Human Development Research Articles

Digitalization's contribution towards sustainable development and climate change mitigation: An empirical evidence from EU economies

The current study aims to test the usage of econometric and machine learning approaches to study the relationship between methane (CH4), a hydrocarbon component of natural gas, as a proxy of carbon emission, GDP as economic growth, financial development (FIN), and medium and high technologies as a proxy of information technology (ICT) and human development (HDI). This study observes two extended moderating effect models of human development index and financial development via medium and high technologies on carbon emissions over the 15-year periods from 2007 to 2021 for the 27 EU economies. Results indicate that when considered solely, ICT, economic growth, and HDI improve environmental quality and contribute to climate change mitigation, reducing methane emissions, whereas financial development seems to damage environmental quality. However, the crossed effects of ICT with HDI, and that of ICT with FIN, were considered in estimations, with results pointing out that those favorably affect climate change mitigation. Jointly considering ICT, HDI, and financial development proves to have a synergistic effect in promoting environmental health than each element on its own. Green and yellow countries were also identified revealing the countries for which a reduction and increase, respectively, in the value of methane emissions is predicted after three years. In the case of the entire panel, the STR (linear regression tree) algorithm predicts an average growth in methane emissions of around 3.64 %. Important policy directions are drawn considering the results obtained.

Single-cell epigenomic reconstruction of developmental trajectories from pluripotency in human neural organoid systems

Cell fate progression of pluripotent progenitors is strictly regulated, resulting in high human cell diversity. Epigenetic modifications also orchestrate cell fate restriction. Unveiling the epigenetic mechanisms underlying human cell diversity has been difficult. In this study, we use human brain and retina organoid models and present single-cell profiling of H3K27ac, H3K27me3 and H3K4me3 histone modifications from progenitor to differentiated neural fates to reconstruct the epigenomic trajectories regulating cell identity acquisition. We capture transitions from pluripotency through neuroepithelium to retinal and brain region and cell type specification. Switching of repressive and activating epigenetic modifications can precede and predict cell fate decisions at each stage, providing a temporal census of gene regulatory elements and transcription factors. Removing H3K27me3 at the neuroectoderm stage disrupts fate restriction, resulting in aberrant cell identity acquisition. Our single-cell epigenome-wide map of human neural organoid development serves as a blueprint to explore human cell fate determination.

Estimating and predicting the human development index with uncertain data: a common weight fuzzy benefit-of-the-doubt machine learning approach

Estimating and predicting the human development index with uncertain data: a common weight fuzzy benefit-of-the-doubt machine learning approach

Immunoexpression Pattern of Autophagy-Related Proteins in Human Congenital Anomalies of the Kidney and Urinary Tract.

The purpose of this study was to evaluate the spatiotemporal immunoexpression pattern of microtubule-associated protein 1 light chain 3 beta (LC3B), glucose-regulated protein 78 (GRP78), heat shock protein 70 (HSP70), and lysosomal-associated membrane protein 2A (LAMP2A) in normal human fetal kidney development (CTRL) and kidneys affected with congenital anomalies of the kidney and urinary tract (CAKUT). Human fetal kidneys (control, horseshoe, dysplastic, duplex, and hypoplastic) from the 18th to the 38th developmental week underwent epifluorescence microscopy analysis after being stained with antibodies. Immunoreactivity was quantified in various kidney structures, and expression dynamics were examined using linear and nonlinear regression modeling. The punctate expression of LC3B was observed mainly in tubules and glomerular cells, with dysplastic kidneys displaying distinct staining patterns. In the control group's glomeruli, LAMP2A showed a sporadic, punctate signal; in contrast to other phenotypes, duplex kidneys showed significantly stronger expression in convoluted tubules. GRP78 had a weaker expression in CAKUT kidneys, especially hypoplastic ones, while normal kidneys exhibited punctate staining of convoluted tubules and glomeruli. HSP70 staining varied among phenotypes, with dysplastic and hypoplastic kidneys exhibiting stronger staining compared to controls. Expression dynamics varied among observed autophagy markers and phenotypes, indicating their potential roles in normal and dysfunctional kidney development.

Features of The Influence of Neuropsychological Correction Methods on Human Physical Development

Features of The Influence of Neuropsychological Correction Methods on Human Physical Development

Human resource development: enhancing entrepreneurial potential in MSMEs

Human resource development: enhancing entrepreneurial potential in MSMEs

Pengaruh Dana Bagi Hasil, Dana Alokasi Umum, dan Dana Alokasi Khusus terhadap Indeks Pembangunan Manusia di Provinsi Nusa Tenggara Timur

Improving the Human Development Index (HDI) is not directly aimed at boosting the economy, but rather at improving the overall quality of human life. This study aims to analyse the effect of Revenue Sharing Funds (DBH), General Allocation Funds (DAU), and Special Allocation Funds (DAK) on the HDI in East Nusa Tenggara (NTT). This study uses a descriptive statistical analysis method with the help of the EViews 10 analysis tool. The study found that partially, the DBH and DAK variables have a positive effect on the HDI. This means that an increase in these variables will increase the HDI. Meanwhile, DAU has a negative influence. This means that each increase in DAU will actually lower the HDI in NTT. Furthermore, simultaneously, the DBH, DAU, and DAK variables have a significant effect on the HDI in NTT.

A Study of the Education-Poverty Relationship in the RA

Poverty and its forms remain a key socio-economic issue worldwide, including in the Republic of Armenia Despite the numerous initiatives developed and implemented to alleviate poverty in Armenia, targeted strategies to overcome this enduring issue continue to evolve, yet the problem remains unresolved. Today, while crafting policies to combat poverty, governments primarily focus not only on meeting the basic material needs of the impoverished population through various social support programs but also on addressing human development issues, emphasizing the provision of a dignified life, social integration, educational opportunities, and overcoming health-related disadvantages.

The nexus between FDI and human development: non-linear evidence from South Asia

PurposeHuman development is critical for fostering economic growth and development. Given the importance of human development, this study examines the asymmetric impact of Foreign Direct Investment (FDI) on human development by decomposing total FDI into positive and negative shocks in five South Asian countries from 1990 to 2021.Design/methodology/approachThe study uses the panel Non-linear Autoregressive Distributive Lag model (NARDL) to examine asymmetric long and short-run effects of FDI. Further, the direction of causality between HDI and FDI is examined using the recently developed (Joudis et al., 2021) panel granger non-causality test.FindingsThe positive and negative FDI shocks positively impact HDI, but positive shocks have a higher effect than negative shocks in the long run. The Wald Test rejects the long-run symmetric effect, confirming the asymmetric relationship between FDI and human development. More importantly, causality results reveal the FDI-led HDI and HDI-led FDI development in South Asia.Practical implicationsFDI should be encouraged by formulating a well-tailored policy intervention. The development policies should be interlinked with FDI policies. Absorptive capacities such as infrastructure facilities, a threshold level of human capital, and institutions should be strengthened to attract higher FDI into high-tech sectors.Originality/valueUnlike the previous empirical studies, this study provides asymmetric evidence between FDI and human development in South Asia.Peer reviewThe peer review history for this article is available at: https://publons.com/publon/10.1108/IJSE-05-2023-0380.

Strategic Management of Human Resources Development (HR) Lecturer at STAI Al Islahiyah Binjai City

This research aims to analyze the strategic management of human resource development for lecturers at STAI Al Islahiyah Binjai. A qualitative approach with analytical methods is this type of research, then data collection efforts are carried out using observation, interviews and documentation methods. The data was declared valid after being tested by data triangulation techniques, and analyzed through the process of data reduction, data display, and drawing conclusions. The results of this research conclude that in quantity the number of lecturers continues to increase (increases) every year. Meanwhile, the weakness is that there are still many lecturers who do not have doctoral qualifications and the number of professors is still small. In the learning aspect, integration-based learning has not yet been realized. Research productivity, publications and community service are also still low. Meanwhile, the challenge currently faced is the demand for the availability of professional and qualified lecturers.

Strategic Management of Human Resources Development (HR) Lecturer at STAI Al Islahiyah Binjai City

This research aims to analyze the strategic management of human resource development for lecturers at STAI Al Islahiyah Binjai. A qualitative approach with analytical methods is this type of research, then data collection efforts are carried out using observation, interviews and documentation methods. The data was declared valid after being tested by data triangulation techniques, and analyzed through the process of data reduction, data display, and drawing conclusions. The results of this research conclude that in quantity the number of lecturers continues to increase (increases) every year. Meanwhile, the weakness is that there are still many lecturers who do not have doctoral qualifications and the number of professors is still small. In the learning aspect, integration-based learning has not yet been realized. Research productivity, publications and community service are also still low. Meanwhile, the challenge currently faced is the demand for the availability of professional and qualified lecturers.

Soft Polyethylene Glycol Hydrogels Support Human PSC Pluripotency and Morphogenesis.

Lumenogenesis within the epiblast represents a critical step in early human development, priming the embryo for future specification and patterning events. However, little is known about the specific mechanisms that drive this process due to the inability to study the early embryo in vivo. While human pluripotent stem cell (hPSC)-based models recapitulate many aspects of the human epiblast, most approaches for generating these 3D structures rely on ill-defined, reconstituted basement membrane matrices. Here, we designed synthetic, nonadhesive polyethylene glycol (PEG) hydrogel matrices to better understand the role of matrix mechanical cues in iPSC morphogenesis, specifically elastic modulus. First, we identified a narrow range of hydrogel moduli that were conducive to the hPSC viability, pluripotency, and differentiation. We then used this platform to investigate the effects of the hydrogel modulus on lumenogenesis, finding that matrices of intermediate stiffness yielded the most epiblast-like aggregates. Conversely, stiffer matrices impeded lumen formation and apico-basal polarization, while the softest matrices yielded polarized but aberrant structures. Our approach offers a simple, modular platform for modeling the human epiblast and investigating the role of matrix cues in its morphogenesis.

Transhumanism and One Health

Abstract In this article, we draw on an interdisciplinary seminar at the University of Basel in the spring semester 2023. The seminar firstly discussed technical transhumanism between improving human lives through technological innovation and breathtaking advances in artificial intelligence (AI). Secondly, integrative approaches to health such as One Health have a transhumanist dimension, meaning that the interaction of human and animal health contributes to human health and development. As technological and biological dimensions of transhumanism raise philosophical, anthropological and ethical questions, we ask what is specifically human and what kind of future human-technology interactions is societally acceptable. With the rapid recent development of AI, questions arise about algorithms taking over human intellectual functions. Transhumanism can be described as a current of a posthumanist turn that generally asks where the limits of the human body and also of human existence lie. From an anthropological point of view a controversial discussion is held ‘beyond the human’ about blurring of the boundaries between humans, animals and nature. The One Health approach demands that animals should not suffer in place of humans and that the health of humans, animals, plants and the environment must be promoted simultaneously. This places the One Health approach in a tension and dilemma between conflicting ethical and purely human demands for the protection and welfare of animals, as well as the legitimate demands for animal food and sheer survival in many areas of the world. A biological transhumanism certainly has less of a claim to surpass specifically human performance and thus stands less or not at all in the more gnostic technological current of technical transhumanism, which replaces human labour and suddenly achieves the ability to turn against humans. One Health impact statement Integrative approaches to health such as One Health have a transhumanist dimension, meaning that the interaction of human and animal health contributes to human health and development. The One Health approach demands that animals should not suffer in place of humans and that the health of humans, animals, plants and the environment must be promoted simultaneously. This places the One Health approach in a tension and dilemma between conflicting ethical and purely human demands for the protection and welfare of animals, as well as the legitimate demands for animal food and sheer survival in many areas of the world. Because of the high variability of the culturally-religiously shaped human-animal-environment relationship, such a transdisciplinary, participatory consensus would need to be contextually adapted, that is, to geographically, culturally-religiously distinct situations.Keywords: Transhumanism, Technical, Biological, One Health, Anthropology, Ontology, Ethics

Pengaruh Pertumbuhan Ekonomi, Indeks Pembangunan Manusia (IPM) dan Pengangguran terhadap Kemiskinan di Provinsi Nusa Tenggara Timur

Poverty is a challenge to development in various sectors characterized by deprivation, inability, and lack. People living in poverty often experience nutritional problems, poor health, high illiteracy rates, inappropriate environments, and limited access, both in rural and urban areas, such as in small poor villages or isolated seaside communities. This research is a quantitative study, which uses a statistical approach to test hypotheses. Specifically, this study analyzes the effect of Economic Growth, Human Development Index, and unemployment rate on the poverty rate in East Nusa Tenggara. Statistical analysis was conducted using panel data regression with the help of Eviews10 software processing. The results show that: the Human Development Index (HDI) has a significant effect on poverty in East Nusa Tenggara Province, while Economic Growth and Unemployment have no significant effect on the poverty rate in East Nusa Tenggara Province.

Perceptual Awareness in Human Infants: What is the Evidence?

Perceptual awareness in infants during the first year of life is understudied, despite the philosophical, scientific, and clinical importance of understanding how and when consciousness emerges during human brain development. Although parents are undoubtedly convinced that their infant is conscious, the lack of adequate experimental paradigms to address this question in preverbal infants has been a hindrance to research on this topic. However, recent behavioral and brain imaging studies have shown that infants are engaged in complex learning from an early age and that their brains are more structured than traditionally thought. I will present a rapid overview of these results, which might provide indirect evidence of early perceptual awareness and then describe how a more systematic approach to this question could stand within the framework of global workspace theory, which identifies specific signatures of conscious perception in adults. Relying on these brain signatures as a benchmark for conscious perception, we can deduce that it exists in the second half of the first year, whereas the evidence before the age of 5 months is less solid, mainly because of the paucity of studies. The question of conscious perception before term remains open, with the possibility of short periods of conscious perception, which would facilitate early learning. Advances in brain imaging and growing interest in this subject should enable us to gain a better understanding of this important issue in the years to come.

Factors that influence the Islamic Perspective Human Development Index as Evidence of the Development of the Muslim Community

This study aims to analyze the relationship between macroeconomics and zakat on the Human Development Index (HDI) and the Islamic Human Development Index (I-HDI) using the maqāṣid al-sharī'ah theory approach. We also calculate I-HDI based on maqāṣid al-sharī'ah theory by combining material and non-material aspects and then compare between I-HDI and HDI. The indicators used in the calculation of I-HDI are indicators that are relevant and in accordance with the objectives of maqāṣid al-sharīʿah, so that I-HDI can give a general picture of the results of human development. By employing the dynamic panel regression two-step Generalized Method of Moments (GMM) the study finds that there is a significant difference and quite a large disparity between the results of the HDI and I-HDI, in 34 provinces of Indonesia. The study reveals that economic growth, health fiscal policy, and zakat have a positive effect both on HDI and I-HDI. Nevertheless, the education fiscal policy variable has a positive effect on I-HDI, and conversely, has a negative effect on HDI. This condition occurs because the target and strategy for absorption of the education budget are not optimally carried out by the government. This research suggests that in formulating budget policies, the government should not only focus on material elements but also non-material elements which are reflected in the I-HDI model.

Analysis of the Effect of Poverty and Economic Growth on the Human Development Index (HDI) in Kalimantan Island

The Human Development Index (HDI) is a tool to assess the effectiveness of a development aimed at improving living standards and can be used as a measure of the status or level of progress of a particular region or country. According to data from the Central Bureau of Statistics (BPS), the poverty rate in Kalimantan Island has decreased between 2013 and 2023, although its economic growth tends to be unstable. However, the HDI in Kalimantan Island continues to experience a significant increase. This research applies quantitative methods with panel data regression analysis. This study was conducted to determine the effect of poverty and economic growth on HDI in Kalimantan Island. The findings of this study show that in Kalimantan Island, HDI is significantly affected by poverty, but not by economic growth. However, when analyzed together, poverty and economic growth have a significant influence on HDI in Kalimantan Island. Following up on the findings of this study, it is important to optimize the Human Development Index to increase the effectiveness of maximum development in Kalimantan Island.

The ENCODE mouse postnatal developmental time course identifies regulatory programs of cell types and cell states.

Postnatal genomic regulation significantly influences tissue and organ maturation but is under-studied relative to existing genomic catalogs of adult tissues or prenatal development in mouse. The ENCODE4 consortium generated the first comprehensive single-nucleus resource of postnatal regulatory events across a diverse set of mouse tissues. The collection spans seven postnatal time points, mirroring human development from childhood to adulthood, and encompasses five core tissues. We identified 30 cell types, further subdivided into 69 subtypes and cell states across adrenal gland, left cerebral cortex, hippocampus, heart, and gastrocnemius muscle. Our annotations cover both known and novel cell differentiation dynamics ranging from early hippocampal neurogenesis to a new sex-specific adrenal gland population during puberty. We used an ensemble Latent Dirichlet Allocation strategy with a curated vocabulary of 2,701 regulatory genes to identify regulatory "topics," each of which is a gene vector, linked to cell type differentiation, subtype specialization, and transitions between cell states. We find recurrent regulatory topics in tissue-resident macrophages, neural cell types, endothelial cells across multiple tissues, and cycling cells of the adrenal gland and heart. Cell-type-specific topics are enriched in transcription factors and microRNA host genes, while chromatin regulators dominate mitosis topics. Corresponding chromatin accessibility data reveal dynamic and sex-specific regulatory elements, with enriched motifs matching transcription factors in regulatory topics. Together, these analyses identify both tissue-specific and common regulatory programs in postnatal development across multiple tissues through the lens of the factors regulating transcription.

The Risk Factors Associated with the Prevalence of Multimorbidity of Anaemia, Malaria, and Malnutrition among Children Aged 6-59 Months in Nigeria.

In the last ten years, multimorbidity in children under the age of five years has become an emerging health issue in developing countries. The study of multimorbidity of anaemia, malaria, and malnutrition (MAMM) among children in Nigeria has not received significant attention. This study aims to investigate what risk factors are associated with the prevalence of multimorbidity among children aged 6 to 59 months in Nigeria. This study used two nationally representative cross-sectional surveys, the 2018 Nigeria Demographic and Health Survey and the 2018 National Human Development Report. A series of multilevel mixed-effect ordered logistic regression models were used to investigate the associations between child/parent/household variables (at level 1), community-related variables (at level 2) and area-related variables (at level 3), and the multimorbidity outcome (no disease, one disease only, two or more diseases). The results show that 48.3% (4917/10,184) of the sample of children aged 6-59 months display two or more of the disease outcomes. Being a female child, the maternal parent having completed higher education, the mother being anaemic, the household wealth quintile being in the richest category, the proportion of community wealth status being high, the region being in the south, and place of residence being rural were among the significant predictors of MAMM (p < 0.05). The prevalence of MAMM found in this study is unacceptably high. If suitable actions are not urgently taken, Nigeria's ability to actualise SDG-3 will be in grave danger. Therefore, suitable policies are necessary to pave the way for the creation/development of integrated care models to ameliorate this problem.

Natural Disasters and Human Development in Asia–Pacific: The Role of External Debt

The average country in Asia–Pacific experiences more natural disasters than average countries of other developing regions. This paper presents stylized facts on natural disasters, human development, and external debt in Asia–Pacific. The paper also contains estimates of the effects that natural disasters have on human development. Controlling for country- and time-fixed effects, the dynamic panel model estimates show that external debt has a mitigating effect on the adverse impacts that natural disasters have on human development; in countries with low external debt-to-GDP ratios, natural disasters significantly decrease the human development index, but not so in countries with high external debt-to-GDP ratios. External debt (i.e., borrowing from abroad) is a financial contract for obtaining resources from abroad (i.e., imports of goods and services). When a country experiencing a natural disaster borrows from abroad to increase imports of goods and services, the population suffers less when a natural disaster strikes. Natural disasters destroy goods and capital (e.g., food, machinery, buildings, and roads) in the countries in which they occur. If imports of goods and services do not increase, then the population has less goods and services to consume following a natural disaster. By increasing imports, which are mirrored on the financial side by an increase in external debt, the population of a country that was struck by a natural disaster can experience consumption smoothing. As the incidence of natural disasters increases globally, a policy recommendation for disaster-prone countries, supported by the empirical results of this paper, is the need for deeper and innovative mechanisms of access to international financing, including reforms in both domestic and international financial systems. The paper’s most significant contribution is the unique lens through which it analyzes the often-studied subject of natural disasters. Rather than looking at disasters as merely adverse events and debt as an unwelcome obligation in isolation, it connects the two and uncovers the paradoxically positive and beneficial role a healthy level of external debt can play in mitigating the adverse effects of these disasters. It provides a fresh perspective, a shift in thinking that may immensely benefit external debt and disaster management policies.