The energy and delay consumed by the off-chip memory (DRAM) and memory-to-logic chip data movement becomes the bottleneck (known as the memory wall) for the computing systems nowadays, especially for abundant-data computing and neural network accelerators. Larger on-chip memory capacity with high bandwidth can be a solution, yet it is difficult to achieve using SRAM and DRAM. Oxide semiconductor FET (OSFET)-based gain cell memory on the logic platform provides higher density than SRAM due to 3D stacking and is an attractive complement to off-chip DRAM. OSFET with extremely low leakage is used as the write transistor for long retention time, while the read transistor can either adopt OSFET for multiple-layer stacking (OS-OS gain cell) or Si FET for higher read speed (Hybrid gain cell). Designing OSFET gain cell is more than simply choosing materials/device designs that have the lowest off-state leakage current for the longest retention time. Atomic Layer Deposition (ALD) Indium Tin Oxide (ITO) FET is chosen to balance retention time with memory bandwidth. With material, process, and device co-design, the ITO films deposited by ALD with TMIn precursor, 9:1 In:Sn cycle ratio, and 2nm thickness exhibited optimized characteristics for OSFET-based gain cell. The experimentally optimized device exhibits low off-current 2×10-18 A/µm, high on-current 26.8 µA/µm, low SS 70 mV/dec, and high mobility 27 cm2/Vs. It also shows good stability with small VTH shift < 0.2 V under 125 °C, low PBS shift < 0.35 V and low NBS shift < 0.1 V under 1000s bias stress. Oxide semiconductor transistors is an accumulation mode transistor that requires a gate electric field to turn off the transistor. The transistor design calls for nanometer-thin oxide semiconductor channels. Significant device design tradeoffs exists between high on-current, low off-current, short gate length scalability, and the setting of proper threshold voltages. This talk will give an overview of the above experimental achievements today and the device design considerations for future gain cell memories.