Type 2 diabetes mellitus (T2DM) incidence is rising among Asian Americans, including Vietnamese, and is associated with increasing rates of urbanization, population aging, and overweight/obesity. We examined literature targeting diabetes self-management (DSM) beliefs, practices, and culturally informed interventions specific to Vietnamese adults. Using PRISMA systematic review guidelines, we searched CINAHL, Ovid, and Medline databases for research articles published from 2001 to 2019 examining DSM beliefs, practices, and/or interventions among Vietnamese adults with T2DM and/or family members. Of the 971 articles identified, 12 articles representing 11 studies (N = 2,628) met inclusion criteria. Cultural knowledge and beliefs influence Vietnamese health practices and nutrition-based interventions that infuse traditional dietary norms are common. Two studies incorporated digital technology and community health workers in interventions. Appreciating unique health beliefs and practices of Vietnamese adults is critical to designing and testing culturally congruent interventions. Further research involving community-centered approaches to enhance DSM is warranted.