Purpose- Creativity and innovation in the workplace have been recognized as important determinants of organizational performance and success. In order to fully understand the effect of personality traits of healthcare professionals on job performance, this study aimed to determine the relationship between innovative work behavior and personality traits. Methodology- In this study, it was aimed to evaluate the relationship between innovative work behavior and personality traits. The research was conducted with 120 health managers working in three public hospitals in Istanbul. In the study, data were collected with the Personality Traits Scale developed by Raad et al. (2008) and the Innovative Behavior Scale developed by Scott and Bruce (1994) and adapted into Turkish by Çalışkan et al. (2019). In the study, NCSS (Number Cruncher Statistical System) 2007 (Kaysville, Utah, USA) program was used for statistical analysis. While evaluating the study data, the distribution of the data as well as descriptive statistical methods (Mean, Standard Deviation, Median, Frequency, Ratio, Minimum, Maximum) Shapiro -Assessed with the Wilk Test. Kruskall-Wallis test for comparison of quantitative data of three or more groups; Mann-Whitney U Test was used for comparison of two groups. Spearman's correlation analysis was used to determine the relationship between quantitative data. Simple linear regression analysis was used to determine the factors affecting the dependent variable. Cronbach's Alpha values were found to be at a high level of reliability. Findings- Of the participants, 70.3% (n=64) were male, 39.6% (n=36) were 25-29 years old, 73.6% (n=67) were university graduates. When the work experiences of the participants are examined; It was determined that 38.5% (n=35) of them had 10 years or more experience. When examining the differences between personality traits and innovative work behavior; Compatibility personality traits of male participants were found to be higher than female participants (p=0.001;p<0.05). There is a statistically significant difference in extraversion personality traits according to the experience period of the employees (p=0.013;p<0.05). The extraversion personality trait value of employees aged 1-5 years was found to be statistically significant compared to those working between 5-10 years (p=0.001;p<0.05). It was found statistically significant that the value of the extraversion personality trait of employees aged 1-5 years was higher than those of 10 years or more (p=0.001;p<0.05). The fact that the extraversion value of the manager group was higher than that of the department managers was found to be statistically significant (p=0.001;p<0.05). It was found that the extraversion value of department managers was higher than those in charge of clinics (p=0.001;p<0.05). There was no statistically significant relationship between personality traits of agreeableness, honesty, emotional stability and gender, work experience, age, education level, and duration of experience (p>0.05). There is a positive and weakly significant relationship between extraversion and innovative behavior (r=.247, p<0.05). There was no statistically significant relationship between personality traits of adaptability, honesty, emotional stability and innovative behavior (p>0.05). Conclusion- As a result of the findings obtained based on the analysis in this study; It has been evaluated that innovative behavior is not associated with personality traits of agreeableness, honesty, and emotional stability, but only extroversion personality trait and innovative work behavior. According to the task status, the value of extraversion shows a statistically significant difference. It can be said that the value of extraversion increases as the status of individuals in their duties increases, due to the increase in the quality and quantity of the people they communicate with due to their duties. According to the duration of experience, the value of extraversion shows a statistically significant difference, and as the duration of experience increases, the value of extraversion decreases. In this situation; It can be said that the value of extraversion decreases as the duration of experience increases due to the fact that people have experienced business life more socially and technically. A positive and significant relationship was found between the personality trait of extroversion and innovative work behavior. Keywords: Innovative Behavior, Personality, Personality, Manager, Health Professional JEL Kodlar: J20, M10, L20