Human Development Research Articles

Three Phases of Human Development Index Towards Global Common Stewardship Based on Environmental Kuznets Curve

Three Phases of Human Development Index Towards Global Common Stewardship Based on Environmental Kuznets Curve

Digital wind of changes: navigating competitiveness in the maritime sector through the transformation in human resource development

PurposeThe maritime industry, a linchpin of global trade, has embarked on a transformative journey catalysed by the relentless advance of digitalisation. There is a discernible gap in the literature concerning the specific consequences of digitalisation within the maritime sector. This research aims to examine the current body of literature on the influence of digitalisation in human resource development (HRD) on the competitive advantage of organisations and its potential within the maritime industry.Design/methodology/approachThis research paper conducts a comprehensive bibliometric analysis.FindingsThe findings of this research explore the literature landscape encompassing digitalisation in HRD, its influence on HR operations, learning and development, performance management, employee experience, and strategic alignment within maritime organisations.Originality/valueThis research provides valuable recommendations for maritime organisations and HRD practitioners seeking to leverage digitalisation to gain a competitive edge. Thus, the maritime industry can adopt digital HRD practices to streamline operations, improve performance, and align HR strategies with broader organisational goals.

Effect of prematurely elevated late follicular progesterone on pregnancy outcomes following ovarian stimulation-intrauterine insemination for unexplained infertility: secondary analysis of the AMIGOS trial.

What is the relationship between late follicular phase progesterone levels and clinic pregnancy and live birth rates in couples with unexplained infertility undergoing ovarian stimulation with IUI (OS-IUI)? Late follicular progesterone levels between 1.0 and <1.5 ng/ml were associated with higher live birth and clinical pregnancy rates while the outcomes in groups with higher progesterone levels did not differ appreciably from the <1.0 ng/ml reference group. Elevated late follicular progesterone levels have been associated with lower live birth rates after fresh embryo transfer following controlled ovarian stimulation and egg retrieval, but less is known about whether an association exists with outcomes in OS-IUI cycles. Existing studies are few and have been limited to ovarian stimulation with gonadotrophins, but the use of oral agents, such as clomiphene citrate and letrozole, is common with these treatments and has not been well studied. The study was a prospective cohort analysis of the Assessment of Multiple Intrauterine Gestations from Ovarian Stimulation (AMIGOS) randomized controlled trial. Frozen serum was available for evaluation from 2121 cycles in 828 AMIGOS participants. The primary pregnancy outcome was live birth per cycle, and the secondary pregnancy outcome was clinical pregnancy rate per cycle. Couples with unexplained infertility in the AMIGOS trial, for whom female serum from day of trigger with hCG was available in at least one cycle of treatment, were included. Stored frozen serum samples from day of hCG trigger during treatment with OS-IUI were evaluated for serum progesterone level. Progesterone level <1.0 ng/ml was the reference group for comparison with progesterone categorized in increments of 0.5 ng/ml up to ≥3.0 ng/ml. Unadjusted and adjusted risk ratios (RR) and 95% CI were estimated using cluster-weighted generalized estimating equations to estimate modified Poisson regression models with robust standard errors. Compared to the reference group with 110/1363 live births (8.07%), live birth rates were significantly increased in cycles with progesterone 1.0 to <1.5 ng/ml (49/401 live births, 12.22%) in both the unadjusted (RR 1.56, 95% CI 1.14, 2.13) and treatment-adjusted models (RR 1.51, 95% CI 1.10, 2.06). Clinical pregnancy rates were also higher in this group (55/401 clinical pregnancies, 13.72%) compared to reference group with 130/1363 (9.54%) (unadjusted RR 1.46, 95% CI 1.10, 1.94 and adjusted RR 1.42, 95% CI 1.07, 1.89). In cycles with progesterone 1.5 ng/ml and above, there was no evidence of a difference in clinical pregnancy or live birth rates relative to the reference group. This pattern remained when stratified by ovarian stimulation treatment group but was only statistically significant in letrozole cycles. The AMIGOS trial was not designed to answer this clinical question, and with small numbers in some progesterone categories our analyses were underpowered to detect differences between some groups. Inclusion of cycles with progesterone values above 3.0 ng/ml may have included those wherein ovulation had already occurred at the time the IUI was performed. These cycles would be expected to experience a lower success rate but pregnancy may have occurred with intercourse in the same cycle. Compared to previous literature focusing primarily on OS-IUI cycles using gonadotrophins, these data include patients using oral agents and therefore may be generalizable to the wider population of infertility patients undergoing IUI treatments. Because live births were significantly higher when progesterone ranged from 1.0 to <1.5 ng/ml, further study is needed to clarify whether this progesterone range may truly represent a prognostic indicator in OS-IUI cycles. Oklahoma Shared Clinical and Translational Resources (U54GM104938) National Institute of General Medical Sciences (NIGMS). AMIGOS was funded by the Eunice Kennedy Shriver National Institute of Child Health and Human Development: U10 HD077680, U10 HD39005, U10 HD38992, U10 HD27049, U10 HD38998, U10 HD055942, HD055944, U10 HD055936, and U10HD055925. Research made possible by the funding by American Recovery and Reinvestment Act. Dr Burks has disclosed that she is a member of the Board of Directors of the Pacific Coast Reproductive Society. Dr Hansen has disclosed that he is the recipient of NIH grants unrelated to the present work, and contracts with Ferring International Pharmascience Center US and with May Health unrelated to the present work, as well as consulting fees with May Health also unrelated to the present work. Dr Diamond has disclosed that he is a stockholder and a member of the Board of Directors of Advanced Reproductive Care, Inc., and that he has a patent pending for the administration of progesterone to trigger ovulation. Dr Anderson, Dr Gavrizi, and Dr Peck do not have conflicts of interest to disclose. N/A.

The Imagery of Death in the Visual Discourse of French Illumination of the 13th-15th Centuries: Iconographic Typologies and Artistic Practice

Classical historical and art studies in the context of the development of modern humanities are frequently synthesised with research on visual culture and social art history, forming a broad discourse on the study of the culture of a particular era, country, or community. This optics is taken as the basis for this study, wherein such a fundamental philosophical concept as the attitude towards death is considered from the standpoint of art history iconographic and cultural studies to identify worldviews and ideology in the development of visual narratives that cover and represent them. In this dimension, illuminated manuscripts are the research subject and object where, through the synthesis of text and image, the ability to semiotically read images and decode the symbolic content of cultural categories opens up wide interpretative possibilities for the researcher. The purpose of this study is to outline the wide variability of iconographic typologies associated with the theme of death in the late medieval European culture of the Latin West and to cover the features of the connection of visual culture with the system of worldview representations based on symbolism rooted in religion, folklore, and court aristocratic culture. The proposed study uses an interdisciplinary scientific approach and an art history approach. The research is based on the methods of stylistic and formal analysis, semiotics, and hermeneutics. The typological approach allowed identifying groups of images united by identical semantics of image interpretation, joint compositional and plot solutions designed to accessibly decode their semantics. First, the ontological and metaphysical foundations of the perception of death as a phenomenon in the philosophical and anthropological dimension in culture in general, and in western European culture in particular, are defined and characterised. In the context of the analysis of the features of the symbolic and iconographic interpretation of images of death in the visual culture of illumination of the 13th-15th centuries, groups of images are identified, united by identical semantics of interpretation of these images, joint compositional and plot solutions designed to accessibly decode their semantics, namely the imagery of the death of saints and clergy, imagery of the death of monarchs, the death of soldiers, noble chivalry, the death of fallen in battle, the death of women, imagery of suicides, as well as imagery of violent death, murder. This study covers a wide range of potential recipients in modern humanitarianism and can be useful for historians, medievalists, art historians, anthropologists, and cultural scientists.

In vitro modeling of skeletal muscle ischemia-reperfusion injury based on sphere differentiation culture from human pluripotent stem cells

Skeletal muscle ischemia-reperfusion (IR) injury poses significant challenges due to its local and systemic complications. Traditional studies relying on two-dimensional (2D) cell culture or animal models often fall short of faithfully replicating the human in vivo environment, thereby impeding the translational process from animal research to clinical applications. Three-dimensional (3D) constructs, such as skeletal muscle spheroids with enhanced cell-cell interactions from human pluripotent stem cells (hPSCs) offer a promising alternative by partially mimicking human physiological cellular environment in vivo processes. This study aims to establish an innovative in vitro model, human skeletal muscle spheroids based on sphere differentiation from hPSCs, to investigate human skeletal muscle developmental processes and IR mechanisms within a controlled laboratory setting. By eticulously recapitulating embryonic myogenesis through paraxial mesodermal differentiation of neuro-mesodermal progenitors, we successfully established 3D skeletal muscle spheroids that mirror the dynamic colonization observed during human skeletal muscle development. Co-culturing human skeletal muscle spheroids with spinal cord spheroids facilitated the formation of neuromuscular junctions, providing functional relevance to skeletal muscle spheroids. Furthermore, through oxygen-glucose deprivation/re-oxygenation treatment, 3D skeletal muscle spheroids provide insights into the molecular events and pathogenesis of IR injury. The findings presented in this study significantly contribute to our understanding of skeletal muscle development and offer a robust platform for in vitro studies on skeletal muscle IR injury, holding potential applications in drug testing, therapeutic development, and personalized medicine within the realm of skeletal muscle-related pathologies.

Standardizing a method for functional assessment of neural networks in brain organoids

During the last decade brain organoids have emerged as an attractive model system, allowing stem cells to be differentiated into complex 3D models, recapitulating many aspects of human brain development. Whilst many studies have analysed anatomical and cytoarchitectural characteristics of organoids, their functional characterisation has been limited, and highly variable between studies. Standardised, consistent methods for recording functional activity are critical to providing a functional understanding of neuronal networks at the synaptic and network level that can yield useful information about functional network phenotypes in disease and healthy states. In this study we outline a detailed methodology for calcium imaging and Multi-Electrode Array (MEA) recordings in brain organoids. To illustrate the utility of these functional interrogation techniques in uncovering induced differences in neural network activity we applied various stimulating media protocols. We demonstrate overlapping information from the two modalities, with comparable numbers of active cells in the four treatment groups and an increase in synchronous behaviour in BrainPhys treated groups. Further development of analysis pipelines to reveal network level changes in brain organoids will enrich our understanding of network formation and perturbation in these structures, and aid in the future development of drugs that target neurological disorders at the network level.

국내 과학기술인의 주도적 경력행동 연구: 조직 맥락 요인, 기관 유형, 인재개발 결과와의 구조적 관계 탐색

Not only is there an ever-growing need for career development among science and technology professionals, but the focus of individual career development has also shifted towards one’s proactive career behaviors. Yet, scholarly efforts to investigate the means to promote such behaviors among professionals in the field of science and technology and the potential outcomes of proactive career behaviors remain scarce to date. The current study aims to elucidate science and technology professionals' proactive career behaviors and how their outcomes vary depending on contextual factors within the organization in which they are employed by drawing on the social information process theory. Specifically, we examined the effects of organizational context, categorizing it into role-related factors(jobcontent and structural career plateau) and sociocultural factors(person-supervisor fit and organizational culture). Furthermore, we explored whether these effects differ based on the type of institutions(public institutions and private enterprises), and also whether organizational context factors influenced the professionals' personal development outcomes(career satisfaction and task performance) through proactive career behaviors. We analyzed the 2022 survey data of 2,066 science and technology professionals, provided by the Korea Institute of Human Resources Development in Science &amp; Technology (KIRD). Results revealed that structural career plateau had a negative impact on proactive career behaviors, while personsupervisor fit and innovation-oriented culture had a positive effect. Additionally, both innovation-oriented and task-oriented cultures were found to have a stronger impact on proactive career behaviors in private enterprises. Structural career plateau, person-supervisor fit, and innovation-oriented culture had significant effects on science and technology professionals' career satisfaction and task performance through proactive career behaviors. These findings not only contribute to the expansion of research in the field of science and technology professionals' career development but also provide valuable insights for supporting effective career development for science and technology professionals.

Exploring Canine Connections: Unraveling Human Bonds, Loyalty, Attachment, and Character Development in Anuradha Roy’s Masterpiece ‘The Earth Spinner’

Human beings are dependent on animals in different ways; many animals have been known to sacrifice their life to the owners. One popular animal that lives as a closer companion to the human world is the dog which can be domesticated easily. Among domesticated animals, dogs are generally connected with loyalty and security; they are also represented as catalysts that highlight the finest and worst elements of relationships. Many writers highlighted the characteristics of dogs and used them in their works for several reasons. Anuradha Roy, a noted novelist in contemporary literature effectively combines symbolism and imagery in ‘The Earth Spinner’which shows a strong passion for dogs, both in her professional and personal lives. Applying the Attachment Theory (Bowlby, 1969) this article addresses the significance of the dog in three ways. The first one is the symbolism of loyalty and security; the second one is the exploration of the bonding between the dogs and humans and the last one is to facilitate character development. A dog character in the novel appears as Tashi but plays a pivotal role in making all-round characters important; when Tashi becomes Chinna to another owner it loses its dynamicity. The Communal Riots and religious occurrences negotiate complicated interactions among people and illuminate the novel's numerous topics and Animals symbolism expresses the awareness of ethical considerations about conservation and coexistence which are also highlighted in this paper.

공공연구기관 연구자의 내부결속력, 무형식학습, 지식공유, 혁신행동 간 구조적 관계

The purpose of this study is to investigate the relationship among internal bonding, knowledge sharing, informal learning, and innovative behavior of public research organization researchers. To pursue it, we used the 2022 survey on human resource development in science and technology panel data and analyzed the relationship among four variables; internal bonding, knowledge sharing, informal learning, and innovative behavior through the structural equation modeling and bootstrapping. The results of the study are as follows: Firstly, we found no statistically significant direct impact of internal bonding within public research organizations on innovative behavior. Secondly, Public Research Organization Researchers’ internal bonding influenced informal learning, knowledge sharing. Thirdly, there was no statistically significant direct impact of knowledge sharing within public research organizations on innovative behavior. Additionally, it was difficult to confirm the indirect effect of knowledge sharing between internal bonding and innovation behavior. Fourthly, direct impact between informal learning and the innovative behavior of researchers in public research organizations was not significant. However, informal learning was significant indirect effect between internal bonding and their innovative behavior. Based on these findings, the study suggests several implications for practical interventions and future limitation were outlined.

The Perception of Educators on Gender Equality: A Study in Ecuador

Gender equality is a prerequisite for people-centered human development. This exploratory and descriptive study was conducted to investigate the perception of gender among Ecuadorian primary school teachers. Quantitative data were obtained from teachers in public and urban educational establishments. In order to collect the data, an online survey-type opinion questionnaire was applied with the aim of finding out teachers’ perception of gender equality within their institutions in educational establishments in the Republic of Ecuador, considering the dimensions of personal perceptions of the subject, the organizational culture, and the implementation of gender equality in the internal management of the educational organizations where they work. The results of the questionnaire show that teachers perceive that there is currently more receptiveness to gender issues than in the past. From the answers received, it can be concluded that people identify with gender issues, even though there is a need for elements and support to enable them to be expressed effectively, on a daily basis and sustained over time.

INBio: its innovative work in the knowledge and sustainable use of biodiversity in Costa Rica

The National Institute of Biodiversity of Costa Rica (INBio), the first institution of its kind worldwide, was created in 1989 as a civil society organization, with the mission of promoting greater awareness of the value of biodiversity, to achieve its conservation and promote human development. It operated within the framework of a national biodiversity conservation strategy consisting of three types of actions: “save, know and use”, forming a public-private alliance with the National System of Conservation Areas, whose work represented the first step of “saving”. INBio focused on the generation of scientific knowledge of Costa Rican biodiversity (knowing) and the search and promotion of its intelligent use (using). This article describes the genesis of the institution and its main contributions to the knowledge and use of Costa Rican biodiversity between 1989-2015. These include the results of the protected areas biodiversity inventory process and the development of the largest systematic collection of biological specimens in the country's history, fully systematized; the development of an information management system that integrated all the information from the inventory and the specimens in its collection in digital format, allowing global access to this information or its correlation with that of other sources. The results of promoting and facilitating the use of information through five programs: Natural Sciences and Conservation Biology, for scientific purposes; Bioliteracy and Education, conceptually designed for the teaching and development of awareness about the value of biodiversity; Bioprospecting, the systematic search for economic uses of biodiversity for medicinal, agricultural and industrial purposes; Conservation for Development, the use of the information for wild areas conservation purposes, surrounding communities or nature tourism, among others; Technical Assistance and Training, program in charge of assisting public and private entities, inside and outside the country, in the development of initiatives in which Biodiversity was the central element. The main results of its work and the national and international awards that INBio received for its innovative approaches and contributions are described, as well as the financial and political reasons why INBio discontinued its activities in the period 2015-2016 are summarized. Viewing the work of INBio as a first stage, the importance and need to continue with a state program on the knowledge and use of Costa Rican biodiversity is raised, in addition to its protection, with the goal of creating awareness of its value before the serious threats to life on Earth.

Education Investment and Human Capital Development in India

Purpose: The aim of the study was to analyze the education investment and human capital development in India. Methodology: This study adopted a desk methodology. A desk study research design is commonly known as secondary data collection. This is basically collecting data from existing resources preferably because of its low cost advantage as compared to a field research. Our current study looked into already published studies and reports as the data was easily accessed through online journals and libraries. Findings: Investments in education have boosted human capital development in India, with rising enrollment rates and literacy levels. Challenges like regional disparities and education quality persist, requiring reforms in curriculum, teacher training, and technology integration. Enhancing education quality is vital for India to leverage its demographic dividend for sustainable economic growth. Unique Contribution to Theory, Practice and Policy: Human capital theory, social capital theory &amp; institutional theory may be used to anchor future studies on analyze the education investment and human capital development in India. Invest in comprehensive teacher training programs and professional development opportunities to enhance the quality of teaching and learning in schools. Prioritize education expenditure and allocate a higher proportion of the national budget towards education to ensure adequate funding for infrastructure development, teacher recruitment, student scholarships, and educational initiatives.

CASH WAQF FOR MICROFINANCE: A BIBLIOMETRIC ANALYSIS

Introduction: Waqf is one of the Islamic social financial instruments, having the distinctive characteristic that waqf assets are donated voluntarily by the wakif and are permanently designated for social benefits. Waqf can be used for productive or commercial activities to generate profits by Sharia law. Cash waqf can play a role in supporting the overall development process, both in human resource development, as well as in economic and social development. This study tries to explore the role of cash waqf for microfinance which can subsequently help the people's economy. Methods: The research method used in this research is quantitative research with bibliometric analysis. Data sources collected secondary data obtained from the Google Scholar database. Data were obtained using Publish or Perish (POP) software and analyzed using VOSviewer software. Results: The results of this research show that, from data searches using the keywords "cash waqf", "microfinance" and "sharia microfinance" by limiting 500 papers in the 2010-2024 time period, the words "microfinance institutions" are the most frequent keywords, indicated by a darker color than other keywords. Conclusion and suggestion: Based on the results and analysis, it can be concluded that, from year to year, research on the topic of cash waqf for microfinance is most often used. However, research on the topic of cash waqf for Sharia microfinance is still limited. Therefore, future research can be carried out regarding cash waqf for sharia microfinance. Cash waqf plays an important role in supporting the overall development process, both in human resource development, as well as in economic and social development. The potential of cash waqf can be used as a means of economic empowerment for lower-middle-class communities with the role played by microfinance institutions.

Transformation of Human Resources Development in Realizing a World Class Bureaucracy at the Employment and Human Resources Development Agency of Ogan Ilir District

Transformation of Human Resources Development in Realizing a World Class Bureaucracy at the Employment and Human Resources Development Agency of Ogan Ilir District

The Causal Effects of Nuclear Fusion Reactors, Human Development, and Economic Growth on Nuclear Energy Consumption in the United States

The Causal Effects of Nuclear Fusion Reactors, Human Development, and Economic Growth on Nuclear Energy Consumption in the United States

Do human capital development and innovation matter in sustaining economic development? Panel data evidence from selected developing economies

Do human capital development and innovation matter in sustaining economic development? Panel data evidence from selected developing economies

Global H. pylori recurrence, recrudescence, and re-infection status after successful eradication in pediatric patients: a systematic review and meta-analysis.

Little information is available regarding global H. pylori recurrence, recrudescence, and re-infection in pediatric patients after successful eradication, nor are their influencing factors clear. We conducted a systematic review and meta-analysis to determine global H. pylori recurrence status and its influencing factors in children and adolescents to improve infection management and disease prevention. Published studies on H. pylori recurrence in children and adolescents were collected from major public databases until January 2023. H. pylori recurrences were determined using randomized-effect and fixed-effect models. Stratified analysis was performed based on various regions, countries, publication time, human development indexes (HDIs), and ages. A total of 3310 relevant articles were screened, and 30 articles (1915 participants) were finally enrolled for analysis. The overall H. pylori recurrence rate was 19%, and the annual recurrence rate was 13%. In stratified analysis, H. pylori annual recurrence rate in Asian children was higher than that in Europe (17% vs. 6%) and higher in developing countries than in developed countries (18% vs. 5%). In children aged ≤ 5years, ≤ 10years, and 11-18years, the H. pylori recurrence rates were 30%, 14%, and 8%, respectively. H. pylori recrudescence and re-infection rates were 6% and 10%, respectively, and its recurrence was inversely correlated with HDI. These results provide insights into global H. pylori recurrence, annual recurrence, recrudescence, and re-infection status in pediatric population. The stratified analysis revealed the pattern and seriousness of infection, which requires further efforts to improve patient care.

Digital tools and digital pedagogy for placemaking

PurposeThe surge of digital technologies and information communication technologies poses a challenge to traditional placemaking, influencing how people live, communicate and connect with their environments. In response, placemaking practices are integrating emerging digital technologies, giving rise to digital placemaking. This digital approach aims to present new opportunities for establishing a sense of place, encouraging unique interactions and adding value to communities in social, economic, cultural and environmental aspects.Design/methodology/approachThis paper aims to examine the current landscape of digital tools and apps that facilitate digital placemaking. Conducting an extensive literature review, the research evaluates these tools based on their positive contributions to placemaking, categorizing them according to the aspects they enhance in the placemaking process. These aspects include social dynamics, cultural influences, environmental considerations, artistic qualities, heritage preservation, support for human well-being, urban development and opportunities for digital collaboration among citizens. Additionally, the paper explores digital pedagogy for placemaking, analyzing various tools for their educational approach, knowledge production methods and learning outcomes.FindingsThe findings indicate a growing trend in utilizing digital tools for placemaking, driven by technological advancements like augmented and virtual reality, artificial intelligence and the internet of things. Similar to traditional placemaking, digital practices are collaborative and context-dependent, requiring engagement from multiple stakeholders for optimal success. Notably, successful digital placemaking apps often incorporate interactivity and multimodality. Digital collaborative platforms can significantly impact placemaking and sustainable urban design, serving as effective tools for both bottom-up and top-down knowledge production and learning related to placemaking.Research limitations/implicationsThe findings of this study must be seen considering certain limitations. The scoping review utilized analysis of most relevant bibliometric databases, however, in the domain of digital placemaking there are undertakings by private companies, nongovernmental as well as governmental organizations which are not cited in the scientific databases. This limitation was tackled by using conventional search engines like Google and Bing to identify and study such projects. Also, it must be noted that the digital domain is rapidly developing and being integrated in digital placemaking. Even more, the artificial intelligence technology, which is being applied across all disciplines, with so far unforeseen possibilities, should be further examined how it is being adopted and implemented in the domain of digital placemaking and which are its impacts in the placemaking processes and outcomes.Originality/valueDespite these advancements, many digital tools lack a comprehensive approach to address the various aspects of sustainability in placemaking. Consequently, further research is needed to develop digital tools that adopt a holistic approach, ensuring justifiability and feasibility in social, environmental and economic terms. Furthermore, in alignment with the goals of the EU Green Deal, incorporating Circular Economy principles into the development of new digital placemaking methods and tools is crucial.

Kidney Organoid Modeling of WT1 Mutations Reveals Key Regulatory Paths Underlying Podocyte Development.

Wilms tumor-1(WT1) is a crucial transcription factor that regulates podocyte development. However, the epigenomic mechanism underlying the function of WT1 during podocyte development has yet to be fully elucidated. Here, single-cell chromatin accessibilityand gene expressionmaps of foetal kidneys and kidney organoids are generated. Functional implications of WT1-targeted genes, which are crucial for the development of podocytes and the maintenance of their structure, including BMPER/PAX2/MAGI2 that regulates WNT signaling pathway, MYH9 that maintains actin filament organization and NPHS1 that modulates cell junction assembly are identified. To further illustrate the functional importance of WT1-mediated transcriptional regulation during podocyte development, cultured and implanted patient-derived kidney organoids derived from the Induced Pluripotent Stem Cell (iPSCs) of a patient with a heterozygous missense mutation in WT1 are generated. Results from single-cell RNA sequencing (scRNA-seq)and functional assays confirm that the WT1 mutation leads to delays in podocyte development and causes damage to cell structures, due to its failure to activate the targeting genes MAGI2, MYH9, and NPHS1. Notably, correcting the mutation in the patient iPSCs using CRISPR-Cas9 gene editing rescues the podocyte phenotype. Collectively, this work elucidates the WT1-related epigenomic landscape with respect to human podocyte development and identifies the disease-causing role of a WT1 mutation.

MiR-449a: A Promising Biomarker and Therapeutic Target in Cancer and Other Diseases.

In the regulation of gene expression, epigenetic factors like non-coding RNAs (ncRNAs) play an equal role in genetics. The role of microRNAs (miRNAs), which are members of the ncRNA family, in post-transcriptional gene regulation is well-documented and has important implications for both normal and abnormal biological processes, such as angiogenesis, proliferation, survival, and apoptosis. The purpose of this study was to synthesize previous research on miR-449a by analyzing published results from various databases, as there have been a number of investigations on miR-449's potential involvement in the development of human disorders. Based on our findings, miR-449 is strongly dysregulated in a wide range of diseases, from various cancers to cardiovascular diseases, cognitive impairments, and respiratory diseases, and it may play a pivotal role in the development of these problems. In addition, miR-449a functions as a crucial regulator of the expression of several well-known genes, including E2F-3, BCL2, NOTCH1, and SOX4. This, in turn, modulates various pathways and processes related to cancer, including Notch, PI3K, and TGF-β, and contributes to the improvement of cancer drug sensitivity. Curiously, abnormalities in the expression of this miRNA may serve as diagnostic or prognostic indicators for distinguishing between healthy people and patients or to evaluate the survival rates for specific disorders. This article provides a synopsis of the current understanding of miR-449a's role in human disease development through its regulation of gene expression and the biological processes related to these genes and their linked processes. In addition, we have covered the topic of miR-449a's potential as a clinical feature (diagnosis and prognosis) indicator for a range of disorders, both neoplastic and non-neoplastic. In general, our goal was to gain a thorough comprehension of the numerous functions of miR-449a in different disorders.