Diabetic Mastopathy Research Articles

Diabetic Mastopathy – A Case Report

Introduction: Diabetic mastopathy is a rare benign condition that can occur in patients with long standing Type I or II diabetes mellitus male or female of any age. Diabetic mastopathy is a fibroinflammatory condition that resembles carcinoma of breast. Here, we report a case of Type II Diabetic female patient with suspicious breast lump in right breast Case presentation: A 62 year old female presented with complaints of lump in right breast for 10 days. Clinically, hard lump of size 8x6 cm was palpable in upper outer quadrant. Trucut biopsy showed features of Diabetic mastopathy. Patient undergone wide local excision and biopsy confirmed the diagnosis. Post operative period was uneventful. Discussion: Diabetic mastopathy is an uncommon tumor-like proliferation of fibrous tissue of the breast, clinically and radiologically mimicking breast cancer. Histopathologically, it involves periductal, perilobular and perivascular lymphocytic infiltration. Primary excision with adequate normal tissue margins is the treatment of choice Conclusion: Diabetic mastopathy is a rare clinical entity, however due to increase in prevalence of Diabetes, diagnosis of Diabetic mastopathy should be considered in patients with breast lumps

Case Report: Sclerosing lymphocytic lobulitis of the breast: case report and literature review

Sclerosing lymphocytic lobulitis, also known as diabetic mastopathy, is a rare and benign pathology predominantly observed in young women with type I diabetes, typically with degenerative complications. Clinically, the lesion can mimic carcinoma. Biopsy remains the gold standard for a definitive diagnosis. Radical surgery is generally unnecessary when histological verification can be achievedusing core needle biopsy. This case report details the clinical and radiological findings, as well as the management of a 33-year-old patient with a 22-year history of type I diabetes who presented with sclerosing lymphocytic lobulitis.

Correction to “Diabetic mastopathy: A case report and literature review on a mimic of breast carcinoma in patients with diabetes”

Correction to “Diabetic mastopathy: A case report and literature review on a mimic of breast carcinoma in patients with diabetes”

Diabetic mastopathy in an adult female patient with type 2 diabetes in Indonesia: a case report and literature review

Background: Diabetic mastopathy (DMP) is a rare pathological condition characterized by the formation of tumor-like fibroepithelial lesions in the breast region, typically observed in individuals afflicted with type 1 diabetes mellitus. This study presents an atypical occurrence of diabetic mastopathy found in a 29-year-old female with type 2 diabetes mellitus of the non-insulin-dependent subtype. Case Presentation: The physical examination revealed the presence of a firm and palpable lump near the nipple of the right breast. An ultrasound (US) examination was conducted, illustrating the presence of tissue distortion and nipple retraction of the breast. Lymphadenopathy in the right axilla and infraclavicular regions was also found. Histological findings demonstrated typical DMP with fibrosis without evidence of malignancy. Conclusion: Diabetic mastopathy is a rare disorder that may pose a challenge. However, meticulous monitoring and assertive management, along with timely identification and effective administration of medical care, can ultimately result in a positive prognosis.

A case of diabetic mastopathy: An unusual breast lesion mimicking cancer in type 1 diabetes mellitus

Diabetic mastopathy is a rare fibroinflammatory disorder seen among middle aged and premenopausal age group. It is also called lymphocytic mastopathy or sclerosing lymphocytic mastitis. This is seen associated with type 1 diabetes mellitus and other autoimmune disorders specially related to endocrine disorders like thyroid. The definite diagnosis of diabetic mastopathy is truly based on biopsy and histopathological examination.A 33 year old female came to hospital with complaints of swelling in right breast since one month and pain since one week. She was a known case of type 1 diabetes mellitus since 10 years and on regular medications. Radiological Impression was possibilities of mastitis with abscess formation more likely to be considered. But infiltrating malignant neoplasm with areas of necrosis is also a differential diagnosis. Our histopathology laboratory, we received incision biopsy from right breast and microscopic examination from multiple tissue sections showed breast parenchyma with extensive fibrosis and periductal inflammatory infiltrate predominantly lymphocytes, plasma cells and a few neutrophils. Some of the ducts show epithelial proliferation forming bridges and micropapillae. Histopathological diagnosis was Lymphocytic Mastitis with features of Atypical Ductal Hyperplasia.: The diagnosis of Diabetic Mastopathy is based on clinical details, radiological evaluation and biopsy correlation. Sometimes it’s difficult to differentiate from carcinoma breast, so histopathological examination is indicated for a definitive diagnosis and management.

Diabetic Mastopathy- a diagnostic dilemma

Diabetic Mastopathy- a diagnostic dilemma

Diabetic mastopathy: A case report and literature review on a mimic of breast carcinoma in patients with diabetes

AbstractDiabetic mastopathy is a rare benign breast condition that mimics breast carcinoma in patients with diabetes. Clinicians must differentiate it from malignant causes because of differences in prognosis and management. This paper presents a case report of an 87‐year‐old lady with type 2 diabetes and diabetic mastopathy. We also review the literature on the pathogenesis, clinical presentation, diagnostic workup and management of diabetic mastopathy.

Diabetic mastopathy: A review of a breast carcinoma mimic

Abstract Diabetic mastopathy is a rare fibro-inflammatory breast disease that closely mimics breast carcinoma. The disease predominantly affects insulin-dependent diabetics, and the etiology is still unclear. A proper physical examination, imaging, and core-needle biopsy usually lead to a diagnosis. Management is conservative and revolves around counseling the patient to allay fears and regular follow-up. In this review, we highlight the recent information on diabetic mastopathy with emphasis on historical background, epidemiology, etiopathogenesis, diagnostic approaches, and treatment choices.

Lymphocytic Mastitis with Fibroadenoma – A Case Report

Diabetic mastopathy is an uncommon fibrous tissue lesion of the breast which is usually seen in patients with longstanding type 1 diabetes mellitus. We report a case of diabetic mastopathy in an insulin dependent type 2 diabetes mellitus patient. 47-year-old postmenopausal woman, presented with two lumps, one firm mobile mass and another, a firm-hard mass in the upper inner quadrant of the left breast. Mammography and ultrasonography came out to be BIRADS III lesion. Fine-needle aspiration cytology [FNAC] was performed showing features of fibroadenoma with fibrocystic change. Histopathological examination and Immunohistochemistry studies revealed it to be fibroadenoma along with lymphocytic mastopathy. Keywords: Fibroadenoma, Lymphocytic mastitis, Mimicker, Diabetes

Diabetic Lymphocytic Mastopathy: A Case Report

Diabetic mastopathy (DM) is a recently described pathological entity, rare and benign; occurring in young patients with type I diabetes, or autoimmune disease. Clinically, it mimics breast cancer. Iconographic examinations provide little information. The diagnosis of certainty is histological. We present a case of diabetic mastopathy in a diabetic patient who had been on insulin for 16 years and had multiple degenerative complications. We review the clinical, radiological and evolutionary aspects of this condition.

Diabetic Fibrous Mastopathy: Imaging Features With Histopathologic Correlation.

Diabetic fibrous mastopathy (DFM) is a rare benign fibrotic disease of the breast that develops in patients with longstanding and often uncontrolled diabetes mellitus. Clinically, patients may present with an irregular, firm, palpable mass, which may be solitary or multiple, occurring in one or both breasts. Diabetic fibrous mastopathy occurs most often in premenopausal women with heterogeneously or extremely dense breasts; mammography may show focal asymmetry or, less often, a noncalcified mass with indistinct or obscured margins, but there are usually no discrete findings. On US, DFM may have marked hypoechogenicity and posterior shadowing secondary to extensive fibrosis. Diabetic fibrous mastopathy features on contrast-enhanced MRI are also nonspecific, with gradual persistent nonmass enhancement reported. Because the clinical presentation and US features of DFM overlap with those of breast cancer, histopathologic correlation is needed to confirm diagnosis and exclude malignancy. These findings include collagenous stroma often with keloidal features and chronic perilobular and perivascular inflammation. Histopathologic findings of lymphocytic lobulitis and perivascular inflammation are common to other autoimmune conditions.

Benign breast disease with malignant imaging features: a case report

BackgroundDiabetic mastopathy is a rare breast condition that occurs in women with poorly controlled diabetes and is characterized by hardening of the breast tissue. The purpose of this case report is to provide an overview of the clinical characteristics and therapeutic principles of this rare disease to support front-line physicians in their crucial activity of case identification.Case presentationA 64-year-old Asian female patient with a history of type II diabetes mellitus was referred to our clinic for an evaluation of a newly discovered breast mass. The patient had been diagnosed with diabetes more than 20 years prior and was being managed with oral hypoglycemic agents. Her past medical history was otherwise unremarkable. Physical examination of the breast revealed a palpable, mobile, and firm mass measuring 6 × 4 cm in the upper quadrant of the right breast. Ultrasound images showed an uneven hypoechoic nodule, BI-RADS 4B. Mammography showed the compact and flaky nature of the two breasts and the heterogeneity of the substantive density increases. The patient’s clinical manifestations and imaging findings suggest the possibility of breast cancer. The patient opted for surgical excision of the mass. Through surgery, the mass was completely excised with negative margins. Pathological examination of the mass revealed a proliferation of fibroblastic cells, with an increased nuclear/cytoplasmic ratio, consistent with a diagnosis of diabetic mastopathy.ConclusionsThis case report serves to highlight the importance of recognizing diabetic mastopathy as a possible differential diagnosis of a breast mass in patients with diabetes mellitus. In our patient, early diagnosis and treatment with lumpectomy resulted in a favorable outcome, emphasizing the importance of prompt medical and surgical management. In addition, more research is needed to mine the diagnostic marker of diabetic mastopathy and provide data related to its prognosis.

Dynamic contrast-enhanced MRI (DCE-MRI) features of diabetic mastopathy in T1DM and T2DM: Case report and a review of the literature

BackgroundThe aim of this study was to investigate the imaging features of diabetic mastopathy (DMP) in patients with type 1 and 2 diabetes mellitus (DM) to improve the diagnostic process. In addition, we report two cases from the study hospital and provide a review of the relevant literature. MethodsDynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and pathological findings of patients with diabetic mastopathy (DMP) were reviewed. We searched for DMP studies that included DCE-MRI information between 1980 and 2021 using the MEDLINE database. Cases were dichotomized into two groups: type 1 DM with DMP (T1DMP) and type 2 DM with DMP (T2DMP). DCE-MRI features were compared between the two groups. Statistical analyses were performed using two-sample t-tests and Fisher's exact chi-square tests. ResultsWe retrieved 21 cases of DMP (2/21 were patients of our hospital): 11 patients with T1DMP and 10 with T2DMP. Patients had a 10- to 42-year history of DM. The average onset of age in the T1DMP and T2DMP groups was 41.90 ± 12.261 and 65.00 ± 8.233 years, respectively. Twelve benign lesions presented with no enhancement or mild gradual enhancement (10 cases, T1DMP; 2 cases, T2DMP), and 9 cases showed malignant or suspicious lesions with mass or non-mass early intense enhancement on DCE-MRI (1 case, T1DMP; 8 cases, T2DMP). A comparison of DCE-MRI features between the two DMP groups showed a statistically significant difference (p < 0.001). ConclusionDMP is more likely to occur in patients with long-term poorly controlled DM. MRI findings may support a diagnosis of DMP. Two DCE-MRI types were observed in patients with DMP. Mild gradual enhancement dominated in masses of patients with T1DMP, while intense early enhancement dominated in those with T2DMP, which suggested suspicious or malignant MRI characteristics.

Diabetic mastopathy: A rare clinicopathologic entity with considerable autoimmune potential.

Introduction and importanceDiabetic mastopathy is a rare entity affecting diabetic patients. It has been previously linked to type 1 diabetes mellitus; however, due to the several accompanying conditions, a theory of autoimmune factors contributing to the origin of this condition has been on the rise. In this paper, we report a case of diabetic mastopathy associated with several autoimmune diseases to highlight the immunological potential of this condition.Case presentationA 25-year-old female, known to have type 1 diabetes mellitus, hypertension, hypothyroidism, adrenal insufficiency, dilated cardiomyopathy and end-stage renal disease, was referred to our clinic for a breast lump. Radiological investigations showed a dense mass with irregular borders in the retroareolar area of the left breast. A core biopsy was obtained which revealed keloid-like fibrosis along with lymphocytes infiltrated, suggestive of lymphocytic mastopathy.Clinical discussionFibrous mastopathy has been merely attributed to a long-standing use of insulin therapy by diabetic patients; recent observations, however, proved the major contribution of immunity to etiopathogenesis. Even though human leukocyte antigen (HLA) association has not been supported in the literature, the histological changes of breast lymphocytic infiltrate are seen in patients who not only have T1DM, but also thyroiditis, systemic lupus erythematosus, Sjogren's syndrome, and Addison's disease. The frequent presence of several possible autoimmune conditions has promoted the theory of an autoimmune process affecting connective tissues, however, these claims are yet to be proven by future studies.ConclusionRecent observations have proved the major contribution of immunity to etiopathogenesis of diabetic mastopathy. We shed light on the role of the immune system in triggering the disease process by reporting a case of diabetic mastopathy with a cluster of autoimmune diseases. Future studies should explore the genetic background of the condition as it would potentially have several clinical implications. The discussed pathophysiologic explanations raise the possibility of autoimmunity as a key driver in pathogenesis and indicate the need to change the nomenclature of this condition.

Diabetic Mastopathy Coexisting with Appendix Neuroendocrine Tumor in A Type 1 Diabetic Woman: A Case Report

Diabetic Mastopathy Coexisting with Appendix Neuroendocrine Tumor in A Type 1 Diabetic Woman: A Case Report

Diabetic Mastopathy. Review of Diagnostic Methods and Therapeutic Options.

Diabetic mastopathy is a rare breast condition that may occur in insulin-treated men and women of any age. The etiology is still unclear; however, the autoimmunological background of the disease is highly suspected. The changes in diabetic mastopathy may mimic breast cancer; therefore, its diagnostic process is demanding, and treatment options are not clear and limited. Lesions in DM are usually multiple; therefore, surgical removal is not fully effective. A well-done anamnesis with core-needle biopsy is essential and definitive in most cases. In this review, we summarize up-to-date knowledge of diagnostic methods and therapeutic options for diabetic mastopathy treatment and present three cases of diabetic mastopathy-type lesions in ultrasound and radiological examinations.

"What Do You Mean It's Not Cancer?" A Review of Autoimmune and Systemic Inflammatory Diseases Involving the Breast.

Autoimmune and systemic inflammatory diseases represent a heterogeneous group of immune-mediated conditions with a wide range of clinical presentations and various affected organs. Autoimmune diseases can present in the breast as localized disease or as part of systemic involvement. Although breast involvement is uncommon, the spectrum of imaging findings can include breast masses, axillary adenopathy, calcifications, and skin changes, the appearance of which can mimic breast cancer. Common etiologies include diabetic mastopathy, systemic lupus erythematosus, scleroderma, rheumatoid arthritis, idiopathic granulomatous mastitis, sarcoidosis, and Immunoglobulin-G4 related mastopathy. This educational review will present multimodality imaging findings of breast manifestations of systemic inflammatory and autoimmune diseases and coexisting complications. It will also review how these disorders may affect breast cancer risk and breast cancer treatment options, including radiation therapy.

Diabetic Mastopathy Simulating Breast Cancer: A Case Report with Review of the Literature

Diabetic Mastopathy Simulating Breast Cancer: A Case Report with Review of the Literature

Diabetic mastopathy

Diabetic mastopathy is used to describe the breast related complications of diabetes mellitus. It is a benign breast disease. Its accurate diagnosis in appropriate clinical and radiological setting shall avoid unnecessary surgical excision. Authors report a case of 25 years old female, a known case of Type 1 diabetes mellitus who presented with a rare finding of diabetic mastopathy.

Use of deep inferior epigastric perforator flap reconstruction as single-stage definitive treatment of symptomatic diabetic mastopathy: a case report

Use of deep inferior epigastric perforator flap reconstruction as single-stage definitive treatment of symptomatic diabetic mastopathy: a case report