MIP sensor. Using differential pulse stripping voltammetry (DPSV), selective detection of PCM in a linear concentration range of 1μM–4mM was obtained, revealing wider linear response and higher upper detection limit of detection compared to previously reported PCM electrochemical sensors, which was attributed to numerous effective recognition sites among the polymer matrix due to the large specific surface area of MIP micelles. In addition, this MIP sensor showed excellent selectivity to PCM, and the interferences from structurely similar analogs were effectively avoided. Excellent stability and repeatability has also been exhibited. Finally, it was successfully applied to detect PCM in real samples with good recoveries. Together, these results indicate that our MIP sensor is a promising platform for accurate and reproducible detection of PCM.