Eight new dibasic acid esters of 3-quinuclidinol have been synthesized and isolated as their free bases using an alcoholysis reaction. A ninth compound, 3-quinuclidinyl hydrogen homophthalate, could not be isolated with sufficient purity to obtain an elemental analysis. However, this compound showed characteristic ester bands and gave a positive hydroxamic acid test. In a preliminary pharmacological evaluation in dogs, 3-quinuclidinyl hydrogen phthalate and 3-quinuclidinyl hydrogen 2,3-pyridinedicarboxylate gave a substantial increase in blood pressure and produced central stimulation as evidenced by a marked increase in respiration. Five compounds showed varying degrees of local anesthetic activity.