Abstract
Nano size surface of sodium montmorillonite was prepared via a colloidal physical approach and deposited onto glassy carbon electrodes and used as working electrode. A highly sensitive electrochemical biosensor for the detection of trace amount of calcium channel blocking drug has been designed. The cyclic voltametric behaviour of the drug was studied in media with five ranges of pH. Among the pHs studied, pH 13.0 showed good response for the drug. Differential pulse stripping voltammetry was employed and the optimum condition was arrived at. Accumulation of the substrate was ascertained from SEM analysis. A simple, sensitive and time-saving differential pulse stripping voltammetric procedure has been developed for determination of antihypertensive drug in its commercial tablet. The method was successfully applied to the determination of the drug in tablets and proved to be reliable.
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